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    PROCESS FOR PREPARING 5-SULFAMOYL BENZOIC ACID SUBSTITUTED BY HETEROCYCLIC COMPOUND
    1.
    发明授权
    PROCESS FOR PREPARING 5-SULFAMOYL BENZOIC ACID SUBSTITUTED BY HETEROCYCLIC COMPOUND 失效

    公开(公告)号：KR800001133B1

    公开(公告)日：1980-10-12

    申请号：KR740003720

    申请日：1974-09-28

    Applicant: HOECHST AG

    Inventor： BORMANN D ,  MERKEL W ,  MUSHABECK R

    IPC: C07D207/00

    Abstract: Title compds. (I; R1, R2 = H, C1-4 alkyl, alkoxymethyl, phenoxymethyl, phenylthiomethyl; R3 = H, C1-4 alkyl, C5-6 cycloalkyl, Ph, benzyl, benzhydryl, C3-5 alkanoyloxymethyl; x = halogen, CF3, CCl3, alkyl, alkoxy; A = single bond, substituted alkylene), useful diuretic, were prepd. from 3-substituted sulfamoyl benzoic acid derivs.(II, z = two H, one O) by redn. with HB complex in the presence of Lewis acid or various methods.

    PROCESS FOR PREPARING SULFAMYL BENZOIC ACID
    2.
    发明授权
    PROCESS FOR PREPARING SULFAMYL BENZOIC ACID 失效

    公开(公告)号：KR800001135B1

    公开(公告)日：1980-10-12

    申请号：KR790004569

    申请日：1979-12-22

    Applicant: HOECHST AG

    Inventor： MANIA D ,  BORMANN D ,  MERKEL W

    IPC: C07D207/04

    Abstract: This patent refers mainly to the method how to manuf. sulfamyl-benzoic acid (I) by reacting formula II or III with L-CH2-A-CH2-L and hydro-analyze B in formula III. In I, A represents hydrocarbon like Z1-Z2C-(CH2)n-CZ3-Z4, Z2C-Z1, where Z means double bond, X bears OR2, SR2, SOR2, SO2R2, where R2 means alkyl, phenyl, cyclic compound, sometimes also bears disubstituted amino group, R shows alkyl group, L represents isolating radical, B means a protecting group like CR4-NR5-Rb. R means alkyl group of low grade and the three of R's can form a ring.

    PROCESS FOR PREPARING 5-SULFAMOYL BENZOIC ACID SUBSTITUTED BY HEFEROCYCLIC COMPOUND
    3.
    发明授权
    PROCESS FOR PREPARING 5-SULFAMOYL BENZOIC ACID SUBSTITUTED BY HEFEROCYCLIC COMPOUND 失效

    公开(公告)号：KR800001132B1

    公开(公告)日：1980-10-12

    申请号：KR790002788

    申请日：1979-08-16

    Applicant: HOECHST AG

    Inventor： BORMANN D ,  MERKEL W ,  MUSHABECK R

    IPC: C07D207/00

    Abstract: Heterocylic group substituted 5-sulfamoyl benzoic acid and its salts (I; R1, R2 = H, C1-4 alkyl; when R1 is H, R2 is C2-5 alkoxymethyl, phenoxymethyl or phenylthiomethyl; R3 = H, C1-4 alkyls, C5-6 cycloalkyl, phenyl, benzyl; X = halogen, CF3, CCl3, C1-6 satd. or unsatd. alkyl or alkoxy, benzyl, OR4, SR4, SOR4, SO2R4 (R4 = Hal, OH, NH2, CF3, NO2); A= halogen, alkyl, aralkyl or side chain aryl group substituted C1-3 alkylene or singled bond; L = eliminatig group), useful as diuretic agent, were prepd. by treating sulfamoyl benzoic acid derivs. (II) with acid or base for eliminating HL group.

    PROCESS FOR PREPARING SULFAMYL BENZOIC ACID
    4.
    发明授权
    PROCESS FOR PREPARING SULFAMYL BENZOIC ACID 失效

    公开(公告)号：KR800001130B1

    公开(公告)日：1980-10-12

    申请号：KR750001561

    申请日：1975-07-18

    Applicant: HOECHST AG

    Inventor： BORMANN D ,  MANIA D ,  MERKEL W

    IPC: C07D207/04

    Abstract: Sulfamylbenzoic acid derivs [I; R = C1-10 alkyl; X = OR2, SR2, SOR2, SO2R2(R2 = C1-5 branched alkyl, etc.), A = Z1-C-Z2(Z1 = Z2 or other H, C1-4 lower alkyl, aryl, halogen) are useful as diuretics and saluretics were prepd. by nitration of II [Y = halogen, B = protected gp. of CR4-NR5R6(R4 = R5 = R6 or other alkyl gp., R4, R5, R6 is joined to each other) , reducting, followed by redn. with NaBH4 to give III. Hydrolysis of III with acid or alkali give I.

    PROCESS FOR PREPARING SULFAMYL BENZOIC ACID
    5.
    发明授权
    PROCESS FOR PREPARING SULFAMYL BENZOIC ACID 失效

    公开(公告)号：KR800001134B1

    公开(公告)日：1980-10-12

    申请号：KR790004568

    申请日：1979-12-22

    Applicant: HOECHST AG

    Inventor： MANIA D ,  MERKEL W ,  BORMANN D

    IPC: C07D207/04

    Abstract: Sulfamoylbenzoic acids I(R = OR2, SR2, SOR2, SO2R2; R2 = C1-5 alkyl, cycloalkyl, phenyl) X = desubstituted amino group, R = H, C1-10 alkyl) were prepd. by reducing pyrrolo-compd. II (R6, R7 = H, halogen, C1-C4 alkyl). Thus, 4-chloro-5 sulfamo- ylbenzoic acid was stirred with DMF and SOCl2 at room temp. for 2 hr to give 4-chloro-5-N, N-dimethylaminomethyleneamino-sulfonybenzoic acid. I are useful as diurecics.

    PROCESS FOR PREPARING 5-SULFAMOYL BENZOIC ACID SUBSTITUTED BY HETEROCYCLIC COMPOUND
    6.
    发明授权
    PROCESS FOR PREPARING 5-SULFAMOYL BENZOIC ACID SUBSTITUTED BY HETEROCYCLIC COMPOUND 失效

    公开(公告)号：KR800001131B1

    公开(公告)日：1980-10-12

    申请号：KR790002786

    申请日：1979-08-16

    Applicant: HOECHST AG

    Inventor： BORMANN D ,  MERKEL W ,  MUSHABECK R

    IPC: C07D207/00

    Abstract: Title compds. (I; R1, R2 = H, C1-4 alkyl; R3 = H, C1-4 alkyl, phenyl, benzyl, C3-5 alkanoyloxymethyl; X = halogen, CF3, C1-6 alkyl etc.; A = single bond or C1-3 alkylene), with diuretic and saluretic action are prepd. by treating 5-halo- genosulfonyl benzoic acid derivs.(II; Hal = halogen) with III. If, necessary a process such as adding hydrogen to double bond, inducing double bond, esterifying carboxylic acid, hydrolysing carboxylic ester, separating protected group and liberating hydroxyl, amino or mercapto group and treating carboxylic acid with base or acid can be accepted.

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