公开(公告)号：WO2015038708A1

公开(公告)日：2015-03-19

申请号：PCT/US2014/055087

申请日：2014-09-11

Applicant: STC.UNM ,  LEIDOS, INC.

Inventor： PEABODY, David, S. ,  CHACKERIAN, Bryce ,  PANNUCCI, James ,  GUTIERREZ, Gabriel, M. ,  NOE, Amy, Rene ,  WINRAM, Scott, Budd ,  HUANG, Steve, Chienwen

IPC: A61K39/02 ,  A61K38/16 ,  A61K39/39 ,  A61P31/12

CPC classification number: A61K39/015 ,  A61K35/76 ,  A61K39/39 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/55566 ,  C07K2319/40 ,  C12N7/00 ,  C12N15/1037 ,  C12N2795/18122 ,  C12N2795/18123 ,  C12N2795/18134 ,  Y02A50/412

Abstract: Embodiments are directed to malaria vaccines comprising a bacteriophage VLP displaying a heterologous peptide identified by affinity selection as an anti-malaria mimotope.

Abstract translation: 实施方案涉及疟疾疫苗，其包含显示通过亲和选择鉴定的异源肽作为抗疟疾模拟表位的噬菌体VLP。

公开(公告)号：AU2024278284A1

公开(公告)日：2025-01-02

申请号：AU2024278284

申请日：2024-12-11

Applicant: LEIDOS INC

Inventor： CHRISTIAN NOAH PETER

IPC: H01J49/04

Abstract: A low power mass spectrometer assembly includes at least an ionization component, an electrostatic analyzer, a lens assembly, a magnet assembly and at least one detector located in a same plane as the entrance to the magnet assembly for detecting the deflected sample ions and/or fragments of sample ions, including ions or ion fragments indicative of the Vitamin D metabolite within the sample.

公开(公告)号：MX2024002636A

公开(公告)日：2024-03-19

申请号：MX2024002636

申请日：2020-10-30

Applicant: LEIDOS INC

Inventor： CHRISTIAN NOAH PETER

IPC: H01J49/04 ,  G01N33/82 ,  H01J49/02 ,  H01J49/06 ,  H01J49/16 ,  H01J49/20 ,  H01J49/24

Abstract: Un montaje de espectrómetro de masas de baja energía incluye al menos un componente de ionización, un analizador electrostático, un montaje de lente, un montaje de imán y al menos un detector ubicado en un mismo plano que la entrada al montaje de imán para detectar los iones de muestra desviados y/o fragmentos de iones de muestra, incluidos iones o fragmentos de iones indicativos del metabolito de vitamina D dentro de la muestra.

公开(公告)号：AU2017325866B2

公开(公告)日：2021-09-09

申请号：AU2017325866

申请日：2017-09-15

Applicant: LEIDOS INC

Inventor： GUTIERREZ GABRIEL M ,  KOTRAIAH VINAYAKA ,  PANNUCCI JAMES ,  AYALA RAMSES

IPC: C07K7/08 ,  A61K38/10 ,  A61P31/00 ,  A61P35/00

Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor "programmed death 1" (PD-1). These peptides block the interaction of PD-1 with its ligand PDL1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, treating infectious diseases, enhancing a response to vaccination, and treating sepsis.

公开(公告)号：CA3141162A1

公开(公告)日：2020-11-26

申请号：CA3141162

申请日：2020-05-21

Applicant: LEIDOS INC

Inventor： GUTIERREZ GABRIEL M ,  KOTRAIAH VINAYAKA ,  PHARES TIMOTHY W ,  PANNUCCI JAMES ,  MANSOUR MARC

IPC: C07K7/08 ,  A61K38/17 ,  A61P35/00 ,  C07K14/00 ,  C07K14/705 ,  C07K19/00 ,  C12N5/10 ,  C12N7/01 ,  C12N15/62

Abstract: This disclosure provides peptides which bind to LAG3 and can be used to block the interaction of LAG 3 with other molecules such as MHC-II, FGL1, and a-synuclein. These peptides can be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, or inhibiting the progression of a synucleinopathy, inhibiting the progression of sepsis, inhibiting the progression of an infectious disease, and enhancing a response to a vaccine.

公开(公告)号：CA3036251A1

公开(公告)日：2018-03-22

申请号：CA3036251

申请日：2017-09-15

Applicant: LEIDOS INC

Inventor： GUTIERREZ GABRIEL M ,  KOTRAIAH VINAYAKA ,  PANNUCCI JAMES ,  AYALA RAMSES

IPC: A61K38/10 ,  A61P31/00 ,  A61P35/00 ,  C07K7/08

Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor "programmed death 1" (PD-1). These peptides block the interaction of PD-1 with its ligand PDL1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, treating infectious diseases, enhancing a response to vaccination, and treating sepsis.

公开(公告)号：AU2013201044B2

公开(公告)日：2014-02-27

申请号：AU2013201044

申请日：2013-02-22

Applicant: UNIV GEORGETOWN ,  LEIDOS INC

Inventor： CURRIE JOHN F ,  PARANJAPE MAKARAND ,  PECK CARL C ,  WHITE ROBERT C ,  SCHNEIDER THOMAS W

IPC: A61B5/00 ,  G01N1/10 ,  G01N33/48 ,  G01N33/53 ,  G01N37/00

Abstract: Abstract The present invention pertains to a system and method for transdermal sampling, comprising: at least one sampler for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject; at least one detector system for identifying and quantifying said at least one analyte; and at least one logic module for: (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at least one sampler and at least one detector. o C} 0& - a

公开(公告)号：WO2022081426A1

公开(公告)日：2022-04-21

申请号：PCT/US2021/054127

申请日：2021-10-08

Applicant: LEIDOS, INC.

Inventor： GUTIERREZ, Gabriel M. ,  PANNUCCI, James ,  WEIL, Michael Ryan ,  PHARES, Timothy W. ,  KOTRAIAH, Vinayaka ,  BROWNE, Cecille D. ,  BUONTEMPO, Peter J.

IPC: A61P35/00 ,  A61K38/10 ,  C07K7/08 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K2039/505 ,  A61K2039/507 ,  A61K35/17 ,  A61K35/76 ,  A61K39/00 ,  A61K45/06 ,  A61P31/00 ,  A61Q7/00 ,  C07K14/70521 ,  C07K16/2818 ,  C07K2317/76 ,  C07K7/06 ,  C12N15/00 ,  C12N15/86

Abstract: This disclosure provides peptides which can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.

公开(公告)号：WO2022026496A2

公开(公告)日：2022-02-03

申请号：PCT/US2021/043373

申请日：2021-07-28

Applicant: LEIDOS, INC.

Inventor： GUTIERREZ, Gabriel M. ,  PANNUCCI, James ,  KOTRAIAH, Vinayaka ,  PHARES, Timothy W. ,  BROWNE, Cecille D.

IPC: C07K14/705 ,  A61K39/39 ,  A61P25/28 ,  A61P35/00 ,  A61K38/10 ,  A61K45/06 ,  C07K14/70503 ,  C07K7/08

Abstract: This disclosure provides peptides that bind to LAG3 and can be used to block its interaction with other molecules such as MHC-II, FGL1, and α-synuclein. These peptides, with their demonstrated activity and short half-life, can be used to activate cellular immunity while significantly reducing the potential for adverse events that is often associated with the antibodybased checkpoint inhibitors. The peptides can be used as stand-alone therapeutics or can be used as immune modulators in combination with other therapies.

公开(公告)号：WO2019168524A1

公开(公告)日：2019-09-06

申请号：PCT/US2018/020209

申请日：2018-02-28

Applicant: LEIDOS, INC.

Inventor： GUTIERREZ, Gabriel, M. ,  KOTRAIAH, Vinayaka ,  PANNUCCI, James ,  AYALA, Ramses

IPC: A61K38/10 ,  A61K38/16 ,  A61Q5/00 ,  A61Q19/02 ,  A61K48/00 ,  C12N15/00 ,  A61P31/00 ,  A61P31/04 ,  A61P17/02 ,  A61P35/00 ,  A61P17/00

Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor programmed death 1 (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.