公开(公告)号：JPH10139640A

公开(公告)日：1998-05-26

申请号：JP29503696

申请日：1996-11-07

Applicant: KAO CORP

Inventor： SASAJIMA MICHIYO ,  HOTTA MITSUYUKI ,  NISHIJIMA AYUMI ,  KANAZAWA SATOSHI ,  NISHIZAWA YOSHINORI

IPC: A61K8/49 ,  A61K8/00 ,  A61Q9/04 ,  A61K7/155 ,  A61K7/00

Abstract: PROBLEM TO BE SOLVED: To obtain a hair growth-inhibiting agent containing a specific phthalazinone compound as an active ingredient, capable of effectively inhibiting the growth of hair to reduce the number of hair-removing treatments, and excellent in safety over a long period. SOLUTION: This hair growth-inhibiting agent contains a phthalazinone compound of formula I (R is a 1-4C alkyl; R is a hydroxyalkyl, an alkenyl, phenyl) or a benzoxazinone compound of formula II as an active ingredient. The active ingredient of the hair growth-inhibiting agent is preferably added to a cosmetic in an amount of 0.001-3wt.%.

公开(公告)号：JP2009167160A

公开(公告)日：2009-07-30

申请号：JP2008185813

申请日：2008-07-17

Applicant: Kao Corp ,  花王株式会社

Inventor： NAGASAWA AZUMI ,  MORIWAKI SHIGERU ,  SAKASAI MITSUYOSHI ,  MATSUOKA MEGUMI ,  SASAJIMA MICHIYO ,  ITO NORIKO

IPC: A61K36/23 ,  A61K8/97 ,  A61P1/16 ,  A61P3/10 ,  A61P9/10 ,  A61P11/06 ,  A61P15/00 ,  A61P17/06 ,  A61P17/14 ,  A61P21/00 ,  A61P25/00 ,  A61P29/00 ,  A61P31/04 ,  A61P35/02 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  A61Q7/00 ,  A61Q19/00

Abstract: PROBLEM TO BE SOLVED: To provide a novel external preparation, a hair restorer, an NFAT (nuclear factor of activated T cells) signal inhibitor, a calcineurin inhibitor, an NFAT signal inhibiting method, and a calcineurin activity inhibiting method. SOLUTION: The external preparation, the hair restorer, the NFAT signal inhibitor, and the calcineurin inhibitor comprise an extract obtained by previously washing Angelica atropurprea or the root of the plant with the use of an ethanol aqueous solution one to nine times, and thereafter extracting the ethanol washed plant or its root with the use of a 25-45 vol.% ethanol aqueous solution as an active ingredient. COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 要解决的问题：提供新颖的外用制剂，毛发修复剂，NFAT（活化T细胞的核因子）信号抑制剂，钙调神经磷酸酶抑制剂，NFAT信号抑制法和钙调神经磷酸酶活性抑制法。 解决方案：外用制剂，毛发恢复剂，NFAT信号抑制剂和钙调神经磷酸酶抑制剂包含通过使用乙醇水溶液预先洗涤当归阿托普兰或植物根而获得的提取物一至九次， 然后用25-45体积％的乙醇水溶液作为活性成分萃取乙醇洗涤的植物或其根部。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2009139353A

公开(公告)日：2009-06-25

申请号：JP2007338801

申请日：2007-12-28

Applicant: Kao Corp ,  花王株式会社

Inventor： SASAJIMA MICHIYO ,  ITO NORIKO ,  MORIWAKI SHIGERU ,  FUSE CHIE

IPC: G01N33/50 ,  G01N33/15

Abstract: PROBLEM TO BE SOLVED: To provide a method for evaluating or screening a hair growth-regulating agent which utilizes a readily available animal.
SOLUTION: The method for evaluating or screening the hair growth-regulating agent is characterized by subjecting hair follicles of a pig to an organ culture in the presence of a test substance, and evaluating or selecting a substance which promotes or suppresses growth of the hair follicles.
COPYRIGHT: (C)2009,JPO&INPIT

Abstract translation: 待解决的问题：提供一种评估或筛选利用易于获得的动物的毛发生长调节剂的方法。 解决方案：用于评价或筛选毛发生长调节剂的方法的特征在于，在测试物质存在下使猪的毛囊进行器官培养，并且评估或选择促进或抑制生长调节剂的生物物质 毛囊。 版权所有（C）2009，JPO＆INPIT

公开(公告)号：JP2007070305A

公开(公告)日：2007-03-22

申请号：JP2005261218

申请日：2005-09-08

Applicant: Kao Corp ,  花王株式会社

Inventor： TAKIGAWA HIROBUMI ,  SASAJIMA MICHIYO ,  ITO NORIKO

IPC: A61K8/00 ,  A61Q5/00 ,  C12N1/20

Abstract: PROBLEM TO BE SOLVED: To provide a hair restore agent capable of promoting hair growth/restore and effective for alopecia of every kind regardless of symptoms or constitution. SOLUTION: This hair growth/restore agent contains an extract with an organic solvent from a culture solution of a lactic acid bacterium as an active ingredient. The lactic acid bacterium preferably belongs to the genus Lactobacillus, the genus Pediococcus, or the Leuconostoc. The lactic acid bacterium more preferably comprises Lactobacillus lactis, Pediococcus acidilactici, or Leuconostoc mesenteroides. COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 待解决的问题：提供能够促进头发生长/恢复并且对于各种秃发有效的头发还原剂，而不管症状或体质如何。 解决方案：该毛发生长/还原剂含有来自乳酸菌的培养液作为有效成分的有机溶剂的提取物。 乳酸菌优选属于乳杆菌属，类球菌属或明串珠菌属。 更优选乳酸菌包括乳酸乳杆菌，酸性乳球菌或肠系膜梭菌。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JP2006152003A

公开(公告)日：2006-06-15

申请号：JP2006066941

申请日：2006-03-13

Applicant: Kao Corp ,  花王株式会社

Inventor： SASAJIMA MICHIYO ,  YOSHIZUKA NAONOBU

IPC: A61K8/97 ,  A61Q15/00

Abstract: PROBLEM TO BE SOLVED: To provide a highly safe deodorant agent capable of fundamentally reducing the generation of unpleasant body odor, especially the smell of the armpit, exemplified by the smell of perspiration.
SOLUTION: The deodorant agent comprises a plant selected from Phellodendron amurense, Gallae Rhois, rice, logwood, arnica, fennel, Plectranthus rugosus, Coptis japonica, Asarum sieboldi, Zanthoxylum piperitum, Geranium nepalense, Hedera helix, cinnamon, Melissa officinalis, Aesculus hippocastanum, catechu, Nuphar japonicum, Centella asiatica and Sanguisorba officinalis, or an extract thereof.
COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种高度安全的除臭剂，其能够从根本上减少令人不快的身体气味的产生，特别是腋下的气味，以出汗的气味为例。 解毒剂：除臭剂包括选自黄柏，高粱，水稻，木材，山金车，茴香，茯苓，黄连，沙蒿，辣椒，山茱萸，海参，桂皮， 七叶树，马铃薯，日本七叶子，积雪草，三叶草，或其提取物。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2003292427A

公开(公告)日：2003-10-15

申请号：JP2002098900

申请日：2002-04-01

Applicant: Kao Corp ,  花王株式会社

Inventor： SASAJIMA MICHIYO ,  YOSHIZUKA NAONOBU

IPC: A61K8/00 ,  A61K8/97 ,  A61K36/18 ,  A61K36/23 ,  A61K36/25 ,  A61K36/28 ,  A61K36/48 ,  A61K36/53 ,  A61K36/71 ,  A61K36/73 ,  A61K36/75 ,  A61K36/899 ,  A61P17/00 ,  A61Q15/00 ,  A61K7/32 ,  A61K35/78

Abstract: PROBLEM TO BE SOLVED: To provide a deodorant agent or an apolipoprotein D-secretion inhibitor useful as a highly safe cosmetic or the like having excellent deodorant activities because of sustainably inhibiting the formation of unpleasant body odor. SOLUTION: The deodorant agent or the apolipoprotein D-secretion inhibitor comprises a plant selected from Phellodendri cortex, Phellodendron amurens Ruprecht, Gallae rhois, Rhus javanica L, seeds of Oryza sativa L., Haematoxylon campechianum L., Arnica montana L., Foeniculi fructus, Isodonis herba, Isodon japonicus Hara, Coptidis rhizome, Asiasari radix, Zanthoxyli fructus, Astragalus sinicus, Hedera helix, Cinnamomi cortex, Melissa officinalis, Aesculus hippocastanum, Uncaria gambir Roxburgh, Upharis rhizome, Centella asiatica and Sanguisorba officinalis L, or an extract thereof. COPYRIGHT: (C)2004,JPO

Abstract translation: 要解决的问题：提供一种除臭剂或载脂蛋白D-分泌抑制剂，其可用作高度安全的化妆品等，因为可持续地抑制不愉快的身体气味的形成，具有优异的除臭活性。 解毒剂：除臭剂或载脂蛋白D-分泌抑制剂包括选自Phellodendri cortex，Phellodendron amurens Ruprecht，Gallae rhois，Rhus javanica L，Oryza sativa L.，Haematoxylon campechianum L.，Arnica montana L. ，茯苓，异黄ba，异根us，黄连，黄芪，黄芪，黑檀，樟脑皮，Melissa officinalis，七叶树七叶树，乌头草甘草，乌龙属根茎，积雪草和Sanguisorba officinalis L，或 其提取物。 版权所有（C）2004，JPO

公开(公告)号：JPH10139639A

公开(公告)日：1998-05-26

申请号：JP29503596

申请日：1996-11-07

Applicant: KAO CORP

Inventor： SASAJIMA MICHIYO ,  HOTTA MITSUYUKI ,  NISHIJIMA AYUMI ,  KANAZAWA SATOSHI ,  NISHIZAWA YOSHINORI

IPC: A61K8/96 ,  A61K8/00 ,  A61K8/97 ,  A61K36/28 ,  A61P17/00 ,  A61Q9/04 ,  A61Q19/00 ,  A61K7/155 ,  A61K7/00 ,  A61K7/48 ,  A61K35/78

Abstract: PROBLEM TO BE SOLVED: To obtain a hair growth-inhibiting agent excellent in a hair growth- inhibiting effect and high in safety for human bodies. SOLUTION: This hair growth-inhibiting agent contains a galenical selected from Pleione sp., Curcuma longa L., Diopyros kaki L.f., Angelica dahurica Bentham et Hooker, Pistia stratiotes L., Polygonum multiflorum THUNB., Angelica actutiloba Kitagawa, Atractylodos lancea De Candolle, Commiphora molmol ENGL., Rubia cordifolia L., Tussilago farfara L., Glycyrrhiza uralensis Fisher. G.glabra Linne, Isodon japonicus (BURM.) HARA, Hizikia fusiforme OKAMURA, Gracilaria bursa-pastris SILVA or Gracilaria compressa GREVILLE, Champia parvula J.AGARDH, Gracilaria verrucosa PAPENFUSS or Gracilaria confervoides GREVILLE, Sargassum riggoldianum HARVERY, and Sargassum tortile C.AGARDH, and its extract as an active ingredient.

公开(公告)号：JPH0912432A

公开(公告)日：1997-01-14

申请号：JP15933295

申请日：1995-06-26

Applicant: KAO CORP

Inventor： SASAJIMA MICHIYO ,  OUCHI ATSUSHI ,  HOTTA MITSUYUKI

IPC: A61K8/00 ,  A61K8/42 ,  A61K8/44 ,  A61K8/64 ,  A61K8/66 ,  A61Q5/00 ,  A61Q7/00 ,  A61K7/06

Abstract: PURPOSE: To obtain a hair tonic capable of promoting hair follicle tissue proliferation, excellent in hair growth promotive effect, thus presenting excellent hair tonic activity on various apopecia irrespective of the symptoms and individual variation. CONSTITUTION: This hair tonic contains 0.0001-20 (pref. 0.01-10)wt.% of an ingredient having plasminogen activator inhibitory action. The ingredient is selected from a plasminogen activator inhibitor 1 (and 2, 3), protease nexin 1, benzamine, 6-aminocaproic acid, tranexamic acid, aprotinin, soybean-derived trypsin inhibitors, oligopeptides of the formula, X -Arg-Met-Y (X is H, Ala, ser-Ala-, etc.; Y is H, Ala, Ala-Pro, etc.). Besides, according as appropriate, 0.001-5wt.% of such ingredient(s) as blood circulation promoter, antimicrobial agent, keratolytic agent, antiseborrheic agent, local stimulant, anti-inflammatory agent, moisturizer, antiandrogen and/or hair follicle activator is (are) formulated in this hair tonic.