公开(公告)号：DK3795167T3

公开(公告)日：2022-08-29

申请号：DK20204314

申请日：2017-09-15

Applicant: LEIDOS INC

Inventor： GUTIERREZ GABRIEL M ,  KOTRAIAH VINAYAKA ,  PANNUCCI JAMES ,  AYALA RAMSES

IPC: A61K38/10 ,  A61P31/00 ,  A61P35/00 ,  C07K7/08

公开(公告)号：AU2018273958B2

公开(公告)日：2022-07-21

申请号：AU2018273958

申请日：2018-05-25

Applicant: LEIDOS INC

Inventor： GUTIERREZ GABRIEL M ,  KOTRAIAH VINAYAKA ,  PHARES TIMOTHY ,  PANNUCCI JAMES

IPC: A61K38/17 ,  C07K14/705

Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor "programmed death 1" (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 as well as the interaction of CTLA4 with CD86 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.

公开(公告)号：DK3512536T3

公开(公告)日：2020-11-23

申请号：DK17778394

申请日：2017-09-15

Applicant: LEIDOS INC

Inventor： GUTIERREZ GABRIEL M ,  PANNUCCI JAMES ,  AYALA RAMSES ,  KOTRAIAH VINAYAKA

IPC: A61K38/10 ,  A61P31/00 ,  A61P35/00 ,  C07K7/08

公开(公告)号：AU2017325866A1

公开(公告)日：2019-04-18

申请号：AU2017325866

申请日：2017-09-15

Applicant: LEIDOS INC

Inventor： GUTIERREZ GABRIEL M ,  KOTRAIAH VINAYAKA ,  PANNUCCI JAMES ,  AYALA RAMSES

IPC: C07K7/08 ,  A61K38/10 ,  A61P31/00 ,  A61P35/00

Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor "programmed death 1" (PD-1). These peptides block the interaction of PD-1 with its ligand PDL1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, treating infectious diseases, enhancing a response to vaccination, and treating sepsis.

公开(公告)号：CA3064023A1

公开(公告)日：2018-11-29

申请号：CA3064023

申请日：2018-05-25

Applicant: LEIDOS INC

Inventor： GUTIERREZ GABRIEL M ,  KOTRAIAH VINAYAKA ,  PHARES TIMOTHY ,  PANNUCCI JAMES

IPC: C07K14/705 ,  A61K38/17

Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor "programmed death 1" (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 as well as the interaction of CTLA4 with CD86 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.