公开(公告)号：WO1997009077A1

公开(公告)日：1997-03-13

申请号：PCT/US1996003191

申请日：1996-03-08

Applicant: MEDRAD, INC. ,  REILLY, David, M. ,  HAVRILLA, Joseph, B.

Inventor： MEDRAD, INC.

IPC: A61M05/145

CPC classification number: A61M5/14546 ,  A61M5/1456 ,  A61M5/14566 ,  A61M5/1458 ,  Y10S128/01

Abstract: An adapter (42) for releasably attaching syringes (14) of various types to a front-loading injector head (12), the adapter (42) including a syringe carrier (44) having a front end (45), a rear end (46), and syringe retaining channel (54) located between the carrier front and rear ends (45, 46) for engaging at least a portion of syringe flange (24); mounting flanges (48a, 48b) near the carrier rear end (46) for releasably mounting the carrier (44) in a desired position relative to a front wall (31) of the injector head (12); a follower (50) reciprocally mounted within the carrier (44) having a front end (51) engageable with a syringe plunger (28) when the syringe (14) is installed in the carrier (44); and a drive head opening (55) communicating with a pair of drive head slots (56a, 56b) positioned proximate to a rear end (53) of the follower (50) for releasably mounting the follower (50) in a desired position relative to a drive head (36) of the injector.

Abstract translation: 一种用于将各种类型的注射器（14）可释放地连接到前装载注射器头（12）的适配器（42），所述适配器（42）包括具有前端（45），后端 46）和位于所述载体前端和后端（45,46）之间的注射器保持通道（54），用于接合注射器凸缘（24）的至少一部分; 在托架后端（46）附近安装凸缘（48a，48b），用于将托架（44）相对于喷射头（12）的前壁（31）可释放地安装在所需位置。 当所述注射器（14）安装在所述托架（44）中时，往复地安装在所述托架（44）内的从动件（50）具有可与针筒柱塞（28）接合的前端部（51）。 以及与靠近所述从动件（50）的后端（53）定位的一对驱动头槽（56a，56b）连通的驱动头开口（55），用于将所述从动件（50）可释放地安装在相对于 喷射器的驱动头（36）。

公开(公告)号：WO1997008054A1

公开(公告)日：1997-03-06

申请号：PCT/US1996013559

申请日：1996-08-20

Applicant: MEDRAD, INC.

Inventor： MEDRAD, INC. ,  REILLY, David, M. ,  RHINEHART, Edward, J. ,  GELBLUM, Eugene, A. ,  HITCHINS, Mark ,  ROBINSON, Michelle

IPC: B65B55/02

CPC classification number: B65B3/003 ,  Y10T29/49808 ,  Y10T29/4984

Abstract: This invention relates to a process for manufacturing prefilled syringes where at least one of the syringe components is manufactured in at least a class 100 environment. The process includes the steps of manufacturing syringe components, such as the barrel and plunger substrate, within at least a class 100 and MCB-3 environment (210-218, 242-250); manufacturing syringe components, such as the plunger cover and tip seal in an environment less clean than a class 100 environment (252-262, 222-232); decontaminating the plunger cover and tip seal (264-265, 234-236); lubricating at least one of the barrel, plunger substrate, plunger cover and tip seal (220, 266, 238); assembling the barrel and tip seal to form a barrel/tip seal combination (240); assembling the plunger cover and plunger substrate to form a plunger (268); filling the barrel/tip seal combination with a predetermined amount of fluid (276); and final assembling of the prefilled syringe by inserting the plunger into the barrel/tip seal combination (278). When the syringe components are manufactured at different locations, each component is tripled-bagged to maintain the component substantially free from contaminants, and transported to an assembly site where the components are unpackaged and assembled into the barrel/tip seal combination and plunger. When filling and final assembly of the barrel/tip seal combination takes place at a location separate from its assembly site, the barrel/tip seal combination is tripled-bagged to maintain it substantially free from contaminants, and transported to a filling and final assembling site for filling and final assembling into a prefilled syringe.

Abstract translation: 本发明涉及一种用于制造预灌装注射器的方法，其中至少一个注射器组件在至少100级环境中制造。 该方法包括在至少100级和MCB-3环境（210-218,242-250）内制造注射器部件（例如筒体和柱塞基底）的步骤; 在比100级环境（252-262,222-232）更干净的环境中制造注射器部件，例如柱塞盖和末端密封; 去除柱塞盖和顶端密封（264-265,234-236）; 润滑筒，柱塞基底，柱塞盖和末端密封件（220,266,238）中的至少一个; 组装筒和尖端密封以形成筒/尖端密封组合（240）; 组装柱塞盖和柱塞基板以形成柱塞（268）; 用预定量的流体（276）填充桶/尖端密封组合; 以及通过将柱塞插入筒/尖端密封组合（278）中来预先填充的注射器的最终组装。 当注射器组件在不同位置制造时，每个组件被三倍重装，以保持组件基本上没有污染物，并且被运输到组件的未被包装并组装到筒/尖端密封组合和柱塞中的组装位置。 当筒/尖端密封组合的填充和最终组装在与其组装位置分离的位置处发生时，筒/尖端密封组合被三倍增加以保持其基本上没有污染物，并被运送到填充和最终组装位置 用于填充和最终组装成预充式注射器。

公开(公告)号：WO1987003386A1

公开(公告)日：1987-06-04

申请号：PCT/US1986002521

申请日：1986-11-24

Applicant: MEDRAD, INC.

Inventor： MEDRAD, INC. ,  JOHANSSON, Leif, A. ,  HELLMICK, Mark ,  WEBER, Otto

IPC: G03B42/02

CPC classification number: G03B42/021

Abstract: A programmable X-ray film changer for use, for example, in making angiograms, is provided with an improved pressure plate mechanism (56), feed and removal mechanism (88, 90, 92, 94) and control methodology. The improvements in combination permit a substantial reduction of the number of parts in the film changer resulting in increased reliability, a decrease in the expense of manufacture, and decreased weight. Furthermore the X-ray photographic film changer is arbitrarily orientable in space and independent of gravity feed mechanisms or the interference of gravity with respect to its operation. The improved pressure plate (56) is normally substantially flat and is bowed to form a convex surface by a pressure plate bowing mechanism (100, 102, 104, 106). Misfeeds of multiple numbers of photographic plates are thus tolerated by the natural resiliency of the pressure plate (56). Bowing of the pressure plate (56) is used to actuate feeding and removal of the photographic plates into the exposure position. Alphanumeric information is arbitrarily photographically printed onto the photographic plate subject to programmable control.

公开(公告)号：WO1997037240A1

公开(公告)日：1997-10-09

申请号：PCT/US1997004907

申请日：1997-03-27

Applicant: MEDRAD, INC. ,  DAVIS, Steven ,  MISIC, George, J.

Inventor： MEDRAD, INC.

IPC: G01R33/36

CPC classification number: G01R33/3621

Abstract: The present invention provides an apparatus and method for reducing temperature increases in a circuit (26) for an MRI receive only coil (28). The circuit (26) includes, a receive only coil circuit output (30) coupled to the MRI receive only coil (28), a tuning capacitor (32) and matching capacitor (34) for coupling the MRI receive only coil (28) to the output (30), and a transmission line (36) and p-i-n diode (42) for distributing heat over a large surface area, the transmission line (36) and p-i-n diode (42) coupled to the tuning and matching capacitors (32, 34). The p-i-n diode (42) is forward biased during a transmit cycle and reverse biased during a receive cycle.

Abstract translation: 本发明提供一种用于降低用于仅MRI线圈（28）的电路（26）中的温度升高的装置和方法。 电路（26）包括：仅耦合到MRI接收线圈（28）的接收线圈电路输出（30），调谐电容器（32）和匹配电容器（34），用于将仅MRI接收线圈（28）耦合到 输出（30）以及用于在大表面积上分配热量的传输线（36）和引脚二极管（42），耦合到调谐和匹配电容器（32,32）的传输线（36）和引脚二极管（42） 34）。 p-i-n二极管（42）在发射周期期间被正向偏置，并且在接收周期期间被反向偏置。

公开(公告)号：WO1997007841A2

公开(公告)日：1997-03-06

申请号：PCT/US1996013324

申请日：1996-08-19

Applicant: MEDRAD, INC.

Inventor： MEDRAD, INC. ,  REILLY, David, M. ,  UBER, Arthur, E. ,  HIRSCHMAN, Alan, D. ,  GELBLUM, Eugene, A.

IPC: A61M05/145

CPC classification number: B05C17/01 ,  A61M5/14546 ,  A61M5/14566 ,  A61M2005/14553 ,  Y10S128/01

Abstract: A pressure jacket system of the invention is used to permit the front loading and removal of a syringe (214) from an injector (20), and includes a jacket cylinder (216) having an open front end (218) for receiving a syringe (214) and a rear end coupled to the injector front face (23), first and second tie rods (238, 240) having rear ends pivotally attached to the injector front face (23) by pivots and bushings (230, 234, 232, 236), and a front retaining plate (222) attached to the front ends of the first and second tie rods (238, 240), such that the retaining plate (222) and tie rods (238, 240) are pivotable between a closed position for holding the syringe (214) within the jacket cylinder (216) and an open position to allow the insertion and removal of the syringe (214) from the jacket cylinder (216).

Abstract translation: 使用本发明的压力护套系统来允许从注射器（20）向前装载和移除注射器（214），并且包括具有用于接收注射器的敞开的前端（218）的护套筒（216） 214）和连接到所述注射器正面（23）的后端，第一和第二拉杆（238,240）具有通过枢轴和衬套（230,234,232）枢轴地附接到所述喷射器前面（23）的后端， 236），以及附接到第一和第二拉杆（238,240）的前端的前保持板（222），使得保持板（222）和拉杆（238,240）可在闭合 用于将注射器（214）保持在护套筒（216）内的位置和允许注射器（214）从护套筒（216）插入和移除的打开位置。

公开(公告)号：WO1994000181A1

公开(公告)日：1994-01-06

申请号：PCT/US1993006165

申请日：1993-06-28

Applicant: MEDRAD, INC. ,  MICROWAVE MEDICAL SYSTEMS, INC.

Inventor： MEDRAD, INC. ,  MICROWAVE MEDICAL SYSTEMS, INC. ,  CARR, Kenneth ,  REGAN, James ,  WADDELL, Seid

IPC: A61M31/00

CPC classification number: A61M5/16836 ,  A61M2005/1588 ,  Y10S128/13

Abstract: A system is disclosed for detecting extravasation of injected liquid from the blood vessel of a patient. The system operates by monitoring electromagnetic microwave emission from the patient at the injection site by means of a microwave antenna assembly (18, 22, 24) and processing apparatus (10) connected to the antenna assembly (18, 22, 24) for responding to changes in the microwave emission characteristics representative of extravasation. The antenna assembly (18, 22, 24) has a reusable antenna element (18) connected to the processing apparatus, a disposable attachment element (20) for adhering to the patient's skin, and interfitting male and female coupling formations on the attachment element (20) and the antenna element (18) respectively for releasably coupling the reusable element (18) to the disposable element (20).

Abstract translation: 公开了一种用于检测来自患者的血管的注射液体的外渗的系统。 该系统通过利用连接到天线组件（18,22,24）的微波天线组件（18,22,24）和处理设备（10）来监视来自注射位置处患者的电磁微波发射，以响应于 微波辐射特性的变化代表外渗。 天线组件（18,22,24）具有连接到处理设备的可重复使用的天线元件（18），用于粘附到患者皮肤上的一次性附接元件（20），以及在附接元件上配合阳和阴耦合结构 20）和天线元件（18），用于将可再用元件（18）可释放地联接到一次性元件（20）。

公开(公告)号：WO1993003393A1

公开(公告)日：1993-02-18

申请号：PCT/US1992006608

申请日：1992-08-10

Applicant: MEDRAD, INC.

Inventor： MEDRAD, INC. ,  MISIC, George, J. ,  REID, Eric, D.

IPC: G01R33/20

CPC classification number: G01R33/34046 ,  G01R33/3415

Abstract: A magnetic resonance imaging receiving coil (10) having an improved signal-to-noise ratio comprising two or more separate quadrature volume coils (12, 14), each intercepting the two quadrature components of the magnetic resonance signal within its own sensitive volume, and the two or more quadrature coils (12, 14) being magnetically isolated from each other by overlap geometry along the axis normal to the plane of the magnetic resonance rotating field. The coils (12, 14) are connected to independent image processing channels (30a, 30b, 32a, 32b) of a data acquisition system (34), the outputs of the processing channels (30a, 30b, 32a, 32b) being combined to form an overall image.

公开(公告)号：WO1993003391A1

公开(公告)日：1993-02-18

申请号：PCT/US1992006491

申请日：1992-08-05

Applicant: MEDRAD, INC.

Inventor： MEDRAD, INC. ,  MISIC, George, J. ,  REID, Eric, D.

IPC: G01R33/20

CPC classification number: G01R33/3678 ,  A61B5/0555 ,  G01R33/34084 ,  G01R33/341

Abstract: A quadrature surface probe (10) comprising two individual mirror image coil loops (20, 30) arranged so that the magnetic field vectors of the respective coil loops (20, 30) are substantially perpendicular. An area of overlap between the first and second coil loops (20, 30) is adjusted to minimize the mutual coupling between the individual coils. Also disclosed is the method of manufacturing the quadrature surface probe.