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    11.
    发明专利
    未知

    公开(公告)号：DK313875A

    公开(公告)日：1976-01-12

    申请号：DK313875

    申请日：1975-07-10

    Applicant: HOECHST AG

    Inventor： MAUZ O ,  GRANZER E

    IPC: C07D211/02 ,  C07D211/76 ,  C07D

    Abstract: Piperidone derivatives of the formula in which R1 and R2, which may be identical or different, each represent a hydrogen atom or a halogen atom or an alkyl or alkoxy group of 1 to 9 carbon atoms, process for preparing them and pharmaceutical preparations consisting of, or containing, these compounds.

    PARTIALLY HYDROGENATED 1H-INDENO <1,2-B>-PYRIDINE DERIVATIVES AND PROCESS FOR PREPARING THEM
    12.
    发明专利
    PARTIALLY HYDROGENATED 1H-INDENO <1,2-B>-PYRIDINE DERIVATIVES AND PROCESS FOR PREPARING THEM 未知

    公开(公告)号：ZA743148B

    公开(公告)日：1975-05-28

    申请号：ZA743148

    申请日：1974-05-17

    Applicant: HOECHST AG

    Inventor： GRANZER E ,  KUNSTMANN R

    IPC: C07D221/16 ,  C07D39/00

    Abstract: Partially hydrogenated 1H-indeno[1,2-b]-pyridine derivatives of the general formula I in which R1 and R2, which may be identical or different, represent hydrogen, halogen or alkoxy of 1 to 4 carbon atoms, R3 represents pyridyl, phenyl, or phenyl mono- or di-substituted by halogen, nitro, amino, acylamino, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or amino substituted by 1 or 2 aliphatic or aromatic hydrocarbon groups having 2 to 18 carbon atoms or substituted amino wherein the amino-nitrogen is included in a heterocycle, A represents a single or double bond, and X represents oxygen or sulfur, AND THEIR PHYSIOLOGICALLY TOLERATED SALTS, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM.

    6-PHENOXYMETHYL-4-HYDROXYTETRAHYDROPYRAN-2-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS; INTERMEDIATES IN THE SYNTHESIS OF SUCH COMPOUNDS
    14.
    发明专利
    6-PHENOXYMETHYL-4-HYDROXYTETRAHYDROPYRAN-2-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS; INTERMEDIATES IN THE SYNTHESIS OF SUCH COMPOUNDS 未知

    公开(公告)号：NZ217366A

    公开(公告)日：1989-08-29

    申请号：NZ21736686

    申请日：1986-08-27

    Applicant: HOECHST AG

    Inventor： WESS G ,  GRANZER E ,  BECK G ,  LAU H-H

    IPC: A61K31/365 ,  C07D309/10 ,  C07D309/30 ,  C07F7/18 ,  C07C59/68 ,  A61K31/19

    Abstract: 1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE A 6-phenoxymethyl-4-hydroxytetrahydropyran-2-one of the general formula I see diagramm : EP0216127,P57,F1 in which R**1 and R**5 are identical or different and denote a) halogen, b) cycloalkyl having 4-8 carbon atoms, or a phenyl radical which can be substituted in the nucleus once to 3 times by halogen, trifluoromethyl, and/or alkyl or alkoxy each having 1-4 carbon atoms, or c) a straight-chain or branched alkyl radical having 1 to 18 carbon atoms, or a straight-chain or branched alkenyl radical having 2 to 18 carbon atoms, it being possible for the alkyl and alkenyl radicals in turn to be substituted 1-3 times by alpha) straight-chain or branched alkoxy radicals having up to 10 carbon atoms, or cycloalkyl radicals having 3 to 7 carbon atoms, or straight-chain or branched alkenyloxy or alkynyloxy radicals having 3 to 6 carbon atoms, beta) halogen, hydroxyl, cycloalkyl having 3-7 carbon atoms, unsubstituted phenyl or alpha- or beta-thienyl radicals, or phenyl or alpha- or beta-thienyl radicals which in turn are substituted in the nucleus once to 3 times by halogen, trifluoromethyl and/or alkyl or alkoxy having 1-4 carbon atoms, gamma) unsubstituted phenoxy, benzyloxy, alpha- or beta-thienyloxy radicals, or phenoxy, benzyloxy, alpha- or beta-thienyloxy radicals which in turn are substituted in the nucleus once to 3 times by halogen, trifluoromethyl and/or alkyl or alkoxy having 1 to 4 carbon atoms, delta) the group see diagramm : EP0216127,P57,F2 R**6 denoting : a straight-chain or branched alkyl or alkenyl radical having up to 8 carbon atoms, or a cycloalkyl or cycloalkenyl radical each having 3-8 carbon atoms, or an unsubstituted phenyl radical, or a phenyl radical which in turn is substituted in the nucleus once to 3 times by halogen, trifluoromethyl and/or alkyl or alkoxy having 1-4 carbon atoms, or a 3-pyridyl radical, R**2 and R**4 denote hydrogen, and R**3 is alkyl or alkenyl having up to 4 carbon atoms, halogen or alkoxy having 1-4 carbon atoms, and the corresponding open-chain dihydroxy carboxylic acid, their pharmacologically tolerated salts with bases, and their pharmacologically tolerated esters. 1. Claims for the Contracting State : AT A process for the preparation of a 6-phenoxymethyl-4-hydroxytetrahydropyran-2-one of the general formula I see diagramm : EP0216127,P62,F1 in which R**1 and R**5 are identical or different and denote a) halogen, b) cycloalkyl having 4-8 carbon atoms, or a phenyl radical which can be substituted in the nucleus once to 3 times by halogen, trifluoromethyl and/or alkyl or alkoxy each having 1-4 carbon atoms, or c) a straight-chain or branched alkyl radical having 1 to 18 carbon atoms, or a straight-chain or branched alkenyl radical having 2 to 18 carbon atoms, it being possible for the alkyl and alkenyl radicals in turn to be substituted 2-3 times by alpha) straight-chain or branched alkoxy radicals having up to 10 carbon atoms, or cycloalkoxy radicals having 3 to 7 carbon atoms, or straight-chain or branched alkenyloxy or alkynyloxy radicals having 3 to 6 carbon atoms, beta) halogen, hydroxyl, cycloalkyl having 3-7 carbon atoms, unsubstituted phenyl or alpha- or beta-thienyl radicals, or phenyl or alpha- or beta-thienyl radicals which in turn are substituted in the nucleus once to 3 times by halogen, trifluoromethyl and/or alkyl or alkoxy having 1-4 carbon atoms, gamma) unsubstituted phenoxy, benzyloxy, alpha- or beta-thienyloxy radicals, or phenoxy, benzyloxy, alpha- or beta-thienyloxy radicals which in turn are substituted in the nucleus once to 3 times by halogen, trifluoromethyl and/or alkyl or alkoxy having 1 to 4 carbon atoms, delta) the group see diagramm : EP0216127,P62,F2 R**6 denoting : a straight-chain or branched alkyl or alkenyl having up to 8 carbon atoms, or a cycloalkyl or cycloalkenyl radical each having 3-8 carbon atoms, or an unsubstituted phenyl radical, or a phenyl radical which in turn is substituted in the nucleus once to 3 times by halogen, trifluoromethyl and/or alkyl or alkoxy having 1-4 carbon atoms, or a 3-pyridyl radical, R**2 and R**4 denote hydrogen, and R**3 is alkyl or alkenyl having up to 4 carbon atoms, halogen or alkoxy having 1-4 carbon atoms, and the corresponding open-chain dihydroxy carboxylic acid, their pharmacologically tolerated salts with bases, and their pharmacologically tolerated esters, which comprises a) conversion of an appropriately substituted phenol of the formula II see diagramm : EP0216127,P62,F3 in which R**1 , R**2 , R**3 , R**4 and R**5 have the indicated meanings, with the chiral iodide of the formula III see diagramm : EP0216127,P63,F1 in which R**10 denotes a protective group which is stable to bases and weak acids, into an ether of the formula IV see diagramm : EP0216127,P63,F2 in which R**1 to R**5 have the meanings indicated for formula I and R**10 has the meanings indicated for formula III, b) hydrolysis of the ether of the formula IV to give the corresponding hemiacetal of the formula V see diagramm : EP0216127,P63,F3 in which R**1 to R**5 and R**10 have the meanings indicated for formula I or III, c) oxidation of the hemiacetal of the formula V to give the corresponding lactone of the formula VI see diagramm : EP0216127,P64,F1 in which R**1 to R**5 have the meanings indicated for formula I and R**10 has the meanings indicated for formula III, and d) conversion of the protected hydroxylactone of the formula VI into the 6-phenoxymethyl-4-hydroxytetrahydropyran-2-one of the formula I see diagramm : EP0216127,P64,F2 where appropriate the compound of the formula I which has been obtained being converted into the corresponding open-chain dihydroxy carboxylic acid of the formula VII see diagramm : EP0216127,P64,F3 its salt or its ester, where appropriate a salt or ester which has been obtained being converted into the free dihydroxy carboxylic acid or, where appropriate, the free carboxylic acid being converted into the salt or ester.

    16.
    发明专利
    未知

    公开(公告)号：SE7710084L

    公开(公告)日：1978-03-09

    申请号：SE7710084

    申请日：1977-09-08

    Applicant: HOECHST AG

    Inventor： KNABE B ,  LANG H-J ,  GRANZER E

    IPC: A61K31/425 ,  A61K31/428 ,  A61P3/06 ,  C07C45/63 ,  C07C205/45 ,  C07D277/60 ,  C07D277/84 ,  C07D513/04

    Abstract: Thiazolidine derivatives of the formula I I in which the substituents R1 to R7 have the meanings as indicated in the following and which have in the free form or in the form of their non toxic acid addition salts valuable pharmaceutical properties, processes for preparing them, pharmaceutical preparations on the basis of these compounds and their use as medicines.

    SUBSTITUTE HYDROXYPHENYL-PIPERIDONES
    20.
    发明专利
    SUBSTITUTE HYDROXYPHENYL-PIPERIDONES 未知

    公开(公告)号：ZA754430B

    公开(公告)日：1976-06-30

    申请号：ZA754430

    申请日：1975-07-10

    Applicant: HOECHST AG

    Inventor： GRANZER E ,  MAUZ O

    IPC: C07D211/02 ,  C07D211/76 ,  C07D

    Abstract: Piperidone derivatives of the formula in which R1 and R2, which may be identical or different, each represent a hydrogen atom or a halogen atom or an alkyl or alkoxy group of 1 to 9 carbon atoms, process for preparing them and pharmaceutical preparations consisting of, or containing, these compounds.

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