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    OPTICALLY PURE R(-) ALBUTEROL FOR TREATING ASTHMA
    13.
    发明申请
    OPTICALLY PURE R(-) ALBUTEROL FOR TREATING ASTHMA 审中-公开
    光学纯度R（ - ）阿尔伯特尔治疗哮喘

    公开(公告)号：WO1991009596A1

    公开(公告)日：1991-07-11

    申请号：PCT/US1991000088

    申请日：1991-01-04

    Applicant: SEPRACOR INC.

    Inventor： SEPRACOR INC. ,  BARBERICH, Timothy, J. ,  YOUNG, James, W.

    IPC: A61K31/135

    CPC classification number: A61K31/135

    Abstract: The optically pure R(-) isomer of albuterol, which is substantially free of the S(+) isomer, is a potent bronchodilator for relieving the symptoms associated with asthma in individuals. A method is disclosed utilizing the optically pure R(-) isomer of albuterol for treating asthma while minimizing the side effects associated with albuterol.

    Abstract translation: 基本上不含S（+）异构体的沙丁胺醇的光学纯的R（ - ）异构体是用于缓解个体哮喘相关症状的有效支气管扩张剂。 公开了利用沙丁胺醇的光学纯的R（ - ）异构体治疗哮喘，同时最小化与沙丁胺醇相关的副作用的方法。

    USE OF CIS-HYDROXYITRACONAZOLE IN ORDER TO AVOID SIDE-EFFECTS OF ITRACONAZOLE AND HYDROXYINTRACONAZOLE
    14.
    发明申请
    USE OF CIS-HYDROXYITRACONAZOLE IN ORDER TO AVOID SIDE-EFFECTS OF ITRACONAZOLE AND HYDROXYINTRACONAZOLE 审中-公开
    使用CIS-羟基噻唑酮避免亚硝酸和羟基吡咯并唑的副作用

    公开(公告)号：WO1998020876A1

    公开(公告)日：1998-05-22

    申请号：PCT/US1997020290

    申请日：1997-11-11

    Applicant: SEPRACOR INC.

    Inventor： SEPRACOR INC. ,  MCCULLOUGH, John, R. ,  KOCH, Patrick

    IPC: A61K31/495

    CPC classification number: A61K31/496

    Abstract: The invention involves prophylactic methods and methods of treatment using cis-hydroxyitraconazole, a metabolic derivative of cis-itraconazole, for the treatment or prevention of microbial, particularly fungal infection and other disorders, while avoiding the concomitant liability of adverse side effects associated with the administration of cis-itraconazole. Methods of treating or preventing such infections in the brain and other areas of CNS are also disclosed.

    Abstract translation: 本发明涉及使用顺式 - 羟基特他康唑（顺式伊曲康唑的代谢衍生物）治疗或预防微生物，特别是真菌感染和其他疾病的预防方法和治疗方法，同时避免与给药相关的副作用的伴随的责任 的顺式伊曲康唑。 还公开了在CNS的大脑和其他区域中治疗或预防这种感染的方法。

    METHODS FOR TREATING EMESIS AND CENTRAL NERVOUS SYSTEM DISORDERS USING OPTICALLY PURE (+) NORCISAPRIDE
    15.
    发明申请
    METHODS FOR TREATING EMESIS AND CENTRAL NERVOUS SYSTEM DISORDERS USING OPTICALLY PURE (+) NORCISAPRIDE 审中-公开
    使用光学纯净（+）NORCISAPRIDE治疗EMESIS和中枢神经系统疾病的方法

    公开(公告)号：WO1998003173A1

    公开(公告)日：1998-01-29

    申请号：PCT/US1997011629

    申请日：1997-07-02

    Applicant: SEPRACOR INC.

    Inventor： SEPRACOR INC. ,  McCULLOUGH, John, R. ,  JERUSSI, Thomas, P.

    IPC: A61K31/445

    CPC classification number: A61K31/4468 ,  A61K31/495 ,  A61K31/445 ,  A61K2300/00

    Abstract: Compositions employing and methods utilizing the optically pure (+) isomer of norcisapride are disclosed. This compound has surprisingly been found to be a potent drug for the treatment of disorders of the central nervous system. The compound, (+) norcisapride, has also been found to be a potent antiemetic agent. Finally, the (+) isomer of norcisapride also avoids certain adverse side effects and certain adverse drug interactions.

    Abstract translation: 公开了使用和使用旋光纯（+）异构体的诺西沙必利的方法的组合物。 令人惊讶地发现，该化合物是用于治疗中枢神经系统疾病的有效药物。 化合物（+）诺西沙必利还被发现是一种有效的止吐剂。 最后，诺西沙必利的（+）异构体也避免了某些不良副作用和某些不良药物相互作用。

    METHODS OF USING (+) CISAPRIDE FOR THE TREATMENT OF GASTRO-ESOPHAGEAL REFLUX DISEASE AND OTHER DISORDERS
    18.
    发明申请
    METHODS OF USING (+) CISAPRIDE FOR THE TREATMENT OF GASTRO-ESOPHAGEAL REFLUX DISEASE AND OTHER DISORDERS 审中-公开
    使用（+）CISAPRIDE治疗胃食管反流病和其他疾病的方法

    公开(公告)号：WO1994001111A1

    公开(公告)日：1994-01-20

    申请号：PCT/US1993006378

    申请日：1993-07-06

    Applicant: SEPRACOR INC.

    Inventor： SEPRACOR INC. ,  GRAY, Nancy, M. ,  YOUNG, James, W.

    IPC: A61K31/445

    CPC classification number: A61K31/445 ,  A61K31/4468

    Abstract: Methods are disclosed utilizing the optically pure (+) isomer of cisapride. This compound is a potent drug for the treatment of gastro-esophageal reflux disease while avoiding the concomitant liability of adverse effects associated with the racemic mixture of cisapride. This compound is also useful in treating or preventing emesis while avoiding the adverse effects associated with racemic cisapride. The optically pure (+) isomer of cisapride is also useful for the treatment of dyspepsia and such other conditions as may be related to the activity of (+) cisapride as a prokinetic agent such as gastroparesis, constipation, post-operative ileus, and intestinal pseudo-obstruction without the concomitant liability of adverse effects associated with the racemic mixture of cisapride. The (+) isomer of cisapride has been found to exhibit higher bioavailability over the racemic cisapride.

    Abstract translation: 公开利用西沙必利的光学纯（+）异构体的方法。 该化合物是用于治疗胃食管反流疾病的有效药物，同时避免与西沙必利的外消旋混合物相关的副作用的伴随的责任。 该化合物也可用于治疗或预防呕吐，同时避免与外消旋西沙必利有关的不良反应。 西沙必利的光学纯（+）异构体也可用于治疗消化不良和其他可能与（+）西沙必利作为促动力剂如胃轻瘫，便秘，手术后肠梗阻和肠道的活性相关的其他病症 假性梗阻与西沙必利的外消旋混合物相关的副作用没有伴随的责任。 已经发现西沙必利的（+）异构体在外消旋西沙必利素上表现出较高的生物利用度。

    PASSIVATED AND STABILIZED POROUS SUPPORTS AND METHODS FOR THE PREPARATION AND USE OF SAME
    19.
    发明申请
    PASSIVATED AND STABILIZED POROUS SUPPORTS AND METHODS FOR THE PREPARATION AND USE OF SAME 审中-公开
    经过钝化和稳定的多孔支持物及其制备和使用方法

    公开(公告)号：WO1994000214A1

    公开(公告)日：1994-01-06

    申请号：PCT/US1993005793

    申请日：1993-06-18

    Applicant: SEPRACOR INC.

    Inventor： SEPRACOR INC. ,  GIROT, Pierre ,  BOSCHETTI, Egisto

    IPC: B01D15/08

    CPC classification number: B01D15/20 ,  B01D15/3804 ,  B01J20/103 ,  B01J20/28004 ,  B01J20/28057 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/288 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/327 ,  B01J20/3289 ,  B01J39/17 ,  B01J39/26 ,  B01J41/20 ,  B01J2220/54 ,  B01J2220/58

    Abstract: This invention relates generally to modified porous solid supports and processes for the preparation and use of same. In particular, passivated porous mineral oxide, polymeric, or polymer-coated mineral oxide supports are disclosed which are characterized by a reversible high sorptive capacity substantially unaccompanied by non-specific adsorption of or interaction with biomolecules. Passivation is achieved by use of a passivation mixture comprising a main monomer, a passivating monomer and a crosslinking agent, which mixture upon polymerization results in the substantial elimination of the undesirable non-specific interaction with biomolecules.

    Abstract translation: 本发明一般涉及改性的多孔固体载体及其制备和使用方法。 特别地，公开了钝化的多孔矿物氧化物，聚合物或聚合物涂覆的矿物氧化物载体，其特征在于基本上不伴随生物分子的非特异性吸附或相互作用的可逆的高吸附能力。 通过使用包含主单体，钝化单体和交联剂的钝化混合物实现钝化，该聚合物上的该混合物导致基本上消除了与生物分子的不期望的非特异性相互作用。

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