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    PROCESS FOR THE PREPARATION OF 2,4-11-DEOXYPGE SERIES PROSTAGLANDIN
    1.
    发明授权
    PROCESS FOR THE PREPARATION OF 2,4-11-DEOXYPGE SERIES PROSTAGLANDIN 失效

    公开(公告)号：KR820000509B1

    公开(公告)日：1982-04-10

    申请号：KR780003626

    申请日：1978-11-30

    Applicant: HOECHST AG

    Inventor： BICKEL M ,  BARTMANN W ,  BECK G ,  LERCH U

    IPC: C07C177/00

    Abstract: Title compds.(I; R1 = H, C1-10 hydrocarbon, ammonium ion; R2 = C1-6 aliphatic hydrocarbon) were prepd. by the hydrolysis of IV(R3 = protecting group; Z = CH2 or -C(CH3)2 group) obtained from the reaction of II and III (R4 = C1-4 alkyl or phenyl). Thus, 111.2 g 3-carbomethoxy-2-propenyl-2-triphenyl-phosphonium bromide and 71.6 g methyl-γ-bromo-crotonate were stirred at 26oC for 1.5 hr to give I.

    PROCESS FOR THE PREPARATION OF CYCLOPENTANE DERIVATIVES
    2.
    发明授权
    PROCESS FOR THE PREPARATION OF CYCLOPENTANE DERIVATIVES 失效

    公开(公告)号：KR790001979B1

    公开(公告)日：1979-12-30

    申请号：KR790002417

    申请日：1979-09-20

    Applicant: HOECHST AG

    Inventor： BARTMANN W ,  MILOS BABEJ ,  BECK G

    IPC: C07C177/00

    Abstract: Prostaglandin analogues and their intermediates (I; R1 and R2 are different, H or hydroxyl group, R3 = C1-5 alkyl, R4 = C1-5 alkyl, R5 = tetrahydropyranyl of H,U = (CH2)m, m = 0-5, R6 and R7 are same or not, H or C1-5 alkyl group, V = C1-5 alkyl, W =C1-5 alkyl, X = (CH2) m, m = 0-5). The compds, had strong antiprostaglandin activity. Thus, compd. II was reacted with hydrated metal complex to give I.

    PROCESS FOR THE MANUFACTURE OF NOVEL PROSTAGLANDIN ANALOGS
    3.
    发明授权
    PROCESS FOR THE MANUFACTURE OF NOVEL PROSTAGLANDIN ANALOGS 失效

    公开(公告)号：KR820001258B1

    公开(公告)日：1982-07-14

    申请号：KR770003102

    申请日：1977-12-30

    Applicant: HOECHST AG

    Inventor： BARTMANN W ,  BECK G ,  LERCH U ,  TEUFEL H ,  SCHOELKENS B

    IPC: C07C177/00

    Abstract: Title compds. I(R1,R2 = O, H, HO; R3 = H, C1-8 alip. or Cycloalip. group, C7-9 aralip., substituted ammonium ion; R4 = C1-10 alip. hydrocarbon, C3-7 cycloalip. hydrocarbon; R5 = H, alkyl, alkenyl, alkynyl; R6 = H, alkyl; A = trans -CH=CH- or -CH2-CH2-), useful hypertensives, were prepd. by reacting compd. II with acylating agent contg. C2-11 carboxylic group. Thus, 9-keto-15α--hydroxy-16,16-dimethyl-18- oxa -prosta-2,13-dienic acid methyl ester was dissolved in anhydrous dimethoxy ethane and added to a mixt. of dimethoxy ethane, pyridine and acetyl chloride to give 9-keto-15α-acetoxy-16,16-dimethyl-18-oxa-prosta-2,13-dienic acid methyl ester.

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