公开(公告)号：SE7804956A

公开(公告)日：1978-10-29

申请号：SE7804956

申请日：1978-04-28

Applicant: HOECHST AG

Inventor： STURM K ,  MUSCHAWECK R

IPC: A61K31/635 ,  A61P7/10 ,  C07D307/52 ,  C07D333/20

CPC classification number: C07D333/20 ,  C07D307/52 ,  Y10S514/869

公开(公告)号：DK577477A

公开(公告)日：1978-06-25

申请号：DK577477

申请日：1977-12-23

Applicant: HOECHST AG

Inventor： MERKEL W ,  BORMANN D ,  MANIA D ,  MUSCHAWECK R

IPC: A61K31/40 ,  A61P7/10 ,  C07D207/32 ,  C07D207/327 ,  C07D295/155 ,  C07D317/64 ,  C07D

公开(公告)号：SE7802176L

公开(公告)日：1978-02-27

申请号：SE7802176

申请日：1978-02-27

Applicant: HOECHST AG

Inventor： BORMANN D ,  MERKEL W ,  MUSCHAWECK R ,  MANIA D

IPC: C07D207/04 ,  A61K20060101 ,  A61K31/125 ,  A61K31/18 ,  A61K31/33 ,  A61K31/395 ,  A61K31/397 ,  A61K31/40 ,  A61K31/4015 ,  A61K31/402 ,  A61K31/403 ,  A61K31/4035 ,  A61K31/445 ,  A61K31/45 ,  A61K31/635 ,  A61P7/10 ,  C07C20060101 ,  C07D20060101 ,  C07D205/04 ,  C07D205/10 ,  C07D207/02 ,  C07D207/06 ,  C07D207/08 ,  C07D207/10 ,  C07D207/18 ,  C07D207/20 ,  C07D207/32 ,  C07D207/327 ,  C07D207/40 ,  C07D207/404 ,  C07D207/44 ,  C07D207/452 ,  C07D209/00 ,  C07D209/44 ,  C07D209/48 ,  C07D209/52 ,  C07D209/94 ,  C07D211/04 ,  C07D211/14 ,  C07D211/18 ,  C07D211/30 ,  C07D211/32 ,  C07D211/34 ,  C07D211/38 ,  C07D211/70 ,  C07D211/88 ,  C07D265/32 ,  C07D265/33 ,  C07D295/00 ,  C07D295/02 ,  C07D295/04 ,  C07D295/08 ,  C07D295/10 ,  C07D295/116 ,  C07D295/12 ,  C07D295/14 ,  C07D295/155 ,  C07D295/18 ,  C07D295/192 ,  C07D317/00 ,  C07D403/10 ,  C07D405/10 ,  C07D407/10 ,  C07D413/10 ,  C07C143/78 ,  C07C149/44

Abstract: 1504505 Sulphonamides HOECHST AG 25 April 1975 [25 April 1974 27 Dec 1974] 17337/75 Heading C2C The invention comprises novel compounds (I) (including salts thereof) in which R 1 and R 2 , which may be identical or different, each represents a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms, and, if R 1 represents a hydrogen atom, R 2 may also represent an alkoxymethyl group having from 1 to 4 carbon atoms in the alkoxy radical, a phenoxymethyl group or a phenylthiomethyl group, R 3 represents a hydrogen atom, a straight or branched chain alkyl group having from 1 to 4 carbon atoms, a cycloalkyl group, having 5 or 6 ring members, one of which may be replaced by an oxygen or sulphur atom, a phenyl or benzyl group which may be substituted in the phenyl nucleus by one or more substituents selected from nitro groups, alkyl groups having from 1 to 3 carbon atoms, alkoxy groups having from 1 to 5 carbon atoms and halogen atoms, or represents a benzhydryl group or an alkanoyloxymethyl group having 2 to 4 carbon atoms in the alkanoyl part, X represents a halogen atom, a CF 3 or CCl 3 group, a straight or branched chain, saturated or unsaturated alkyl group having from 1 to 6 carbon atoms, a benzyl group which may be substituted in the phenyl nucleus by one or more substituents selected from halogen atoms, hydroxy and amino groups, and alkyl and alkoxy groups, or represents one of the groups -O-R 4 , -S-R 4 , SO-R 4 , SO 2 -R 4 and NR 4 R 5 , in which R 4 represents a phenyl group which may be substituted by one or more substituents selected from halogen atoms, CF 3 , OH and amino groups, alkyl and alkoxy groups having from 1 to 4 carbon atoms, and SO 2 NH 2 groups, or represents a straight or branched chain alkyl group having from 1 to 4 carbon atoms which may be substituted by a phenyl, pyridyl, furyl or thienyl group, and R 5 represents a hydrogen atom, a straight or branched chain alkyl group having from 1 to 4 carbon atoms, and the group NR 4 R 5 may represent a saturated, heterocyclic, 5- or 6-membered ring which may be interrupted by an O-, N- or S- atom, A represents a single bond, or an alkylene chain of 1 to 3 carbon atoms which may be unsaturated, interrupted by O-, N- or S-atoms or substituted by halogen atoms and/or substituted by alkyl, aralkyl, aryl groups or by mono-nuclear hetero-aromatic rings, or A represents an ortho-phenylene radical or the grouping in which Y represents a single bond or an alkylene group having from 1 to 4 carbon atoms, and R 6 and R 7 , which may be identical or different, each represents a hydrogen or halogen atom or an alkyl group having from 1 to 4 carbon atoms. They are made by standard methods. Pharmaceutical preparations having diuretic and saluretic action contain (I) as active ingredient. Administration is enterally or parenterally.

公开(公告)号：SE7700500A

公开(公告)日：1977-07-21

申请号：SE7700500

Applicant: HOECHST AG

Inventor： LANG H-J ,  MUSCHAWECK R

IPC: A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61P7/10 ,  C07D233/42 ,  C07D277/12 ,  C07D277/14 ,  C07D277/16 ,  C07D277/60

CPC classification number: C07D277/60 ,  C07C309/00 ,  C07D233/42 ,  C07D277/14 ,  C07D277/16 ,  Y10S514/869

公开(公告)号：ZA754772B

公开(公告)日：1976-06-30

申请号：ZA754772

申请日：1975-07-24

Applicant: HOECHST AG

Inventor： MUSCHAWECK R ,  LANG H

IPC: A61K31/425 ,  A61K31/165 ,  A61K31/426 ,  A61K31/44 ,  A61K31/505 ,  A61P7/10 ,  C07C67/00 ,  C07C301/00 ,  C07C303/22 ,  C07C303/38 ,  C07C303/40 ,  C07C311/16 ,  C07C325/00 ,  C07C335/30 ,  C07C335/32 ,  C07D277/18 ,  C07D295/26 ,  C07D417/12 ,  C07D513/04 ,  C07D

Abstract: The invention relates to thiazolidine derivatives having in 4-position a hydroxy group and a 3'-sulphamyl-phenyl substituent, in 2-position an imino group and in 1-position an aliphatic or cycloaliphatic substituent. Said thiazolidines have diuretic activity.

公开(公告)号：ZA7504772B

公开(公告)日：1976-06-30

申请号：ZA7504772

申请日：1975-07-24

Applicant: HOECHST AG

Inventor： MUSCHAWECK R ,  LANG H

IPC: A61K31/165 ,  A61K31/425 ,  A61K31/426 ,  A61K31/44 ,  A61K31/505 ,  A61P7/10 ,  C07C67/00 ,  C07C301/00 ,  C07C303/22 ,  C07C303/38 ,  C07C303/40 ,  C07C311/16 ,  C07C325/00 ,  C07C335/30 ,  C07C335/32 ,  C07D277/18 ,  C07D295/26 ,  C07D417/12 ,  C07D513/04 ,  C07D

CPC classification number: C07D295/26 ,  C07D277/18 ,  C07D417/12 ,  C07D513/04 ,  Y10S514/869

公开(公告)号：ZA75452B

公开(公告)日：1976-01-28

申请号：ZA75452

申请日：1975-01-22

Applicant: HOECHST AG

Inventor： BABEJ M ,  MUSCHAWECK R ,  KNABE B ,  LANG H ,  DRUCKREY E

IPC: C07C67/00 ,  C07C209/00 ,  C07C209/08 ,  C07C209/16 ,  C07C209/24 ,  C07C209/50 ,  C07C209/52 ,  C07C209/60 ,  C07C211/35 ,  C07C213/00 ,  C07C217/58 ,  C07D317/58 ,  C07D319/18 ,  C07C ,  A61K

Abstract: N-Cycloalkyl-benzylamine derivatives of the formula in which R1 represents hydrogen or lower alkyl of 1 to 4 carbon atoms, R2 represents a cycloalkyl radical of a total of 7 to 12 carbon atoms which may be alkyl-substituted and may contain hydrocarbon bridges of 1 to 3 carbon atoms, R3 represents hydrogen, alkoxy of 1 to 4 carbon atoms, R4 represents hydrogen or alkoxy of 1 to 4 carbon atoms or halogen, and R5 represents alkoxy of 1 to 4 carbon atoms, methylene dioxy, ethylene dioxy, benzyloxy or halogen, and the physiologically tolerated salts thereof are disclosed as having diuretic and saluretic activity.

公开(公告)号：NO752636A

公开(公告)日：1976-01-28

申请号：NO752636

申请日：1975-07-25

Applicant: HOECHST AG

Inventor： LANG H-J ,  MUSCHAWECK R

IPC: A61K31/165 ,  A61K31/425 ,  A61K31/426 ,  A61K31/44 ,  A61K31/505 ,  A61P7/10 ,  C07C67/00 ,  C07C301/00 ,  C07C303/22 ,  C07C303/38 ,  C07C303/40 ,  C07C311/16 ,  C07C325/00 ,  C07C335/30 ,  C07C335/32 ,  C07D277/18 ,  C07D295/26 ,  C07D417/12 ,  C07D513/04 ,  C07D

CPC classification number: C07D295/26 ,  C07D277/18 ,  C07D417/12 ,  C07D513/04 ,  Y10S514/869

公开(公告)号：DK340475A

公开(公告)日：1976-01-28

申请号：DK340475

申请日：1975-07-25

Applicant: HOECHST AG

Inventor： LANG H J ,  MUSCHAWECK R

IPC: A61K31/165 ,  A61K31/425 ,  A61K31/426 ,  A61K31/44 ,  A61K31/505 ,  A61P7/10 ,  C07C67/00 ,  C07C301/00 ,  C07C303/22 ,  C07C303/38 ,  C07C303/40 ,  C07C311/16 ,  C07C325/00 ,  C07C335/30 ,  C07C335/32 ,  C07D277/18 ,  C07D295/26 ,  C07D417/12 ,  C07D513/04 ,  C07D

Abstract: The invention relates to thiazolidine derivatives having in 4-position a hydroxy group and a 3'-sulphamyl-phenyl substituent, in 2-position an imino group and in 1-position an aliphatic or cycloaliphatic substituent. Said thiazolidines have diuretic activity.

公开(公告)号：ZA741916B

公开(公告)日：1975-03-26

申请号：ZA741916

申请日：1974-03-25

Applicant: HOECHST AG

Inventor： MUSCHAWECK R ,  NAHM H ,  STURM K

IPC: A61K31/18 ,  C07C