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    Self-adhesive composition, and percutaneous absorption-type preparation
    11.
    发明专利
    Self-adhesive composition, and percutaneous absorption-type preparation 有权
    自粘性组合物和经皮吸收型制备

    公开(公告)号：JP2010070550A

    公开(公告)日：2010-04-02

    申请号：JP2009190725

    申请日：2009-08-20

    Applicant: Nipro Patch Co Ltd ,  ニプロパッチ株式会社

    Inventor： KAWAMURA NAOHISA ,  SAKURAI NORIAKI ,  SUGAYA CHIE

    IPC: A61K47/12 ,  A61K9/70 ,  A61K31/192 ,  A61K47/22 ,  A61K47/30 ,  A61K47/32 ,  A61P29/00

    Abstract: PROBLEM TO BE SOLVED: To provide a self-adhesive composition, and a percutaneous absorption-type preparation containing a rubber-based self-adhesive, having an excellent control ability of bleeding, and controlling an increase in crystal deposition of a medicament with time. SOLUTION: The self-adhesive composition used for the percutaneous absorption-type preparation includes: the medicament; a medicament solubilizer for improving the solubility of the medicament; the rubber-based self-adhesive; polyvinylpyrrolidone; and a higher fatty acid. The polyvinylpyrrolidone is contained in an amount effective for inhibiting volatilization of the medicament solubilizer. The higher fatty acid preferably contains isostearic acid. The medicament solubilizer preferably contains N-methyl-2-pyrrolidone. COPYRIGHT: (C)2010,JPO&INPIT

    Abstract translation: 待解决的问题：提供一种自粘组合物和含有橡胶系自粘合剂的经皮吸收型制剂，具有优异的出血控制能力，并控制药物的晶体沉积增加 随着时间的推移。 用于经皮吸收型制剂的自粘组合物包括：药物; 用于改善药物溶解度的药物增溶剂; 橡胶基自粘胶; 聚乙烯吡咯烷酮; 和高级脂肪酸。 聚乙烯吡咯烷酮的含量为有效抑制药物增效剂挥发的量。 高级脂肪酸优选含有异硬脂酸。 药物增溶剂优选含有N-甲基-2-吡咯烷酮。 版权所有（C）2010，JPO＆INPIT

    Supporter for patch, patch, and wrapper
    12.
    发明专利
    Supporter for patch, patch, and wrapper 有权
    配件，配件和包装的支持者

    公开(公告)号：JP2009082701A

    公开(公告)日：2009-04-23

    申请号：JP2008234241

    申请日：2008-09-12

    Applicant: Nipro Patch Co Ltd ,  ニプロパッチ株式会社

    Inventor： KAWAMURA NAOHISA

    IPC: A61F13/02 ,  A61K9/70

    Abstract: PROBLEM TO BE SOLVED: To provide a supporter which surely facilitates drawing of a patch from a package, and a patch with the supporter or the like. SOLUTION: A patch 10 has a supporter 20, a self-adhesive layer 30 located on the supporter 20, and a detachable liner 40 which covers the self-adhesive layer 30. The supporter 20 has a plurality of bulging parts 23 which are located on at least the peripheral parts 24 and bulges to the opposite side to the self-adhesive layer 30. A vacancy 29 with a prescribed thickness T is present between the bulging parts 23 and the adhesive self-layer 30. COPYRIGHT: (C)2009,JPO&INPIT

    Abstract translation: 要解决的问题：提供一种支持者，其确实有助于从包装中绘制贴片，以及具有支撑件等的贴片。 解决方案：贴片10具有支撑件20，位于支撑件20上的自粘层30和覆盖自粘层30的可拆卸衬垫40.支撑件20具有多个凸出部23， 位于至少外围部分24上并且凸出到与自粘层30相反的一侧。具有规定厚度T的空位29存在于凸出部23和粘合剂自层30之间。 （C）2009，JPO＆INPIT

    Adhesive skin patch
    13.
    发明专利
    Adhesive skin patch 有权
    粘合皮肤贴

    公开(公告)号：JP2013227355A

    公开(公告)日：2013-11-07

    申请号：JP2013168530

    申请日：2013-08-14

    Applicant: Nipro Patch Co Ltd ,  ニプロパッチ株式会社

    Inventor： KAWAMURA NAOHISA ,  SAWADA HIDENORI ,  SUGIZAKI YOSHIKI ,  SUGAYA CHIE ,  SAKURAI NORIAKI

    IPC: A61K31/192 ,  A61K9/70 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/32 ,  A61K47/34 ,  A61K47/44 ,  A61K47/46 ,  A61P29/00

    CPC classification number: A61K9/7053 ,  A61K9/7076 ,  A61K31/137 ,  A61K31/192 ,  A61K31/195 ,  A61K31/405

    Abstract: PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for external application and an adhesive skin patch capable of improving releasability, transdermal absorbability and stability of loxoprofen and a salt thereof and capable of reducing aggravation of irritation to skin.SOLUTION: An adhesive skin patch includes a support and an adhesive layer laminated on the support. The adhesive layer includes a styrene-isoprene-styrene copolymer, a tackifier, a plasticizer, sodium loxoprofen, oxyacid and N-methyl-2-pyrrolidone. Preferably, the adhesive layer includes no crotamiton.

    Abstract translation: 要解决的问题：提供一种用于外用的药物组合物和能够改善洛索洛芬及其盐的脱皮能力，经皮吸收性和稳定性的粘合性皮肤贴剂，并且能够减轻对皮肤刺激的加重。解决方案：粘合性皮肤贴剂包括 支撑体和层压在支撑体上的粘合剂层。 粘合层包括苯乙烯 - 异戊二烯 - 苯乙烯共聚物，增粘剂，增塑剂，洛索洛芬钠，含氧酸和N-甲基-2-吡咯烷酮。 优选地，粘合剂层不包括克罗他米通。

    Water-containing patch
    14.
    发明专利
    Water-containing patch 审中-公开
    含水包

    公开(公告)号：JP2013216636A

    公开(公告)日：2013-10-24

    申请号：JP2012090471

    申请日：2012-04-11

    Applicant: Nipro Patch Co Ltd ,  ニプロパッチ株式会社

    Inventor： KAWAMURA NAOHISA

    IPC: A61K31/192 ,  A61K9/70 ,  A61K47/02 ,  A61K47/22 ,  A61P29/00

    Abstract: PROBLEM TO BE SOLVED: To provide a water-containing patch superior in stability of an active ingredient having a predetermined cyclic ketone structure such as loxoprofen.SOLUTION: In a water-containing patch having a support and an adhesive layer positioned on the support, the adhesive layer includes: an active ingredient consisting of a compound having a predetermined cyclic ketone structure, or a pharmaceutically acceptable salt or solvate thereof; 2-mercaptobenzimidazole; and water. Preferably, the adhesive layer includes a sulfite.

    Abstract translation: 要解决的问题：提供具有预定的环酮结构的活性成分如洛索丙芬的稳定性优异的含水贴剂。溶液：在具有载体和位于载体上的粘合剂层的含水补片中， 粘合剂层包括：由具有预定环酮结构的化合物或其药学上可接受的盐或溶剂化物组成的活性成分; 2-巯基苯并咪唑; 和水。 优选地，粘合剂层包括亚硫酸盐。

    Crosslinkable pressure-sensitive adhesive for skin
    15.
    发明专利
    Crosslinkable pressure-sensitive adhesive for skin 有权
    可交联式压敏胶粘剂

    公开(公告)号：JP2009149660A

    公开(公告)日：2009-07-09

    申请号：JP2009023068

    申请日：2009-01-09

    Applicant: Kosumedei Seiyaku Kk ,  Nipro Patch Co Ltd ,  コスメディ製薬株式会社 ,  ニプロパッチ株式会社

    Inventor： KAMIYAMA FUMIO ,  GON EISHUKU ,  KAWAMURA NAOHISA ,  SAWADA HIDENORI

    IPC: A61K47/32 ,  A61F13/02 ,  A61K8/02 ,  A61K8/81 ,  A61K9/70 ,  A61L15/58 ,  C08L33/14 ,  C08L33/24 ,  C09J7/02 ,  C09J133/06

    CPC classification number: A61L24/043 ,  A61K8/8158 ,  A61K9/7061 ,  A61L15/585 ,  A61Q19/00 ,  C08L33/14 ,  C08L33/24 ,  C08L2666/04

    Abstract: PROBLEM TO BE SOLVED: To provide a composition for production of a crosslinkable pressure-sensitive adhesive for skin, having satisfactory pressure-sensitive adhesion and releasability for human skin, low in irritation, suitable for medical and cosmetic uses, suitable for production, and having superior preservability. SOLUTION: The composition is formed with 100 pts.mass acrylic copolymer (copolymer A) comprising an alkyl (meth)acrylate as a main constituent, and 3-45 mass% diacetone acrylamide as an essential constituent, and containing no free carboxy group, and 0.1-30 pts.mass acrylic copolymer (copolymer B) comprising an alkyl (meth)acrylate as a main constituent and a primary amino group and/or carboxyhydrazide group on a side chain, and containing no free carboxy group. The copolymer B contains two or more primary amino groups and/or carboxyhydrazide groups in one molecular chain, and the primary amino groups and/or carbohydrazide groups in the copolymer B are contained at a ratio of one in 5-100 molecular chains of the (meth)acrylate comonomer. COPYRIGHT: (C)2009,JPO&INPIT

    Abstract translation: 要解决的问题：提供一种用于生产用于皮肤的交联性压敏粘合剂的组合物，其具有令人满意的压敏粘合性和对人体皮肤的释放性，适用于医疗和化妆品用途的刺激性低，适于生产 ，具有优异的保存性。 解决方案：组合物由包含（甲基）丙烯酸烷基酯作为主要成分的100质量份丙烯酸共聚物（共聚物A）和3-45质量％的双丙酮丙烯酰胺作为必需组分形成，不含游离羧基 和在侧链上含有（甲基）丙烯酸烷基酯作为主要成分和伯氨基和/或羧酰肼基团的0.1-30重量份丙烯酸共聚物（共聚物B），不含游离羧基。 共聚物B在一个分子链中含有两个或多个伯氨基和/或羧基酰肼基团，共聚物B中的伯氨基和/或碳酰肼基团的含量为 甲基）丙烯酸酯共聚单体。 版权所有（C）2009，JPO＆INPIT

    ADHESIVE SKIN PATCH
    17.
    发明专利
    ADHESIVE SKIN PATCH 未知

    公开(公告)号：CA2883930A1

    公开(公告)日：2014-03-06

    申请号：CA2883930

    申请日：2013-09-02

    Applicant: NIPRO PATCH CO LTD

    Inventor： KAWAMURA NAOHISA ,  SAWADA HIDENORI

    IPC: A61K31/27 ,  A61K9/70 ,  A61K47/32 ,  A61K47/34 ,  A61P25/28

    Abstract: The purpose of the present invention is to provide a rivastigmine-containing adhesive skin patch which has excellent skin permeability of rivastigmine contained therein and has excellent adhesion performance. The present invention provides an adhesive skin patch comprising a support and an adhesive agent layer arranged on the support, wherein the adhesive agent layer contains at least rivastigmine and/or a pharmaceutically acceptable salt thereof and a specific acrylic adhesive agent. The adhesive skin patch according to the present invention may be composed of only the support and the adhesive agent layer. The adhesive agent layer may have a single-layered structure.

    ВЛАГОСОДЕРЖАЩИЙ АДГЕЗИВНЫЙ КОЖНЫЙ ПЛАСТЫРЬ
    18.
    发明专利
    ВЛАГОСОДЕРЖАЩИЙ АДГЕЗИВНЫЙ КОЖНЫЙ ПЛАСТЫРЬ 未知

    公开(公告)号：EA026084B1

    公开(公告)日：2017-02-28

    申请号：EA201490409

    申请日：2012-08-24

    Applicant: NIPRO PATCH CO LTD

    Inventor： KAWAMURA NAOHISA ,  RYOO JE PHIL

    IPC: A61K31/167 ,  A61K9/70 ,  A61K47/10 ,  A61K47/32 ,  A61P29/00 ,  A61P31/22

    Abstract: Визобретениипредставленвлагосодержащийадгезивныйкожныйпластырь, содержащийподложкуи слойадгезивногоагента, нанесенногонаподложку, гдев слоеадгезивногоагентасодержатсялидокаинилиегофармакологическиприемлемаясоль, гидрофильныйадгезивныйагенти 2-10 мас.% поотношениюк слоюадгезивногоагентамоноалкиловогоэфирадиэтиленгликоля, выбранногоизгруппы, состоящейизмонометиловогоэфирадиэтиленгликоля, моноэтиловогоэфирадиэтиленгликоляи монобутиловогоэфирадиэтиленгликоля. Визобретениитакжепредложенспособлеченияилипредупрежденияопоясывающегогерпесаилипостгерпетическойневралгииу пациента, включающийстадиюнанесенияуказанноговлагосодержащегоадгезивногокожногопластырянакожупациента.

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