公开(公告)号：WO1996000095A1

公开(公告)日：1996-01-04

申请号：PCT/US1994007112

申请日：1994-06-23

Applicant: MINIMED INC.

Inventor： MINIMED INC. ,  VAN ANTWERP, William, P. ,  INDRAVUHD, Virote

IPC: A61M01/00

CPC classification number: A61M5/14276 ,  A61M5/14216 ,  A61M39/24

Abstract: A medication infusion pump (10) is provided for use in the programmable delivery of the selected medication to a patient, wherein the pump (10) includes a fluoropolymer valve seat (38) engageable with a nonmetallic valve member (36). The fluoropolymer valve seat (38) defines a substantially inert and non-adherent surface to prevent accumulation of medication deposits thereon. Such deposits are believed to occur as a result of shear denaturation and/or precipitation in the vicinity of the valve seat (38), in response to relatively high compression forces applied to the medication as the valve member (36) opens and closes. The fluoropolymer valve seat (38) provides a surface which is particularly non-adherent to protein based medications, such as insulin.

Abstract translation: 提供了一种药物输注泵（10），用于将所选择的药物可编程递送给患者，其中所述泵（10）包括可与非金属阀构件（36）接合的氟聚合物阀座（38）。 氟聚合物阀座（38）限定了基本上惰性和非粘附的表面，以防止其上的药物沉积物积聚。 相应地，当阀构件（36）打开和关闭时响应于施加到药物上的相对高的压缩力，这种沉积物被认为是由于阀座（38）附近的剪切变性和/或沉淀而发生的。 含氟聚合物阀座（38）提供了特别不依赖于基于蛋白质的药物，例如胰岛素的表面。