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公开(公告)号：AU755115B2
公开(公告)日：2002-12-05
申请号：AU5362199
申请日：1999-10-12
Applicant: SERVIER LAB
Inventor： LANGLOIS MICHEL , MATHE-ALLAINMAT MONIQUE , GALL MARIE LEFAS-LE , BENNEJEAN CAROLINE , RENARD PIERRE , DELAGRANGE PHILIPPE
IPC: C07D339/00 , A61K31/16 , A61K31/165 , A61K31/17 , A61K31/335 , A61K31/343 , A61K31/352 , A61K31/353 , A61K31/38 , A61K31/381 , A61K31/395 , A61K31/4355 , A61K31/437 , A61P1/00 , A61P3/04 , A61P3/10 , A61P9/00 , A61P15/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P43/00 , C07C233/18 , C07C233/23 , C07C233/74 , C07C235/34 , C07C235/40 , C07C275/26 , C07D307/79 , C07D307/80 , C07D307/81 , C07D311/92 , C07D333/58 , C07D333/60 , C07D471/04 , C07D491/04 , C07D491/048 , C07D493/04 , C07C233/58 , C07C233/17 , C07C233/22 , C07D307/83 , C07D311/74
Abstract: Cycloalkene substituted cyclic derivatives (I) are new. Cycloalkene substituted cyclic derivatives of formula (I), their enantiomers, diastereoisomers and their acid or base addition salts are new. A = a group of formula (i) or (ii) (optionally substituted by Ra, ORa, OH, CORa, formyl, COORa, COOH or OCORa; Ra = 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, 1-6C polyhaloalkyl, 3-8C cycloalkyl, 3-8C cycloalkyl-(1-6C) alkyl, 3-8C cycloalkenyl, 3-8C cycloalkenyl-(1-6C) alkyl (all optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, amino or halo), aryl, aryl-(1-6C) alkyl, heteroaryl or heteroaryl-(1-6C) alkyl; X, Y' = O, S or CH2; D' = benzene or naphthalene; a-d = single or double bond; Z = O, S, CH2 or NR ; R = H, 1-6C alkyl, aryl or aryl-(1-6C) alkyl; D'' = benzene or pyridine; R = H, halo, OH, SH, Ra, ORa, S(O)nRa or a (un)saturated 5- to 7-membered ring of formula (iii) (optionally substituted with at least one 1-6C alkyl, 1-6C alkoxy, carboxy, 1-6C alkoxycarbonyl, OH or =O); n = 0-2; E = O or -S(O)n-; G1, G2 = single bond, -(CH2)t- (optionally substituted with at least one OH, COOH, formyl, Ra, ORa, COORa, CORa or halo; p, q = 0-4; p + q = 1-4; B' = -NR aC(Q)R a, -NR aC(Q)NR aR a or -C(Q)NR aR a; R a-R a = H or Ra; Q = O or S; aryl = phenyl, naphthyl, biphenyl (all optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, CN, COOH, 1-6C alkoxycarbonyl, NO2, amino or halo); heteroaryl = 5- to 10-membered mono- or polycyclic aromatic ring containing 1-3 N, O or S (optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, CN, COOH, 1-6C alkoxycarbonyl, NO2, amino or halo); and provided that q = 0 and p = 4, or q = 4 and p = 0 do not apply, when A is naphthyl (optionally substituted with methoxy or methyl), G1 and G2 are single bonds and B' is a group of formula (iv) or NHCOCH3; that A is other than halo substituted naphthyl, when G1 is a single bond and p + q is 1; B' is other than urea, when A is indolyl substituted on position 2 with a group of formula (v); and that B' is other than CONH-aryl, when A is indolyl substituted on position 2 with carboxyl or alkoxycarbonyl, p is 1, q is 0 (p is 0 and q is 1) and G1 is single bond. A Independent claim is also included for the preparation of (I).
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12.发明专利
公开(公告)号：AU747301B2
公开(公告)日：2002-05-16
申请号：AU3610499
申请日：1999-05-10
Applicant: SERVIER LAB
Inventor： LESIEUR DANIEL , KLUPSCH FREDERIQUE , GUILLAUMET GERALD , VIAUD MARIE-CLAUDE , LANGLOIS MICHEL , BENNEJEAN CAROLINE , RENARD PIERRE , DELAGRANGE PHILIPPE
IPC: C07D295/12 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/19 , A61K31/27 , A61K31/341 , A61K31/343 , A61K31/352 , A61K31/357 , A61K31/381 , A61K31/382 , A61K31/4025 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/4184 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4402 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/4453 , A61K31/453 , A61K31/454 , A61K31/473 , A61K31/5355 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61P1/00 , A61P3/06 , A61P3/10 , A61P5/02 , A61P9/00 , A61P15/08 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P43/00 , C07C233/36 , C07C233/40 , C07C233/43 , C07C233/62 , C07C233/65 , C07C237/48 , C07C271/20 , C07C271/30 , C07C275/24 , C07C275/40 , C07C311/46 , C07C317/32 , C07C323/40 , C07C323/41 , C07C323/44 , C07C323/62 , C07D207/26 , C07D207/27 , C07D209/08 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/20 , C07D209/60 , C07D209/90 , C07D213/70 , C07D221/08 , C07D221/10 , C07D233/42 , C07D233/84 , C07D235/06 , C07D235/14 , C07D261/20 , C07D295/18 , C07D307/68 , C07D307/77 , C07D307/81 , C07D307/92 , C07D311/58 , C07D311/60 , C07D311/92 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/38 , C07D333/40 , C07D333/50 , C07D333/56 , C07D333/58 , C07D333/74 , C07D335/06 , C07D335/08 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/12 , C07D409/06 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/048 , C07D491/052 , C07D493/04 , C07D495/04 , C07D495/14 , C07D521/00 , C07C311/37 , C07D307/85
Abstract: The invention concerns compounds of formula (I): R-A-R' wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R 1 , R 2 , R 3 , v and R 4 are as defined in the description; R' represents a -(CH 2 )t-R 5 group wherein t and R 5 are as defined in the description.
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13.发明专利
公开(公告)号：AU4872993A
公开(公告)日：1994-04-14
申请号：AU4872993
申请日：1993-10-01
Applicant: SERVIER LAB
Inventor： LANGLOIS MICHEL , RENARD PIERRE , ADAM GERARD
IPC: C07D319/20 , A61K31/135 , A61K31/165 , A61K31/275 , A61K31/335 , A61K31/34 , A61K31/343 , A61K31/357 , A61K31/40 , A61K31/403 , A61K31/404 , A61P3/08 , A61P3/10 , A61P13/02 , A61P15/00 , A61P25/00 , A61P25/28 , A61P35/00 , A61P37/00 , A61P43/00 , C07C217/56 , C07C217/84 , C07C233/18 , C07C233/20 , C07C233/22 , C07C233/25 , C07C233/60 , C07C255/59 , C07D209/08 , C07D307/79 , C07D319/18 , C07C233/19
Abstract: Compounds of formula (I): in which - A represents a -CH2-CH2- chain which is unsubstituted or substituted by a lower alkyl, - R1 represents a hydrogen atom or a lower alkyl, - R2 represents a hydrogen atom, a halogen atom or a lower alkyl, - R5 represents a hydrogen atom or a lower alkyl, - R6 represents a group in which X represents a sulphur or oxygen atom. The compounds of the invention had a remarkable activity on the melatoninergic system. They are therefore candidates for the treatment of disorders of the melatoninergic system.
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公开(公告)号：PL195664B1
公开(公告)日：2007-10-31
申请号：PL34183798
申请日：1998-12-11
Applicant: SERVIER LAB
Inventor： LANGLOIS MICHEL , MATHE-ALLAINMAT MONIQUE , JELLIMANN CAROLE , ANDRIEUX JEAN , BENNEJEAN CAROLINE , RENARD PIERRE , DELAGRANGE PHILIPPE
IPC: C07C233/18 , C07D333/74 , A61K31/165 , A61K31/17 , A61K31/343 , A61K31/381 , A61K31/403 , A61P9/06 , A61P25/08 , A61P25/20 , A61P25/22 , A61P35/00 , A61P43/00 , C07C233/05 , C07C233/60 , C07C235/34 , C07C275/24 , C07C275/26 , C07D209/60 , C07D209/90 , C07D307/77 , C07D307/92 , C07D307/93 , C07D333/78
Abstract: The invention concerns compounds of formula (I) in which: A forms a tricyclic system of formula A1, A2, A3 or A4; R1 represents a hydrogen atom, an alkyl, hydroxy, alkoxy or oxo group; (R2)m and (R3)m' are such as defined in the description; n represents an integer such that 0
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公开(公告)号：ES2255260T3
公开(公告)日：2006-06-16
申请号：ES99918036
申请日：1999-05-10
Applicant: SERVIER LAB
Inventor： LESIEUR DANIEL , KLUPSCH FREDERIQUE , GUILLAUMET GERALD , VIAUD MARIE-CLAUDE , LANGLOIS MICHEL , BENNEJEAN CAROLINE
IPC: C07D295/12 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/19 , A61K31/27 , A61K31/341 , A61K31/343 , A61K31/352 , A61K31/357 , A61K31/381 , A61K31/382 , A61K31/4025 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/4184 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4402 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/4453 , A61K31/453 , A61K31/454 , A61K31/473 , A61K31/5355 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61P1/00 , A61P3/06 , A61P3/10 , A61P5/02 , A61P9/00 , A61P15/08 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P43/00 , C07C233/36 , C07C233/40 , C07C233/43 , C07C233/62 , C07C233/65 , C07C237/48 , C07C271/20 , C07C271/30 , C07C275/24 , C07C275/40 , C07C311/46 , C07C317/32 , C07C323/40 , C07C323/41 , C07C323/44 , C07C323/62 , C07D207/26 , C07D207/27 , C07D209/08 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/20 , C07D209/60 , C07D209/90 , C07D213/70 , C07D221/08 , C07D221/10 , C07D233/42 , C07D233/84 , C07D235/06 , C07D235/14 , C07D261/20 , C07D295/18 , C07D307/68 , C07D307/77 , C07D307/81 , C07D307/92 , C07D311/58 , C07D311/60 , C07D311/92 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/38 , C07D333/40 , C07D333/50 , C07D333/56 , C07D333/58 , C07D333/74 , C07D335/06 , C07D335/08 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/12 , C07D409/06 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/048 , C07D491/052 , C07D493/04 , C07D495/04 , C07D495/14 , C07D521/00
Abstract: Compuestos de **fórmula** en la cual: A representa: - un sistema cíclico de fórmula (II): donde u X representa un átomo de oxígeno o de azufre, o un grupo NR0 (en el cual R0 representa un átomo de hidrógeno, un grupo alquilo(C1-C6) lineal o ramificado, arilo, arilalquilo(C1-C6) lineal o ramificado o SO2Ph), u la representación ¿. significa que el enlace puede ser simple o doble quedando claro que se respeta la valencia de los átomos, u R¿¿ representa un grupo Ra, ORa, CORa, COORa, OCORa, OSO2CF3, ciano, nitro o átomos de halógeno, donde Ra representa un átomo de hidrógeno, un grupo alquilo(C1-C6) lineal o ramificado, sustituido o no, alquenilo(C2-C6) lineal o ramificado, sustituido o no, alquinilo(C2-C6) lineal o ramificado, sustituido o no, polihaloalquilo(C1-C6) lineal o ramificado, cicloalquilo(C3-C8) sustituido o no, cicloalquil(C3-C8)alquil(C1-C6) lineal o ramificado, sustituido o no, cicloalquenilo(C3- C8) sustituido o no, cicloalquenil(C3- C8)alquilo(C1-C6) lineal o ramificado.
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Patent Agency Ranking
公开(公告)号：AT312073T
公开(公告)日：2005-12-15
申请号：AT99918037
申请日：1999-05-10
Applicant: SERVIER LAB
Inventor： LESIEUR DANIEL , KLUPSCH FREDERIQUE , GUILLAUMET GERALD , VIAUD MARIE-CLAUDE , LANGLOIS MICHEL , BENNEJEAN CAROLINE , RENARD PIERRE , DELAGRANGE PHILIPPE
IPC: C07D295/12 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/19 , A61K31/27 , A61K31/341 , A61K31/343 , A61K31/352 , A61K31/357 , A61K31/381 , A61K31/382 , A61K31/4025 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/4184 , A61K31/423 , A61K31/435 , A61K31/4355 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4402 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/4453 , A61K31/453 , A61K31/454 , A61K31/473 , A61K31/5355 , A61K31/5375 , A61K31/5377 , A61K31/55 , A61P1/00 , A61P3/06 , A61P3/10 , A61P5/02 , A61P9/00 , A61P15/08 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P35/00 , A61P43/00 , C07C233/36 , C07C233/40 , C07C233/43 , C07C233/62 , C07C233/65 , C07C237/48 , C07C271/20 , C07C271/30 , C07C275/24 , C07C275/40 , C07C311/46 , C07C317/32 , C07C323/40 , C07C323/41 , C07C323/44 , C07C323/62 , C07D207/26 , C07D207/27 , C07D209/08 , C07D209/14 , C07D209/16 , C07D209/18 , C07D209/20 , C07D209/60 , C07D209/90 , C07D213/70 , C07D221/08 , C07D221/10 , C07D233/42 , C07D233/84 , C07D235/06 , C07D235/14 , C07D261/20 , C07D295/18 , C07D307/68 , C07D307/77 , C07D307/81 , C07D307/92 , C07D311/58 , C07D311/60 , C07D311/92 , C07D319/18 , C07D319/20 , C07D333/20 , C07D333/38 , C07D333/40 , C07D333/50 , C07D333/56 , C07D333/58 , C07D333/74 , C07D335/06 , C07D335/08 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/12 , C07D409/06 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/048 , C07D491/052 , C07D493/04 , C07D495/04 , C07D495/14 , C07D521/00 , C07C311/37 , C07D307/85
Abstract: The invention concerns compounds of formula (I): R-A-R' wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R 1 , R 2 , R 3 , v and R 4 are as defined in the description; R' represents a -(CH 2 )t-R 5 group wherein t and R 5 are as defined in the description.
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公开(公告)号：FR2857010B1
公开(公告)日：2005-09-16
申请号：FR0307949
申请日：2003-07-01
Applicant: SERVIER LAB
Inventor： LANGLOIS MICHEL , MATHE ALLAINMAT MONIQUE , CHAHED MONCEF AMINE , BOUTIN JEAN ALBERT , AUDINOT VALERIE , BENNEJEAN CAROLINE , DELAGRANGE PHILIPPE , RENARD PIERRE
IPC: A61P25/00 , A61P35/00 , C07C233/05 , A61K31/165
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公开(公告)号：DE69824046T2
公开(公告)日：2005-06-30
申请号：DE69824046
申请日：1998-12-11
Applicant: SERVIER LAB
Inventor： LANGLOIS MICHEL , MATHE-ALLAINMAT MONIQUE , JELLIMANN CAROLE , ANDRIEUX JEAN , BENNEJEAN CAROLINE , RENARD PIERRE , DELAGRANGE PHILIPPE
IPC: C07D333/74 , A61K31/165 , A61K31/343 , A61K31/381 , A61K31/403 , A61P9/06 , A61P25/20 , A61P25/22 , A61P43/00 , C07C233/05 , C07C233/18 , C07C233/60 , C07C235/34 , C07C275/24 , C07C275/26 , C07D209/60 , C07D209/90 , C07D307/77 , C07D307/92 , C07D307/93 , C07D333/78
Abstract: The invention concerns compounds of formula (I) in which: A forms a tricyclic system of formula A1, A2, A3 or A4; R1 represents a hydrogen atom, an alkyl, hydroxy, alkoxy or oxo group; (R2)m and (R3)m' are such as defined in the description; n represents an integer such that 0
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公开(公告)号：ES2221999T3
公开(公告)日：2005-01-16
申请号：ES98959957
申请日：1998-12-11
Applicant: SERVIER LAB
Inventor： LANGLOIS MICHEL , MATHE-ALLAINMAT MONIQUE , JELLIMANN CAROLE , ANDRIEUX JEAN , BENNEJEAN CAROLINE , RENARD PIERRE
IPC: C07D333/74 , A61K31/165 , A61K31/343 , A61K31/381 , A61K31/403 , A61P9/06 , A61P25/20 , A61P25/22 , A61P43/00 , C07C233/05 , C07C233/18 , C07C233/60 , C07C235/34 , C07C275/24 , C07C275/26 , C07D209/60 , C07D209/90 , C07D307/77 , C07D307/92 , C07D307/93 , C07D333/78
Abstract: Compuestos de **Fórmula** en la cual: R1 representa un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo de1 a 6 carbonos lineal o ramificado, alcoxilo de1 a 6 carbonos lineal o ramificado, hidroxilo, u oxo, R2 y R3, idénticos o diferentes, representan un átomo de halógeno, un grupo Ra, ORa, CORa, OCORa o COORa (donde Ra representa un átomo de hidrógeno, un grupo alquilo de 1 a 6 carbonos lineal o ramificado eventualmente sustituido, trihalogenoalquilo de 1 a 6 carbonos lineal o ramificado, un grupo alquenilo de 2 a 6 carbonos lineal o ramificado eventualmente sustituido, un grupo alquinilo de 2 a 6 carbonos lineal o ramificado eventualmente sustituido, un grupo cicloalquilo de 3 a 8 carbonos eventualmente sustituido, un grupo cicloalquil(C3-C8)alquilo(C1-C6) lineal o ramificado eventualmente sustituido o un grupo arilo eventualmente sustituido, la representación (R2)m y (R3)m¿ significa que el ciclo al que se refieren puede estar sustituido con 1 a 3 grupos (idénticos o diferentes) que pertenecen a las definiciones de R2 y R3, X representa un grupo (CH2)q (en el cual q vale 1 o 2) o -CH=CH-, n es un entero tal que 0=n=3 p es un entero tal que 1=p=3 cuando n vale 1, 2 o 3 y que la cadena está en posición b, y tal que 0=p=3 en todos los demás casos, la cadena puede estar sustituida o no con uno o varios grupos, idénticos o diferentes elegidos entre Ra, ORa, CORa, COORa o átomos de halógeno, sus enantiómeros y diaestereoisómeros, así como sus sales de adición a un ácido o una base farmaceúticamente aceptables.
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公开(公告)号：DE69824046D1
公开(公告)日：2004-06-24
申请号：DE69824046
申请日：1998-12-11
Applicant: SERVIER LAB
Inventor： LANGLOIS MICHEL , MATHE-ALLAINMAT MONIQUE , JELLIMANN CAROLE , ANDRIEUX JEAN , BENNEJEAN CAROLINE , RENARD PIERRE , DELAGRANGE PHILIPPE
IPC: C07D333/74 , A61K31/165 , A61K31/343 , A61K31/381 , A61K31/403 , A61P9/06 , A61P25/20 , A61P25/22 , A61P43/00 , C07C233/05 , C07C233/18 , C07C233/60 , C07C235/34 , C07C275/24 , C07C275/26 , C07D209/60 , C07D209/90 , C07D307/77 , C07D307/92 , C07D307/93 , C07D333/78
Abstract: The invention concerns compounds of formula (I) in which: A forms a tricyclic system of formula A1, A2, A3 or A4; R1 represents a hydrogen atom, an alkyl, hydroxy, alkoxy or oxo group; (R2)m and (R3)m' are such as defined in the description; n represents an integer such that 0
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