公开(公告)号：JP2013046826A

公开(公告)日：2013-03-07

申请号：JP2012254139

申请日：2012-11-20

Applicant: Nipro Patch Co Ltd ,  ニプロパッチ株式会社

Inventor： KAWAMURA NAOHISA

IPC: A61F13/02 ,  A61K9/70 ,  A61K47/32 ,  A61K47/34

Abstract: PROBLEM TO BE SOLVED: To provide a supporter which surely facilitates drawing of a patch from a package, and a patch with the supporter or the like.SOLUTION: A patch 10 has: a supporter 20; a self-adhesive layer 30 located on the supporter 20; and a detachable liner 40 which covers the self-adhesive layer 30. The supporter 20 has a plurality of bulging parts 23 which are located on at least the peripheral parts 24 and bulges to the opposite side to the self-adhesive layer 30. A vacancy 29 with a prescribed thickness T is present between the bulging parts 23 and the self-adhesive layer 30, the top parts of the bulging parts 23 have length not less than 0.2 mm and not more than 0.9 mm, and the interval of the bulging parts 23 is not more than 2.1 mm.

Abstract translation: 要解决的问题：提供一种支持者，其确实有助于从包装中绘制贴片，以及具有支撑件等的贴片。 解决方案：贴片10具有：支撑件20; 位于支架20上的自粘层30; 以及覆盖自粘层30的可拆卸衬垫40.支撑件20具有至少位于周边部分24上的多个凸出部分23，并且向与自粘层30相反的一侧凸出。空位 在凸起部23与自粘合层30之间存在规定厚度T的凸部29的长度为0.2mm以上0.9mm以下的凸部的间隔， 23不超过2.1毫米。 版权所有（C）2013，JPO＆INPIT

公开(公告)号：JP2011088890A

公开(公告)日：2011-05-06

申请号：JP2010214369

申请日：2010-09-24

Applicant: Nipro Patch Co Ltd ,  ニプロパッチ株式会社

Inventor： KAWAMURA NAOHISA

IPC: A61K31/167 ,  A61K9/70 ,  A61K47/22 ,  A61P9/06 ,  A61P23/00

Abstract: PROBLEM TO BE SOLVED: To provide a transdermal patch in which the transdermal absorption of the ingredient lidocaine changes little with its water content. SOLUTION: The transdermal patch includes a support and a pressure-sensitive adhesive layer situated on the support, wherein the pressure-sensitive layer contains lidocaine and/or a pharmacologically acceptable salt thereof, a surfactant having an HLB value of 12 or lower, and water. It is desirable that the pressure-sensitive adhesive layer further contains N-methyl-2-pyrrolidone. COPYRIGHT: (C)2011,JPO&INPIT

Abstract translation: 要解决的问题：提供透皮贴剂，其中成分利多卡因的透皮吸收与其含水量变化很小。 透皮贴剂包括载体和位于载体上的压敏粘合剂层，其中压敏层含有利多卡因和/或其药理学上可接受的盐，HLB值为12或更低的表面活性剂 ，和水。 理想的是，粘合剂层还含有N-甲基-2-吡咯烷酮。 版权所有（C）2011，JPO＆INPIT

公开(公告)号：JP2014156498A

公开(公告)日：2014-08-28

申请号：JP2014116588

申请日：2014-06-05

Applicant: Nipro Patch Co Ltd ,  ニプロパッチ株式会社

Inventor： KAWAMURA NAOHISA

IPC: A61K31/192 ,  A61K9/70 ,  A61K47/02 ,  A61K47/10

CPC classification number: A61K9/7038 ,  A61K31/122 ,  A61K31/192

Abstract: PROBLEM TO BE SOLVED: To provide a water-containing patch excellent in stability of active ingredients including loxoprofen.SOLUTION: Disclosed is a water-containing patch which contains an active ingredient comprising loxoprofen, pharmacologically acceptable salt or solvate thereof, water, inorganic powder, and menthol. Preferably one or more selected from kaoline, zinc oxide, titanium oxide, and silicic acid anhydride is contained as the inorganic powder, and preferably silicic acid anhydride is contained.

Abstract translation: 要解决的问题：提供包括洛索洛芬在内的活性成分的稳定性优异的含水贴剂。解决方案：公开了含有活性成分的含水贴剂，其包含洛索洛芬，其药理学上可接受的盐或溶剂合物，水，无机粉末， 和薄荷脑。 作为无机粉末，优选含有高岭土，氧化锌，氧化钛，硅酸酐中的一种以上，优选含有硅酸酐。

公开(公告)号：JP2012140460A

公开(公告)日：2012-07-26

申请号：JP2012088596

申请日：2012-04-09

Applicant: Nipro Patch Co Ltd ,  ニプロパッチ株式会社

Inventor： KAWAMURA NAOHISA ,  SAWADA HIDENORI ,  NAGAI TAKESHI ,  SUGIZAKI YOSHIKI

IPC: A61K47/32 ,  A61K9/70 ,  A61K31/196 ,  A61K47/12 ,  A61K47/34 ,  A61P29/00

CPC classification number: A61K9/7061 ,  A61K31/192

Abstract: PROBLEM TO BE SOLVED: To provide a composition for a hydrous adhesive patch for external use which contains a specific amount of an alkyl acrylate ester compound, and to provide an adhesive patch comprising the composition.SOLUTION: The composition for a hydrous adhesive patch for external use comprises an alkyl acrylate ester compound including alkyl acrylate ester as an essential copolymer component and including the other alkyl acrylate ester and/or (meth)acrylic acid as a copolymer component. The composition for a hydrous adhesive patch for external use comprises a water-dispersible surfactant of 0.01 to 10.0 mass% to the whole of the composition for a hydrous adhesive patch for external use.

Abstract translation: 要解决的问题：提供含有特定量的丙烯酸烷基酯化合物的外用含水粘合剂贴剂的组合物，并提供包含该组合物的粘合剂贴剂。 解决方案：用于外用的含水粘合剂贴剂的组合物包含丙烯酸烷基酯化合物，包括丙烯酸烷基酯作为必需共聚物组分，并且包括作为共聚物组分的其它丙烯酸烷基酯和/或（甲基）丙烯酸。 用于外用的含水粘合剂贴剂的组合物包含用于外用含水粘合剂贴剂的整个组合物的0.01至10.0质量％的水分散性表面活性剂。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：JP2009235065A

公开(公告)日：2009-10-15

申请号：JP2009048952

申请日：2009-03-03

Applicant: Nipro Patch Co Ltd ,  ニプロパッチ株式会社

Inventor： KAWAMURA NAOHISA ,  TSUCHIYA JUNKO

IPC: A61K47/14 ,  A61K9/06 ,  A61K9/08 ,  A61K9/10 ,  A61K9/12 ,  A61K9/70 ,  A61K31/137

Abstract: PROBLEM TO BE SOLVED: To provide a percutaneous absorption promotor stimulating percutaneous absorption of a drug and containing a highly safe higher fatty acid triglyceride with less irritation to the skin, and to provide a skin treatment pharmaceutical preparation and the percutaneous absorption type pharmaceutical preparation, containing the higher fatty acid glyceride. SOLUTION: This percutaneous absorption promotor contains a higher fatty acid triglyceride of 14C or more and can stimulate percutaneous absorption of a drug by application before use of a medicant drug. In addition, the skin treatment pharmaceutical preparation and the percutaneous absorption type pharmaceutical preparation are components constructing human sebum, thus are low irritant to the skin and excellent in safety. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 待解决的问题：提供刺激药物的经皮吸收并含有对皮肤刺激性低的高度安全的高级脂肪酸甘油三酯的经皮吸收促进剂，并提供皮肤治疗药物制剂和经皮吸收型药物 制备，含有高级脂肪酸甘油酯。 解决方案：该经皮吸收促进剂含有14℃或更高的高级脂肪酸甘油三酯，并且可以在使用药物之前通过施用来刺激药物的经皮吸收。 此外，皮肤治疗药物制剂和经皮吸收型药物制剂是构成人类皮脂的成分，因此对皮肤的刺激性低，安全性优异。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：HK1116099A1

公开(公告)日：2008-12-19

申请号：HK08105633

申请日：2008-05-21

Applicant: NIPRO PATCH CO LTD

Inventor： KAWAMURA NAOHISA ,  SAWADA HIDENORI ,  KOBAYASHI TAKAYUKI

IPC: A61K20060101 ,  A61L20060101 ,  C09J20060101

Abstract: A medical tape preparation which comprises a support and, superposed on one side thereof in the following order, a pressure-sensitive adhesive layer and a release liner. The pressure-sensitive adhesive layer can contain a large amount of an oleophilic oily matter. The tape preparation is excellent in adhesion, cohesiveness, and stability even when no crosslinking agent is used. The pressure-sensitive adhesive layer in the medical tape preparation comprises a blend of two tacky polymers, which are a tacky polymer (A) comprising a copolymer obtained from 2-acetoacetoxyethyl methacrylate and other vinyl monomer(s) as constituent ingredients and a tacky polymer (B) comprising a copolymer which is obtained from a C 4-10 -alkyl (meth)acrylate and other vinyl monomer(s) as constituent ingredients and is different from the tacky polymer (A).

公开(公告)号：CA2671636A1

公开(公告)日：2008-06-12

申请号：CA2671636

申请日：2007-12-06

Applicant: NIPRO PATCH CO LTD

Inventor： TSUCHIYA JUNKO ,  KAWAMURA NAOHISA ,  SAITOH TAKASHI ,  SUGAYA CHIE

IPC: A61K9/70 ,  A61K31/137 ,  A61K31/192 ,  A61K31/195 ,  A61K31/405 ,  A61K47/10 ,  A61K47/12 ,  A61K47/22 ,  A61K47/32 ,  A61K47/44

Abstract: Disclosed are a pharmaceutical composition for external application, an a dhesive skin patch and others which are improved in a drug release property, transdermal absorbability and stability of a pharmacologically active ingre dient contained therein and can reduce the aggravation of irritation to the skin. Specifically disclosed is an adhesive skin patch comprising a support and an adhesive layer laminated on the support, wherein the adhesive layer c ontains a pharmaceutical composition for external application. The pharmaceu tical composition for external application comprises a pharmacologically act ive ingredient, an auxiliary component and a pyrrolidone compound, wherein o ne of the pharmacologically active ingredient and the auxiliary component ha s a carboxylate group in the molecule and the other has a hydroxy group in t he molecule. Preferably, the adhesive layer further comprises a hydrogenated oil.

公开(公告)号：HK1102109A1

公开(公告)日：2007-11-09

申请号：HK07110101

申请日：2007-09-17

Applicant: NIPRO PATCH CO LTD

Inventor： KAMIYAMA FUMIO ,  QUAN YING SHU ,  KAWAMURA NAOHISA ,  SAWADA HIDENORI

IPC: A61F20060101 ,  A61F13/02 ,  A61K20060101 ,  A61K9/70 ,  A61K47/32 ,  A61L15/58 ,  C08L33/14 ,  C08L33/24 ,  C09J20060101 ,  C09J7/02 ,  C09J133/06

Abstract: It is an object of the invention to provide a crosslinkable pressure-sensitive adhesive for skin that exhibits satisfactory adhesion and releasability for human skin and low irritation to skin, and a crosslinkable pressure-sensitive adhesive sheet for skin that is suitable for medical and cosmetic use, as well as to provide a composition for production of a crosslinkable pressure-sensitive adhesive for skin that has superior storage properties and is suitable for preparation of the crosslinkable pressure-sensitive adhesive for skin. The crosslinkable pressure-sensitive adhesive for skin of the invention is formed by 100 parts by weight of an acrylic copolymer (copolymer A) comprising a (meth) acrylic acid alkyl ester as the main constituent component and 3-45 wt% diacetoneacrylamide as an essential constituent component, and containing no free carboxyl groups, and 0.1-30 parts by weight of an acrylic copolymer (copolymer B) comprising a (meth) acrylic acid alkyl ester as the main constituent component and a primary amino group and/or carboxyhydrazide group on a side chain, and containing no free carboxyl groups. A composition of copolymer A and copolymer B dissolved in a solvent containing at least 5.0 wt% acetone and/or butanone with respect to the total amount of solvent can be stored for prolonged periods.

公开(公告)号：JP2014156499A

公开(公告)日：2014-08-28

申请号：JP2014116589

申请日：2014-06-05

Applicant: Nipro Patch Co Ltd ,  ニプロパッチ株式会社

Inventor： KAWAMURA NAOHISA

IPC: A61K31/192 ,  A61K9/70 ,  A61K47/34 ,  A61P29/00

CPC classification number: A61K9/7038 ,  A61K31/122 ,  A61K31/192

Abstract: PROBLEM TO BE SOLVED: To provide a water-containing patch excellent in stability of active ingredients containing loxoprofen.SOLUTION: Disclosed is a water-containing patch which has a support and an adhesive layer located on this support, wherein the adhesive layer contains loxoprofen, an active ingredient consisting of a pharmacologically acceptable salt thereof or a solvate, a nonionic surfactant and water, and the nonionic surfactant has a HLB value of 6.0 or more to 9.5 or less and/or has an addition mol number of ethylene oxide of 5 mol or less.

Abstract translation: 要解决的问题：提供一种含有洛索洛芬的活性成分的稳定性优异的含水贴片。解决方案：公开了一种含水贴剂，其具有位于该支持体上的支持体和粘合剂层，其中粘合剂层含有洛索洛芬， 由其药理学可接受的盐或溶剂化物，非离子表面活性剂和水组成的活性成分和非离子表面活性剂的HLB值为6.0以上至9.5以下，和/或具有5摩尔的环氧乙烷的加成摩尔数 或更少。

公开(公告)号：JP2014156497A

公开(公告)日：2014-08-28

申请号：JP2014116587

申请日：2014-06-05

Applicant: Nipro Patch Co Ltd ,  ニプロパッチ株式会社

Inventor： KAWAMURA NAOHISA

IPC: A61K31/192 ,  A61K9/70 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/24 ,  A61K47/32 ,  A61K47/36 ,  A61P29/00

CPC classification number: A61K9/7038 ,  A61K31/122 ,  A61K31/192

Abstract: PROBLEM TO BE SOLVED: To provide a water-containing patch excellent in stability of active ingredients containing loxoprofen.SOLUTION: Disclosed is a water-containing patch which contains loxoprofen sodium dihydrate, partially neutralized polyacrylic acid product, polyacrylic acid Na, carmellose Na, methyl acrylate/2-ethylhexyl acrylate copolymer, dried aluminium hydroxide gel, inorganic powder, pH regulator, l-menthol, N-methyl-2-pyrrolidone, glycerol, nonionic surfactant, and a purified water, wherein the nonionic surfactant is polyoxyethylene hardened castor oil (addition mol number of ethylene oxide is 5).

Abstract translation: 要解决的问题：提供含有洛索洛芬的活性成分的稳定性优异的含水贴剂。解决方案：公开了含有洛索洛芬钠二水合物，部分中和的聚丙烯酸产物，聚丙烯酸钠，羧甲纤维素钠，甲基 丙烯酸酯/丙烯酸2-乙基己酯共聚物，干燥氢氧化铝凝胶，无机粉末，pH调节剂，l-薄荷醇，N-甲基-2-吡咯烷酮，甘油，非离子表面活性剂和纯化水，其中非离子表面活性剂是聚氧乙烯硬化蓖麻油 （环氧乙烷的加成摩尔数为5）。