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公开(公告)号：US3792034A
公开(公告)日：1974-02-12
申请号：US3792034D
申请日：1972-03-29
Applicant: HOFFMANN LA ROCHE
Inventor： BOGUTH W , STUDER R , ACHTERRATH U , KUNZI H
IPC: C07K5/08 , C07K5/097 , C07C103/52
CPC classification number: C07K5/0825 , C07K5/0827
Abstract: L-PYROGLUTAMYL-2,5-DIIODO-L-HISTIDYL-PROLINAMIDE AND ITS ACID ADDITION SALTS ARE ACTIVE AS THYROIDAL AGENTS, SUCH AS FOR EXAMPLE IN THE TREATMENTOF HYPERTHYREOSIS. THE IODINATED TRIPEPTIDE IS CONVENIENTLY PREPARED BY IODINATING 1PYROGLUTAMYL-L-HISTIDYL-PROLINAMIDE.
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公开(公告)号：US3816385A
公开(公告)日：1974-06-11
申请号：US26002272
申请日：1972-06-01
Applicant: HOFFMANN LA ROCHE
Inventor： GILLESSEN D , RUDINGER J , STUDER R
IPC: A61K38/00 , C07K7/16 , A61K27/00 , C07C103/52 , C07G7/00
CPC classification number: C07K7/16 , A61K38/00 , Y10S514/807 , Y10S930/15
Abstract: DIURETICALLY ACTIVE NONAPEPTIDES WHICH ARE ANALOGS OF VASOPRESSIN ARE DISCLOSED. PARTICULAR EMBODIMENTS INCLUDE (ILE3,LEU4) - ARGINING-VASOPRESSIN AND (ILE3,LEU4)-LYSINEVASOPRESSIN. INTERMEDIATES USEFUL IN THE PREPARATION OF THE ABOVE COMPOUNDS ARE ALSO DISCLOSED.
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公开(公告)号：US3772264A
公开(公告)日：1973-11-13
申请号：US3772264D
申请日：1971-09-17
Applicant: HOFFMANN LA ROCHE
Inventor： BAYER E , MUTTER M , GILLESSEN D , KUENZI H , STUDER R
IPC: C07C233/09 , C07K1/04 , C07K5/103 , C07C103/52 , C07G7/00 , C08H1/00
CPC classification number: C07K1/042 , C07K5/1005
Abstract: PEPTIDES ARE PREPARED IN A HOMOGENEOUS SYSTEM BY COUPLING A FIRST AMINO ACID TO A SOLUBLE POLYMER SUPPORT AND THEREAFTER COUPLING ADDITIONAL AMINO ACIDS IN DESIRED SEQUENCE UNTIL THE ULTIMATE PEPTIDE IS OBTAINED. REAGENTS USED IN THE INTERMEDIATE STEPS ARE READILY SEPARATED FROM THE COUPLED POLYMER-AMINO ACID CHAIN BY SELECTIVE FILTRATION TECHNIQUES. IN THE FINAL STEP THE DESIRED PEPTIDE IS CLEAVED FROM THE POLYMER SUPPORT AND SEPARATED FROM THE SOLUBLE POLYMER BY USE OF ULTRAFILTRATION.
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公开(公告)号：NO752947A
公开(公告)日：1976-03-02
申请号：NO752947
申请日：1975-08-27
Applicant: HOFFMANN LA ROCHE
Inventor： GILLESSEN D , STUDER R , TRZECIAK A
CPC classification number: C07K5/0202 , C07K5/06147
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公开(公告)号：ZA7201155B
公开(公告)日：1972-11-29
申请号：ZA7201155
申请日：1972-02-21
Applicant: HOFFMANN LA ROCHE
Inventor： BOGUTH W , STUDER R , ACHTERRATH U , KUNZI H
CPC classification number: C07K5/0825 , C07K5/0827
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Patent Agency Ranking
公开(公告)号：ZA7504724B
公开(公告)日：1976-06-30
申请号：ZA7504724
申请日：1975-07-22
Applicant: HOFFMANN LA ROCHE
Inventor： GILLESSEN D , STUDER R , TRZECIAK A
CPC classification number: C07K5/0202 , C07K5/06147
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公开(公告)号：SE7509532L
公开(公告)日：1976-03-01
申请号：SE7509532
申请日：1975-08-27
Applicant: HOFFMANN LA ROCHE
Inventor： GILLESSEN D , STUDER R , TRZECIAK A
IPC: C07K1/113 , A61K38/04 , C07K5/02 , C07K5/078 , C07C103/52
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公开(公告)号：ZA7303419B
公开(公告)日：1974-03-27
申请号：ZA7303419
申请日：1973-05-21
Applicant: HOFFMANN LA ROCHE
Inventor： RUDINGER J , GILLESSEN D , STUDER R
CPC classification number: C07K7/16 , A61K38/00 , C07K5/1005
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公开(公告)号：SE7509532A
公开(公告)日：1976-03-01
申请号：SE7509532
申请日：1975-08-27
Applicant: HOFFMANN LA ROCHE
Inventor： GILLESSEN D , STUDER R , TRZECIAK A
IPC: C07K1/113 , A61K38/04 , C07K5/02 , C07K5/078 , C07C103/52
CPC classification number: C07K5/0202 , C07K5/06147
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公开(公告)号：ZA735680B
公开(公告)日：1974-07-31
申请号：ZA735680
申请日：1973-08-20
Applicant: HOFFMANN LA ROCHE
Inventor： STUDER R , GILLESSEN D , RUDINGER J
Abstract: The novel title polypeptides are of formula (where X is the radical of an aminoacid or a linear peptide contg. 2-6 aminoacids, and Q is Arg or Lys), all the aminoacids having the 1-configuration, together with their pharmaceutically acceptable acid addn. salts. They may be prepd. by removal of the protecting gps. from peptides of formula (where R1 is an opt. protected aminoacid or a 2-6 aminoacid linear peptide, R2 is H or an amide protecting gp, Q' is -NHCH (CH2)3NH-C(=NH)-NHR3 CO- or NHCH -(CH2)4NHR4-CO-, where R3 is H or a guanidine-protecting gp. and R4 is H or a lysine-protecting gp).
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