公开(公告)号：ZA9202722B

公开(公告)日：1992-11-25

申请号：ZA9202722

申请日：1992-04-14

Applicant: HOECHST AG

Inventor： BILLHARDT UTA-MARIA ,  UTA-MARIA BILLHARDT ,  ROESNER MANFRED ,  MANFRED ROESNER ,  RIESS GUENTHER ,  GUENTHER RIESS ,  WINKLER IRVIN ,  IRVIN WINKLER ,  BENDER RUDOLF ,  RUDOLF BENDER

IPC: A61K20060101 ,  C07D20060101 ,  C07D241/40 ,  C07D ,  A61K

公开(公告)号：ZA9102015B

公开(公告)日：1991-12-24

申请号：ZA9102015

申请日：1991-03-19

Applicant: HOECHST AG

Inventor： JAEHNE GERHARD ,  GERHARD JAEHNE ,  ROESNER MANFRED ,  MANFRED ROESNER ,  WINKLER IRVIN ,  IRVIN WINKLER ,  HELSBERG MATTHIAS ,  MATTHIAS HELSBERG ,  SCHOLL THOMAS ,  THOMAS SCHOLL

IPC: A61K31/52 ,  A61K31/522 ,  A61P31/12 ,  A61P31/22 ,  C07D473/00 ,  C07D473/04 ,  C07D473/16 ,  C07D473/18 ,  C07D473/20 ,  C07D473/22 ,  C07D473/24 ,  C07D473/28 ,  C07D473/32 ,  C07D473/34 ,  C07D473/36 ,  C07D473/40 ,  C07D ,  A61K

CPC classification number: C07D473/04 ,  C07D473/16 ,  C07D473/18 ,  C07D473/24 ,  C07D473/32 ,  C07D473/40

公开(公告)号：ZA922722B

公开(公告)日：1992-11-25

申请号：ZA922722

申请日：1992-04-14

Applicant: HOECHST AG

Inventor： BILLHARDT UTA-MARIA ,  UTA-MARIA BILLHARDT ,  ROESNER MANFRED ,  MANFRED ROESNER ,  RIESS GUENTHER ,  GUENTHER RIESS ,  WINKLER IRVIN ,  IRVIN WINKLER ,  BENDER RUDOLF ,  RUDOLF BENDER

IPC: A61K31/495 ,  A61K20060101 ,  A61K31/535 ,  A61K31/54 ,  A61P31/12 ,  A61P31/16 ,  A61P31/18 ,  C07D20060101 ,  C07D241/38 ,  C07D241/40 ,  C07D241/44 ,  C07D241/52 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D405/04 ,  C07D405/06 ,  C07D409/04 ,  C07D409/06 ,  C07D471/04 ,  C07D487/04 ,  C07D ,  A61K

Abstract: Compounds of the formula I or Ia in which n and the substituents R - R and also X have the same meaning, have antiviral activity.

公开(公告)号：ZA912015B

公开(公告)日：1991-12-24

申请号：ZA912015

申请日：1991-03-19

Applicant: HOECHST AG

Inventor： JAEHNE GERHARD ,  GERHARD JAEHNE ,  ROESNER MANFRED ,  MANFRED ROESNER ,  WINKLER IRVIN ,  IRVIN WINKLER ,  HELSBERG MATTHIAS ,  MATTHIAS HELSBERG ,  SCHOLL THOMAS ,  THOMAS SCHOLL

IPC: A61K31/52 ,  A61K31/522 ,  A61P31/12 ,  A61P31/22 ,  C07D473/00 ,  C07D473/04 ,  C07D473/16 ,  C07D473/18 ,  C07D473/20 ,  C07D473/22 ,  C07D473/24 ,  C07D473/28 ,  C07D473/32 ,  C07D473/34 ,  C07D473/36 ,  C07D473/40 ,  C07D ,  A61K

Abstract: Purine derivs. of formula (I) and their salts are new. R1 = H, halo, NH3, OH, 1-6C alkoxy, -O-CH2Ph, -OPh, SH, 1-6C alkylthio, -S-CH2Ph, -SPh, NH2, 1-6C alkylamino, -NH-CH2Ph, -NH-Ph, 2-12C dialkylamino, -N(CH2Ph)2, cyclic dialkylamino, -N(Ph)2, 1-8C acylamino, 2-16C diacylamino, (N-alkyl-2-pyrrolidin-yliden)amino or 2-10C dialkylaminomethylidenamino; R2 = H, halo, N3, OH, SH, NH2, 1-6C alkylamino, 2-12C dialkylamino, -NH-CH2Ph, -N-(CH2Ph)2, cyclic dialkylamino, -NH-Ph, -N(Ph)2, 1-8C acylamino or thioacylamino, 2-16C diacylamino or di(thioacyl)amino; R3 = H, 1-6C alkyl (opt. substd.) or R8, where R8 is a phosphate ester-contg. gp.; R4 = H, 1-6C alkyl, OH, SH, NH2, halo, N3, 1-6C alkoxy, alkylthio or alkylamino, 2-12C dialkylamino, -O-CH2Ph, -S-CH2Ph, -NH-CH2Ph, -N(CH2Ph)2, -NHPh, -N(Ph)2, -OPh, -SPh, 1-8C acyloxy, 1-8C acylthio, 1-8C acylamino, 2-16C diacylamino, -O-(1-4C alkyl)-P(O)(OR6)(OR7) or -O(1-4C alkyl)-P(1-6C alkyl)(=O)(OR6); R5 = H, 1-6C alkyl (opt. substd.). A number of provisos are given in the specification.