公开(公告)号：DE19539016A1

公开(公告)日：1996-04-25

申请号：DE19539016

申请日：1995-10-19

Applicant: KAO CORP

Inventor： JOKURA YOJI ,  UESAKA TOSHIO ,  HONMA SEIJI ,  KATO YURI ,  ISHIDA KOICHI

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/36 ,  A61K8/362 ,  A61K8/42 ,  A61K8/68 ,  A61Q19/00 ,  A61K7/48

Abstract: A skin cosmetic compsn. contains: (A) a ceramide or pseudoceramide of formula (I) or (II); (B) a dicarboxylic acid of formula (III); and (C) a salt of (III). R ,R =linear or branched, (un)satd. 9-39C hydrocarbyl (opt. mono- or poly-substd. by OH); R ,R =H, phosphate residue, sulphate residue or sugar residue; X=1-6C divalent hydrocarbyl.

公开(公告)号：DE3786795T2

公开(公告)日：1994-03-31

申请号：DE3786795

申请日：1987-12-21

Applicant: KAO CORP

Inventor： IWASAKI TETSUJI ,  UESAKA TOSHIO

IPC: A01N63/02 ,  A61K35/74 ,  A61P31/04 ,  A61P35/00 ,  C07G11/00 ,  C12N1/20 ,  C12P1/04 ,  C12R1/38

Abstract: New antibiotic Y1-HU3 has the following characteristics: (a) mol. wt. 469; (b) m.pt. 180-190oC, pale yellow crystals; (c) UV spectrum has two maxima at 312 nm and 300 nm (in chloroform); (d) soluble in methanol, chloroform; (e) insol. in n-hexane. The IR, 1H NMR and 13C NMR spectra are given. Antiobiotic Y1-HU3 is obtd. by culture of Pseudomonas species Y1-Hu (FERM-BP 1610). In an example Pseudomonas sp. Y1-HU is cultured in potato dextrose medium at pH and 28 deg. C for four days. The cell bodies are sepd. and the culture filtrate extracted with chloroform. The extract is concd. and chromatographed on silica gel (Wakogel C-200) using chloroform as eluent. The produce is dissolved in chloroform/methanol and hexane added to give antibiotic Y1-HU (10 mg from 1 litre culutre).