公开(公告)号：JPH1077279A

公开(公告)日：1998-03-24

申请号：JP20757497

申请日：1997-08-01

Applicant: HOECHST AG

Inventor： BOSSLET KLAUS ,  CZECH JOERG ,  VASELLA ANDREA ,  HOOS ROLAND

IPC: C07D309/28 ,  A61K31/35 ,  A61K31/351 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D211/74 ,  C07D211/78 ,  C07D309/30 ,  C07D335/02 ,  C07F9/59 ,  C07F9/655 ,  C07F9/6553

Abstract: PROBLEM TO BE SOLVED: To obtain a compound which is useful as a β-gluculonidase inhibitor which inhibit tumors from growing and metastasizing. SOLUTION: This compound is represented by formula I [Y is -COOH, -PO3 H2 , -P(O)(OR )(OH); R is a 1-4 alkyl; X is NH, O, S; R is H, -C(O)NHC6 (R )5 ; R is H, OH, a halogen] and formula II (R -R is H, OH a halogen, -COOH, -PO3 H2 ), typically (Z)-O-(D-glucopyranuronosilidene)amino-N- phenyl carbamate. The formulation of the compound of formula I and formula II affords a medicine effective for treatment of postoperative carcinomatous diseases or the inhibition of tumor metastasis and treatment of inflammatory diseases. The compounds of formulas I and II can be prepared by a known process. The does is

公开(公告)号：ES2166031T3

公开(公告)日：2002-04-01

申请号：ES97112940

申请日：1997-07-28

Applicant: HOECHST AG

Inventor： BOSSLET KLAUS ,  CZECH JOERG ,  VASELLA ANDREA ,  HOOS ROLAND

IPC: A61K31/35 ,  A61K31/351 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D211/74 ,  C07D309/28 ,  C07D211/78 ,  C07D309/30 ,  C07D335/02 ,  C07F9/59 ,  C07F9/655 ,  C07F9/6553

Abstract: Trihydroxyheterocyclylamino compounds of formula (I) and their salts are new. Y = COOH, PO3H2, P(O)(OR6)(OH), P(O)R6(OH), tetrazole or SO3H; R6 = 1-4C alkyl; X = NH, O or S; R = H or CONH-C6(R7)5; and R7 = H, OH, halo, COOH, PO3H2 or SO3H.

公开(公告)号：AT207067T

公开(公告)日：2001-11-15

申请号：AT97112940

申请日：1997-07-28

Applicant: HOECHST AG

Inventor： BOSSLET KLAUS ,  CZECH JOERG ,  VASELLA ANDREA ,  HOOS ROLAND

IPC: C07D309/28 ,  A61K31/35 ,  A61K31/351 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D211/74 ,  C07D211/78 ,  C07D309/30 ,  C07D335/02 ,  C07F9/59 ,  C07F9/655 ,  C07F9/6553

Abstract: Trihydroxyheterocyclylamino compounds of formula (I) and their salts are new. Y = COOH, PO3H2, P(O)(OR6)(OH), P(O)R6(OH), tetrazole or SO3H; R6 = 1-4C alkyl; X = NH, O or S; R = H or CONH-C6(R7)5; and R7 = H, OH, halo, COOH, PO3H2 or SO3H.

公开(公告)号：PT642799E

公开(公告)日：2002-04-29

申请号：PT94113388

申请日：1994-08-26

Applicant: HOECHST AG ,  HOECHST HOUDE S A LAB

Inventor： MONNERET CLAUDE ,  FLORENT JEAN-CLAUDE ,  GESSON JEAN-PIERRE ,  JACQUESY JEAN-CLAUDE ,  KOCH MICHEL ,  TILLEQUIN FRANCOIS ,  BOSSLET KLAUS ,  AZOULAY MICHEL ,  JORG CZECH DR ,  VASELLA ANDREA ,  DIETER HOFFMANN DR ,  HOOS ROLAND

IPC: C07H15/203 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61K47/48 ,  A61P35/00 ,  A61P43/00 ,  C07H15/244

Abstract: Enzymatically cleavable prodrugs with reduced Michaelis-Menten constant (Km) are described.

公开(公告)号：PT822192E

公开(公告)日：2002-03-28

申请号：PT97112940

申请日：1997-07-28

Applicant: HOECHST AG

Inventor： BOSSLET KLAUS ,  CZECH JOERG ,  VASELLA ANDREA ,  HOOS ROLAND

IPC: A61K31/35 ,  A61K31/351 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D211/74 ,  C07D309/28 ,  C07D211/78 ,  C07D309/30 ,  C07D335/02 ,  C07F9/59 ,  C07F9/655 ,  C07F9/6553

Abstract: Trihydroxyheterocyclylamino compounds of formula (I) and their salts are new. Y = COOH, PO3H2, P(O)(OR6)(OH), P(O)R6(OH), tetrazole or SO3H; R6 = 1-4C alkyl; X = NH, O or S; R = H or CONH-C6(R7)5; and R7 = H, OH, halo, COOH, PO3H2 or SO3H.

公开(公告)号：DK0822192T3

公开(公告)日：2002-02-11

申请号：DK97112940

申请日：1997-07-28

Applicant: HOECHST AG

Inventor： HOOS ROLAND ,  CZECH JOERG ,  BOSSLET KLAUS ,  VASELLA ANDREA

IPC: C07D309/28 ,  A61K31/35 ,  A61K31/351 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D211/74 ,  C07D211/78 ,  C07D309/30 ,  C07D335/02 ,  C07F9/59 ,  C07F9/655 ,  C07F9/6553

Abstract: Trihydroxyheterocyclylamino compounds of formula (I) and their salts are new. Y = COOH, PO3H2, P(O)(OR6)(OH), P(O)R6(OH), tetrazole or SO3H; R6 = 1-4C alkyl; X = NH, O or S; R = H or CONH-C6(R7)5; and R7 = H, OH, halo, COOH, PO3H2 or SO3H.

公开(公告)号：DE59704940D1

公开(公告)日：2001-11-22

申请号：DE59704940

申请日：1997-07-28

Applicant: HOECHST AG

Inventor： BOSSLET KLAUS ,  CZECH JOERG ,  VASELLA ANDREA ,  HOOS ROLAND

IPC: C07D309/28 ,  A61K31/35 ,  A61K31/351 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D211/74 ,  C07D211/78 ,  C07D309/30 ,  C07D335/02 ,  C07F9/59 ,  C07F9/655 ,  C07F9/6553

Abstract: Trihydroxyheterocyclylamino compounds of formula (I) and their salts are new. Y = COOH, PO3H2, P(O)(OR6)(OH), P(O)R6(OH), tetrazole or SO3H; R6 = 1-4C alkyl; X = NH, O or S; R = H or CONH-C6(R7)5; and R7 = H, OH, halo, COOH, PO3H2 or SO3H.

公开(公告)号：AU717219B2

公开(公告)日：2000-03-23

申请号：AU3241997

申请日：1997-07-31

Applicant: HOECHST AG

Inventor： BOSSLET KLAUS ,  CZECH JOERG ,  VASELLA ANDREA ,  HOOS ROLAND

IPC: C07D309/28 ,  A61K31/35 ,  A61K31/351 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D211/74 ,  C07D211/78 ,  C07D309/30 ,  C07D335/02 ,  C07F9/59 ,  C07F9/655 ,  C07F9/6553

Abstract: Trihydroxyheterocyclylamino compounds of formula (I) and their salts are new. Y = COOH, PO3H2, P(O)(OR6)(OH), P(O)R6(OH), tetrazole or SO3H; R6 = 1-4C alkyl; X = NH, O or S; R = H or CONH-C6(R7)5; and R7 = H, OH, halo, COOH, PO3H2 or SO3H.

公开(公告)号：AU3241997A

公开(公告)日：1998-02-12

申请号：AU3241997

申请日：1997-07-31

Applicant: HOECHST AG

Inventor： BOSSLET KLAUS ,  CZECH JOERG ,  VASELLA ANDREA ,  HOOS ROLAND

IPC: C07D309/28 ,  A61K31/35 ,  A61K31/351 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D211/74 ,  C07D211/78 ,  C07D309/30 ,  C07D335/02 ,  C07F9/59 ,  C07F9/655 ,  C07F9/6553

Abstract: Trihydroxyheterocyclylamino compounds of formula (I) and their salts are new. Y = COOH, PO3H2, P(O)(OR6)(OH), P(O)R6(OH), tetrazole or SO3H; R6 = 1-4C alkyl; X = NH, O or S; R = H or CONH-C6(R7)5; and R7 = H, OH, halo, COOH, PO3H2 or SO3H.

公开(公告)号：CA2212200C

公开(公告)日：2007-05-22

申请号：CA2212200

申请日：1997-08-01

Applicant: HOECHST AG

Inventor： CZECH JORG ,  BOSSLET KLAUS ,  HOOS ROLAND ,  VASELLA ANDREA

IPC: C07D309/28 ,  C07H5/10 ,  A61K31/35 ,  A61K31/351 ,  A61K31/38 ,  A61K31/445 ,  A61K31/66 ,  A61K31/70 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D211/72 ,  C07D211/74 ,  C07D211/78 ,  C07D309/30 ,  C07D335/02 ,  C07D401/04 ,  C07D409/04 ,  C07F9/59 ,  C07F9/655 ,  C07F9/6553 ,  C07H5/06 ,  C07H7/033 ,  C07H13/12

Abstract: Novel inhibitors of .beta.-glucuronidase Compounds of the formulae I and II are suitable for the suppression of tumor growth and of tumor metastasis.