公开(公告)号：WO2006075881A1

公开(公告)日：2006-07-20

申请号：PCT/KR2006/000130

申请日：2006-01-12

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KWON, Ick Chan ,  JEONG, Seo Young ,  KIM, In-san ,  CHUNG, Hesson ,  SEO, Sang Bong ,  PARK, Jae Hyung ,  KWON, Seunglee ,  KIM, Kwangmyung ,  KIM, Jong-ho

Inventor： KWON, Ick Chan ,  JEONG, Seo Young ,  KIM, In-san ,  CHUNG, Hesson ,  SEO, Sang Bong ,  PARK, Jae Hyung ,  KWON, Seunglee ,  KIM, Kwangmyung ,  KIM, Jong-ho

IPC: A61K9/00

CPC classification number: A61K31/337 ,  A61K9/0019 ,  A61K9/5123 ,  A61K9/5161 ,  A61K47/61

Abstract: Disclosed are a cholanic acid-chitosan complex forming self-aggregates and a preparation method thereof, and more particularly, a cholanic acid-chitosan complex which is composed of hydrophobic cholanic acid and hydrophilic chitosan and forms self-aggregates in an aquatic environment, and a method of preparing the cholanic acid- chitosan complex. The cholanic acid-chitosan complex forms self -aggregates, which prolong the drug release period, enhance the selectivity of the complex for tumor tissue, and greatly increase drug loading content when a drug is incorporated into the self -aggregates, compared to chemical bonding, which limits drug incorporation. Thus, the cholanic acid-chitosan complex is useful for anticancer chemotherapy.

Abstract translation: 公开了形成自聚集体的胆酸 - 壳聚糖复合物及其制备方法，更具体地说，涉及由疏水性胆酸和亲水性壳聚糖构成并在水生环境中形成自聚集体的胆酸 - 壳聚糖复合物， 制备胆酸 - 壳聚糖复合物的方法。 与化学键合相比，胆酸 - 壳聚糖复合物形成自聚集体，其延长药物释放时间，增强复合物对肿瘤组织的选择性，并且当药物掺入自聚集体时大大增加药物负载量， 这限制了药物并入。 因此，胆酸 - 壳聚糖复合物可用于抗癌化疗。

公开(公告)号：EP1835888B1

公开(公告)日：2017-07-12

申请号：EP06702900.9

申请日：2006-01-12

Applicant: Korea Institute of Science and Technology

Inventor： KWON, Ick Chan ,  JEONG, Seo Young ,  KIM, In-san ,  CHUNG, Hesson ,  SEO, Sang Bong Jakwang Co., Ltd. ,  PARK, Jae Hyung ,  KWON, Seunglee ,  KIM, Kwangmyung ,  KIM, Jong-ho

IPC: A61K9/19 ,  A61K47/28 ,  A61K47/36 ,  A61K31/337

CPC classification number: A61K31/337 ,  A61K9/0019 ,  A61K9/5123 ,  A61K9/5161 ,  A61K47/61

公开(公告)号：EP1835888A1

公开(公告)日：2007-09-26

申请号：EP06702900.9

申请日：2006-01-12

Applicant: Korea Institute of Science and Technology

Inventor： KWON, Ick Chan ,  JEONG, Seo Young ,  KIM, In-san ,  CHUNG, Hesson ,  SEO, Sang Bong Jakwang Co., Ltd. ,  PARK, Jae Hyung ,  KWON, Seunglee ,  KIM, Kwangmyung ,  KIM, Jong-ho

IPC: A61K9/00

CPC classification number: A61K31/337 ,  A61K9/0019 ,  A61K9/5123 ,  A61K9/5161 ,  A61K47/61

Abstract: Disclosed are a cholanic acid-chitosan complex forming self-aggregates and a preparation method thereof, and more particularly, a cholanic acid-chitosan complex which is composed of hydrophobic cholanic acid and hydrophilic chitosan and forms self-aggregates in an aquatic environment, and a method of preparing the cholanic acid- chitosan complex. The cholanic acid-chitosan complex forms self -aggregates, which prolong the drug release period, enhance the selectivity of the complex for tumor tissue, and greatly increase drug loading content when a drug is incorporated into the self -aggregates, compared to chemical bonding, which limits drug incorporation. Thus, the cholanic acid-chitosan complex is useful for anticancer chemotherapy.