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11.发明申请PACLITAXEL MIXED COMPOSITION AND WATER-IN-OIL TYPE EMULSION FORMULATION FOR CHEMOEMBOLIZATION AND PREPARATION METHOD THEREOF 审中-公开PACLITAXEL混合组合物和油类型乳化制剂用于化学反应及其制备方法
公开(公告)号：WO2003022264A1
公开(公告)日：2003-03-20
申请号：PCT/KR2001/001613
申请日：2001-09-26
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , DAEHWA PHARM. CO., LTD. , CHUNG, Hesson , JEONG, Seo, Young , KWON, Ick, Chan , PARK, Jae, Hyung , CHUNG, Jin, Wook , KIM, Young, Man , LEE, In-Hyun
Inventor： CHUNG, Hesson , JEONG, Seo, Young , KWON, Ick, Chan , PARK, Jae, Hyung , CHUNG, Jin, Wook , KIM, Young, Man , LEE, In-Hyun
IPC: A61K31/335
CPC classification number: A61K31/337 , A61K9/0019 , A61K47/44 , A61K49/0452
Abstract: The present invention relates to the paclitaxel mixed composition and water-in-oil type emulsion formulation for chemoembolization and preparation method thereof. The combinatory formulation of anticancer drugs can be easily prepared since the emulsion formulation of the present invention can include other hydrophilic or lipophilic drugs.
Abstract translation: 本发明涉及用于化学栓塞的紫杉醇混合组合物和油包水型乳液制剂及其制备方法。 由于本发明的乳液制剂可以包括其它亲水或亲脂性药物，因此可以容易地制备抗癌药物的组合制剂。
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12.发明申请OILY PACLITAXEL COMPOSITION AND FORMULATION FOR CHEMOEMBOLIZATION AND PREPARATION METHOD THEREOF 审中-公开油酰胺组合物及其制备方法及其制备方法
公开(公告)号：WO2003022248A1
公开(公告)日：2003-03-20
申请号：PCT/KR2002/001722
申请日：2002-09-13
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , DAEHWA PHARM. CO., LTD. , CHUNG, Hesson , JEONG, Seo, Young , KWON, Ick, Chan , PARK, Yeong, Taek , LEE, In, Hyun , PARK, Jae, Hyung , CHUNG, Jin, Wook , KIM, Young, Man
Inventor： CHUNG, Hesson , JEONG, Seo, Young , KWON, Ick, Chan , PARK, Yeong, Taek , LEE, In, Hyun , PARK, Jae, Hyung , CHUNG, Jin, Wook , KIM, Young, Man
IPC: A61K9/10
CPC classification number: A61K31/337 , A61K9/0019 , A61K47/44 , A61K49/0452
Abstract: Oily paclitaxel composition and formulation for chemoembolization and preparation method thereof solubilizing paclitaxel in an oily contrast medium. The composition of the present invention solubilizes paclitaxel and has an advantage of delivering anticancer drug to the target cells by chemoembolization since it is possible to visualize the blood vessel during the chemoembolization process. The present invention also relates to oily paclitaxel composition and formulation additionally comprising chemicals that prevent paclitaxel precipitation for prolonged preservation and the preparation method thereof. Since the composition of the present invention solubilize paclitaxel effectively and can be visualized during chemoembolization, it can be used for TACE to treat hepatoma and other solid tumors.
Abstract translation: 油性紫杉醇组合物和化疗栓塞制剂及其在油性造影剂中增溶紫杉醇的制备方法。 本发明的组合物溶解紫杉醇，并且具有通过化学栓塞将抗癌药物递送至靶细胞的优点，因为在化学栓塞过程中可以使血管可视化。 本发明还涉及另外包含防止紫杉醇沉淀用于延长保存的化学物质的油性紫杉醇组合物和制剂及其制备方法。 由于本发明的组合物有效地溶解紫杉醇并且可以在化学栓塞期间可视化，所以可用于TACE治疗肝癌和其他实体瘤。
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13.发明公开ANTICANCER DRUG-CHITOSAN COMPLEX FORMING SELF-AGGREGATES AND PREPARATION METHOD THEREOF 有权壳聚糖复为AUTO单位用于制造癌症治疗的成因及过程
公开(公告)号：EP1383539A1
公开(公告)日：2004-01-28
申请号：EP02758920.9
申请日：2002-08-14
Inventor： KWON, Ick Chan , KIM, In-San , JEONG, Seo Young , CHUNG, Hesson , CHO, Yong Woo , SON, Yoen Ju,106-1404 Sinkongduk samsung Apt. , PARK, Chong Rae,Ga-102 Seoul Univ. kyosu Apt. , SEO, Sang, Bong
IPC: A61K47/48
CPC classification number: A61K31/704 , A61K47/61 , A61K47/6907
Abstract: The present invention relates to an anticancer drug-chitosan complex forming self-aggregates and the preparation method thereof. More precisely, the present invention relates to the anticancer drug-chitosan complex forming self-aggregates in aqueous media composed of a hydrophobic anticancer agent and a hydrophilic chitosan, and the preparation method thereof. The anticancer drug-chitosan complex of the present invention not only works selectively against target tumor tissue but also continues to release the medicine over a long period of time. Besides, the anticancer drug-chitosan complex could have greater amount of drug by adding the anticancer drug into self-aggregates, which is generally limited by chemical bond. Therefore, the anticancer drug-chitosan complex of the present invention can be effectively used for the cancer chemotherapy.
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14.发明公开OILY PACLITAXEL COMPOSITION AND FORMULATION FOR CHEMOEMBOLIZATION AND PREPARATION METHOD THEREOF 审中-公开油性成分紫杉醇制剂及用于生产化学栓塞和过程
公开(公告)号：EP1435908A1
公开(公告)日：2004-07-14
申请号：EP02760874.4
申请日：2002-09-13
Inventor： CHUNG, Hesson , JEONG, Seo Y. , KWON, Ick, Chan , PARK, Yeong, Taek , LEE, In, Hyun , PARK, Jae, Hyung , CHUNG, Jin, Wook , KIM, Young, Man
CPC classification number: A61K31/337 , A61K9/0019 , A61K47/44 , A61K49/0452
Abstract: Oily paclitaxel composition and formulation for chemoembolization and preparation method thereof solubilizing paclitaxel in an oily contrast medium. The composition of the present invention solubilizes paclitaxel and has an advantage of delivering anticancer drug to the target cells by chemoembolization since it is possible to visualize the blood vessel during the chemoembolization process. The present invention also relates to oily paclitaxel composition and formulation additionally comprising chemicals that prevent paclitaxel precipitation for prolonged preservation and the preparation method thereof. Since the composition of the present invention solubilize paclitaxel effectively and can be visualized during chemoembolization, it can be used for TACE to treat hepatoma and other solid tumors.
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15.发明公开CHOLANIC ACID-CHITOSAN COMPLEX FORMING SELF-AGGREGATES AND PREPARATION METHOD THEREOF 有权自骨料LOWER胆 - 壳聚糖复合物和方法
公开(公告)号：EP1835888A1
公开(公告)日：2007-09-26
申请号：EP06702900.9
申请日：2006-01-12
Applicant: Korea Institute of Science and Technology
Inventor： KWON, Ick Chan , JEONG, Seo Young , KIM, In-san , CHUNG, Hesson , SEO, Sang Bong Jakwang Co., Ltd. , PARK, Jae Hyung , KWON, Seunglee , KIM, Kwangmyung , KIM, Jong-ho
IPC: A61K9/00
CPC classification number: A61K31/337 , A61K9/0019 , A61K9/5123 , A61K9/5161 , A61K47/61
Abstract: Disclosed are a cholanic acid-chitosan complex forming self-aggregates and a preparation method thereof, and more particularly, a cholanic acid-chitosan complex which is composed of hydrophobic cholanic acid and hydrophilic chitosan and forms self-aggregates in an aquatic environment, and a method of preparing the cholanic acid- chitosan complex. The cholanic acid-chitosan complex forms self -aggregates, which prolong the drug release period, enhance the selectivity of the complex for tumor tissue, and greatly increase drug loading content when a drug is incorporated into the self -aggregates, compared to chemical bonding, which limits drug incorporation. Thus, the cholanic acid-chitosan complex is useful for anticancer chemotherapy.
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Patent Agency Ranking16.发明公开MUCOADHESIVE COMPOSITION AND FORMULATION FOR SOLUBILIZATION OF INSOLUBLE DRUGS AND PREPARATION METHOD THEREOF 审中-公开MUKOADHûSIVE组成及配方用于溶解UNL SLICHEN药物和方法DAF [R
公开(公告)号：EP1545622A1
公开(公告)日：2005-06-29
申请号：EP03741601.3
申请日：2003-07-21
Applicant: Korea Institute of Science and Technology
Inventor： CHUNG, Hesson , JEONG, Seo-Young; , KWON, Ick-Chan , PARK, Yeong-Taek , LEE, In-Hyun
IPC: A61K47/44
CPC classification number: A61K9/006 , A61K9/0019 , A61K9/1075 , A61K31/225 , A61K47/14 , A61K47/44
Abstract: The present invention relates to a novel mucoadhesive composition for solubilization of insoluble drugs; its formulation including pharmaceutical compounds; and the preparation methods thereof wherein said solubilizing composition comprises 4~90% by weight of at least one selected from the monoglycerides and 0.01~90% by weight of at least one oil. The present invention relates to a novel mucoadhesive composition including pharmaceutical compounds; and the preparation methods thereof wherein said solubilizing composition including emulsifiers is composed of 4~90% by weight of at least one selected from the monoglycerides, 0.01~90% by weight, of at least one oil, and 0.01~90% by weight of at least one selected from the emulsifiers. The compositions of the present invention is suitable as drug delivery systems since they exist as mucoadhesive liquid at physiological temperatures even though they exist as liquid or semi-solid at room temperature.
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17.发明公开
公开(公告)号：EP1100464A1
公开(公告)日：2001-05-23
申请号：EP99935145.5
申请日：1999-07-30
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： JEONG, Seo Young , KWON, Ick Chan , CHUNG, Hesson
IPC: A61K9/107
CPC classification number: A61K9/5123 , A61K9/1075 , A61K9/1272 , A61K48/00 , C12N15/88
Abstract: The present invention relates to oil-in-water lipid emulsions composed of non-triglyceride oils and solid lipid nanoparticles (SLN) composed of triglyceride or ethyl stearate used as gene transfection agents and drug delivery systems and method for preparing thereof. The present invention also concerns the method of transferring genes or drugs efficiently into cells by using the lipid emulsions and solid lipid nanoparticles. Also the present invention relates to the method of preparing lipid emulsions containing lipophilic or amphiphilic drugs by using squalene or squalane as the core-oil. The present invention also concerns the method of preparing the solid lipid nanoparticles containing lipophilic or amphiphilic drugs by using ethyl stearate as the core-fat.
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18.发明公开PACLITAXEL COMPOSITION FOR THE INTRAVESICAL TREATMENT OF BLADDER TUMOR AND PREPARATION METHOD THEREOF 审中-公开紫杉醇组成膀胱肿瘤膀胱内的用于生产的热处理工艺
公开(公告)号：EP1545500A1
公开(公告)日：2005-06-29
申请号：EP03765385.4
申请日：2003-07-21
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： CHUNG, Hesson , JEONG, Seo-Young,Munchonmaeul Life Apt , KWON, Ick-Chan , PARK, Yeong-Taek , LEE, In-Hyun , KIM, Se-Woong , LEE, Seung-Ju,Mokdonghyundai Apt.
IPC: A61K31/337
CPC classification number: A61K47/06 , A61K9/0019 , A61K9/0024 , A61K31/337 , A61K47/14 , A61K47/44
Abstract: The present invention relates to a paclitaxel composition and the preparation methods thereof for the treatment of bladder cancer wherein said paclitaxel composition comprises 4~90% by weight of at least one selected from the monoglycerides, 0.01~90% by weight of at least one oil, 0.01~90% by weight of at least one emulsifier and 0.01~20% by weight of paclitaxel. The composition of the present invention can treat bladder cancer effectively since the composition solubilizes paclitaxel, does not form aggregates, adsorbs well on the bladder wall and penetrates into the muscle layer of the bladder.
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19.发明公开P-GLYCOPROTEIN INHIBITOR COMPRISING OCTILONIUM BROMIDE AS AN EFFECTIVE INGREDIENT 有权P-糖蛋白抑制剂与OCTILONIUMBROMID为活动
公开(公告)号：EP1545495A1
公开(公告)日：2005-06-29
申请号：EP03741600.5
申请日：2003-07-21
Applicant: Korea Institute of Science and Technology
Inventor： CHUNG, Hesson , JEONG, Seo-Young,Munchonmaeul Life Apt. , KWON, Ick-Chan , PARK, Yeong-Taek , LEE, In-Hyun , YUK, Soon-Hong
IPC: A61K31/245
CPC classification number: A61K9/5078 , A61K9/0095 , A61K9/5026 , A61K9/5031 , A61K31/14 , A61K31/245 , A61K45/06 , A61K2300/00
Abstract: The present invention relates to a new use of octylonium bromide as p-glycoprotein inhibitor to increase cellular uptake of drugs. More particularly, the present invention provides octylonium bromide as a p-glycoprotein inhibitor to increase cellular uptake of drugs such as anticancer drugs by taking octylonium bromide simultaneously with or proceding drug administration.
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20.发明授权CHOLANIC ACID-CHITOSAN COMPLEX FORMING SELF-AGGREGATES AND PREPARATION METHOD THEREOF 有权形成自聚集体的胆酸 - 壳聚糖复合物及其制备方法
公开(公告)号：EP1835888B1
公开(公告)日：2017-07-12
申请号：EP06702900.9
申请日：2006-01-12
Applicant: Korea Institute of Science and Technology
Inventor： KWON, Ick Chan , JEONG, Seo Young , KIM, In-san , CHUNG, Hesson , SEO, Sang Bong Jakwang Co., Ltd. , PARK, Jae Hyung , KWON, Seunglee , KIM, Kwangmyung , KIM, Jong-ho
IPC: A61K9/19 , A61K47/28 , A61K47/36 , A61K31/337
CPC classification number: A61K31/337 , A61K9/0019 , A61K9/5123 , A61K9/5161 , A61K47/61
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