-
公开(公告)号：JPH1077279A
公开(公告)日：1998-03-24
申请号：JP20757497
申请日：1997-08-01
Applicant: HOECHST AG
Inventor： BOSSLET KLAUS , CZECH JOERG , VASELLA ANDREA , HOOS ROLAND
IPC: C07D309/28 , A61K31/35 , A61K31/351 , A61P29/00 , A61P35/00 , A61P43/00 , C07D211/74 , C07D211/78 , C07D309/30 , C07D335/02 , C07F9/59 , C07F9/655 , C07F9/6553
Abstract: PROBLEM TO BE SOLVED: To obtain a compound which is useful as a β-gluculonidase inhibitor which inhibit tumors from growing and metastasizing. SOLUTION: This compound is represented by formula I [Y is -COOH, -PO3 H2 , -P(O)(OR )(OH); R is a 1-4 alkyl; X is NH, O, S; R is H, -C(O)NHC6 (R )5 ; R is H, OH, a halogen] and formula II (R -R is H, OH a halogen, -COOH, -PO3 H2 ), typically (Z)-O-(D-glucopyranuronosilidene)amino-N- phenyl carbamate. The formulation of the compound of formula I and formula II affords a medicine effective for treatment of postoperative carcinomatous diseases or the inhibition of tumor metastasis and treatment of inflammatory diseases. The compounds of formulas I and II can be prepared by a known process. The does is
-
公开(公告)号：ES2166031T3
公开(公告)日：2002-04-01
申请号：ES97112940
申请日：1997-07-28
Applicant: HOECHST AG
Inventor： BOSSLET KLAUS , CZECH JOERG , VASELLA ANDREA , HOOS ROLAND
IPC: A61K31/35 , A61K31/351 , A61P29/00 , A61P35/00 , A61P43/00 , C07D211/74 , C07D309/28 , C07D211/78 , C07D309/30 , C07D335/02 , C07F9/59 , C07F9/655 , C07F9/6553
Abstract: Trihydroxyheterocyclylamino compounds of formula (I) and their salts are new. Y = COOH, PO3H2, P(O)(OR6)(OH), P(O)R6(OH), tetrazole or SO3H; R6 = 1-4C alkyl; X = NH, O or S; R = H or CONH-C6(R7)5; and R7 = H, OH, halo, COOH, PO3H2 or SO3H.
-
公开(公告)号：AT208213T
公开(公告)日：2001-11-15
申请号：AT94113388
申请日：1994-08-26
Applicant: HOECHST AG , HOECHST HOUDE S A LAB
Inventor： BOSSLET DR KLAUS , CZECH DR JOERG , HOFFMANN DR DIETER , TILLEQUIN PROF FRANCOIS , FLORENT DR JEAN-CLAUDE , AZOULAY DR MICHEL , MONNERET DR CLAUDE , JACQUESY PROF JEAN-CLAUDE , GESSON PROF JEAN-PIERRE , KOCH PROF MICHEL , VASELLA PROF ANDREA , HOOS ROLAND
IPC: C07H15/203 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K47/48 , A61P35/00 , A61P43/00 , C07H15/244
Abstract: Enzymatically cleavable prodrugs with reduced Michaelis-Menten constant (Km) are described.
-
公开(公告)号：AT207067T
公开(公告)日：2001-11-15
申请号：AT97112940
申请日：1997-07-28
Applicant: HOECHST AG
Inventor： BOSSLET KLAUS , CZECH JOERG , VASELLA ANDREA , HOOS ROLAND
IPC: C07D309/28 , A61K31/35 , A61K31/351 , A61P29/00 , A61P35/00 , A61P43/00 , C07D211/74 , C07D211/78 , C07D309/30 , C07D335/02 , C07F9/59 , C07F9/655 , C07F9/6553
Abstract: Trihydroxyheterocyclylamino compounds of formula (I) and their salts are new. Y = COOH, PO3H2, P(O)(OR6)(OH), P(O)R6(OH), tetrazole or SO3H; R6 = 1-4C alkyl; X = NH, O or S; R = H or CONH-C6(R7)5; and R7 = H, OH, halo, COOH, PO3H2 or SO3H.
-
公开(公告)号：DE69428957D1
公开(公告)日：2001-12-13
申请号：DE69428957
申请日：1994-08-26
Applicant: HOECHST AG , HOECHST HOUDE S A LAB
Inventor： BOSSLET DR KLAUS , CZECH DR JOERG , HOFFMANN DR DIETER , TILLEQUIN PROF FRANCOIS , FLORENT DR JEAN-CLAUDE , AZOULAY DR MICHEL , MONNERET DR CLAUDE , JACQUESY PROF JEAN-CLAUDE , GESSON PROF JEAN-PIERRE , KOCH PROF MICHEL , VASELLA PROF ANDREA , HOOS ROLAND
IPC: C07H15/203 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K47/48 , A61P35/00 , A61P43/00 , C07H15/244
Abstract: Enzymatically cleavable prodrugs with reduced Michaelis-Menten constant (Km) are described.
-
Patent Agency Ranking
公开(公告)号：AU3241997A
公开(公告)日：1998-02-12
申请号：AU3241997
申请日：1997-07-31
Applicant: HOECHST AG
Inventor： BOSSLET KLAUS , CZECH JOERG , VASELLA ANDREA , HOOS ROLAND
IPC: C07D309/28 , A61K31/35 , A61K31/351 , A61P29/00 , A61P35/00 , A61P43/00 , C07D211/74 , C07D211/78 , C07D309/30 , C07D335/02 , C07F9/59 , C07F9/655 , C07F9/6553
Abstract: Trihydroxyheterocyclylamino compounds of formula (I) and their salts are new. Y = COOH, PO3H2, P(O)(OR6)(OH), P(O)R6(OH), tetrazole or SO3H; R6 = 1-4C alkyl; X = NH, O or S; R = H or CONH-C6(R7)5; and R7 = H, OH, halo, COOH, PO3H2 or SO3H.
-
公开(公告)号：DE19631288A1
公开(公告)日：1998-02-05
申请号：DE19631288
申请日：1996-08-02
Applicant: HOECHST AG
Inventor： BOSSLET KLAUS , CZECH JOERG , VASELLA ANDREA , HOOS ROLAND
IPC: C07D309/28 , A61K31/35 , A61K31/351 , A61P29/00 , A61P35/00 , A61P43/00 , C07D211/74 , C07D211/78 , C07D309/30 , C07D335/02 , C07F9/59 , C07F9/655 , C07F9/6553 , C07H7/033 , A61K31/70
Abstract: Trihydroxyheterocyclylamino compounds of formula (I) and their salts are new. Y = COOH, PO3H2, P(O)(OR6)(OH), P(O)R6(OH), tetrazole or SO3H; R6 = 1-4C alkyl; X = NH, O or S; R = H or CONH-C6(R7)5; and R7 = H, OH, halo, COOH, PO3H2 or SO3H.
-
公开(公告)号：CA2212200A1
公开(公告)日：1998-02-02
申请号：CA2212200
申请日：1997-08-01
Applicant: HOECHST AG
Inventor： BOSSLET KLAUS , CZECH JOERG , VASELLA ANDREA , HOOS ROLAND
IPC: C07D309/28 , A61K31/35 , A61K31/351 , A61P29/00 , A61P35/00 , A61P43/00 , C07D211/74 , C07D211/78 , C07D309/30 , C07D335/02 , C07F9/59 , C07F9/655 , C07F9/6553 , C07H7/033 , C07D401/04 , C07D409/04 , C07H5/06 , C07H5/10 , A61K31/38 , A61K31/445 , A61K31/66 , A61K31/70 , C07D211/72
Abstract: Novel inhibitors of .beta.-glucuronidase Compounds of the formulae I and II (see fig.I) (see fig.II) are suitable for the suppression of tumor growth and of tumor metastasis.
-
公开(公告)号：PT642799E
公开(公告)日：2002-04-29
申请号：PT94113388
申请日：1994-08-26
Applicant: HOECHST AG , HOECHST HOUDE S A LAB
Inventor： MONNERET CLAUDE , FLORENT JEAN-CLAUDE , GESSON JEAN-PIERRE , JACQUESY JEAN-CLAUDE , KOCH MICHEL , TILLEQUIN FRANCOIS , BOSSLET KLAUS , AZOULAY MICHEL , JORG CZECH DR , VASELLA ANDREA , DIETER HOFFMANN DR , HOOS ROLAND
IPC: C07H15/203 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K47/48 , A61P35/00 , A61P43/00 , C07H15/244
Abstract: Enzymatically cleavable prodrugs with reduced Michaelis-Menten constant (Km) are described.
-
公开(公告)号：PT822192E
公开(公告)日：2002-03-28
申请号：PT97112940
申请日：1997-07-28
Applicant: HOECHST AG
Inventor： BOSSLET KLAUS , CZECH JOERG , VASELLA ANDREA , HOOS ROLAND
IPC: A61K31/35 , A61K31/351 , A61P29/00 , A61P35/00 , A61P43/00 , C07D211/74 , C07D309/28 , C07D211/78 , C07D309/30 , C07D335/02 , C07F9/59 , C07F9/655 , C07F9/6553
Abstract: Trihydroxyheterocyclylamino compounds of formula (I) and their salts are new. Y = COOH, PO3H2, P(O)(OR6)(OH), P(O)R6(OH), tetrazole or SO3H; R6 = 1-4C alkyl; X = NH, O or S; R = H or CONH-C6(R7)5; and R7 = H, OH, halo, COOH, PO3H2 or SO3H.
-
-
-
-
-
-
-
-
-
Search Results
17
records
(took 0.02 seconds)
