公开(公告)号：WO1995026765A1

公开(公告)日：1995-10-12

申请号：PCT/US1995003550

申请日：1995-03-20

Applicant: MINIMED INC.

Inventor： MINIMED INC. ,  VAN ANTWERP, William, P.

IPC: A61M05/32

CPC classification number: A61L29/085 ,  A61M25/0017

Abstract: An improved indwelling catheter (10) adapted for long-term usage includes a stable enzyme coating (14, 40) to prevent occlusion of the catheter lumen (16). The enzyme coating includes a fibrinolytic and/or lipolytic enzyme incorporated in a catheter coating to resist or control proteolytic degradation, thereby maintaining the enzyme in an active state for dissolving clots and occlusions within the catheter lumen over an extended period of time.

Abstract translation: 适于长期使用的改进的留置导管（10）包括用于防止导管内腔（16）堵塞的稳定的酶涂层（14,40）。 酶涂层包括掺入导管涂层中以抵抗或控制蛋白水解降解的纤维蛋白溶解和/或脂肪分解酶，从而将酶维持在活性状态，以在延长的时间段内溶解凝块和闭塞。

公开(公告)号：WO1996040324A1

公开(公告)日：1996-12-19

申请号：PCT/US1996006656

申请日：1996-05-10

Applicant: MINIMED INC.

Inventor： MINIMED INC. ,  LIVINGSTON, John, H. ,  KONOPKA, April, A.

IPC: A61M05/00

CPC classification number: A61M25/0637 ,  A61M2005/1581 ,  A61M2005/1585

Abstract: A subcutaneous injection set comprises a base (10) adapted for press on attachment to the skin of a patient. The base includes a connector sleeve for connecting a length of infusion tubing to the soft cannula. The soft cannula is threaded through an eye formed near the distal end of the injection needle which is mounted on a collapsible injector (22) that is detachably mounted to the base.

Abstract translation: 皮下注射装置包括适于在附着于患者皮肤上按压的基部（10）。 基座包括用于将一段长度的输注管连接到软插管的连接器套筒。 软套管穿过形成在注射针的远端附近的眼睛，该眼睛安装在可拆卸地安装到基部的可收缩注射器（22）上。

公开(公告)号：WO1996025088A1

公开(公告)日：1996-08-22

申请号：PCT/US1996001672

申请日：1996-02-08

Applicant: MINIMED INC.

Inventor： MINIMED INC. ,  HALILI, Edgardo, C. ,  MASTROTOTARO, John, J.

IPC: A61B05/00

CPC classification number: A61B5/6849 ,  A61B5/14532 ,  A61M25/0606 ,  A61M2005/1726 ,  A61M2230/201

Abstract: An insertion set (10) is provided for transcutaneous placement of a sensor (12) such as a glucose sensor at a selected site within the body of a patient. The insertion set (10) comprises a slotted insertion needle (14) extending through a mounting base (26) adapted for mounting onto the patient's skin. A flexible thin film sensor (12) includes a proximal segment (20) carried by the mounting base (26) and defining conductive contacts, unnumbered, adapted for electrical connection to a suitable monitor (22), and a distal segment (16) protruding from the mounting base (26) with sensor electrodes (18) for transcutaneous placement. The distal segment of the sensor extends within a protective cannula (15), a portion of which is slidably disposed within the insertion needle (14). Placement of the mounting base (26) onto the patient's skin causes the insertion needle (14) to pierce the skin for transcutaneous placement of the cannula (15) with the sensor (12) therein.

Abstract translation: 插入组（10）被提供用于在患者体内的选定位置处经皮放置诸如葡萄糖传感器的传感器（12）。 插入组（10）包括延伸穿过适于安装到患者皮肤上的安装基座（26）的开槽插入针（14）。 柔性薄膜传感器（12）包括由安装基座（26）承载的近端段（20），并且限定导电接触件（未编号），适于与合适的监视器（22）电连接;以及远端段（16）突出 来自具有用于经皮放置的传感器电极（18）的安装基座（26）。 传感器的远侧段在保护套管（15）内延伸，其一部分可滑动地设置在插入针（14）内。 将安装基座（26）放置在患者皮肤上使得插入针（14）刺穿皮肤，以便将传感器（12）经由插管（15）放置在其中。

公开(公告)号：WO1996014096A2

公开(公告)日：1996-05-17

申请号：PCT/US1995014632

申请日：1995-10-12

Applicant: MINIMED INC.

Inventor： MINIMED INC. ,  FUNDERBURK, Jeffery, V. ,  McINTYRE, Deborah, C.

IPC: A61M00/00

CPC classification number: A61M39/14 ,  A61M2005/1581 ,  A61M2039/1027 ,  A61M2039/1072 ,  Y10S604/905

Abstract: A quick-connect coupling is provided for use in a medication infusion system, to permit temporary disconnection and subsequent re-connection of a medication infusion pump relative to a patient without requiring removal of a transcutaneous infusion cannula. The coupling is mounted in-line with a length of infusion tubing and includes a female component with a needle recessed therein and adapted for slide-fit connection with a male component having a self-sealing septum. Radial tabs on the male component slide freely into longitudinally open slots formed in the female component, whereupon the male component is rotatable to displace the tabs with interference fit past undercut cam surfaces into alignment with radially open ports formed in the female component. When connected, the male and female components are effectively locked against longitudinal separation. However, the male and female components can be separated safely and easily, and without applying substantial longitudinal forces, by rotating the male component to displace the tabs back to alignment with the longitudinally open slots in the female component.

Abstract translation: 提供用于药物输注系统中的快速连接联接器，以允许药物输注泵相对于患者的临时断开和随后的重新连接，而不需要去除经皮输液套管。 联接器与一段输注管线成直线安装，并且包括阴部件，其中凹入其中的针，并适于与具有自密封隔膜的阳部件滑动配合连接。 阳部件上的径向突片自由地滑入形成在阴部件中的纵向开口槽中，于是阳部件可旋转，以使过盈配合过去的底切凸轮表面移动突片，以与形成在阴部件中的径向开放的端口对准。 当连接时，阳和阴部件有效地被锁定以防止纵向分离。 然而，可以安全且容易地分离阳部件和母部件，并且不施加实质的纵向力，通过旋转阳部件以将突出部移回以与母部件中的纵向开口的槽对准。

公开(公告)号：WO1995031016A1

公开(公告)日：1995-11-16

申请号：PCT/US1995005414

申请日：1995-05-01

Applicant: MINIMED INC.

Inventor： MINIMED INC. ,  LORD, Peter, C. ,  VAN ANTWERP, William, P. ,  MASTROTOTARO, John, J. ,  CHENEY, Paul, S., II ,  SCHNABEL, Nannette, M.

IPC: H01R09/09

CPC classification number: H01R12/774 ,  A61B2562/227 ,  H01R12/78 ,  H01R12/88 ,  H05K3/325 ,  H05K3/361 ,  H05K3/365 ,  H05K2201/0133

Abstract: A connector (10) is provided for electrical connection to a flex circuit (12) in a hermetically sealed manner. The flex circuit comprises thin film conductors (26) encased between layers of insulative material, and including a proximal end (20), with conductive contact pads (30) exposed through one of the insulative layers. In a preferred form, the proximal ends of two flex circuits are assembled in face-to-face relation and compressed by a clamp fixture (16) against opposite side faces of a compressible terminal block (18). The terminal block is formed from a resilient insulative elastomer such as silicone rubber with embedded conductive strips (40) having opposite edges exposed at the opposite side faces of the terminal block for electrically connecting aligned pairs of the contact pads on the two flex circuits.

Abstract translation: 提供连接器（10）用于以气密方式电连接到柔性电路（12）。 柔性电路包括封装在绝缘材料层之间的薄膜导体（26），并且包括近端（20），其中导电接触焊盘（30）通过绝缘层之一露出。 在优选形式中，两个柔性电路的近端以面对面的关系组装，并通过夹紧夹具（16）压靠在压缩端子块（18）的相对侧面上。 端子块由诸如硅橡胶的弹性绝缘弹性体形成，其中嵌入的导电条（40）具有暴露在端子块的相对侧面处的相对边缘，用于电连接两个柔性电路上的对准的接触焊盘对。

公开(公告)号：WO1996037246A1

公开(公告)日：1996-11-28

申请号：PCT/US1996006649

申请日：1996-05-10

Applicant: MINIMED INC.

Inventor： MINIMED INC. ,  COLMAN, Fredric, C. ,  LORD, Peter, C.

IPC: A61M05/20

CPC classification number: A61M5/14244 ,  A61M5/1723 ,  G06F19/00

Abstract: A medication infusion device (10) such as a programmable infusion pump includes data input regarding a selected patient parameter such as a current blood glucose reading. The infusion device includes a controller responsive to this data input to develop a medication delivery protocol.

Abstract translation: 诸如可编程输注泵的药物输注装置（10）包括关于所选择的患者参数（例如当前血糖读数）的数据输入。 输注装置包括响应于该数据输入以开发药物递送方案的控制器。

公开(公告)号：WO1996030431A1

公开(公告)日：1996-10-03

申请号：PCT/US1996003987

申请日：1996-03-25

Applicant: MINIMED INC.

Inventor： MINIMED INC. ,  VAN ANTWERP, William, P.

IPC: C08G77/26

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/411 ,  C08G18/4833 ,  C08G18/61 ,  C08G18/6674 ,  C08G77/458 ,  C08J5/2287 ,  C08J2383/02 ,  C12Q1/002 ,  C12Q1/006

Abstract: A homogenous polymer composition useful as a membrane for biosensors is disclosed. The polymer composition comprises the reaction products of a diisocyanate, a hydrophilic diol or diamine, and a silicone material. An aliphatic diol or diamine may also be included. Membranes prepared from the composition allow for increasing oxygen permeability and decreased analyte permeability (e.g. glucose). They also possess the necessary physical properties of an outer polymeric biosensor membrane.

Abstract translation: 公开了可用作生物传感器的膜的均匀聚合物组合物。 聚合物组合物包含二异氰酸酯，亲水性二醇或二胺与硅酮材料的反应产物。 还可以包括脂族二醇或二胺。 由组合物制备的膜允许增加透氧性和降低的分析物渗透性（例如葡萄糖）。 它们还具有外部聚合物生物传感器膜所需的物理性质。

公开(公告)号：WO1996025089A1

公开(公告)日：1996-08-22

申请号：PCT/US1996002006

申请日：1996-02-14

Applicant: MINIMED INC.

Inventor： MINIMED INC. ,  CHENEY, Paul, S., II ,  MASTROTOTARO, John, J. ,  SCHNABEL, Nannette, M. ,  LORD, Peter, C. ,  VAN ANTWERP, William, P. ,  CLARK, Raymond, D.

IPC: A61B05/00

CPC classification number: A61B5/4839 ,  A61B5/14532 ,  A61B5/6849 ,  A61B17/3403

Abstract: An insertion set (10) is provided for transcutaneous placement of a sensor (12) such as a glucose sensor at a selected site within the body of a patient. The insertion set (10) comprises an insertion needle (14) extending through a mounting base (34) adapted for mounting onto a patient's skin. A flexible thin film sensor (12) includes a proximal segment (20) carried by the mounting base (34) and adapted for electrical connection to a suitable monitor and a distal segment (16) protruding from the mounting base (34) with sensor electrodes (18) thereon for transcutaneous placement. The distal segment (16) of the sensor (12) and a distal segment (66) of the insertion needle (14) are positioned within a flexible cannula (15) which extends from the mounting base (34), whereby placement of the mounting base (34) onto the patient's skin causes insertion needle (14) to pierce the skin for transcutaneous placement of the cannula (15) with the sensor (12) therein.

Abstract translation: 插入组（10）被提供用于在患者体内的选定位置处经皮放置诸如葡萄糖传感器的传感器（12）。 插入组（10）包括延伸穿过适于安装到患者皮肤上的安装基座（34）的插入针（14）。 柔性薄膜传感器（12）包括由安装基座（34）承载并适于与合适的监视器电连接的近端段（20）和从安装基座（34）突出的远端段（16），传感器电极 （18），用于经皮放置。 传感器（12）的远端段（16）和插入针（14）的远端段（66）位于从安装基座（34）延伸的柔性套管（15）内，从而安装 基部（34）到患者皮肤上，导致插入针（14）刺穿皮肤，以便将传感器（12）经由插管（15）放置在其中。

公开(公告)号：WO1996008281A1

公开(公告)日：1996-03-21

申请号：PCT/US1995011524

申请日：1995-09-11

Applicant: MINIMED INC.

Inventor： MINIMED INC. ,  FUNDERBURK, Jeffery, V. ,  JORDAN, Matthew ,  McINTYRE, Deborah, C.

IPC: A61M05/145

CPC classification number: A61M5/1456 ,  A61M5/1458

Abstract: An improved medication infusion pump is provided of the type for receiving and supporting a medication-containing syringe, wherein the pump and syringe include matingly interfitted components to ensure use of the pump with a compatible and correctly installed syringe. The infusion pump comprises a pump housing defining a syringe compartment for receiving and supporting the syringe, in combination with a drive member for engaging and programmably displacing a syringe plunger to administer medication to a patient. In one preferred form, the drive member and plunger include a matingly interfitting tab and notch which are engaged when the syringe is fully and properly positioned within the syringe compartment. In another form, the tab and notch are formed on the syringe plunger and a portion of the pump housing.

Abstract translation: 提供了用于接收和支撑含药物注射器的类型的改进的药物输注泵，其中所述泵和注射器包括配合配合的部件，以确保使用具有相容且正确安装的注射器的泵。 输注泵包括限定用于接收和支撑注射器的注射器室的泵壳体，与用于接合并可编程地移位针筒柱塞以向患者施用药物的驱动构件组合。 在一个优选形式中，驱动构件和柱塞包括配合互相配合的突片和凹口，当注射器完全和适当地定位在注射器隔间内时，该突出部和凹口接合。 在另一种形式中，突片和凹口形成在注射器柱塞和泵壳体的一部分上。

公开(公告)号：WO1998019627A1

公开(公告)日：1998-05-14

申请号：PCT/IB1997001375

申请日：1997-09-18

Applicant: MINIMED INC.

Inventor： MINIMED INC. ,  VAN ANTWERP, William, P. ,  GULATI, Poonam, S. ,  DECKER, Christian, C. ,  ADOMIAN, Gerald, E. ,  DY, Norman, V.

IPC: A61F02/00

CPC classification number: A61M5/14276 ,  A61L31/10 ,  C08L75/04

Abstract: A medication infusion pump is provided for use in the delivery of a selected medication to a patient, wherein the pump includes internal surface coatings defining protein stable surfaces. In accordance with the invention, hydrophilic internal surfaces and related coating methods are provided to reduce or eliminate accumulation of medication deposits which can otherwise occur when handling complex protein-based medication. Preferred hydrophilic pump surfaces include hydrophilic surfactants (PEO) or (PEG) coatings which exhibit very low protein adsorption characteristics. Several methods are disclosed for producing such coatings, including direct surface modification, covalent and noncovalent attachment of polymers, and covalent attachment through a saline primer.

Abstract translation: 提供用于将选定药物递送给患者的药物输注泵，其中所述泵包括限定蛋白质稳定表面的内表面涂层。 根据本发明，提供亲水性内表面和相关的涂覆方法以减少或消除当处理复杂的基于蛋白质的药物时可能发生的药物沉积物的积累。 优选的亲水泵表面包括表现出非常低的蛋白质吸附特性的亲水性表面活性剂（PEO）或（PEG）涂层。 公开了用于制备这种涂层的几种方法，包括直接表面改性，聚合物的共价和非共价连接以及通过盐底漆的共价连接。