公开(公告)号：KR780000115B1

公开(公告)日：1978-04-15

申请号：KR720001960

申请日：1972-12-28

Applicant: HOECHST AG

Inventor： GEBERT U ,  GRANZER E

IPC: C07D233/54 ,  C07D233/64 ,  C07D235/12 ,  C07D235/18 ,  C07D235/20

公开(公告)号：AU514855B2

公开(公告)日：1981-03-05

申请号：AU3181477

申请日：1977-12-21

Applicant: HOECHST AG

Inventor： GEBERT U ,  GRANZER E ,  GREVE H-G ,  THORWART W

IPC: C07D295/08 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P19/06 ,  C07D209/14 ,  C07D211/14 ,  C07D213/53 ,  C07D213/80 ,  C07D295/088 ,  C07D303/12 ,  C07D303/36 ,  C07D333/22 ,  C07D409/12 ,  C07D211/28 ,  C07D211/18 ,  C07D401/12 ,  C07D403/12

Abstract: Compounds of general formula (I) wherein R1 represents a member selected from the group consisting of (a) an unsubstituted at most binuclear aryl group having from 6 to 10 carbon atoms, such groups substituted by from 1 to 3 equal or different radicals selected from the group consisting of alkyl, halogenoalkyl, alkoxy, dialkylamino each having up to 4 carbon atoms in the alkyl moiety, halogen phenyl, carboxyl, cyano, nitro and hydroxy groups, (b) a 5- to 6-membered heteroaromatic ring wherein the heteroatom is selected from nitrogen, oxygen and sulfur atoms and such rings anellated to a benzene nucleus; R2 represents a member selected from the group consisting of hydrogen, alkyl having up to 3 carbon atoms, phenyl, cycloalkyl having up to 6 carbon atoms in the ring and cycloalkyl bearing a hydrocarbon bridging radical having up to 2 carbon atoms; R3 represents hydrogen, hydroxy or acyloxy; R4 and R5 are the same or different and each represents a member selected from the group consisting of halogen, alkyl, and halogenoalkyl each having up to 3 carbon atoms, and nitro; and X represents nitrogen or methine and physiologically acceptable acid addition salts thereof and a pharmaceutical composition containing said compounds.

公开(公告)号：AU509651B2

公开(公告)日：1980-05-22

申请号：AU2865777

申请日：1977-09-08

Applicant: HOECHST AG

Inventor： KNABE B ,  LANG H-J ,  GRANZER E

IPC: A61K31/425 ,  A61K31/428 ,  A61P3/06 ,  C07C45/63 ,  C07C205/45 ,  C07D277/60 ,  C07D277/84 ,  C07D513/04 ,  C07C49/80 ,  C07C79/36 ,  C07C149/26 ,  A61K31/505

Abstract: Thiazolidine derivatives of the formula I I in which the substituents R1 to R7 have the meanings as indicated in the following and which have in the free form or in the form of their non toxic acid addition salts valuable pharmaceutical properties, processes for preparing them, pharmaceutical preparations on the basis of these compounds and their use as medicines.

公开(公告)号：NZ185078A

公开(公告)日：1979-03-28

申请号：NZ18507877

申请日：1977-09-02

Applicant: HOECHST AG

Inventor： WEYER R ,  HITZEL V ,  GRANZER E

IPC: A61K31/195 ,  A61K31/38 ,  A61K31/381 ,  A61P3/06 ,  C07C229/38 ,  C07C233/81 ,  C07C235/52 ,  C07D333/38

Abstract: Benzoic acids of the general formula I I in which R, R1, R2 and Y have the meanings as mentioned in the following, and which in the form of the free compounds or in the form of the physiologically tolerated salts and esters possess valuable pharmacological properties, processes for preparing them, pharmaceutical preparations containing them, and their use as or in medicaments.

公开(公告)号：ZA7707584B

公开(公告)日：1978-11-29

申请号：ZA7707584

申请日：1977-12-21

Applicant: HOECHST AG

Inventor： GEBERT U ,  GREVE H ,  GRANZER E ,  THORWART W

IPC: C07D295/08 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P19/06 ,  C07D209/14 ,  C07D211/14 ,  C07D213/53 ,  C07D213/80 ,  C07D295/088 ,  C07D303/12 ,  C07D303/36 ,  C07D333/22 ,  C07D409/12 ,  A61K31/15 ,  A61K31/50 ,  C07C131/00

CPC classification number: C07D213/53 ,  C07D209/14 ,  C07D211/14 ,  C07D213/80 ,  C07D295/088 ,  C07D303/12 ,  C07D333/22

公开(公告)号：ZA7705333B

公开(公告)日：1978-07-26

申请号：ZA7705333

申请日：1977-09-02

Applicant: HOECHST AG

Inventor： WEYER R ,  HITZEL V ,  GRANZER E

IPC: A61K31/195 ,  A61K31/38 ,  A61K31/381 ,  A61P3/06 ,  C07C229/38 ,  C07C233/81 ,  C07C235/52 ,  C07D333/38 ,  C07C ,  A61K

CPC classification number: C07C229/38 ,  C07D333/38

公开(公告)号：ZA7705045B

公开(公告)日：1978-07-26

申请号：ZA7705045

申请日：1977-08-19

Applicant: HOECHST AG

Inventor： HITZEL V ,  GRANZER E ,  WEYER R

IPC: C07D213/80 ,  C07D213/85 ,  C07D

CPC classification number: C07D213/80 ,  C07C255/00 ,  C07D213/85

公开(公告)号：SE7714684L

公开(公告)日：1978-06-25

申请号：SE7714684

申请日：1977-12-22

Applicant: HOECHST AG

Inventor： GEBERT U ,  GRANZER E ,  GREVE H-G ,  THORWART W

IPC: C07D295/08 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P19/06 ,  C07D209/14 ,  C07D211/14 ,  C07D213/53 ,  C07D213/80 ,  C07D295/088 ,  C07D303/12 ,  C07D303/36 ,  C07D333/22 ,  C07D409/12 ,  C07D295/12

Abstract: Compounds of general formula (I) wherein R1 represents a member selected from the group consisting of (a) an unsubstituted at most binuclear aryl group having from 6 to 10 carbon atoms, such groups substituted by from 1 to 3 equal or different radicals selected from the group consisting of alkyl, halogenoalkyl, alkoxy, dialkylamino each having up to 4 carbon atoms in the alkyl moiety, halogen phenyl, carboxyl, cyano, nitro and hydroxy groups, (b) a 5- to 6-membered heteroaromatic ring wherein the heteroatom is selected from nitrogen, oxygen and sulfur atoms and such rings anellated to a benzene nucleus; R2 represents a member selected from the group consisting of hydrogen, alkyl having up to 3 carbon atoms, phenyl, cycloalkyl having up to 6 carbon atoms in the ring and cycloalkyl bearing a hydrocarbon bridging radical having up to 2 carbon atoms; R3 represents hydrogen, hydroxy or acyloxy; R4 and R5 are the same or different and each represents a member selected from the group consisting of halogen, alkyl, and halogenoalkyl each having up to 3 carbon atoms, and nitro; and X represents nitrogen or methine and physiologically acceptable acid addition salts thereof and a pharmaceutical composition containing said compounds.

公开(公告)号：DK575077A

公开(公告)日：1978-06-25

申请号：DK575077

申请日：1977-12-22

Applicant: HOECHST AG

Inventor： GEBERT U ,  GRANZER E ,  GREVE H G ,  THORWART W

IPC: C07D295/08 ,  A61K31/445 ,  A61K31/451 ,  A61K31/495 ,  A61P3/06 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P19/06 ,  C07D209/14 ,  C07D211/14 ,  C07D213/53 ,  C07D213/80 ,  C07D295/088 ,  C07D303/12 ,  C07D303/36 ,  C07D333/22 ,  C07D409/12 ,  C07D

Abstract: Compounds of general formula (I) wherein R1 represents a member selected from the group consisting of (a) an unsubstituted at most binuclear aryl group having from 6 to 10 carbon atoms, such groups substituted by from 1 to 3 equal or different radicals selected from the group consisting of alkyl, halogenoalkyl, alkoxy, dialkylamino each having up to 4 carbon atoms in the alkyl moiety, halogen phenyl, carboxyl, cyano, nitro and hydroxy groups, (b) a 5- to 6-membered heteroaromatic ring wherein the heteroatom is selected from nitrogen, oxygen and sulfur atoms and such rings anellated to a benzene nucleus; R2 represents a member selected from the group consisting of hydrogen, alkyl having up to 3 carbon atoms, phenyl, cycloalkyl having up to 6 carbon atoms in the ring and cycloalkyl bearing a hydrocarbon bridging radical having up to 2 carbon atoms; R3 represents hydrogen, hydroxy or acyloxy; R4 and R5 are the same or different and each represents a member selected from the group consisting of halogen, alkyl, and halogenoalkyl each having up to 3 carbon atoms, and nitro; and X represents nitrogen or methine and physiologically acceptable acid addition salts thereof and a pharmaceutical composition containing said compounds.

公开(公告)号：SE7507835L

公开(公告)日：1976-01-12

申请号：SE7507835

申请日：1975-07-08

Applicant: HOECHST AG

Inventor： MAUZ O ,  GRANZER E

IPC: C07D211/02 ,  C07D211/76 ,  C07D211/40

Abstract: Piperidone derivatives of the formula in which R1 and R2, which may be identical or different, each represent a hydrogen atom or a halogen atom or an alkyl or alkoxy group of 1 to 9 carbon atoms, process for preparing them and pharmaceutical preparations consisting of, or containing, these compounds.