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公开(公告)号:AU2017325866B2
公开(公告)日:2021-09-09
申请号:AU2017325866
申请日:2017-09-15
Applicant: LEIDOS INC
Inventor: GUTIERREZ GABRIEL M , KOTRAIAH VINAYAKA , PANNUCCI JAMES , AYALA RAMSES
Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor "programmed death 1" (PD-1). These peptides block the interaction of PD-1 with its ligand PDL1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, treating infectious diseases, enhancing a response to vaccination, and treating sepsis.
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公开(公告)号:CA3036251A1
公开(公告)日:2018-03-22
申请号:CA3036251
申请日:2017-09-15
Applicant: LEIDOS INC
Inventor: GUTIERREZ GABRIEL M , KOTRAIAH VINAYAKA , PANNUCCI JAMES , AYALA RAMSES
Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor "programmed death 1" (PD-1). These peptides block the interaction of PD-1 with its ligand PDL1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, treating infectious diseases, enhancing a response to vaccination, and treating sepsis.
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公开(公告)号:AU2018410849B2
公开(公告)日:2025-02-27
申请号:AU2018410849
申请日:2018-02-28
Applicant: LEIDOS INC
Inventor: GUTIERREZ GABRIEL M , KOTRAIAH VINAYAKA , PANNUCCI JAMES , AYALA RAMSES
IPC: A61K38/10 , A61K38/16 , A61K48/00 , A61P17/00 , A61P17/02 , A61P31/00 , A61P31/04 , A61P35/00 , A61Q5/00 , A61Q19/02 , C12N15/00
Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor programmed death 1 (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.
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公开(公告)号:DK3758732T3
公开(公告)日:2024-10-07
申请号:DK18712047
申请日:2018-02-28
Applicant: LEIDOS INC
Inventor: GUTIERREZ GABRIEL M , KOTRAIAH VINAYAKA , PANNUCCI JAMES , AYALA RAMSES
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公开(公告)号:DK3795167T3
公开(公告)日:2022-08-29
申请号:DK20204314
申请日:2017-09-15
Applicant: LEIDOS INC
Inventor: GUTIERREZ GABRIEL M , KOTRAIAH VINAYAKA , PANNUCCI JAMES , AYALA RAMSES
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公开(公告)号:DK3512536T3
公开(公告)日:2020-11-23
申请号:DK17778394
申请日:2017-09-15
Applicant: LEIDOS INC
Inventor: GUTIERREZ GABRIEL M , PANNUCCI JAMES , AYALA RAMSES , KOTRAIAH VINAYAKA
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公开(公告)号:AU2017325866A1
公开(公告)日:2019-04-18
申请号:AU2017325866
申请日:2017-09-15
Applicant: LEIDOS INC
Inventor: GUTIERREZ GABRIEL M , KOTRAIAH VINAYAKA , PANNUCCI JAMES , AYALA RAMSES
Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor "programmed death 1" (PD-1). These peptides block the interaction of PD-1 with its ligand PDL1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, treating infectious diseases, enhancing a response to vaccination, and treating sepsis.
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公开(公告)号:AU2018410849A1
公开(公告)日:2020-09-10
申请号:AU2018410849
申请日:2018-02-28
Applicant: LEIDOS INC
Inventor: GUTIERREZ GABRIEL M , KOTRAIAH VINAYAKA , PANNUCCI JAMES , AYALA RAMSES
IPC: A61K38/10 , A61K38/16 , A61K48/00 , A61P17/00 , A61P17/02 , A61P31/00 , A61P31/04 , A61P35/00 , A61Q5/00 , A61Q19/02 , C12N15/00
Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor programmed death 1 (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.
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公开(公告)号:CA3091414A1
公开(公告)日:2019-09-06
申请号:CA3091414
申请日:2018-02-28
Applicant: LEIDOS INC
Inventor: GUTIERREZ GABRIEL M , KOTRAIAH VINAYAKA , PANNUCCI JAMES , AYALA RAMSES
IPC: A61K38/10 , A61K38/16 , A61K48/00 , A61P17/00 , A61P17/02 , A61P31/00 , A61P31/04 , A61P35/00 , A61Q5/00 , A61Q19/02 , C12N15/00
Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor programmed death 1 (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.
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