公开(公告)号：DE19631288A1

公开(公告)日：1998-02-05

申请号：DE19631288

申请日：1996-08-02

Applicant: HOECHST AG

Inventor： BOSSLET KLAUS ,  CZECH JOERG ,  VASELLA ANDREA ,  HOOS ROLAND

IPC: C07D309/28 ,  A61K31/35 ,  A61K31/351 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D211/74 ,  C07D211/78 ,  C07D309/30 ,  C07D335/02 ,  C07F9/59 ,  C07F9/655 ,  C07F9/6553 ,  C07H7/033 ,  A61K31/70

Abstract: Trihydroxyheterocyclylamino compounds of formula (I) and their salts are new. Y = COOH, PO3H2, P(O)(OR6)(OH), P(O)R6(OH), tetrazole or SO3H; R6 = 1-4C alkyl; X = NH, O or S; R = H or CONH-C6(R7)5; and R7 = H, OH, halo, COOH, PO3H2 or SO3H.

公开(公告)号：CA2212200A1

公开(公告)日：1998-02-02

申请号：CA2212200

申请日：1997-08-01

Applicant: HOECHST AG

Inventor： BOSSLET KLAUS ,  CZECH JOERG ,  VASELLA ANDREA ,  HOOS ROLAND

IPC: C07D309/28 ,  A61K31/35 ,  A61K31/351 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D211/74 ,  C07D211/78 ,  C07D309/30 ,  C07D335/02 ,  C07F9/59 ,  C07F9/655 ,  C07F9/6553 ,  C07H7/033 ,  C07D401/04 ,  C07D409/04 ,  C07H5/06 ,  C07H5/10 ,  A61K31/38 ,  A61K31/445 ,  A61K31/66 ,  A61K31/70 ,  C07D211/72

Abstract: Novel inhibitors of .beta.-glucuronidase Compounds of the formulae I and II (see fig.I) (see fig.II) are suitable for the suppression of tumor growth and of tumor metastasis.