公开(公告)号：NO931134L

公开(公告)日：1993-09-29

申请号：NO931134

申请日：1993-03-26

Applicant: HOECHST AG

Inventor： JAEHNE GERHARD ,  HELSBERG MATTHIAS ,  WINKLER IRVIN ,  GROSS GERHARD ,  SCHOLL THOMAS

IPC: A61K31/52 ,  A61P31/12 ,  C07D473/00 ,  C07D473/32

Abstract: Compounds of the formula 1 in which the radicals R and/or R independently of one another represent acyl radicals of the formula -C(=O)-R (2> where R denotes C1-C3-alkyl and one of the radicals R and R can also denote hydrogen, and their physiologically tolerable salts have an antiviral action.

公开(公告)号：FI934153A0

公开(公告)日：1993-09-22

申请号：FI934153

申请日：1993-09-22

Applicant: HOECHST AG

Inventor： JAEHNE GERHARD ,  HELSBERG MATTHIAS ,  WINKLER IRVIN ,  GROSS GERHARD ,  SCHOLL THOMAS

IPC: A61K31/505 ,  A61P31/12 ,  C07D487/04 ,  C07F9/6561

Abstract: Compounds of the formula I in which the substituents X, Y, R , R and R have the meanings mentioned, have antiviral activity.

公开(公告)号：HUT63173A

公开(公告)日：1993-07-28

申请号：HU9300162

申请日：1993-01-21

Applicant: HOECHST AG

Inventor： UHLMANN EUGEN ,  PEYMAN ANUSCHIRWAN ,  O'MALLEY GERALD ,  HELSBERG MATTHIAS ,  WINKLER IRVIN

IPC: A61K31/70 ,  A61K31/7125 ,  A61K48/00 ,  A61P31/12 ,  A61P35/00 ,  C07F9/22 ,  C07F9/24 ,  C07H1/00 ,  C07H21/00 ,  C07H21/04 ,  C12Q1/68 ,  C07H19/20 ,  C07H19/10

Abstract: The invention relates to compounds of the formula I in which R is H, alkyl, acyl, aryl or a phosphate residue; R is H, OH, alkoxy, NH2 or halogen; B is a base customary in nucleotide chemistry; a is O or CH2; n is an integer from 1 to 100; W is O, S or Se; V is O, S or NH; Y is O, S, NH or CH2; Y' is O, S, NH or alkylene; X is OH or SH; U is OH, SH, SeH, alkyl, aryl or amine, and Z is OH, SH, SeH, an optionally substituted radical from the series comprising alkyl, aryl, heteroaryl, alkoxy or amino or a group which favours intracellular uptake or as labelling of a DNA probe or which on hybridisation interacts with the target nucleic acid, where if Z is OH, SH, CH3 or OC2H5, at least one of the groups X, Y, Y', V, W is not equal to OH or O, or R is not equal to H; process for their preparation and their use as inhibitors of gene expression, as probes for detecting nucleic acids and as aids in molecular biology.

公开(公告)号：NO930200A

公开(公告)日：1993-07-23

申请号：NO930200

申请日：1993-01-21

Applicant: HOECHST AG

Inventor： UHLMANN EUGEN ,  PEYMAN ANUSCHIRWAN ,  O'MALLEY GERARD ,  HELSBERG MATTHIAS ,  WINKLER IRVIN

IPC: A61K31/70 ,  A61K31/7125 ,  A61K48/00 ,  A61P31/12 ,  A61P35/00 ,  C07F9/24 ,  C07F9/44 ,  C07H21/00 ,  C07H21/04 ,  C12Q1/68 ,  C07H19/20 ,  C07H19/10

CPC classification number: C07H21/00

公开(公告)号：IE922192A1

公开(公告)日：1993-01-13

申请号：IE922192

申请日：1992-07-03

Applicant: HOECHST AG

Inventor： JAHNE GERHARD ,  WINKLER IRVIN ,  HELSBERG MATTHIAS ,  HANEL HEINZ

IPC: C07D249/00 ,  A61K31/395 ,  A61K31/40 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/50 ,  A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  A61P31/12 ,  A61P33/02 ,  C07D209/48 ,  C07D213/64 ,  C07D213/68 ,  C07D237/14 ,  C07D239/32 ,  C07D239/38 ,  C07D239/46 ,  C07D239/47 ,  C07D239/54 ,  C07D239/553 ,  C07D403/04 ,  C07D471/04 ,  C07D473/00 ,  C07D473/18 ,  C07D473/30 ,  C07D473/34 ,  C07D473/38 ,  C07D473/40 ,  C07D487/04 ,  C07D498/04 ,  C07D521/00 ,  C07F7/10 ,  C07D211/74

Abstract: Compounds of the formulae I and II in which the substituents N, R , R and R and also n have the meanings mentioned, have an antiviral and antiparasitic action.

公开(公告)号：ZA912015B

公开(公告)日：1991-12-24

申请号：ZA912015

申请日：1991-03-19

Applicant: HOECHST AG

Inventor： JAEHNE GERHARD ,  GERHARD JAEHNE ,  ROESNER MANFRED ,  MANFRED ROESNER ,  WINKLER IRVIN ,  IRVIN WINKLER ,  HELSBERG MATTHIAS ,  MATTHIAS HELSBERG ,  SCHOLL THOMAS ,  THOMAS SCHOLL

IPC: A61K31/52 ,  A61K31/522 ,  A61P31/12 ,  A61P31/22 ,  C07D473/00 ,  C07D473/04 ,  C07D473/16 ,  C07D473/18 ,  C07D473/20 ,  C07D473/22 ,  C07D473/24 ,  C07D473/28 ,  C07D473/32 ,  C07D473/34 ,  C07D473/36 ,  C07D473/40 ,  C07D ,  A61K

Abstract: Purine derivs. of formula (I) and their salts are new. R1 = H, halo, NH3, OH, 1-6C alkoxy, -O-CH2Ph, -OPh, SH, 1-6C alkylthio, -S-CH2Ph, -SPh, NH2, 1-6C alkylamino, -NH-CH2Ph, -NH-Ph, 2-12C dialkylamino, -N(CH2Ph)2, cyclic dialkylamino, -N(Ph)2, 1-8C acylamino, 2-16C diacylamino, (N-alkyl-2-pyrrolidin-yliden)amino or 2-10C dialkylaminomethylidenamino; R2 = H, halo, N3, OH, SH, NH2, 1-6C alkylamino, 2-12C dialkylamino, -NH-CH2Ph, -N-(CH2Ph)2, cyclic dialkylamino, -NH-Ph, -N(Ph)2, 1-8C acylamino or thioacylamino, 2-16C diacylamino or di(thioacyl)amino; R3 = H, 1-6C alkyl (opt. substd.) or R8, where R8 is a phosphate ester-contg. gp.; R4 = H, 1-6C alkyl, OH, SH, NH2, halo, N3, 1-6C alkoxy, alkylthio or alkylamino, 2-12C dialkylamino, -O-CH2Ph, -S-CH2Ph, -NH-CH2Ph, -N(CH2Ph)2, -NHPh, -N(Ph)2, -OPh, -SPh, 1-8C acyloxy, 1-8C acylthio, 1-8C acylamino, 2-16C diacylamino, -O-(1-4C alkyl)-P(O)(OR6)(OR7) or -O(1-4C alkyl)-P(1-6C alkyl)(=O)(OR6); R5 = H, 1-6C alkyl (opt. substd.). A number of provisos are given in the specification.

公开(公告)号：ZA91762B

公开(公告)日：1991-10-30

申请号：ZA91762

申请日：1991-02-01

Applicant: HOECHST AG

Inventor： BUDT KARLHEINZ ,  WINKLER IRVIN ,  KARLHEINZ BUDT ,  IRVIN WINKLER ,  ANUSCHIRWAN REYMAN ,  UHLMANN EUGEN ,  EUGEN UHLMANN ,  KNOLLE JOCHEN ,  REYMAN ANUSCHIRWAN ,  HELSBERG MATTHIAS ,  JOCHEN KNOLLE ,  MATTHIAS HELSBERG

IPC: A61P31/12 ,  C07F9/38 ,  A61K31/66 ,  C07F9/40 ,  C07F9/6574 ,  C07F ,  A61K

Abstract: The use of a compound of the formula I I in which V is an alkyl group, fluorine, chlorine, bromine, or iodine, n is an integer from 1 to 5, W is an alkyl, alkenyl, alkynyl or alkoxy group, cyanide, nitro, carboxyl, hydrogen or a cycloalkyl, aryl, aralkyl or carboalkoxy group, R1 and R2 are an alkyl, alkenyl, alkynyl, cycloalkyl or halogenoalkyl group, sodium, potassium, calcium, magnesium, aluminum, lithium, ammonium, triethylammonium or hydrogen, R1 and R2 together form a cyclic diester, R3 and R4 are an alkyl, alkenyl, alkynyl, carboalkoxy, cycloalkyl or alkoxy group, hydrogen, fluorine, chlorine, bromine or iodine and X, Y and Z are oxygen or sulfur, for the treatment of diseases caused by DNA viruses or RNA viruses is described.

公开(公告)号：ZA9100762B

公开(公告)日：1991-10-30

申请号：ZA9100762

申请日：1991-02-01

Applicant: HOECHST AG

Inventor： REYMAN ANUSCHIRWAN ,  ANUSCHIRWAN REYMAN ,  BUDT KARLHEINZ ,  KARLHEINZ BUDT ,  WINKLER IRVIN ,  IRVIN WINKLER ,  UHLMANN EUGEN ,  EUGEN UHLMANN ,  KNOLLE JOCHEN ,  JOCHEN KNOLLE ,  HELSBERG MATTHIAS ,  MATTHIAS HELSBERG

IPC: A61K31/66 ,  A61P31/12 ,  C07F9/38 ,  C07F9/40 ,  C07F9/6574 ,  C07F ,  A61K

CPC classification number: C07F9/65742 ,  C07F9/3882 ,  C07F9/4056

公开(公告)号：HU910928D0

公开(公告)日：1991-10-28

申请号：HU92891

申请日：1991-03-20

Applicant: HOECHST AG

Inventor： JAHNE GERHARD ,  ROESNER MANFRED ,  WINKLER IRVIN ,  HELSBERG MATTHIAS ,  SCHOLL THOMAS

IPC: A61K31/52 ,  A61K31/522 ,  A61P31/12 ,  A61P31/22 ,  C07D473/00 ,  C07D473/04 ,  C07D473/16 ,  C07D473/18 ,  C07D473/20 ,  C07D473/22 ,  C07D473/24 ,  C07D473/28 ,  C07D473/32 ,  C07D473/34 ,  C07D473/36 ,  C07D473/40

Abstract: Purine derivs. of formula (I) and their salts are new. R1 = H, halo, NH3, OH, 1-6C alkoxy, -O-CH2Ph, -OPh, SH, 1-6C alkylthio, -S-CH2Ph, -SPh, NH2, 1-6C alkylamino, -NH-CH2Ph, -NH-Ph, 2-12C dialkylamino, -N(CH2Ph)2, cyclic dialkylamino, -N(Ph)2, 1-8C acylamino, 2-16C diacylamino, (N-alkyl-2-pyrrolidin-yliden)amino or 2-10C dialkylaminomethylidenamino; R2 = H, halo, N3, OH, SH, NH2, 1-6C alkylamino, 2-12C dialkylamino, -NH-CH2Ph, -N-(CH2Ph)2, cyclic dialkylamino, -NH-Ph, -N(Ph)2, 1-8C acylamino or thioacylamino, 2-16C diacylamino or di(thioacyl)amino; R3 = H, 1-6C alkyl (opt. substd.) or R8, where R8 is a phosphate ester-contg. gp.; R4 = H, 1-6C alkyl, OH, SH, NH2, halo, N3, 1-6C alkoxy, alkylthio or alkylamino, 2-12C dialkylamino, -O-CH2Ph, -S-CH2Ph, -NH-CH2Ph, -N(CH2Ph)2, -NHPh, -N(Ph)2, -OPh, -SPh, 1-8C acyloxy, 1-8C acylthio, 1-8C acylamino, 2-16C diacylamino, -O-(1-4C alkyl)-P(O)(OR6)(OR7) or -O(1-4C alkyl)-P(1-6C alkyl)(=O)(OR6); R5 = H, 1-6C alkyl (opt. substd.). A number of provisos are given in the specification.

公开(公告)号：HUT56498A

公开(公告)日：1991-09-30

申请号：HU36591

申请日：1991-02-01

Applicant: HOECHST AG

Inventor： PEYMAN ANUSCHIRWAN ,  UHLMANN EUGEN ,  BUDT KARL-HEINZ ,  KNOLLE JOCHEN ,  WINKLER IRVIN ,  HELSBERG MATTHIAS

IPC: A61P31/12 ,  A61K31/66 ,  C07F9/38 ,  C07F9/40 ,  C07F9/6574

Abstract: The use of a compound of the formula I I in which V is an alkyl group, fluorine, chlorine, bromine, or iodine, n is an integer from 1 to 5, W is an alkyl, alkenyl, alkynyl or alkoxy group, cyanide, nitro, carboxyl, hydrogen or a cycloalkyl, aryl, aralkyl or carboalkoxy group, R1 and R2 are an alkyl, alkenyl, alkynyl, cycloalkyl or halogenoalkyl group, sodium, potassium, calcium, magnesium, aluminum, lithium, ammonium, triethylammonium or hydrogen, R1 and R2 together form a cyclic diester, R3 and R4 are an alkyl, alkenyl, alkynyl, carboalkoxy, cycloalkyl or alkoxy group, hydrogen, fluorine, chlorine, bromine or iodine and X, Y and Z are oxygen or sulfur, for the treatment of diseases caused by DNA viruses or RNA viruses is described.