公开(公告)号：CA2883930A1

公开(公告)日：2014-03-06

申请号：CA2883930

申请日：2013-09-02

Applicant: NIPRO PATCH CO LTD

Inventor： KAWAMURA NAOHISA ,  SAWADA HIDENORI

IPC: A61K31/27 ,  A61K9/70 ,  A61K47/32 ,  A61K47/34 ,  A61P25/28

Abstract: The purpose of the present invention is to provide a rivastigmine-containing adhesive skin patch which has excellent skin permeability of rivastigmine contained therein and has excellent adhesion performance. The present invention provides an adhesive skin patch comprising a support and an adhesive agent layer arranged on the support, wherein the adhesive agent layer contains at least rivastigmine and/or a pharmaceutically acceptable salt thereof and a specific acrylic adhesive agent. The adhesive skin patch according to the present invention may be composed of only the support and the adhesive agent layer. The adhesive agent layer may have a single-layered structure.

公开(公告)号：HK1116099A1

公开(公告)日：2008-12-19

申请号：HK08105633

申请日：2008-05-21

Applicant: NIPRO PATCH CO LTD

Inventor： KAWAMURA NAOHISA ,  SAWADA HIDENORI ,  KOBAYASHI TAKAYUKI

IPC: A61K20060101 ,  A61L20060101 ,  C09J20060101

Abstract: A medical tape preparation which comprises a support and, superposed on one side thereof in the following order, a pressure-sensitive adhesive layer and a release liner. The pressure-sensitive adhesive layer can contain a large amount of an oleophilic oily matter. The tape preparation is excellent in adhesion, cohesiveness, and stability even when no crosslinking agent is used. The pressure-sensitive adhesive layer in the medical tape preparation comprises a blend of two tacky polymers, which are a tacky polymer (A) comprising a copolymer obtained from 2-acetoacetoxyethyl methacrylate and other vinyl monomer(s) as constituent ingredients and a tacky polymer (B) comprising a copolymer which is obtained from a C 4-10 -alkyl (meth)acrylate and other vinyl monomer(s) as constituent ingredients and is different from the tacky polymer (A).

公开(公告)号：HK1102109A1

公开(公告)日：2007-11-09

申请号：HK07110101

申请日：2007-09-17

Applicant: NIPRO PATCH CO LTD

Inventor： KAMIYAMA FUMIO ,  QUAN YING SHU ,  KAWAMURA NAOHISA ,  SAWADA HIDENORI

IPC: A61F20060101 ,  A61F13/02 ,  A61K20060101 ,  A61K9/70 ,  A61K47/32 ,  A61L15/58 ,  C08L33/14 ,  C08L33/24 ,  C09J20060101 ,  C09J7/02 ,  C09J133/06

Abstract: It is an object of the invention to provide a crosslinkable pressure-sensitive adhesive for skin that exhibits satisfactory adhesion and releasability for human skin and low irritation to skin, and a crosslinkable pressure-sensitive adhesive sheet for skin that is suitable for medical and cosmetic use, as well as to provide a composition for production of a crosslinkable pressure-sensitive adhesive for skin that has superior storage properties and is suitable for preparation of the crosslinkable pressure-sensitive adhesive for skin. The crosslinkable pressure-sensitive adhesive for skin of the invention is formed by 100 parts by weight of an acrylic copolymer (copolymer A) comprising a (meth) acrylic acid alkyl ester as the main constituent component and 3-45 wt% diacetoneacrylamide as an essential constituent component, and containing no free carboxyl groups, and 0.1-30 parts by weight of an acrylic copolymer (copolymer B) comprising a (meth) acrylic acid alkyl ester as the main constituent component and a primary amino group and/or carboxyhydrazide group on a side chain, and containing no free carboxyl groups. A composition of copolymer A and copolymer B dissolved in a solvent containing at least 5.0 wt% acetone and/or butanone with respect to the total amount of solvent can be stored for prolonged periods.

公开(公告)号：JP2012140460A

公开(公告)日：2012-07-26

申请号：JP2012088596

申请日：2012-04-09

Applicant: Nipro Patch Co Ltd ,  ニプロパッチ株式会社

Inventor： KAWAMURA NAOHISA ,  SAWADA HIDENORI ,  NAGAI TAKESHI ,  SUGIZAKI YOSHIKI

IPC: A61K47/32 ,  A61K9/70 ,  A61K31/196 ,  A61K47/12 ,  A61K47/34 ,  A61P29/00

CPC classification number: A61K9/7061 ,  A61K31/192

Abstract: PROBLEM TO BE SOLVED: To provide a composition for a hydrous adhesive patch for external use which contains a specific amount of an alkyl acrylate ester compound, and to provide an adhesive patch comprising the composition.SOLUTION: The composition for a hydrous adhesive patch for external use comprises an alkyl acrylate ester compound including alkyl acrylate ester as an essential copolymer component and including the other alkyl acrylate ester and/or (meth)acrylic acid as a copolymer component. The composition for a hydrous adhesive patch for external use comprises a water-dispersible surfactant of 0.01 to 10.0 mass% to the whole of the composition for a hydrous adhesive patch for external use.

Abstract translation: 要解决的问题：提供含有特定量的丙烯酸烷基酯化合物的外用含水粘合剂贴剂的组合物，并提供包含该组合物的粘合剂贴剂。 解决方案：用于外用的含水粘合剂贴剂的组合物包含丙烯酸烷基酯化合物，包括丙烯酸烷基酯作为必需共聚物组分，并且包括作为共聚物组分的其它丙烯酸烷基酯和/或（甲基）丙烯酸。 用于外用的含水粘合剂贴剂的组合物包含用于外用含水粘合剂贴剂的整个组合物的0.01至10.0质量％的水分散性表面活性剂。 版权所有（C）2012，JPO＆INPIT

公开(公告)号：ES2416679T3

公开(公告)日：2013-08-02

申请号：ES05814768

申请日：2005-12-12

Applicant: NIPRO PATCH CO LTD

Inventor： KAWAMURA NAOHISA ,  SAWADA HIDENORI ,  KOBAYASHI TAKAYUKI

IPC: A61L15/58 ,  A61K9/70 ,  A61L15/22 ,  C09J7/02 ,  C09J133/08 ,  C09J133/14

Abstract: Una preparación de cinta que tiene una capa de adhesivo sensible a la presión y un revestimiento de liberaciónlaminado en ese orden sobre una cara de un soporte, la preparación de cinta que está caracterizada porque el adhesivosensible a la presión de la capa de adhesivo sensible a la presión es una mezcla de dos adhesivos sensibles a la presión diferentes: (A) un polímero adhesivo A sensible a la presión que comprende un copolímero cuyos componentesconstituyentes comprenden éster de 2-acetoacetoxietil metacrilato y otro monómero vinílico, y (B) un polímero adhesivo B sensible a la presión que comprende un copolímero diferente del polímero adhesivoA sensible a la presión, cuyos componentes constituyentes comprenden un éster de alquil (met)acrilato con un grupoalquilo C4-10 y otro monómero vinílico, en la que el contenido del éster de 2-acetoacetoxietil metacrilato en el polímero adhesivo A sensible a lapresión es del 1%-50% en peso con respecto al peso del copolímero total del polímero adhesivo A sensible a la presión,y en la que la proporción del polímero adhesivo A sensible a la presión como componente (A) y del polímeroadhesivo B sensible a la presión como componente (B) es de 1:9-4:1.

公开(公告)号：ES2395290T3

公开(公告)日：2013-02-11

申请号：ES05730606

申请日：2005-04-12

Applicant: NIPRO PATCH CO LTD

Inventor： KAMIYAMA FUMIO ,  QUAN YING ,  KAWAMURA NAOHISA ,  SAWADA HIDENORI

IPC: A61K47/32 ,  A61F13/02 ,  A61K8/18 ,  A61K9/70 ,  A61L15/58 ,  C08L33/14 ,  C08L33/24 ,  C09J7/02 ,  C09J133/06

Abstract: Un adhesivo piezosensible reticulable para la piel, formado por 100 partes en peso de un copolímero acrílico(copolímero A), que comprende un éster alquílico del ácido (met)acrílico como componente constituyente principal y3-45% en peso de acrilamida de diacetona como componente constituyente fundamental, y que no contiene gruposcarboxilo libres, y 0,1-30 partes en peso de un copolímero acrílico (copolímero B), que comprende un éster alquílicodel ácido (met)acrílico como componente constituyente principal y un grupo amino primario y/o grupocarboxihidrazida sobre una cadena lateral, y que no contiene grupos carboxilo libres.

公开(公告)号：HK1094677A1

公开(公告)日：2007-04-04

申请号：HK07100773

申请日：2007-01-22

Applicant: NIPRO PATCH CO LTD

Inventor： KAWAMURA NAOHISA ,  SAWADA HIDENORI ,  KOBAYASHI TAKAYUKI

IPC: A61K20100101 ,  A61K9/70

Abstract: A nonaqueous pressure-sensitive adhesive for a medicinal tape preparation for percutaneous absorption comprising (a) a support, (b) a pressure-sensitive adhesive layer containing a drug and a nonaqueous pressure-sensitive adhesive and (c) a release film laminated in that order, and a medicinal tape preparation for percutaneous absorption comprising the adhesive. The nonaqueous pressure-sensitive adhesive may comprise a copolymer obtained by copolymerization of a (meth)acrylic monomer having an acetoacetyl group in the molecule and one or more monomers from among other (meth)acrylic monomers without acetoacetyl groups and copolymerizable vinyl monomers, in a nonaqueous solvent. Suitable (meth)acrylic monomers having an acetoacetyl group in the molecule are acetoacetoxyalkyl methacrylates, and especially 2-acetoacetoxyethyl methacrylate. The copolymer nonaqueous pressure-sensitive adhesive of the invention, comprising a (meth)acrylic monomer having an acetoacetyl group as a constituent monomer, is capable of containing large amounts of lipophilic oily substances in the pressure-sensitive adhesive layer, and during heat drying, the acetoacetyl groups undergo self-crosslinking to form a network structure as the solvent evaporates off, so that large amounts of oily substances such as the plasticizer can be included in the network structure. The pressure-sensitive adhesive of the invention uses no polyamine derivatives, isocyanate compounds, polyvalent metal chelate compounds, etc. as crosslinking agents, and therefore toxicity is not a concern and skin is not irritated. A medicinal tape preparation for percutaneous absorption of the invention has superior adhesive strength and cohesive strength, and is highly safe with low skin irritation. It also has excellent drug release and percutaneous absorption properties.

公开(公告)号：HK1115323A1

公开(公告)日：2008-11-28

申请号：HK08110847

申请日：2008-09-29

Applicant: NIPRO PATCH CO LTD

Inventor： KAWAMURA NAOHISA ,  SAWADA HIDENORI ,  SAITOH TAKASHI ,  TAKIZAWA CHIHIRO ,  TSUCHIYA JUNKO

IPC: A61K20060101

Abstract: A skin patch that can enhance the water resistance and handling easiness and can alleviate any irritation on the user. There is provided a skin patch comprising a flexible backing and, superimposed thereon, a plaster layer wherein the plaster layer contains a styrene-isoprene-styrene block copolymer and has a glass transition temperature (Tg) of -45° to -35°C and a tan ´ (lag angle) value, determined at dynamic viscoelasticity measurement (frequency 6.2832 rad/s) at 45°C, of 0.25 or less.

公开(公告)号：HK1103965A1

公开(公告)日：2008-01-04

申请号：HK07108245

申请日：2007-07-27

Applicant: NIPRO PATCH CO LTD

Inventor： KAWAMURA NAOHISA ,  SAWADA HIDENORI ,  SUGIZAKI YOSHIKI ,  SAITOH TAKASHI

IPC: A61K20060101 ,  A61K9/70 ,  A61K31/137 ,  A61P20060101

Abstract: The present invention provides a tulobuterol adhesive patch comprising (a) a support, (b) an acrylic pressure-sensitive adhesive layer containing the percutaneously absorbing drug tulobuterol and if necessary a lipophilic oily plasticizer, and (c) a release liner, laminated in that order, wherein the acrylic pressure-sensitive adhesive is a copolymer obtained by copolymerizing an acrylic monomer which is acetoacetoxyalkyl (meth) acrylate with one or more other vinyl monomers, to yield a tulobuterol adhesive patch with excellent release and skin permeability of tulobuterol from the pressure-sensitive adhesive layer, low skin irritation and excellent safety.

公开(公告)号：JP2013227355A

公开(公告)日：2013-11-07

申请号：JP2013168530

申请日：2013-08-14

Applicant: Nipro Patch Co Ltd ,  ニプロパッチ株式会社

Inventor： KAWAMURA NAOHISA ,  SAWADA HIDENORI ,  SUGIZAKI YOSHIKI ,  SUGAYA CHIE ,  SAKURAI NORIAKI

IPC: A61K31/192 ,  A61K9/70 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/32 ,  A61K47/34 ,  A61K47/44 ,  A61K47/46 ,  A61P29/00

CPC classification number: A61K9/7053 ,  A61K9/7076 ,  A61K31/137 ,  A61K31/192 ,  A61K31/195 ,  A61K31/405

Abstract: PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for external application and an adhesive skin patch capable of improving releasability, transdermal absorbability and stability of loxoprofen and a salt thereof and capable of reducing aggravation of irritation to skin.SOLUTION: An adhesive skin patch includes a support and an adhesive layer laminated on the support. The adhesive layer includes a styrene-isoprene-styrene copolymer, a tackifier, a plasticizer, sodium loxoprofen, oxyacid and N-methyl-2-pyrrolidone. Preferably, the adhesive layer includes no crotamiton.

Abstract translation: 要解决的问题：提供一种用于外用的药物组合物和能够改善洛索洛芬及其盐的脱皮能力，经皮吸收性和稳定性的粘合性皮肤贴剂，并且能够减轻对皮肤刺激的加重。解决方案：粘合性皮肤贴剂包括 支撑体和层压在支撑体上的粘合剂层。 粘合层包括苯乙烯 - 异戊二烯 - 苯乙烯共聚物，增粘剂，增塑剂，洛索洛芬钠，含氧酸和N-甲基-2-吡咯烷酮。 优选地，粘合剂层不包括克罗他米通。