公开(公告)号：WO1994000214A1

公开(公告)日：1994-01-06

申请号：PCT/US1993005793

申请日：1993-06-18

Applicant: SEPRACOR INC.

Inventor： SEPRACOR INC. ,  GIROT, Pierre ,  BOSCHETTI, Egisto

IPC: B01D15/08

CPC classification number: B01D15/20 ,  B01D15/3804 ,  B01J20/103 ,  B01J20/28004 ,  B01J20/28057 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/288 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/327 ,  B01J20/3289 ,  B01J39/17 ,  B01J39/26 ,  B01J41/20 ,  B01J2220/54 ,  B01J2220/58

Abstract: This invention relates generally to modified porous solid supports and processes for the preparation and use of same. In particular, passivated porous mineral oxide, polymeric, or polymer-coated mineral oxide supports are disclosed which are characterized by a reversible high sorptive capacity substantially unaccompanied by non-specific adsorption of or interaction with biomolecules. Passivation is achieved by use of a passivation mixture comprising a main monomer, a passivating monomer and a crosslinking agent, which mixture upon polymerization results in the substantial elimination of the undesirable non-specific interaction with biomolecules.

Abstract translation: 本发明一般涉及改性的多孔固体载体及其制备和使用方法。 特别地，公开了钝化的多孔矿物氧化物，聚合物或聚合物涂覆的矿物氧化物载体，其特征在于基本上不伴随生物分子的非特异性吸附或相互作用的可逆的高吸附能力。 通过使用包含主单体，钝化单体和交联剂的钝化混合物实现钝化，该聚合物上的该混合物导致基本上消除了与生物分子的不期望的非特异性相互作用。

公开(公告)号：EP0588875A1

公开(公告)日：1994-03-30

申请号：EP92911942.0

申请日：1992-05-20

Applicant: SEPRACOR, INC.

Inventor： BOSCHETTI, Egisto ,  BROUARD, Michel ,  DROUET, Ludovic ,  GIROT, Pierre ,  LAURENT, Alexandre ,  WASSER, Michel

IPC: A61K9 ,  A61K31 ,  A61K38 ,  A61K49 ,  A61L24 ,  A61P9

CPC classification number: A61L24/06 ,  A61K9/1676 ,  A61L2400/06 ,  A61L2430/36 ,  C08L33/26 ,  C08L33/14

Abstract: La présente invention concerne l'utilisation de microsphères à des fins d'embolisation thérapeutique, lesdites microsphères étant constituées d'un copolymère acrylique hydrophile enrobé d'un promoteur d'adhésion cellulaire.

公开(公告)号：EP0646038A1

公开(公告)日：1995-04-05

申请号：EP93915384.0

申请日：1993-06-18

Applicant: SEPRACOR, INC.

Inventor： GIROT, Pierre ,  BOSCHETTI, Egisto

IPC: B01J20 ,  B01D15 ,  B01J39 ,  G01N30

CPC classification number: B01D15/20 ,  B01D15/3804 ,  B01J20/103 ,  B01J20/28004 ,  B01J20/28057 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/288 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/327 ,  B01J20/3289 ,  B01J39/17 ,  B01J39/26 ,  B01J41/20 ,  B01J2220/54 ,  B01J2220/58

Abstract: This invention relates generally to modified porous solid supports and processes for the preparation and use of same. In particular, passivated porous mineral oxide, polymeric, or polymer-coated mineral oxide supports are disclosed which are characterized by a reversible high sorptive capacity substantially unaccompanied by non-specific adsorption of or interaction with biomolecules. Passivation is achieved by use of a passivation mixture comprising a main monomer, a passivating monomer and a crosslinking agent, which mixture upon polymerization results in the substantial elimination of the undesirable non-specific interaction with biomolecules.

Abstract translation: 本发明涉及基因的反弹到改良的多孔固体支持物和方法用于制备和使用的相同。 特别地，钝化多孔矿物氧化物，聚合物，或聚合物涂覆的无机氧化物载体是游离缺失盘其通过可逆高吸附能力通过非特异性吸附或与生物分子相互作用基本上陪伴特征的。 钝化是通过使用钝化混合物包括主单体，钝化起始单体和交联剂，其混合物当在与生物分子不期望的非特异性相互作用的基本消除聚合结果的实现。