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    Methods for analysis of somatic mobile elements, and uses thereof
    12.
    发明专利
    Methods for analysis of somatic mobile elements, and uses thereof 未知

    公开(公告)号：AU2015222802A1

    公开(公告)日：2016-10-13

    申请号：AU2015222802

    申请日：2015-02-27

    Applicant: JUMPCODE GENOMICS INC

    Inventor： BROWN KEITH

    IPC: C12Q1/68

    Abstract: Methods and compositions related to the use of Mobile Element Insertions and their adjacent genomic sequences. Methods using MEIs as markers for cellular proliferation, as targets for pharmaceuticals, as markers for tissue fingerprinting and in related methods and compositions are disclosed herein. Methods and compositions relate to the detection, treatment and ongoing monitoring of cell proliferation events, cancer, and deleterious effects of mobile elements in aging, and to the selection, use and monitoring of the success of treatment regimens to address these conditions.

    Methods of sample normalization
    14.
    发明专利
    Methods of sample normalization 未知

    公开(公告)号：AU2021207685A1

    公开(公告)日：2022-08-25

    申请号：AU2021207685

    申请日：2021-01-15

    Applicant: JUMPCODE GENOMICS INC

    Inventor： BROWN KEITH

    IPC: C12Q1/68 ,  C12N9/22 ,  C12N15/10 ,  C12N15/11 ,  C40B40/08

    Abstract: Provided herein are methods of normalizing a population of nucleic acid samples. Methods herein can comprise: contacting a plurality of nucleic acid samples to a normalizing agent, wherein each nucleic acid of the plurality comprises a sample-specific barcode, and wherein the normalizing agent comprises a plurality of labeled enzymes capable of binding to each sample specific barcode; contacting the product to a capture agent to capture the nucleic acids that are bound to the normalizing agent; and treating the product with a protease to release the bound nucleic acids, thereby creating a normalized library having more even representation of each nucleic acid sample than the plurality of nucleic acid samples before normalization.

    De-novo k-mer associations between molecular states
    15.
    发明专利
    De-novo k-mer associations between molecular states 未知

    公开(公告)号：AU2020371699A1

    公开(公告)日：2022-05-19

    申请号：AU2020371699

    申请日：2020-10-22

    Applicant: JUMPCODE GENOMICS INC

    Inventor： BROWN KEITH

    IPC: C12Q1/68 ,  C12Q1/6809 ,  C12Q1/6876 ,  G16B30/20

    Abstract: Provided are methods for preparation and analysis of nucleic acids. Some embodiments include reverse transcribing the RNA with barcoded primers to produce cDNA while maintaining the DNA in the sample, sequencing the DNA and cDNA together, and differentiating the sequenced DNA and cDNA using the barcode or barcodes of the primers. Some embodiments include analyzing the DNA and cDNA sequences of multiple samples separating reads into k-mers, and comparing the k-mers between samples to identify differential sequences between the sequences of the samples.

    Fraccionamiento del genoma
    16.
    发明专利
    Fraccionamiento del genoma 未知

    公开(公告)号：ES2833299T3

    公开(公告)日：2021-06-14

    申请号：ES15746731

    申请日：2015-02-03

    Applicant: JUMPCODE GENOMICS INC

    Inventor： BROWN KEITH ,  DANSKY PETER

    IPC: C12Q1/6811

    Abstract: Un procedimiento para eliminar una secuencia no deseada de una biblioteca de ácidos nucleicos de cadena doble que comprende: 5 (a) proporcionar dicha biblioteca de ácido nucleico de cadena doble, que comprende una pluralidad de moléculas de ácido nucleico de cadena doble, en la que cada molécula de ácido nucleico de cadena doble comprende una primera región adaptadora, una región de secuencia diana y una segunda región adaptadora, y en la que al menos una de dichas moléculas de ácido nucleico de cadena doble comprende dicha secuencia no deseada; (b) poner en contacto dicha biblioteca de ácidos nucleicos de cadena doble con una fracción modificadora de ácidos nucleicos que se une específicamente a dicha secuencia no deseada; en la que dicha fracción modificadora de ácido nucleico comprende una endonucleasa dirigida por una molécula de ARN guía; (c) escindir dicha secuencia no deseada de modo que dicha primera región adaptadora y dicha segunda región adaptadora no estén unidas físicamente a través de dicha región de secuencia diana; y (d) secuenciar dicha biblioteca de ácidos nucleicos de cadena doble usando un enfoque de secuenciación que requiere dicha primera región adaptadora y dicha segunda región adaptadora que abarca dicha región de secuencia diana.

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