公开(公告)号：FI117320B

公开(公告)日：2006-09-15

申请号：FI950010

申请日：1995-01-02

Applicant: HOECHST AG

Inventor： WIRTH KLAUS ,  WINKLER IRVIN ,  LEMBECK FRED ,  BREIPOHL GERHARD ,  HENKE STEPHAN ,  KNOLLE JOCHEN

IPC: A61K38/04 ,  A61K38/08 ,  A61K38/17 ,  A61P31/12

Abstract: Bradykinin antagonists and the physiologically tolerated salts thereof are suitable for the treatment or prophylaxis of viral diseases.

公开(公告)号：CA2032772C

公开(公告)日：2001-10-23

申请号：CA2032772

申请日：1990-12-20

Applicant: HOECHST AG

Inventor： PEYMAN ANUSCHIRWAN ,  UHLMANN EUGEN ,  WINKLER IRVIN ,  HELSBERG MATTHIAS ,  MEICHSNER CHRISTOPH

IPC: A61K31/66 ,  A61K31/662 ,  A61K31/675 ,  A61K31/685 ,  A61P31/12 ,  A61P31/18 ,  C07F9/38 ,  C07F9/40 ,  C07F9/58 ,  C07F9/653 ,  C07F9/6539 ,  C07F9/6558 ,  C07F9/6571 ,  C07F9/547

Abstract: 2-Formylbenzylphosphonic acid derivatives, their prepar- ation and their use for the treatment of diseases caused by viruses The compound of the formula I in which R is an aldehyde group or a group which can be converted into an aldehyde, R1 and R2 are alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, hydrogen, sodium, potas- sium, calcium, magnesium, aluminum, lithium, ammonium or triethylammonium, or R1 and R2 together form a cyclic diester, R3 and R4 are alkyl, alkenyl, alkynyl, cycloalkyl, hydro- gen, alkoxy or halogen, R5 and R8 are alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, alkoxy, phenyl, cyanide, hydroxyl or hydrogen, and X, Y or Z are oxygen or sulfur, or prodrug forms of the compound of the formula I can be used for the treatment of diseases caused by viruses. The preparation of these compounds and pharmaceutical preparations containing them and their use is described.

公开(公告)号：NO306615B1

公开(公告)日：1999-11-29

申请号：NO954139

申请日：1995-10-18

Applicant: HOECHST AG

Inventor： ROESNER MANFRED ,  BILLHARDT-TROUGHTON UTA-MARIA ,  KIRSCH REINHARD ,  KLEIM JOERG-PETER ,  MEICHSNER CHRISTOPH ,  RIESS GUENTHER ,  WINKLER IRVIN

IPC: A61K31/495 ,  A61P31/12 ,  C07D241/44 ,  C07F11/00

Abstract: Quinoxaline derivs. of formula (I) and tautomers of formula (Ia), and their salts and prodrugs are new: R1 = F, Cl,OH or 1-3C alkoxy; R2 = 1-4C alkyl (opt. substd. by OH, 1-4C alkoxy or 1-4C alkylthio); R3 = 1-6C alkoxy-carbonyl or 2-6C alkenyloxy carbonyl; X = 0, S or Se; n = 0-2.

公开(公告)号：AU710238B2

公开(公告)日：1999-09-16

申请号：AU2853195

申请日：1995-08-14

Applicant: HOECHST AG

Inventor： KIRSCH REINHARD ,  KLEIM JORG-PETER ,  RIESS GUNTHER ,  ROSNER MANFRED ,  WINKLER IRVIN

IPC: A61K31/47 ,  A61P31/12 ,  A61P31/18 ,  C07D215/22 ,  C07D215/227 ,  C07D215/24 ,  C07D215/26 ,  C07D215/36 ,  C07D215/38 ,  C07D215/58 ,  C07D221/20 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D215/20

Abstract: 4-Methylene-2-quinolones of formula (I) and their tautomers of formula (Ia) and their isomers, salts and prodrugs are new: n = 0-4; R1 = halo, CF3, OCF3, OH, alkyl, cycloalkyl, alkoxy, alkoxyalkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, NO2, NH2, azido, alkylamino, dialkylamino, piperidino, morpholino, pyrrolidino, acyl, acyloxy, acylamino, CONH2, COOH, alkoxycarbonyl, SO3H, SO2NH2, Ar, OAr, COOAr, SAr, SOAr, SO2Ar, SO3Ar, OSO2Ar, SO2NHAr, NHSO2Ar, COAr, Ar', etc.; Ar,Ar' = phenyl and heteroaryl resp., etc.; X = O, S, Se, NR2 or NOR2; R2 = H; alkyl opt. substd. by halogen, CN, NH2, OH, etc.;R5, R6 = COOH or gps. as defined for R2; or R5+R6 forms a 3-8C carbocyclic ring; R3,R4 = alkyl, alkenyl, cycloalkyl or cycloalkenyl,etc.; or R3+R4 = a 3-8C carbocyclic ring; or R3+R4 = CZ1Z2 gp., where Z1 and Z2 are as defined for R3 and R4 as above; provided that X is not O when R1=R2=R5=R6=H and R3=R4=Me or R3+R4= (CH2)4.

公开(公告)号：AU708293B2

公开(公告)日：1999-07-29

申请号：AU3431695

申请日：1995-10-17

Applicant: HOECHST AG

Inventor： ROSNER MANFRED ,  BILLHARDT-TROUGHTON UTA-MARIA ,  KIRSCH REINHARD ,  KLEIM JORG-PETER ,  MEICHSNER CHRISTOPH ,  RIESS GUNTHER ,  WINKLER IRVIN

IPC: A61K31/495 ,  A61P31/12 ,  C07D241/44 ,  C07F11/00 ,  C07D241/38

Abstract: Quinoxaline derivs. of formula (I) and tautomers of formula (Ia), and their salts and prodrugs are new: R1 = F, Cl,OH or 1-3C alkoxy; R2 = 1-4C alkyl (opt. substd. by OH, 1-4C alkoxy or 1-4C alkylthio); R3 = 1-6C alkoxy-carbonyl or 2-6C alkenyloxy carbonyl; X = 0, S or Se; n = 0-2.

公开(公告)号：PT96287B

公开(公告)日：1998-06-30

申请号：PT9628790

申请日：1990-12-20

Applicant: HOECHST AG

Inventor： UHLMANN EUGEN ,  PEYMAN ANUSCHIRWAN ,  WINKLER IRVIN ,  HELSBERG MATTHIAS ,  MEICHSNER CHRISTOPH

IPC: A61K31/66 ,  A61K31/662 ,  A61K31/675 ,  A61K31/685 ,  A61P31/12 ,  A61P31/18 ,  C07F9/38 ,  C07F9/40 ,  C07F9/58 ,  C07F9/653 ,  C07F9/6539 ,  C07F9/6558 ,  C07F9/6571 ,  C07D487/04

Abstract: The compound of the formula I in which R represents an aldehyde group or a group which can be converted into an aldehyde, R and R represent alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, hydrogen, sodium, potassium, calcium, magnesium, aluminium, lithium, ammonium or triethylammonium or R and R together form a cyclic diester, R and R represent alkyl, alkenyl, alkynyl, cycloalkyl, hydrogen, alkoxy or halogen, R and R represent alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, alkoxy, phenyl, cyanide, hydroxyl or hydrogen, X, Y or Z represent oxygen or sulphur, or prodrug forms of the compound of the formula I can be used for treatment of diseases caused by viruses. The preparation of these compounds and pharmaceutical preparations which contain them and also their use are described.

公开(公告)号：NO945094A

公开(公告)日：1995-07-03

申请号：NO945094

申请日：1994-12-30

Applicant: HOECHST AG

Inventor： WIRTH KLAUS ,  WINKLER IRVIN ,  LEMBECK FRED ,  BREIPOHL GERHARD ,  HENKE STEPHAN ,  KNOLLE JOCHEN

IPC: A61K38/17 ,  A61K38/04 ,  A61K38/08 ,  A61P31/12

CPC classification number: A61K38/043

公开(公告)号：FI950010A0

公开(公告)日：1995-01-02

申请号：FI950010

申请日：1995-01-02

Applicant: HOECHST AG

Inventor： WIRTH KLAUS ,  WINKLER IRVIN ,  LEMBECK FRED ,  BREIPOHL GERHARD ,  HENKE STEPHAN ,  KNOLLE JOCHEN

IPC: A61K38/04 ,  A61K38/17 ,  A61K38/08 ,  A61P31/12 ,  A61K

Abstract: Bradykinin antagonists and the physiologically tolerated salts thereof are suitable for the treatment or prophylaxis of viral diseases.

公开(公告)号：AU6207094A

公开(公告)日：1994-10-11

申请号：AU6207094

申请日：1994-02-25

Applicant: HOECHST AG

Inventor： BUDT KARL-HEINZ ,  STOWASSER BERND ,  PEYMAN ANUSCHIRWAN ,  KNOLLE JOCHEN ,  WINKLER IRVIN ,  BERSCHEID HANS-GERD

IPC: C07D295/08 ,  A61K31/215 ,  A61K31/22 ,  A61K31/27 ,  A61K31/40 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/425 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/47 ,  A61K31/535 ,  A61K31/5355 ,  A61K31/5375 ,  A61K31/66 ,  A61K38/00 ,  A61P31/12 ,  A61P37/00 ,  A61P43/00 ,  C07C317/44 ,  C07C323/52 ,  C07D207/16 ,  C07D213/40 ,  C07D215/48 ,  C07D235/14 ,  C07D277/04 ,  C07D401/12 ,  C07F9/53 ,  C07K5/02 ,  C07K7/02

Abstract: PCT No. PCT/EP94/00561 Sec. 371 Date Sep. 12, 1995 Sec. 102(e) Date Sep. 12, 1995 PCT Filed Feb. 25, 1994 PCT Pub. No. WO94/21604 PCT Pub. Date Sep. 29, 1994The invention concerns prodrugs of enzyme inhibitors in which at least one OH- group in the enzyme inhibitor has been converted into a derivative grouping of the formula III, IV or V: (III) (IV) (V) in which the groups R11 to R25 and s,l, m, o, q, and r are as defined in the description. Such prodrugs exhibit an improved solubility in water and improved pharmaco-kinetic characteristics.

公开(公告)号：CA1328404C

公开(公告)日：1994-04-12

申请号：CA573797

申请日：1988-08-04

Applicant: HOECHST AG

Inventor： SCHRINNER ELMAR ,  WINKLER IRVIN ,  MEICHSNER CHRISTOPH ,  HELSBERG MATTHIAS

IPC: C07D473/06 ,  A61K20060101 ,  A61K31/52 ,  A61K31/70 ,  A61K31/715 ,  A61P31/12 ,  C07D20060101 ,  C07D473/04 ,  C08B20060101 ,  C08B37/00 ,  A61K31/725

Abstract: of the disclosure: A pharmaceutical combination product and the preparation and use thereof A pharmaceutical combination product containing or composed of a) at least one sulfated polysaccharide and b) at least one xanthine derivative. The product is suitable for controlling and preventing virus diseases, especially those caused by retroviruses.