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公开(公告)号：JP2007020449A
公开(公告)日：2007-02-01
申请号：JP2005205574
申请日：2005-07-14
Applicant: Olympus Corp , オリンパス株式会社
Inventor： TAKAGI KOSUKE , SHIMADA YOSHIHIRO , MATSUO YUICHIRO , KAWAI TAKESHI
Abstract: PROBLEM TO BE SOLVED: To carry out the screening of medicines in high accuracy by using a proper morphological character.
SOLUTION: The screening method comprises the analysis of cell images photographed by a microscope, the evaluation of the parameterized value of the deviation of the contour of the cell from circles C
I and C
O as a morphological character representing the morphological character of each cell in the cell images and the screening of medicines based on the evaluation.
COPYRIGHT: (C)2007,JPO&INPITAbstract translation: 要解决的问题：通过适当的形态特征，高精度地进行药物筛选。 解决方案：筛选方法包括通过显微镜拍摄的细胞图像的分析，细胞轮廓偏离参数值的评估圆圈C
I 和C O 作为代表细胞图像中的每个细胞的形态特征和基于评估的药物筛选的形态特征。 版权所有（C）2007，JPO＆INPIT -
公开(公告)号：JP2006030156A
公开(公告)日：2006-02-02
申请号：JP2004254417
申请日：2004-09-01
Applicant: Olympus Corp , オリンパス株式会社
Inventor： MATSUO YUICHIRO
CPC classification number: B01L3/0275 , B01J2219/00641 , B01J2219/00659 , B01J2219/00689 , B01J2219/00693 , B01L2200/025 , B01L2300/0636 , B01L2300/18
Abstract: PROBLEM TO BE SOLVED: To provide a technique for making the direction of a captured image and the arrangement direction of spots aligned in a detection means, such as a CCD camera, and more specifically, to provide a technique for detecting or correcting the direction of a reaction vessel.
SOLUTION: The reaction vessel (101), having a base (102) for solidifying a probe for detecting an organism-related substance, has correction means (105, 106, 107, 108, 109) for aligning the detection direction of a detection means (129) for detecting the reaction of the base and that of the base.
COPYRIGHT: (C)2006,JPO&NCIPIAbstract translation: 要解决的问题：提供一种用于使拍摄图像的方向和在诸如CCD照相机的检测装置中排列的斑点排列方向的技术，更具体地，提供一种用于检测或校正的技术 反应容器的方向。 解决方案：具有用于固化用于检测生物体相关物质的探针的基底（102）的反应容器（101）具有校正装置（105,106,107,108,109），用于将检测方向 检测装置（129），用于检测底座和底座的反作用。 版权所有（C）2006，JPO＆NCIPI
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公开(公告)号：JP2012118126A
公开(公告)日：2012-06-21
申请号：JP2010265441
申请日：2010-11-29
Applicant: Olympus Corp , オリンパス株式会社
Inventor： MATSUO YUICHIRO , HANEDA TOSHIO
CPC classification number: G06K9/0014 , G01N21/6458 , G06T7/0016 , G06T2207/10056 , G06T2207/20016 , G06T2207/30024
Abstract: PROBLEM TO BE SOLVED: To provide an observation device and an observation method capable of observing a state change of an observation object after starting the observation.SOLUTION: An observation device 1 is provided with an optical microscopic observation part 20 to obtain an image of a sample A, a cell state determination part 43 to determine a state of the sample A by comparing the plural images obtained at a time interval by the optical microscopic observation part 20, an area extraction part 44 to extract an area where the cell state determination part 43 has determined the state change, and a scanning microscopic observation part 30 to obtain an image of the area extracted by the area extraction part 44 at higher resolution than the optical microscopic observation part 20.
Abstract translation: 要解决的问题：提供一种能够观察观察对象在开始观察之后的状态变化的观察装置和观察方法。 解决方案：观察装置1设置有光学显微镜观察部20以获得样本A的图像，细胞状态确定部43，通过比较一次获得的多个图像来确定样本A的状态 通过光学显微镜观察部20的间隔，提取单元状态判定部43决定了状态变化的区域的区域提取部44以及通过区域提取而提取的区域的图像的扫描显微镜观察部30 第44部分的分辨率高于光学显微镜观察部分20.版权所有：（C）2012，JPO＆INPIT
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公开(公告)号：JP2009063509A
公开(公告)日：2009-03-26
申请号：JP2007233238
申请日：2007-09-07
Applicant: Olympus Corp , オリンパス株式会社
Inventor： TAKAGI KOSUKE , MATSUO YUICHIRO
Abstract: PROBLEM TO BE SOLVED: To provide a nerve cell image analyzer and a nerve cell image analysis software capable of accurately analyzing at high speed, a projecting portion or a tubular portion in a cell, such as a dendrite, an axon, and an axon collateral on the tip of the axon in a nerve cell. SOLUTION: The nerve cell image analyzer performs a prescribed automatic analysis processing to an image acquired from an image acquisition means for acquiring a light image emitted from the nerve cell as the image. The analyzer has a step S1 of dividing a nerve cell image acquired through the image acquisition means into a plurality of domains including a circular domain, a step S2 of extracting a prescribed parameter amount characterizing a domain relative to each divided domain, a step S3 of acquiring a matrix showing correlation between adjacent domains, a step S4 of detecting a route and a branch state of the nerve cell by using the acquired matrix, and a step S5 of calculating a statistic of acquired information. In the analyzer, a structure of the nerve cell is analyzed through processing in each step. COPYRIGHT: (C)2009,JPO&INPIT
Abstract translation: 要解决的问题：提供能够高速准确分析的神经细胞图像分析仪和神经细胞图像分析软件，诸如树突，轴突和细胞的细胞中的突出部分或管状部分 神经细胞中轴突末端的轴突侧支。 解决方案：神经细胞图像分析仪对从用于获取从神经细胞发射的光图像作为图像的图像获取装置获取的图像执行规定的自动分析处理。 分析仪具有步骤S1，其将通过图像获取装置获取的神经细胞图像划分成包括圆形域的多个域，提取表示相对于每个划分的域的域的规定参数量的步骤S2，步骤S3， 获取表示相邻域之间的相关性的矩阵，通过使用所获取的矩阵来检测神经细胞的路线和分支状态的步骤S4，以及计算获取的信息的统计量的步骤S5。 在分析器中，通过每个步骤中的处理来分析神经细胞的结构。 版权所有（C）2009，JPO＆INPIT
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公开(公告)号：JP2007215472A
公开(公告)日：2007-08-30
申请号：JP2006039184
申请日：2006-02-16
Applicant: Olympus Corp , オリンパス株式会社
Inventor： MATSUO YUICHIRO , KAWAI TAKESHI , SHIMADA YOSHIHIRO
Abstract: PROBLEM TO BE SOLVED: To provide a cell culture container which enables the free selection of a timing and amount for supplying a biochemical substance or the like secreted from one kind of cells in a culture process to the other kind of cells, and thereby facilitating finer observation of the culture.
SOLUTION: This cell culture container is characterized by disposing a dividing wall 2b for approximately horizontally dividing culture regions X, Y for culturing the cells A, B therein in the culture regions X, Y, disposing passages 3 permitting the pass of a culture solution 5 in the dividing wall 2b, and disposing filter members 4 permitting the pass of the culture solution 5 but inhibiting the pass of the cells A, B and an opening or closing means 6 for opening or closing the pass 3 in the dividing wall 2b.
COPYRIGHT: (C)2007,JPO&INPITAbstract translation: 待解决的问题：提供一种细胞培养容器，其能够自由选择将培养过程中从一种细胞分泌的生物化学物质等供给另一种细胞的时间和量，以及 从而促进对文化的更好的观察。 解决方案：该细胞培养容器的特征在于在培养区域X，Y中设置用于大致水平分割用于培养细胞A，B的培养区域X，Y的分隔壁2b， 分离壁2b中的培养液5，并且设置允许培养液5通过但阻止细胞A，B通过的过滤器部件4和用于打开或关闭分隔壁中的通过部3的打开或关闭装置6 2B。 版权所有（C）2007，JPO＆INPIT
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Patent Agency Ranking16.发明专利
公开(公告)号：JP2007187809A
公开(公告)日：2007-07-26
申请号：JP2006004880
申请日：2006-01-12
Applicant: Olympus Corp , オリンパス株式会社
Inventor： MATSUO YUICHIRO
CPC classification number: G02B21/245
Abstract: PROBLEM TO BE SOLVED: To remarkably reduce time and effort required for adjustment of an automatic focusing mechanism. SOLUTION: The microscope includes: an illuminating light source 9; an objective lens 2 that condenses first light, emitted from the illuminating light source 9, onto a specimen 12; the illuminating light source 9 that images first light reflected by the specimen 12 and passed through the objective lens 2; and a focus detecting means 1C that detects the displacement of a microtiter plate 12 from the focused position of the objective lens 2. The focus detecting means 1C has the automatic focusing mechanism that includes a focus detection light source 13 for emitting focus detection light as second light; a focus detection light obtaining means 18 that condenses the focus detection light; and an area setting means 19 by which a focused-state determinable area of the focus detection light obtained by the focus detection light obtaining means 18 can be set to an arbitrary position of the focus detection light obtaining means 18. COPYRIGHT: (C)2007,JPO&INPIT
Abstract translation: 要解决的问题：显着减少调整自动对焦机构所需的时间和精力。 解决方案：显微镜包括：照明光源9; 将从照明光源9发射的第一光凝结到样本12上的物镜2; 对由样本12反射并通过物镜2的第一光进行成像的照明光源9; 以及焦点检测装置1C，其检测微量滴定板12从物镜2的聚焦位置的位移。焦点检测装置1C具有自动对焦机构，其包括用于将焦点检测光作为第二个发射的焦点检测光源13 光; 焦点检测光获取装置18，其聚焦焦点检测光; 以及区域设定装置19，通过该区域设定装置19，可以将由焦点检测光获取装置18获得的焦点检测光的聚焦状态可确定区域设置为焦点检测光获取装置18的任意位置。COPYRIGHT :(（ C）2007，JPO＆INPIT
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公开(公告)号：JP2011128588A
公开(公告)日：2011-06-30
申请号：JP2010167048
申请日：2010-07-26
Applicant: Olympus Corp , オリンパス株式会社
Inventor： MATSUO YUICHIRO
IPC: G02B21/06
CPC classification number: G02B21/0076 , G02B21/0048
Abstract: PROBLEM TO BE SOLVED: To simultaneously stimulate an arbitrary entire region of a specimen, or a plurality of individual regions, without a time lag, or to apply a strong stimulus to an arbitrary region of a specimen. SOLUTION: The microscope apparatus includes: a first stimulation optical system 32 having a galvanometer mirror 34A, 34B that scans a specimen S with first stimulus light, which applies an optical stimulus to a specimen, on the specimen S; a second stimulation optical system 42 which has a plurality of two-dimensionally arrayed movable mirrors and which switches the angle of each movable mirror, so that second stimulus light, which applies an optical stimulus to the specimen S, can be selectively deflected towards the specimen S; and a dichroic mirror 15B that synthesizes a light path of the first stimulation optical system 32 and a light path of the second stimulation optical system 42. COPYRIGHT: (C)2011,JPO&INPIT
Abstract translation: 要解决的问题：同时刺激样本或多个单独区域的任意整个区域而没有时间延迟，或者对样本的任意区域施加强烈的刺激。 解决方案：显微镜装置包括：第一刺激光学系统32，其具有电流计反射镜34A，34B，用于在样本S上对样本S进行光刺激的第一刺激光扫描样本S. 第二刺激光学系统42，其具有多个二维排列的可移动反射镜并且切换每个可移动反射镜的角度，使得对样本S施加光学刺激的第二刺激光可以被选择性地偏转到样本 S; 以及合成第一刺激光学系统32的光路和第二刺激光学系统42的光路的分色镜15B。版权所有（C）2011，JPO＆INPIT
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18.发明专利Image analyzing method for fish cell, image analyzing system for fish cell and image analyzing apparatus for fish cell 有权FISH细胞的图像分析方法，FISH细胞的图像分析系统和FISH细胞的图像分析装置
公开(公告)号：JP2011030492A
公开(公告)日：2011-02-17
申请号：JP2009179592
申请日：2009-07-31
Applicant: Olympus Corp , オリンパス株式会社
Inventor： MATSUO YUICHIRO , TAKAGI KOSUKE , AMAKAWA GENTA , SHIMADA YOSHIHIRO
Abstract: PROBLEM TO BE SOLVED: To provide an image analyzing method for FISH cell, system and apparatus to accurately detect target fluorescent spots unaffected by three-dimensional configuration of fluorescent spots in a cell nucleus, light emission by foreign matter, etc., out of the cell, confusion of fluorescent wavelength, etc.
SOLUTION: The image analyzing apparatus includes an image-pickup device 1 to pick up a plurality of cell images including a first fluorescent reporter molecule to report a cell segment and second and third fluorescent reporter molecules reporting first and second gene sequences, and an image analyzing device 2 having a computer. The image-pickup device takes a plurality of images of a plurality of cells by varying a Z direction, and the image analyzing device has a software to function the computer as a means 2a to construct a three-dimensional cell segment from the images, a means 2b to discriminate inside and outside of the three-dimensional cell segment, a means 2c to recognize a fluorescent signal from the second and third fluorescent reporter molecules in the three-dimensional cell segment, and a means 2d to determine the characteristic value of the recognized fluorescent signal.
COPYRIGHT: (C)2011,JPO&INPITAbstract translation: 要解决的问题：为了提供一种FISH细胞，系统和装置的图像分析方法，用于准确地检测不受细胞核中的荧光斑点的三维构型，异物发光等的影响的目标荧光斑点， 出现细胞，荧光波长混淆等。解决方案：图像分析装置包括摄像装置1，用于拾取包括第一荧光报告分子的多个细胞图像以报告细胞片段和第二和 报告第一和第二基因序列的第三荧光报道分子，以及具有计算机的图像分析装置2。 图像拾取装置通过改变Z方向来获取多个单元的多个图像，并且图像分析装置具有使计算机功能化的软件作为从图像构建三维单元格段的装置2a， 用于区分三维细胞片段的内部和外部的装置2b，用于识别来自三维细胞片段中的第二和第三荧光报道分子的荧光信号的装置2c和用于确定三维细胞片段的特征值的装置 识别荧光信号。 版权所有（C）2011，JPO＆INPIT
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公开(公告)号：JP2009063508A
公开(公告)日：2009-03-26
申请号：JP2007233237
申请日：2007-09-07
Applicant: Olympus Corp , オリンパス株式会社
Inventor： TAKAGI KOSUKE , MATSUO YUICHIRO
Abstract: PROBLEM TO BE SOLVED: To provide a cell image analyzer and a cell image analysis software capable of automating complicated cell classification to some degree, while maximumly saving trouble or labor of an experimenter, and reflecting a desire of a researcher who is a user so that automatic analysis can be progressed with flexibility in some degree. SOLUTION: The analyzer has a function for performing a prescribed processing to an image acquired from an image acquisition means for acquiring a light image emitted from cells as the image, and automatically extracting a cell group having a similar characteristic to specific cells which are interesting to the user among images including a plurality of cells. The device also has a function enabling the user to designate an optional cell as an interesting cell. Preferably, the device has a function for automatically setting a parameter group comprising characteristic quantity parameters by which a cell group having a similar characteristic to specific cells designated by the user can be distinguished from other cell groups, and automatically setting a threshold of each characteristic quantity parameter included in the parameter group. COPYRIGHT: (C)2009,JPO&INPIT
Abstract translation: 要解决的问题：提供一种能够在一定程度上自动化复杂的细胞分类的细胞图像分析器和细胞图像分析软件，同时最大限度地节省了实验者的麻烦或劳动，并且反映了研究者的愿望 用户可以在一定程度上灵活地进行自动分析。 解决方案：分析仪具有对从图像获取装置获取的图像进行规定处理的功能，用于获取从作为图像的单元发射的光图像，并且自动提取具有与特定单元格类似的特征的单元组， 在包括多个单元的图像中对用户感兴趣。 该设备还具有使用户能够将可选单元指定为感兴趣单元的功能。 优选地，该装置具有自动设置包括特征量参数的参数组的功能，通过该特征量参数可以将具有与用户指定的特定小区具有相似特征的小区组与其他小区组区分开，并且自动设置每个特征量的阈值 参数包含在参数组中。 版权所有（C）2009，JPO＆INPIT
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公开(公告)号：JP2006340686A
公开(公告)日：2006-12-21
申请号：JP2005171208
申请日：2005-06-10
Applicant: OLYMPUS CORP
Inventor： MATSUO YUICHIRO , TAKAGI KOSUKE , KAWAI TAKESHI
Abstract: PROBLEM TO BE SOLVED: To accurately count number of cells by reducing load of examiners and inspection mistakes. SOLUTION: The cell analysis method comprises a process for inputting image information accepting lights emitted from cells as two or more images with a predetermined interval, a luminance value operation process for calculating a rate of presence of pixel over a predetermined value of two or more images obtained in the process for inputting the image information and a comparative operation process for comparatively operating the rate of presence of pixel over the predetermined value of two or more images obtained in the process for inputting the image information. COPYRIGHT: (C)2007,JPO&INPIT
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