公开(公告)号：WO1996027398A1

公开(公告)日：1996-09-12

申请号：PCT/US1996002199

申请日：1996-02-20

Applicant: MINIMED INC.

Inventor： MINIMED INC. ,  FELDMANN, William, G. ,  SCHERBENSKE, Vernon, J. ,  HENNING, Craig, M.

IPC: A61M01/00

CPC classification number: A61M5/16854 ,  A61M5/1456

Abstract: An improved occlusion detector is provided in a medication infusion pump (10) to monitor medication delivery to a patient, and to provide an early alarm in the event of medication nondelivery. The detector comprises a force sensor (52) and related control circuit for reading and comparing the pressure applied to the medication at the time of pump operation to administer a dose to the patient, with the same pressure at a later point in time preceding the next dose. If a difference between the pressure readings is less than a predetermined value, an occlusion of the medication delivery line is indicated and an alarm is activated.

Abstract translation: 在药物输注泵（10）中提供改进的闭塞检测器，以监测对患者的药物输送，并且在药物不输送的情况下提供早期报警。 检测器包括力传感器（52）和相关的控制电路，用于读取和比较在泵操作时施加到药物上的压力以向患者施用剂量，在相同压力下在稍后的时间点 剂量。 如果压力读数之间的差异小于预定值，则指示药物输送管线的闭塞并激活警报。

公开(公告)号：WO1996000095A1

公开(公告)日：1996-01-04

申请号：PCT/US1994007112

申请日：1994-06-23

Applicant: MINIMED INC.

Inventor： MINIMED INC. ,  VAN ANTWERP, William, P. ,  INDRAVUHD, Virote

IPC: A61M01/00

CPC classification number: A61M5/14276 ,  A61M5/14216 ,  A61M39/24

Abstract: A medication infusion pump (10) is provided for use in the programmable delivery of the selected medication to a patient, wherein the pump (10) includes a fluoropolymer valve seat (38) engageable with a nonmetallic valve member (36). The fluoropolymer valve seat (38) defines a substantially inert and non-adherent surface to prevent accumulation of medication deposits thereon. Such deposits are believed to occur as a result of shear denaturation and/or precipitation in the vicinity of the valve seat (38), in response to relatively high compression forces applied to the medication as the valve member (36) opens and closes. The fluoropolymer valve seat (38) provides a surface which is particularly non-adherent to protein based medications, such as insulin.

Abstract translation: 提供了一种药物输注泵（10），用于将所选择的药物可编程递送给患者，其中所述泵（10）包括可与非金属阀构件（36）接合的氟聚合物阀座（38）。 氟聚合物阀座（38）限定了基本上惰性和非粘附的表面，以防止其上的药物沉积物积聚。 相应地，当阀构件（36）打开和关闭时响应于施加到药物上的相对高的压缩力，这种沉积物被认为是由于阀座（38）附近的剪切变性和/或沉淀而发生的。 含氟聚合物阀座（38）提供了特别不依赖于基于蛋白质的药物，例如胰岛素的表面。

公开(公告)号：WO1995028878A1

公开(公告)日：1995-11-02

申请号：PCT/US1995004824

申请日：1995-04-24

Applicant: MINIMED INC.

Inventor： MINIMED INC. ,  LORD, Peter, C. ,  COLMAN, Fredric, C.

IPC: A61B05/05

CPC classification number: A61B5/6865 ,  A61B5/0002 ,  A61B5/14532 ,  A61M5/1723 ,  G06F19/00

Abstract: An infusion pump system (10) includes a removable in vivo glucose sensor (16) for monitoring glucose concentration level in a patient (12), and for signaling an infusion pump to deliver a selected medication such as insulin to a patient. The glucose sensor (16) comprises a sensor cable (30) for placement through a catheter to position a distal sensor tip (20) at a selected in vivo sensor site. A proximal end of the sensor cable seats within a connector fitting (18) mounted on the catheter (24) at a convenient and accessible subcutaneous position. The connector fitting (18) couples the sensor cable (30) to an implanted control unit (26) which signals the infusion pump (14) to deliver the patient (12) medication. In a preferred system, the infusion pump (14) is also implanted and receives control signals via a direct or telemetric connection. The sensor cable (30) is easily accessed at the connector fitting (18) for periodic sensor removal and replacement, without requiring removal or replacement of other system components.

Abstract translation: 输液泵系统（10）包括用于监测患者（12）中的葡萄糖浓度水平的可移除的体内葡萄糖传感器（16），并且用于发信号通知输液泵将选定的药物例如胰岛素递送给患者。 葡萄糖传感器（16）包括传感器电缆（30），用于通过导管放置以在选定的体内传感器位置定位远端传感器尖端（20）。 传感器电缆的近端位于安装在导管（24）上的方便和可接近的皮下位置的连接器配件（18）内。 连接器配件（18）将传感器电缆（30）耦合到植入的控制单元（26），其传送输液泵（14）以输送患者（12）药物。 在优选的系统中，输注泵（14）也被植入并通过直接或遥测连接接收控制信号。 在连接器配件（18）处容易地访问传感器电缆（30），用于周期性的传感器移除和更换，而不需要拆卸或更换其他系统部件。