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11.发明专利
公开(公告)号：CA2799640C
公开(公告)日：2018-10-16
申请号：CA2799640
申请日：2011-06-08
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： TRABANCO-SUAREZ ANDRES AVELINO , ROMBOUTS FREDERIK JAN RITA , TRESADERN GARY JOHN , VAN GOOL MICHIEL LUC MARIA , MACDONALD GREGOR JAMES , MARTINEZ LAMENCA CAROLINA , GIJSEN HENRICUS JACOBUS MARIA
IPC: C07D265/30 , A61K31/535 , A61K31/5355 , A61P25/16 , A61P25/28 , C07D413/04
Abstract: The present invention relates to novel 5,6-dihydro-2H-[1,4]oxazin-3-yl-amine derivatives as inhibitors of beta-secretase, also known as beta-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which beta-secretase is involved, such as Alzheimer's disease (AD), mild cognitive impairment, senility, dementia, dementia with Lewy bodies, Down's syndrome, dementia associated with stroke, dementia associated with Parkinson's disease and dementia associated with beta-amyloid. (see above formula)
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公开(公告)号：NO342797B1
公开(公告)日：2018-08-06
申请号：NO20084744
申请日：2008-11-10
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： BRUYN MARCEL FRANS LEOPOLD DE , LESAGE ANNE SIMONE JOSEPHINE , ROOSBROECK YVES EMIEL MARIA VAN , MACDONALD GREGOR JAMES , KEYBUS FRANS ALFONS MARIA VAN DEN , THURING JOHANNES WILHELMUS JOHN F , ZHUANG WEI , DINKLO THEODORUS , DUFFY JAMES EDWARD STEWART
IPC: C07D401/04 , A61K31/4196 , C07D405/04 , C07D405/14 , C07D491/04
Abstract: Den foreliggende oppfinnelsen angår 3-anilin-5-aryltriazolderivater og analoger eller farmasøytisk akseptable salter derav, metoder for å fremstille dem, farmasøytiske sammensetninger inneholdende dem og deres anvendelse i terapi, ifølge formel (I). Oppfinnelsen angår spesielt positive allosteriske modulatorer av nikotinacetylkolinreseptorer, slike positive allosteriske modulatorer har evnen til å øke effektiviteten av nikotinreseptoragonister.
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13.发明专利
公开(公告)号：HUE033768T2
公开(公告)日：2017-12-28
申请号：HUE09802514
申请日：2009-07-29
Applicant: JANSSEN PHARMACEUTICA NV
IPC: A61P25/00
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公开(公告)号：PL3004107T3
公开(公告)日：2017-10-31
申请号：PL14727824
申请日：2014-06-03
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： VAN GOOL MICHIEL LUC MARIA , ALONSO-DE DIEGO SERGIO-ALVAR , CID-NÚÑEZ JOSÉ MARIA , DELGADO-GONZÁLEZ ÓSCAR , DECORTE ANNELIES MARIE ANTONIUS , MACDONALD GREGOR JAMES , MEGENS ANTONIUS ADRIANUS HENDRIKUS PETRUS , TRABANCO-SUÁREZ ANDRÉS AVELINO , GARCÍA-MOLINA ARÁNZAZU , ANDRÉS-GIL JOSÉ IGNACIO
IPC: C07D487/04 , A61K31/4985 , A61P25/00
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公开(公告)号：SI3004107T1
公开(公告)日：2017-09-29
申请号：SI201430322
申请日：2014-06-03
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： VAN GOOL MICHIEL LUC MARIA , ALONSO-DE DIEGO SERGIO-ALVAR , CID-NUNEZ JOSE MARIA , DELGADO-GONZALEZ OSCAR , DECORTE ANNELIES MARIE ANTONIUS , MACDONALD GREGOR JAMES , MEGENS ANTONIUS ADRIANUS HENDRIKUS PETRUS , TRABANCO-SUAREZ ANDRES AVELINO , GARCIA-MOLINA ARANZAZU , ANDRES-GIL JOSE IGNACIO
IPC: C07D487/00 , A61K31/00 , A61P25/00
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Patent Agency Ranking
公开(公告)号：MY160305A
公开(公告)日：2017-02-28
申请号：MYPI2012003971
申请日：2011-03-08
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： BARTOLOMÉ-NEBREDA JOSÉ MANUEL , CONDE-CEIDE SUSANA , MACDONALD GREGOR JAMES , PASTOR-FERNÁNDEZ JOAQUIN , VAN GOOL MICHIEL LUC MARIA , MARTÍN-MARTÍN MARÍA LUZ , VANHOOF GRETA CONSTANTIA PETER
IPC: C07D487/04 , A61K31/4985 , A61P3/00 , A61P25/00
Abstract: THE PRESENT INVENTION RELATES TO NOVEL IMIDAZO[1,2-A]PYRAZINE DERIVATIVES WHICH ARC INHIBITORS OF THE PHOSPHODIESTERASE 10 ENZYME (PDE 10) AND WHICH ARE USEFUL FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL, PSYCHIATRIC AND METABOLIC DISORDERS IN WHICH THE PDE10 ENZYME IS INVOLVED. THE INVENTION IS ALSO DIRECTED TO PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH COMPOUNDS, TO PROCESSES TO PREPARE SUCH COMPOUNDS AND COMPOSITIONS, TO THE USE OF SUCH COMPOUNDS OR PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION OR TREATMENT OF NEUROLOGICAL, PSYCHIATRIC AND METABOLIC DISORDERS AND DISEASES.
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17.发明专利
公开(公告)号：DK2580200T3
公开(公告)日：2017-01-09
申请号：DK11723974
申请日：2011-06-08
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： ROMBOUTS FREDERIK JAN RITA , TRESADERN GARY JOHN , VAN GOOL MICHIEL LUC MARIA , MACDONALD GREGOR JAMES , MARTINEZ LAMENCA CAROLINA , GIJSEN HENRICUS JACOBUS MARIA , TRABANCO-SUÃ�REZ ANDRÉS AVELINO
IPC: C07D265/30 , A61K31/535 , A61K31/5355 , A61P25/16 , A61P25/28 , C07D413/04
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18.发明专利
公开(公告)号：CA2730774C
公开(公告)日：2016-09-13
申请号：CA2730774
申请日：2009-07-29
Applicant: JANSSEN PHARMACEUTICA NV
IPC: C07D213/74 , A61K31/496 , A61P25/00 , C07D213/84
Abstract: The present invention relates to piperazin-1-yl-trifluoromethyl-substituted-pyridines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these com-pounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disor-ders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.
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公开(公告)号：BR112012005960A2
公开(公告)日：2016-03-15
申请号：BR112012005960
申请日：2010-09-16
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： KEYBUS FRANS ALFONS MARIA VAN DEN , MACDONALD GREGOR JAMES , THURING JOHANNES WILHELMUS JOHN F , ROOSBROECK YVES EMIEL MARIA VAN
IPC: C07D401/04 , A61K31/4155 , A61P25/00
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公开(公告)号：PL2504333T3
公开(公告)日：2015-12-31
申请号：PL10782609
申请日：2010-11-25
Applicant: JANSSEN PHARMACEUTICA NV
Inventor： MACDONALD GREGOR JAMES , DE BOECK BENOÎT CHRISTIAN ALBERT GHISLAIN , LEENAERTS JOSEPH ELISABETH
IPC: C07D417/14 , A61K31/427 , A61P25/00
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