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11.发明申请公开(公告)号：US20160074524A1
公开(公告)日：2016-03-17
申请号：US14786841
申请日：2013-04-26
Applicant: NITTO DENKO CORPORATION
Inventor： Hao Bai , Kwok Yin Tsang , Yi Jin , Lei Yu
CPC classification number: A61K47/48207 , A61K47/645 , C08G69/10 , C08G73/028
Abstract: Described herein are processes of making biocompatible water-soluble polymers conjugates. In particular, large scale processes of making poly(L-γ-glutamyl-glutamate) conjugates that can be useful for a variety of drug delivery applications are described herein.
Abstract translation: 本文描述了制备生物相容性水溶性聚合物共轭物的方法。 特别地，本文描述了可用于各种药物递送应用的制备聚（L-γ-谷氨酸 - 谷氨酸）共轭物的大规模方法。
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公开(公告)号：US11413243B2
公开(公告)日：2022-08-16
申请号：US16182571
申请日：2018-11-06
Applicant: Nitto Denko Corporation
Inventor： Kwok Yin Tsang , Bharat Majeti , John Gaudette , Roger Adami , Hao Bai , Wenbin Ying
IPC: A61K9/127 , A61K47/10 , A61K47/69 , A61K31/7105 , A61K47/14 , C07C201/00 , B82Y5/00
Abstract: This invention includes fusogenic compounds, and compositions and methods of use thereof. The fusogenic compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to incorporate or encapsulate active agents, to deliver and distribute the active agents to cells, tissues, organs, and subjects.
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公开(公告)号：US10405749B2
公开(公告)日：2019-09-10
申请号：US14979568
申请日：2015-12-28
Applicant: Nitto Denko Corporation
Inventor： Kenjirou Minomi , Jens Harborth , Cima Cina , Kwok Yin Tsang , Wenbin Ying , Hirokazu Takahashi
IPC: C12N15/113 , C07H21/02 , C07H21/04 , C07F9/6533 , C12Q1/02 , G01N33/58 , A61B5/00 , A61K49/00 , C07D311/30 , A61K31/713
Abstract: This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. A nucleic acid molecule can have a) a polynucleotide sense strand and a polynucleotide antisense strand; b) each strand of the molecule being from 15 to 30 nucleotides in length; c) a contiguous region of from 15 to 30 nucleotides of the antisense strand being complementary to a sequence of an mRNA encoding p21; and d) at least a portion of the sense strand can be complementary to at least a portion of the antisense strand, and the molecule has a duplex region of from 15 to 30 nucleotides in length.
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公开(公告)号：US10023597B2
公开(公告)日：2018-07-17
申请号：US15634771
申请日：2017-06-27
Applicant: Nitto Denko Corporation
Inventor： Kenjirou Minomi , Jens Harborth , Cima Cina , Kwok Yin Tsang , Wenbin Ying , Hirokazu Takahashi
IPC: C12N15/11 , C07F9/6533 , C12N15/113 , G01N33/58 , C12Q1/02
Abstract: This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2′-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.
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公开(公告)号：US09839694B2
公开(公告)日：2017-12-12
申请号：US14786729
申请日：2013-04-26
Applicant: NITTO DENKO CORPORATION
Inventor： Kwok Yin Tsang , Hao Bai , Yi Jin , Lei Yu
CPC classification number: A61K47/645 , A61K31/337 , A61K47/595 , C08G69/10 , C08G69/46 , C08G69/48
Abstract: Described herein are methods of lowering the endotoxin content from a polyanionic polymer conjugate. In particular, methods of reducing the endotoxin content from a polyanionic polymer conjugate that can be useful for a variety of drug delivery applications are described herein.
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Patent Agency Ranking
公开(公告)号：US20170298086A1
公开(公告)日：2017-10-19
申请号：US15634771
申请日：2017-06-27
Applicant: Nitto Denko Corporation
Inventor： Kenjirou Minomi , Jens Harborth , Cima Cina , Kwok Yin Tsang , Wenbin Ying , Hirokazu Takahashi
IPC: C07F9/6533 , G01N33/58 , C12Q1/02 , C12N15/113
CPC classification number: C07F9/6533 , A61K31/713 , C12N15/113 , C12N15/1135 , C12N15/1137 , C12N2310/14 , C12N2310/322 , C12N2310/344 , C12N2310/3515 , C12N2310/531 , C12N2320/30 , C12N2320/32 , C12N2320/35 , C12N2320/53 , C12Q1/02 , G01N33/582 , H05K999/99 , C12N2310/3533 , C12N2310/3531 , C12N2310/321 , C12N2310/3521
Abstract: This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2′-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.
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公开(公告)号：US20130295039A1
公开(公告)日：2013-11-07
申请号：US13791137
申请日：2013-03-08
Applicant: NITTO DENKO CORPORATION
Inventor： Seiji Nukui , Kwok Yin Tsang , Chunfeng Yin , Yi Jin , Lei Yu
IPC: A61K47/48
CPC classification number: A61K47/48207 , A61K47/645
Abstract: This application relates generally to biocompatible water-soluble polymers with pendant functional groups and methods for making them, and particularly to polyglutamate amino acid conjugates that can include a linker to a compound that can include a drug, and their use for a variety of drug delivery applications, e.g., anticancer.
Abstract translation: 本申请一般涉及具有侧链官能团的生物相容性水溶性聚合物及其制备方法，特别涉及可以包括可包含药物的化合物的连接体的聚谷氨酸氨基酸缀合物及其用于各种药物递送的用途 应用，例如抗癌。
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公开(公告)号：US20130272993A1
公开(公告)日：2013-10-17
申请号：US13790995
申请日：2013-03-08
Applicant: NITTO DENKO CORPORATION
Inventor： Kwok Yin Tsang , Hai Wang , Hao Bai , Yi Jin , Lei Yu
IPC: A61K47/48
CPC classification number: A61K47/48207 , A61K47/645 , A61K49/146 , C08G69/10
Abstract: This application relates generally to biocompatible water-soluble polymers with pendant functional groups and methods for making them, and particularly to co-polymer polyglutamate amino acid conjugates useful for a variety of anti-cancer drug delivery applications.
Abstract translation: 本申请一般涉及具有侧链官能团的生物相容性水溶性聚合物及其制备方法，特别涉及可用于各种抗癌药物递送应用的聚谷氨酸氨基酸缀合物共聚物。
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公开(公告)号：US11364200B2
公开(公告)日：2022-06-21
申请号：US16182571
申请日：2018-11-06
Applicant: Nitto Denko Corporation
Inventor： Kwok Yin Tsang , Bharat Majeti , John Gaudette , Roger Adami , Hao Bai , Wenbin Ying
IPC: A61K9/127 , A61K47/10 , A61K47/69 , A61K31/7105 , A61K47/14 , C07C201/00 , B82Y5/00
Abstract: This invention includes fusogenic compounds, and compositions and methods of use thereof. The fusogenic compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to incorporate or encapsulate active agents, to deliver and distribute the active agents to cells, tissues, organs, and subjects.
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公开(公告)号：US11318099B2
公开(公告)日：2022-05-03
申请号：US16182571
申请日：2018-11-06
Applicant: Nitto Denko Corporation
Inventor： Kwok Yin Tsang , Bharat Majeti , John Gaudette , Roger Adami , Hao Bai , Wenbin Ying
IPC: A61K9/127 , A61K47/10 , A61K47/69 , A61K31/7105 , A61K47/14 , C07C201/00 , B82Y5/00
Abstract: This invention includes fusogenic compounds, and compositions and methods of use thereof. The fusogenic compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to incorporate or encapsulate active agents, to deliver and distribute the active agents to cells, tissues, organs, and subjects.
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