公开(公告)号：CH509274A

公开(公告)日：1971-06-30

申请号：CH1098069

申请日：1969-07-17

Applicant: HOECHST AG

Inventor： BEERMANN CLAUS DR ,  GEORGI VOLKMAR DR ,  WALDMANN KARL DR ,  WOLF ERHARD DR

IPC: D06M13/425 ,  C07C125/06

公开(公告)号：SI0812844T1

公开(公告)日：2003-02-28

申请号：SI9730414

申请日：1997-06-03

Applicant: HOECHST AG

Inventor： GEBERT ULRICH DR ,  WOLF ERHARD DR ,  DEFOSSA ELISABETH DR ,  HEINELT UWE DR ,  ANAGNOSTOPULOS HIRISTO DB ,  RUDOLPHI KARL DR ,  GROME JOHN J DR

IPC: C07D473/04 ,  A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  A61P7/08 ,  A61P9/00 ,  A61P9/10 ,  A61P31/04 ,  A61P31/12 ,  A61P43/00 ,  C07D473/06

Abstract: The use of at least one theophylline 1-ether analogue of formula (I) or its diastereoisomer or salt is claimed for the preparation of a medicament for the treatment and/or prophylaxis of shock states. R1 = 1-5C alkyl or (1-2C)alkoxy-(1-3C) alkyl; or phenyl or phenyl-(1-2C)alkyl (both optionally mono- or dihalo-substituted in the ring); A = 1-4C alkylene; R2 = 1-5C alkyl, 3-6C cycloalkyl, 4-8C cycloalkyl, phenyl or phenyl-(1-2C)alkyl. Compounds (I) and their stereoisomers and salts are new, with the exception of compounds in which (a) R2 = n-propyl, R1= Me or Et and A = CH2CH2 or (b) R2 = n-propyl, R1 = Me and A = (CH2)3. Certain intermediates in the preparation of (I) are also new.

公开(公告)号：DK0812844T3

公开(公告)日：2003-02-17

申请号：DK97108870

申请日：1997-06-03

Applicant: HOECHST AG

Inventor： ANAGNOSTOPULOS HIRISTO DB ,  GEBERT ULRICH DR ,  DEFOSSA ELISABETH DR ,  HEINELT UWE DR ,  WOLF ERHARD DR ,  RUDOLPHI KARL DR ,  GROME JOHN J DR

IPC: C07D473/04 ,  A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  A61P7/08 ,  A61P9/00 ,  A61P9/10 ,  A61P31/04 ,  A61P31/12 ,  A61P43/00 ,  C07D473/06

Abstract: The use of at least one theophylline 1-ether analogue of formula (I) or its diastereoisomer or salt is claimed for the preparation of a medicament for the treatment and/or prophylaxis of shock states. R1 = 1-5C alkyl or (1-2C)alkoxy-(1-3C) alkyl; or phenyl or phenyl-(1-2C)alkyl (both optionally mono- or dihalo-substituted in the ring); A = 1-4C alkylene; R2 = 1-5C alkyl, 3-6C cycloalkyl, 4-8C cycloalkyl, phenyl or phenyl-(1-2C)alkyl. Compounds (I) and their stereoisomers and salts are new, with the exception of compounds in which (a) R2 = n-propyl, R1= Me or Et and A = CH2CH2 or (b) R2 = n-propyl, R1 = Me and A = (CH2)3. Certain intermediates in the preparation of (I) are also new.

公开(公告)号：ID19469A

公开(公告)日：1998-07-16

申请号：ID971930

申请日：1997-06-05

Applicant: HOECHST AG

Inventor： GEBERT ULRICH DR ,  WOLF ERHARD DR ,  DEFOSSA ELISABETH DR ,  HEINELT UWE DR ,  ANAGNOSTOPULOS DB HIRISTO ,  RUDOLPHI KARL DR ,  GROME JOHN J DR

IPC: C07D473/04 ,  A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  A61P7/08 ,  A61P9/00 ,  A61P9/10 ,  A61P31/04 ,  A61P31/12 ,  A61P43/00 ,  C07D473/06

Abstract: The use of at least one theophylline 1-ether analogue of formula (I) or its diastereoisomer or salt is claimed for the preparation of a medicament for the treatment and/or prophylaxis of shock states. R1 = 1-5C alkyl or (1-2C)alkoxy-(1-3C) alkyl; or phenyl or phenyl-(1-2C)alkyl (both optionally mono- or dihalo-substituted in the ring); A = 1-4C alkylene; R2 = 1-5C alkyl, 3-6C cycloalkyl, 4-8C cycloalkyl, phenyl or phenyl-(1-2C)alkyl. Compounds (I) and their stereoisomers and salts are new, with the exception of compounds in which (a) R2 = n-propyl, R1= Me or Et and A = CH2CH2 or (b) R2 = n-propyl, R1 = Me and A = (CH2)3. Certain intermediates in the preparation of (I) are also new.

公开(公告)号：CZ9701743A3

公开(公告)日：1997-12-17

申请号：CZ174397

申请日：1997-06-05

Applicant: HOECHST AG

Inventor： GEBERT ULRICH DR ,  WOLF ERHARD DR ,  DEFOSSA ELISABETH DR ,  HEINELT UWE DR ,  ANAGNOSTOPULOS HIRISTO DB ,  RUDOLPHI KARL DR ,  GROME JOHN J DR

IPC: C07D473/04 ,  A61K31/505 ,  A61K31/522 ,  A61P7/08 ,  A61P9/00 ,  A61P9/10 ,  A61P31/04 ,  A61P31/12 ,  A61P43/00 ,  C07D473/06 ,  C07D487/04 ,  A61K31/41 ,  A61K31/52

CPC classification number: C07D473/06

公开(公告)号：CH511807A

公开(公告)日：1971-08-31

申请号：CH1193169

申请日：1969-08-06

Applicant: HOECHST AG

Inventor： BARTMANN WILHELM DR ,  DUEWEL DIETER DR ,  GEORGI VOLKMAR DR ,  WOLF ERHARD DR ,  BEERMANN CLAUS DR ,  LANDAUER FRANZ DR

IPC: A61K31/14 ,  C07C233/00 ,  C07C103/44 ,  C07C125/06

公开(公告)号：MY117910A

公开(公告)日：2004-08-30

申请号：MYPI9702540

申请日：1997-06-06

Applicant: HOECHST AG

Inventor： GEBERT ULRICH DR ,  WOLF ERHARD DR ,  XDFA ELISABETH DEFO DR ,  HEINELT UWE DR ,  ANAGNOSTOPULOS DB HIRISTO ,  RUDOLPHI KARL DR ,  GROME JOHN J DR

IPC: C07D473/04 ,  A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  A61P7/08 ,  A61P9/00 ,  A61P9/10 ,  A61P31/04 ,  A61P31/12 ,  A61P43/00 ,  C07D473/06

Abstract: THEOPHYLLINE DERIVATIVES HAVING AT LEAST ONE ETHER FUNCTION IN THE STRUCTURALLY MODIFIED METHYL RADICAL IN THE I-POSITION THAT ARE USEFUL IN THE TREATMENT AND PROPHYLAXIS OF STATES OF SHOCK, NEW XANTHINE COMPOUNDS HAVING THIS SUBSTITUTION PATTERN, AND PROCESSES FOR THEIR PREPARATION

公开(公告)号：ES2185837T3

公开(公告)日：2003-05-01

申请号：ES97108870

申请日：1997-06-03

Applicant: HOECHST AG

Inventor： GEBERT ULRICH DR ,  WOLF ERHARD DR ,  DEFOSSA ELISABETH DR ,  HEINELT UWE DR ,  ANAGNOSTOPULOS HIRISTO DB ,  RUDOLPHI KARL DR

IPC: C07D473/04 ,  A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  A61P7/08 ,  A61P9/00 ,  A61P9/10 ,  A61P31/04 ,  A61P31/12 ,  A61P43/00 ,  C07D473/06

Abstract: The use of at least one theophylline 1-ether analogue of formula (I) or its diastereoisomer or salt is claimed for the preparation of a medicament for the treatment and/or prophylaxis of shock states. R1 = 1-5C alkyl or (1-2C)alkoxy-(1-3C) alkyl; or phenyl or phenyl-(1-2C)alkyl (both optionally mono- or dihalo-substituted in the ring); A = 1-4C alkylene; R2 = 1-5C alkyl, 3-6C cycloalkyl, 4-8C cycloalkyl, phenyl or phenyl-(1-2C)alkyl. Compounds (I) and their stereoisomers and salts are new, with the exception of compounds in which (a) R2 = n-propyl, R1= Me or Et and A = CH2CH2 or (b) R2 = n-propyl, R1 = Me and A = (CH2)3. Certain intermediates in the preparation of (I) are also new.

公开(公告)号：AT226583T

公开(公告)日：2002-11-15

申请号：AT97108870

申请日：1997-06-03

Applicant: HOECHST AG

Inventor： GEBERT ULRICH DR ,  WOLF ERHARD DR ,  DEFOSSA ELISABETH DR ,  HEINELT UWE DR ,  ANAGNOSTOPULOS HIRISTO DB ,  RUDOLPHI KARL DR ,  GROME JOHN J DR

IPC: C07D473/04 ,  A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  A61P7/08 ,  A61P9/00 ,  A61P9/10 ,  A61P31/04 ,  A61P31/12 ,  A61P43/00 ,  C07D473/06

Abstract: The use of at least one theophylline 1-ether analogue of formula (I) or its diastereoisomer or salt is claimed for the preparation of a medicament for the treatment and/or prophylaxis of shock states. R1 = 1-5C alkyl or (1-2C)alkoxy-(1-3C) alkyl; or phenyl or phenyl-(1-2C)alkyl (both optionally mono- or dihalo-substituted in the ring); A = 1-4C alkylene; R2 = 1-5C alkyl, 3-6C cycloalkyl, 4-8C cycloalkyl, phenyl or phenyl-(1-2C)alkyl. Compounds (I) and their stereoisomers and salts are new, with the exception of compounds in which (a) R2 = n-propyl, R1= Me or Et and A = CH2CH2 or (b) R2 = n-propyl, R1 = Me and A = (CH2)3. Certain intermediates in the preparation of (I) are also new.

公开(公告)号：DE19622737A1

公开(公告)日：1997-12-11

申请号：DE19622737

申请日：1996-06-07

Applicant: HOECHST AG

Inventor： GEBERT ULRICH DR ,  WOLF ERHARD DR ,  DEFOSA ELISABETH DR ,  HEINELT UWE DR ,  ANAGNOSTOPULOS HIRISTO ,  RUDOLPHI KARL DR ,  GROME JOHN J DR

IPC: C07D473/06 ,  A61K31/52 ,  C07D473/08

Abstract: Use of at least one compound of formula (I), or their salts or stereoisomeric forms for preparation of a medicament for treatment and/or prophylaxis of shock disorders is claimed: R1 = 1-5C alkyl, 1-2C alkoxy(1-3C)alkyl, or phenyl or phenyl(1-2C)alkyl (both optionally ring substituted by 1-2 halo); A = a 1-4C alkylene bridge; R2 = 1-5C alkyl, 3-6C cycloalkyl, 4-8C cycloalkyl-alkyl, phenyl or phenyl(1-2C)alkyl. Compounds (I), and their salts and stereoisomeric forms are new with the exception of those compounds in which (a) R2 = n-propyl, R1 = ethyl and A = a (m)ethylene bridge and (b) R2 = n-propyl, R1 = propyl and A = a methylene bridge.