公开(公告)号：AT62226T

公开(公告)日：1991-04-15

申请号：AT86102932

申请日：1986-03-05

Applicant: HOECHST AG

Inventor： LAU HANS-HERMANN DR ,  BARTMANN WILHELM DR ,  BECK GERHARD DR ,  WESS GUENTHER DR

IPC: A61K31/44 ,  A61K31/4406 ,  A61K31/4418 ,  A61P7/02 ,  A61P43/00 ,  C07D213/26 ,  C07D213/30 ,  C07D213/42 ,  C07D213/50 ,  C07D213/53 ,  C07D213/55

公开(公告)号：DE3668451D1

公开(公告)日：1990-03-01

申请号：DE3668451

申请日：1986-03-05

Applicant: HOECHST AG

Inventor： LAU HANS-HERMANN DR ,  BARTMANN WILHELM DR ,  BECK GERHARD DR ,  WESS GUENTHER DR

IPC: A61K31/415 ,  A61P7/02 ,  C07D233/56 ,  C07D233/64 ,  C07D521/00

Abstract: Compounds of the formula I I in which R1, R2 and Y have the indicated meanings, their physiologically tolerated acid addition salts, and a process for the preparation of these compounds are described. The compounds inhibit thromboxane synthetase and can thus be used as medicaments.

公开(公告)号：AT25517T

公开(公告)日：1987-03-15

申请号：AT82103847

申请日：1982-05-05

Applicant: HOECHST AG

Inventor： BECK GERHARD DR ,  BARTMANN WILHELM DR ,  KNOLLE JOCHEN DR ,  RUPP RICHARD HELMUT DR

IPC: A61K31/40 ,  A61K31/4025 ,  A61P43/00 ,  C07D207/24 ,  C07D409/12

公开(公告)号：CH625213A5

公开(公告)日：1981-09-15

申请号：CH704576

申请日：1976-06-03

Applicant: HOECHST AG

Inventor： BARTMANN WILHELM DR ,  BECK GERHARD DR ,  REUSCHLING DIETER-BERND DR ,  SEEGER KARL DR ,  TEUFEL HERMANN DR

IPC: C07D333/16 ,  A61K31/557 ,  A61K31/5575 ,  A61P1/04 ,  A61P7/02 ,  A61P7/10 ,  A61P9/12 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D307/935 ,  C07D333/00 ,  C07D333/32 ,  C07D333/64 ,  C07D333/78 ,  C07D409/12 ,  C07D409/14 ,  C07F9/54 ,  C07C177/00 ,  C07D333/04 ,  C07D333/50

Abstract: The present invention relates to thienyl-prostaglandin derivatives and to a process for their manufacture. The compounds according to the invention have valuable pharmaceutical properties.

公开(公告)号：DE2556326A1

公开(公告)日：1977-06-23

申请号：DE2556326

申请日：1975-12-13

Applicant: HOECHST AG

Inventor： BARTMANN WILHELM DR ,  KUNSTMANN RUDOLF DR ,  LERCH ULRICH DR ,  SCHOELKENS BERNHARD DR

IPC: C07D207/27 ,  A61K31/40 ,  A61K31/4015 ,  A61P43/00 ,  C07D207/26

公开(公告)号：DE2527990A1

公开(公告)日：1977-01-27

申请号：DE2527990

申请日：1975-06-24

Applicant: HOECHST AG

Inventor： REUSCHLING DIETER-BERND DR ,  KUEHLEIN KLAUS DR ,  SCHOELKENS BERNHARD DR ,  BARTMANN WILHELM DR ,  LERCH ULRICH DR

IPC: C07D207/26 ,  C07D207/27

Abstract: Pyrrolidone derivs. of formula (I) and their salts are new. In (1) A is -CH2CH2- or -C C-; B = -CH2CH2- or -CH=CH- but A and B are not both -CH2CH2-; R' = opt. branched alkyl or alkoxy; R2 = H, lower aliphatic hydrocarbon, or cycloaliphatic or araliphatic hydrocarbon of 3-8C; R3 = 1-10C alkyl(opt. substd. by 1-5C O- or S-alkyl), phenoxy (opt. substd. by 1-3C alkyl which may be substd. by halogen, or phenoxy opt. halogenated), O-furyl or O-benzyl (opt. substd. by 1-3C alkyl) and the side chains on the 3- and 4-positions of the pyrrolidone ring are trans to one another. (I) are luteolytics, gastric secretion inhibitors, broncho-spasmolytics and/or anti-hypertensives. Compared with natural prostaglandins they are more specific in action and longer acting. Typical compound is 1-methyl-3-(6-carbomethoxy-2-(I)hexynyl-)-4-(3-(RS)hydroxy-(E)-1- (I) hexenyl) pyrrolidone. The compounds are prepared by an 8-stage process starting from a 4-hydroxymethyl pyrrolidone.

公开(公告)号：DE2452536A1

公开(公告)日：1976-05-13

申请号：DE2452536

申请日：1974-11-06

Applicant: HOECHST AG

Inventor： KUEHLEIN KLAUS DR ,  REUSCHLING DIETER-BERND DR ,  BABEJ MILO DR ,  BARTMANN WILHELM DR ,  BECK GERHARD DR

IPC: C07D207/26 ,  C07D207/277

Abstract: (A) Prrolidone derivs. of formula (I), and the corresp. free acids and their salts with metals and amines, are new: (where R1 is 1-6C alkyl or is 3-7C cycloalkyl opt. substd. by 1-4C alkyl or alkoxy; R2 is 1-4C alkyl; R3 is 1-10C alkyl opt. substd. by 1-5C alkoxy, 1-5C alkylthio, phenoxy (opt. substd. by 1-3C alkyl, 1-3C haloalkyl, halogen phenoxy or halophenoxy), furyloxy, (1-3C alkyl) furyloxy, benzyloxy, (1-3C alkyl)benzyloxy, CF3, 3-7C cycloalkyl, phenyl, (1-3C alkyl)phenyl, furyl or (1-3C alkyl)furyl; m=1 or 2; n=2 or 3; and the 3- and 4-side chains are trans to one another). Cpds. (I) have prostaglandin-like luteolytic, gastric secretion inhibiting, bronchospasmolytic and/or antihypertensive activity, and are useful as intermediates for other cpds. with prostaglandin-like activity.

公开(公告)号：DE2331081A1

公开(公告)日：1975-01-23

申请号：DE2331081

申请日：1973-06-19

Applicant: HOECHST AG

Inventor： BABEJ MILO DR ,  BARTMANN WILHELM DR ,  BECK GERHARD ,  LERCH ULRICH DR

IPC: C07D307/16 ,  A61K31/22 ,  A61K31/557 ,  C07C51/08 ,  C07C53/19 ,  C07C59/68 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D307/33 ,  C07D307/54 ,  C07D309/12 ,  C07C69/74 ,  C07C61/36 ,  A61K31/19

Abstract: The safety barrier, for protection against avalanches and falling rocks or trees comprises a net (1) mounted on pairs of cables (2 -5) at the front and back which are fitted with cable brakes (9) to improve energy absorption. Additional cables (15, 17, 19) fitted with cable brakes (16, 18) are attached to the rear of the net.

公开(公告)号：CH511807A

公开(公告)日：1971-08-31

申请号：CH1193169

申请日：1969-08-06

Applicant: HOECHST AG

Inventor： BARTMANN WILHELM DR ,  DUEWEL DIETER DR ,  GEORGI VOLKMAR DR ,  WOLF ERHARD DR ,  BEERMANN CLAUS DR ,  LANDAUER FRANZ DR

IPC: A61K31/14 ,  C07C233/00 ,  C07C103/44 ,  C07C125/06

公开(公告)号：DE3275465D1

公开(公告)日：1987-04-02

申请号：DE3275465

申请日：1982-05-05

Applicant: HOECHST AG

Inventor： BECK GERHARD DR ,  BARTMANN WILHELM DR ,  KNOLLE JOCHEN DR ,  RUPP RICHARD HELMUT DR

IPC: A61K31/40 ,  A61K31/4025 ,  A61P43/00 ,  C07D207/24 ,  C07D409/12

Abstract: The present invention relates to DELTA 1-pyrroline thiolactim ethers of the general formula I I which have a more specific action and/or a longer-lasting action than PGI2, and to a process for their preparation. The compounds are distinguished by a platelet aggregation-inhibiting action and a blood vessel-relaxing and hypotensive action, and can therefore be used as medicaments.