中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

9 records (took 0.021 seconds)

    POLYPEPTIDES
    2.
    发明专利
    POLYPEPTIDES 未知

    公开(公告)号：ZA735680B

    公开(公告)日：1974-07-31

    申请号：ZA735680

    申请日：1973-08-20

    Applicant: HOFFMANN LA ROCHE

    Inventor： STUDER R ,  GILLESSEN D ,  RUDINGER J

    IPC: A61K38/00 ,  C07K1/113 ,  C07K5/103 ,  C07K7/16 ,  C07K14/575 ,  C07K14/58 ,  C07C

    Abstract: The novel title polypeptides are of formula (where X is the radical of an aminoacid or a linear peptide contg. 2-6 aminoacids, and Q is Arg or Lys), all the aminoacids having the 1-configuration, together with their pharmaceutically acceptable acid addn. salts. They may be prepd. by removal of the protecting gps. from peptides of formula (where R1 is an opt. protected aminoacid or a 2-6 aminoacid linear peptide, R2 is H or an amide protecting gp, Q' is -NHCH (CH2)3NH-C(=NH)-NHR3 CO- or NHCH -(CH2)4NHR4-CO-, where R3 is H or a guanidine-protecting gp. and R4 is H or a lysine-protecting gp).

    NONAPEPTIDES AND PROCESSES FOR THE PREPARATION THEREOF
    4.
    发明专利
    NONAPEPTIDES AND PROCESSES FOR THE PREPARATION THEREOF 未知

    公开(公告)号：ZA723287B

    公开(公告)日：1973-02-28

    申请号：ZA723287

    申请日：1972-05-15

    Applicant: HOFFMANN LA ROCHE

    Inventor： STUDER R ,  GILLESSEN D ,  RUDINGER J

    IPC: A61K38/00 ,  C07K7/16

    Abstract: 1362743 Cyclic nonapeptides F HOFFMANN-LA ROCHE & CO AG 16 June 1972 [18 June 1971] 28339/72 Heading C2C Novel compounds I in which Q is Arg or Lys and their salts are prepared by conventional methods of peptide synthesis. Intermediates isolated are Z-leu-asp(NH 2 )- cys(B 2 ) - OMe; Z - leu - asp(NH 2 ) - cys(B 2 )- NHNH 2 ; Z - leu - asp(NH 2 ) - cys(B 2 ) - proarg(tosyl) - gly - NH 2 ; Z - cys(B 2 ) - tyr - ileleu - asp(NH 2 ) - cys(B 2 ) - pro - arg(tosyl) - gly- NH2; Z - ile - leu - asp(NH 2 ) - cys(B 2 ) - proarg(tosyl) - gly - NH 2 ; Z - tyr(B 2 ) - ile - leuasp(NH 2 ) - cys(B 2 ) - pro - arg(tosyl) - gly - NH 2 ; Z - leu - asp(NH 2 ) - cys(B 2 ) - pro - lys(tosyl)- gly - NH 2 ; Z - ile - leu - asp(NH 2 ) - cys(B 2 )- pro - lys(tosyl) - gly - NH 2 ; and tosyl - cys(B 2 )- tyr - ile - leu - asp(NH 2 ) - cys(B 2 ) - pro - lys- (tosyl)-gly-NH 2 . Pharmaceutical compositions comprise a compound I together with a suitable diluent and/or carrier and have natriuretic activity. They may be administered orally, rectally, nasally or parenterally.

    NONAPEPTIDES AND PROCESS FOR THE PREPARATION THEREOF
    9.
    发明专利
    NONAPEPTIDES AND PROCESS FOR THE PREPARATION THEREOF 未知

    公开(公告)号：ZA733419B

    公开(公告)日：1974-03-27

    申请号：ZA733419

    申请日：1973-05-21

    Applicant: HOFFMANN LA ROCHE

    Inventor： RUDINGER J ,  GILLESSEN D ,  STUDER R

    IPC: A61K38/00 ,  C07K5/103 ,  C07K7/16 ,  C07C

    Abstract: Cpds. of gen. formula (I): where Q = arginine or lysine residue; Mpr = beta-mercaptopropionyl; all amino acids with asymmetric C-atom have L-configuration; including pharmaceutically-acceptable, non-toxic acid-addn. salts of (I); are prepd. by e.g. removing protecting gps. of a cpd. (III): (where R1 = H or an amido-protecting gp. Q1 = NH-CH/-(CH2)3-NH-C(=NH-NHR2/-CO or -NH-CH/-(CH2)4-NHR3/-CO-; R2 = H or a guanidino-protecting gp; R3 = H or an -amino gp. of lysine-protecting gp). (I) have hormonal activity qualitatively equal to that of neurohypophysal hormones. They have esp. natriuretic act. and may be used in the treatment of all types of oedema and general disturbance of the electrolyte metabolism, esp. sodium retention. (I) are more active and are longer lasting in activity than natural (IIe3)-argininvasopressine or known (Leu4) oxytocine, with less hypertensive activity.

Patent Agency Ranking