公开(公告)号：GB2583304A

公开(公告)日：2020-10-21

申请号：GB202010225

申请日：2018-12-04

Applicant: IBM ,  AGENCY SCIENCE TECH & RES

Inventor： JAMES HEDRICK ,  MAREVA FEVRE ,  NATHANIEL PARK ,  VICTORIA PIUNOVA ,  YI YAN YANG ,  PANG KERN JEREMY TAN ,  CHUAN YANG

IPC: C08G73/02 ,  C08G73/06

Abstract: Disclosed is a polymer comprising a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further the repeating ionene unit can have antimicrobial functionality.

公开(公告)号：GB2601680B

公开(公告)日：2023-02-22

申请号：GB202202615

申请日：2020-07-15

Applicant: IBM ,  AGENCY SCIENCE TECH & RES

Inventor： NATHANIEL PARK ,  JAMES HEDRICK ,  GAVIN JONES ,  VICTORIA PIUNOVA ,  YI YAN YANG ,  PANG KERN JEREMY TAN ,  CHUAN YANG ,  CHERYLETTE ANNE ALEXANDER

IPC: A61K31/765 ,  A61P31/00 ,  A61P35/00

Abstract: Techniques regarding enhancing antimicrobial activity of antirheumatic agents by combination therapy are provided. For example, one or more embodiments described herein can regard a chemical composition comprising a polycarbonate polymer functionalized with a guanidinium functional group. The chemical composition can also comprise an antirheumatic agent, and the polycarbonate polymer can enhance an antimicrobial activity of the antirheumatic agent.

公开(公告)号：GB2601680A

公开(公告)日：2022-06-08

申请号：GB202202615

申请日：2020-07-15

Applicant: IBM ,  AGENCY FOR SCIENCE TECH AND RESEARCH ASTARSTAR

Inventor： NATHANIEL PARK ,  JAMES HEDRICK ,  GAVIN JONES ,  VICTORIA PIUNOVA ,  YI YAN YANG ,  PANG KERN JEREMY TAN ,  CHUAN YANG ,  CHERYLETTE ANNE ALEXANDER

IPC: A61K31/765 ,  A61P31/00 ,  A61P35/00

Abstract: Techniques regarding guanidinium functionalized polylysine polymers that can have antimicrobial and/or anticancer activity are provided. For example, one or more embodiments described herein can comprise a chemical composition, which can comprise a polymer comprising a molecular backbone covalently bonded to a pendent guanidinium functional group, wherein the molecular backbone can comprise a polylysine structure.

公开(公告)号：GB2583041B

公开(公告)日：2021-06-09

申请号：GB202010000

申请日：2018-12-03

Applicant: IBM

Inventor： NATHANIEL PARK ,  JAMES HEDRICK ,  GAVIN JONES

IPC: C08F251/00 ,  C08G18/28 ,  C08G18/32 ,  C08G18/83 ,  C08G64/42 ,  C08J7/12

Abstract: Techniques regarding chemical compounds comprising perfluoroaryl groups that can facilitate post-synthesis functionalization are provided. For example, one or more embodiments described herein can comprise a chemical compound. The chemical compound can comprise a molecular backbone. The chemical compound can also comprise a pendent functional group bonded to the molecular backbone. The pendent functional group can comprise a perfluoroaryl group and a methylene group.

公开(公告)号：GB2576277B

公开(公告)日：2021-01-27

申请号：GB201916196

申请日：2018-04-20

Applicant: IBM ,  AGENCY SCIENCE TECH & RES

Inventor： AMOS CAHAN ,  JAMES HEDRICK ,  MAREVA FEVRE ,  NATHANIEL PARK ,  RUDY J WOJTECKI ,  THEODORE VAN KESSEL ,  YI YAN YANG

IPC: A61L27/34 ,  A61K31/765 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  C08G18/52 ,  C08G75/04

Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. In particular, a method for forming an organocatalyzed polythioether coating is provided in which a first solution including a bis-silylated dithiol and a fluoroarene is prepared. A second solution including an organocatalyst is prepared. The first solution and the second solution are mixed to form a mixed solution. The mixed solution is applied to a substrate, and the substrate is cured.

公开(公告)号：GB2583426A

公开(公告)日：2020-10-28

申请号：GB202010334

申请日：2018-12-04

Applicant: IBM ,  AGENCY SCIENCE TECH & RES

Inventor： JAMES HEDRICK ,  MAREVA FEVRE ,  VICTORIA PIUNOVA ,  NATHANIEL PARK ,  PANG KERN JEREMY TAN ,  YI YAN YANG ,  MU SAN ZHANG

IPC: C08G73/00

Abstract: Techniques regarding ionene compositions with antimicrobial functionality are provided. For example, one or more embodiments can comprise a monomer, which can comprise a single ionene unit. The single ionene unit can comprise a cation distributed along a molecular backbone. Also, a hydrophobic functional group can be covalently bonded to the molecular backbone, and the single ionene unit can have antimicrobial functionality.

公开(公告)号：GB2583041A

公开(公告)日：2020-10-14

申请号：GB202010000

申请日：2018-12-03

Applicant: IBM

Inventor： NATHANIEL PARK ,  JAMES HEDRICK ,  GAVIN JONES

IPC: C08F251/00 ,  C08G18/28 ,  C08G18/32 ,  C08G18/83 ,  C08G64/42 ,  C08J7/12

Abstract: Techniques regarding chemical compounds comprising perfluoroaryl groups that can facilitate post-synthesis functionalization are provided. For example, one or more embodiments described herein can comprise a chemical compound. The chemical compound can comprise a molecular backbone. The chemical compound can also comprise a pendent functional group bonded to the molecular backbone. The pendent functional group can comprise a perfluoroaryl group and a methylene group.

公开(公告)号：GB2580240A

公开(公告)日：2020-07-15

申请号：GB202003173

申请日：2018-11-09

Applicant: IBM ,  AGENCY SCIENCE TECH & RES

Inventor： VICTORIA PIUNOVA ,  NOAH FREDERICK FINE NATHEL ,  JAMES HEDRICK ,  YI YAN YANG ,  WILLY CHIN ,  ZHI XIANG VOO

IPC: A61K47/50 ,  A01N33/12 ,  A01N43/90 ,  A01N47/06 ,  A01N59/00 ,  A01P1/00 ,  A61L2/23 ,  C08G64/00 ,  C08G64/42 ,  C09D5/14 ,  C09D169/00

Abstract: Techniques regarding star polymers with enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a core that can have a singlet oxygen generator and that can generate a singlet oxygen species upon irradiation with light. The polymer can also comprise a plurality of polycarbonate arms covalently bonded to the core. The plurality of polycarbonate arms can be degradable and can comprise a cation. Further, the plurality of polycarbonate arms can have antimicrobial functionality.

公开(公告)号：GB2576277A

公开(公告)日：2020-02-12

申请号：GB201916196

申请日：2018-04-20

Applicant: IBM ,  AGENCY SCIENCE TECH & RES

Inventor： AMOS CAHAN ,  JAMES HEDRICK ,  MAREVA FEVRE ,  NATHANIEL PARK ,  RUDY J WOJTECKI ,  THEODORE VAN KESSEL ,  YI YAN YANG

IPC: A61L27/34 ,  A61K31/765 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  C08G18/52 ,  C08G75/04

Abstract: Antibacterial coatings and methods of making the antibacterial coatings are described herein. In particular, a method for forming an organocatalyzed polythioether coating is provided in which a first solution including a bis- silylated dithiol and a fluoroarene is prepared. A second solution including an organocatalyst is prepared. The first solution and the second solution are mixed to form a mixed solution. The mixed solution is applied to a substrate, and the substrate is cured.