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公开(公告)号：SE303831B
公开(公告)日：1968-09-09
申请号：SE614062
申请日：1962-05-30
Applicant: HOFFMANN LA ROCHE
IPC: A01N20060101 , A23C7/02 , A23K20060101 , A23L20060101 , A23L3/3526 , A24B20060101 , A61K8/64 , A61K38/00 , A61Q5/00 , A61Q9/02 , A61Q15/00 , A61Q17/00 , C07C233/45 , C07K5/04 , C07K5/068 , C07K5/09 , C11D20060101 , A01N9/20
Abstract: The invention comprises Ne -palmitoyl-L-lysine and Ng - palmitoyl - (L - a ,g - diamino-butyric) acid and their alkyl esters containing up to six carbon atoms in the alkyl residue characterizing the ester group. The acids are prepared by heating L-lysine hydrochloride a L-a ,g -diamino-butyric acid hydrochloride with basic copper carbonate, acylating the resulting complex under alkaline conditions with palmitoyl chloride, acidifying the acylation product, removing the copper by precipitation with hydrogen sulphide and rendering the mixture neutral to precipitate the product. The acids are esterified by reaction with an alcohol and hydrogen chloride or thionyl chloride.
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公开(公告)号：SE398347B
公开(公告)日：1977-12-19
申请号：SE1213571
申请日：1971-09-24
Applicant: HOFFMANN LA ROCHE
Inventor： GILLESSEN D , KUNZI H , STUDER R , BAYER E , MUTTER M
IPC: C07C233/09 , C07K1/04 , C07K5/103 , C07C103/52
Abstract: 1310656 Peptide process F HOFFMANNLA ROCHE & CO AG 24 Sept 1971 [26 Sept 1970] 44701/71 Heading C2C [Also in Division C3] In a peptide process an amino acid which is linked via an ester or amide bond to a polymer which is soluble in water and/or an organic solvent is stepwise coupled in a homogeneous phase with further amino acids and the polymer removed from the peptide. Polymers have mol. wts. of up to 100,000 and are preferably polyethylene glycol optionally esterified with citric acid or a copolymerizate of vinyl pyrrolidone and acrylic acid #-hydroxyethylacrylate or of acrylamide and vinyl acetate in which the ester groups are partially saponified at least, or a copolymerizate of polyethylene glycol and succinic acid. In the process lower molecular coupling reagents are removed by dialysis, membrane filtration, column chromatography or countercurrent distribution and the polymer is removed from the peptide by treatment with dilute alkali hydroxide. Maleic acid di-(p-nitrophenyl) ester is prepared from the acid and phenol in the presence of dicyclohexylcarbodiimide and then with HI to give mono iodo succinic acid di-(p-nitrophenyl) ester.
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公开(公告)号：ZA754724B
公开(公告)日：1976-06-30
申请号：ZA754724
申请日：1975-07-22
Applicant: HOFFMANN LA ROCHE
Inventor： GILLESSEN D , STUDER R , TRZECIAK A
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公开(公告)号：NO128475B
公开(公告)日：1973-11-26
申请号：NO14456162
申请日：1962-05-29
Applicant: HOFFMANN LA ROCHE
IPC: A01N20060101 , A23C7/02 , A23K20060101 , A23L20060101 , A23L3/3526 , A24B20060101 , A61K8/64 , A61K38/00 , A61Q5/00 , A61Q9/02 , A61Q15/00 , A61Q17/00 , C07C233/45 , C07K5/04 , C07K5/068 , C07K5/09 , C11D20060101 , A61L13/00 , A23B1/00
Abstract: The invention comprises Ne -palmitoyl-L-lysine and Ng - palmitoyl - (L - a ,g - diamino-butyric) acid and their alkyl esters containing up to six carbon atoms in the alkyl residue characterizing the ester group. The acids are prepared by heating L-lysine hydrochloride a L-a ,g -diamino-butyric acid hydrochloride with basic copper carbonate, acylating the resulting complex under alkaline conditions with palmitoyl chloride, acidifying the acylation product, removing the copper by precipitation with hydrogen sulphide and rendering the mixture neutral to precipitate the product. The acids are esterified by reaction with an alcohol and hydrogen chloride or thionyl chloride.
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公开(公告)号：ZA723287B
公开(公告)日：1973-02-28
申请号：ZA723287
申请日：1972-05-15
Applicant: HOFFMANN LA ROCHE
Inventor： STUDER R , GILLESSEN D , RUDINGER J
Abstract: 1362743 Cyclic nonapeptides F HOFFMANN-LA ROCHE & CO AG 16 June 1972 [18 June 1971] 28339/72 Heading C2C Novel compounds I in which Q is Arg or Lys and their salts are prepared by conventional methods of peptide synthesis. Intermediates isolated are Z-leu-asp(NH 2 )- cys(B 2 ) - OMe; Z - leu - asp(NH 2 ) - cys(B 2 )- NHNH 2 ; Z - leu - asp(NH 2 ) - cys(B 2 ) - proarg(tosyl) - gly - NH 2 ; Z - cys(B 2 ) - tyr - ileleu - asp(NH 2 ) - cys(B 2 ) - pro - arg(tosyl) - gly- NH2; Z - ile - leu - asp(NH 2 ) - cys(B 2 ) - proarg(tosyl) - gly - NH 2 ; Z - tyr(B 2 ) - ile - leuasp(NH 2 ) - cys(B 2 ) - pro - arg(tosyl) - gly - NH 2 ; Z - leu - asp(NH 2 ) - cys(B 2 ) - pro - lys(tosyl)- gly - NH 2 ; Z - ile - leu - asp(NH 2 ) - cys(B 2 )- pro - lys(tosyl) - gly - NH 2 ; and tosyl - cys(B 2 )- tyr - ile - leu - asp(NH 2 ) - cys(B 2 ) - pro - lys- (tosyl)-gly-NH 2 . Pharmaceutical compositions comprise a compound I together with a suitable diluent and/or carrier and have natriuretic activity. They may be administered orally, rectally, nasally or parenterally.
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Patent Agency Ranking
公开(公告)号：ZA7203287B
公开(公告)日：1973-02-28
申请号：ZA7203287
申请日：1972-05-15
Applicant: HOFFMANN LA ROCHE
Inventor： STUDER R , GILLESSEN D , RUDINGER J
CPC classification number: C07K7/16 , A61K38/00 , Y10S514/807 , Y10S930/15
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公开(公告)号：FI40545B
公开(公告)日：1968-11-30
申请号：FI107562
申请日：1962-05-29
Applicant: HOFFMANN LA ROCHE
IPC: A01N20060101 , A23C7/02 , A23K20060101 , A23L20060101 , A23L3/3526 , A24B20060101 , A61K8/64 , A61K38/00 , A61Q5/00 , A61Q9/02 , A61Q15/00 , A61Q17/00 , C07C233/45 , C07K5/04 , C07K5/068 , C07K5/09 , C11D20060101 , C07C103/52
Abstract: The invention comprises Ne -palmitoyl-L-lysine and Ng - palmitoyl - (L - a ,g - diamino-butyric) acid and their alkyl esters containing up to six carbon atoms in the alkyl residue characterizing the ester group. The acids are prepared by heating L-lysine hydrochloride a L-a ,g -diamino-butyric acid hydrochloride with basic copper carbonate, acylating the resulting complex under alkaline conditions with palmitoyl chloride, acidifying the acylation product, removing the copper by precipitation with hydrogen sulphide and rendering the mixture neutral to precipitate the product. The acids are esterified by reaction with an alcohol and hydrogen chloride or thionyl chloride.
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公开(公告)号：NO752947L
公开(公告)日：1976-03-02
申请号：NO752947
申请日：1975-08-27
Applicant: HOFFMANN LA ROCHE
Inventor： GILLESSEN D , STUDER R , TRZECIAK A
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公开(公告)号：DK386275A
公开(公告)日：1976-02-29
申请号：DK386275
申请日：1975-08-27
Applicant: HOFFMANN LA ROCHE
Inventor： GILLESSEN D , STUDER R , TRZECIAK A
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公开(公告)号：ZA737898B
公开(公告)日：1974-07-31
申请号：ZA737898
申请日：1973-10-09
Applicant: HOFFMANN LA ROCHE
Inventor： GILLESSEN D , RUDINGER J , STUDER R
IPC: A61K38/00 , C07C323/60 , C07K1/113 , C07K7/16 , C07K14/575 , C07K14/58 , C07C
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