公开(公告)号：WO2008049997A3

公开(公告)日：2008-09-12

申请号：PCT/FR2007001708

申请日：2007-10-17

Applicant: SERVIER LAB ,  MARCHAND PASCAL ,  BADONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  GAIGNARD DANIEL-HENRI

Inventor： MARCHAND PASCAL ,  BADONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  GAIGNARD DANIEL-HENRI

IPC: C07D209/32 ,  A61K31/4045

CPC classification number: C07D209/14

Abstract: Compounds of formula (I): in which: R 1 is an alkyl, cycloalkyl or cycloalkylalkyl group, R 2 and R 3 form, together with the nitrogen atom which bears them, a heterocycle comprising from 5 to 8 ring members, and n is 2 to 6; medicaments.

Abstract translation: 式（I）化合物：其中：R 1是烷基，环烷基或环烷基烷基，R 2和R 3， 带有它们的氮原子，包含5至8个环成员的杂环，n为2至6; 药物。

公开(公告)号：WO2008049997A8

公开(公告)日：2009-05-22

申请号：PCT/FR2007001708

申请日：2007-10-17

Applicant: SERVIER LAB ,  MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI

Inventor： MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI

IPC: C07D209/32 ,  A61K31/4045

CPC classification number: C07D209/14

Abstract: Compounds of formula (I): in which: R1 is an alkyl, cycloalkyl or cycloalkylalkyl group, R2 and R3 form, together with the nitrogen atom which bears them, a heterocycle comprising from 5 to 8 ring members, and n is 2 to 6; medicaments.

Abstract translation: 式（I）化合物：其中：R1是烷基，环烷基或环烷基烷基，R2和R3与带有它们的氮原子一起形成包含5至8个环成员的杂环，n是2至6 ; 药物。

公开(公告)号：WO2008049996A3

公开(公告)日：2008-06-19

申请号：PCT/FR2007001707

申请日：2007-10-17

Applicant: SERVIER LAB ,  MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI

Inventor： MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI

IPC: C07D209/42 ,  A61K31/404 ,  A61P1/00 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P35/00

CPC classification number: C07D209/42

Abstract: The invention relates to compounds of formula (I), in which: R is an alkyl, cycloalkyl or cycloalkylalkyl group, R is a linear or branched (C 1 -C 6 ) alkyl group, and n is 1 to 6, and to the use thereof for the treatment of disorders in the melatoninergic system, such as sleep disorders, stress, anxiety, cardiovascular pathologies, etc..

Abstract translation: 本发明涉及式（I）化合物，其中：R是烷基，环烷基或环烷基烷基，R是直链或支链（C 1 -C 6 - ）烷基，n为1至6，以及其用于治疗褪黑激素系统中的疾病的用途，例如睡眠障碍，应激，焦虑，心血管病变等。

公开(公告)号：UA91646C2

公开(公告)日：2010-08-10

申请号：UAA200904633

申请日：2007-10-17

Applicant: SERVIER LAB

Inventor： MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  GAIGNARD DANIEL-HENRI

IPC: C07D209/42 ,  A61K31/404 ,  A61P3/04 ,  A61P15/00 ,  A61P25/00 ,  A61P35/00

公开(公告)号：MA30795B1

公开(公告)日：2009-10-01

申请号：MA31791

申请日：2009-04-16

Applicant: SERVIER LAB

Inventor： MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI

IPC: C07D209/42 ,  A61K31/404 ,  A61P1/00 ,  A61P15/00 ,  A61P25/00 ,  A61P35/00 ,  A61P9/00

Abstract: COMPOSÉS DE FORMULE (I), DANS LAQUELLE R1 REPRÉSENTE UN GROUPEMENT ALKYLE, CYCLOALKYLE, OU CYCLOALKYLALKYLE; R2 REPRÉSENTE UN GROUPEMENT ALKYLE (C1-C6) LINÉAIRE OU RAMIFIÉ; ET N REPRÉSENTE 1 À 6, ET LEUR UTILISATION POUR TRAITER LES TROUBLES DU SYSTÈME MÉLATONINERGIQUE TELS QUE LES TROUBLES DU SOMMEIL, LE STRESS, L'ANXIÉTÉ, LES PATHOLOGIES CARDIOVASCULAIRES, ETC.

公开(公告)号：AU2007203045A1

公开(公告)日：2008-01-17

申请号：AU2007203045

申请日：2007-06-29

Applicant: SERVIER LAB

Inventor： DELAGRANGE PHILIPPE ,  DESROSES MATTHIEU ,  AUDINOT VALERIE ,  BERTHELOT PASCAL ,  BASILE PERES ,  YOUS SAID ,  CAIGNARD DANIEL-HENRI ,  SPEDDING MICHAEL ,  SABAOUNI AHMED ,  BOUTIN JEAN-ALBERT

IPC: C07C15/24 ,  A61K31/165 ,  A61P25/00 ,  A61P25/08 ,  A61P25/16 ,  A61P25/24 ,  C07C43/20 ,  C07C215/20 ,  C07C233/08 ,  C07C233/18 ,  C07C255/33

Abstract: Naphthalenic derivatives (I) and their enantiomers, diastereoisomer or additive salts of acid or base, are new. Naphthalenic derivatives of formula (I) and their enantiomers, diastereoisomer or additive salts of acid or base, are new. R 1R 4or NHR 4; R 41-6C (halo)alkyl, 1-6C alkenyl, polyhalo(1-6C)alkyl, 3-8C cycloalkyl, 3-8C cycloalkyl(1-6C)alkyl, aryl, aryl(1-6C)alkyl, heteroaryl or heteroaryl(1-6C)alkyl; R 21-6C alkyl substituted 1-6C alkoxy, OH, OSO 2CH 3, N 3, NRR1a, NHCOR1b or NHSO 2R1b; either R, R1a : H or 1-6C alkyl, 3-8C cycloalkyl, aryl or aryl(1-6C)alkyl; or NRR1a : 5-6 membered ring having another heteroatom e.g. N, O or S; R1b : R; and R 3H, halo, 1-6C alkyl or 1-6C alkenyl. Provided that: when R 1is methyl and R 2is hydroxymethyl, then R 3is not hydrogen; the aryl is phenyl, naphthyl or biphenyl; and the heteroaryl is mono or bicyclic heteroaryl with 1-3 heteroatoms e.g. oxygen, sulfur and nitrogen. An independent claim is included for the preparation of (I). [Image] ACTIVITY : Hypnotic; Tranquilizer; Antidepressant; Cardiovascular-Gen; Gastrointestinal-Gen; Muscular-Gen; CNS-Gen; Neuroleptic; Anorectic; Anticonvulsant; Antidiabetic; Antiparkinsonian; Nootropic; Dermatological; Antimigraine; Neuroprotective; Cytostatic; Cerebroprotective; Endocrine-Gen.; Contraceptive. MECHANISM OF ACTION : Melatoninergic receptor agonist. The melatoninergic receptor inhibiting activity of N-[3-methoxy-2-(7-methoxy-1-naphtyl)propyl]acetamide was tested. The result showed that the compound had an inhibition constant (Ki) value of 4.9 mu M.

公开(公告)号：FR2857010B1

公开(公告)日：2005-09-16

申请号：FR0307949

申请日：2003-07-01

Applicant: SERVIER LAB

Inventor： LANGLOIS MICHEL ,  MATHE ALLAINMAT MONIQUE ,  CHAHED MONCEF AMINE ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  BENNEJEAN CAROLINE ,  DELAGRANGE PHILIPPE ,  RENARD PIERRE

IPC: A61P25/00 ,  A61P35/00 ,  C07C233/05 ,  A61K31/165

公开(公告)号：NZ532221A

公开(公告)日：2005-07-29

申请号：NZ53222104

申请日：2004-04-08

Applicant: SERVIER LAB

Inventor： POISSONNIER-DURIEUX SOPHIE ,  WALLEZ VALERIE ,  GASNEREAU ANNE ,  YOUS SAID ,  LESIEUR DANIEL ,  DELAGRANGE PHILIPPE ,  ENARD PIERRE ,  BENNEJEAN CAROLINE ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE

IPC: C07D217/14 ,  A61K31/472 ,  A61P1/00 ,  A61P3/02 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D217/16 ,  C07D217/24 ,  A61K31/4045 ,  A61P9/10 ,  A61P25/14 ,  A61P25/18 ,  C07D221/04

Abstract: Described is a compound of formula (I): wherein n is l, 2 or 3, A represents a group -NR-C(=Z)-R', -C(=Z)-N(R)-R', or a group -NR-C(=Z)-N(R')-R", wherein: Z represents a S or O; R and R", which may be identical or different, each represents a H or alkyl group; R' represents an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, aryl, aryl-alkyl, heteroaryl or heteroaryl-alkyl group; X represents N or N-R1 wherein R1 represents a H or alkyl, cycloalkyl, cycloalkyl-alkyl, aryl, aroyl, aryl-alkyl, heteroaryl, heteroaroyl or heteroaryl-alkyl group; R2 represents an alkoxy, cycloalkoxy or cycloalkyl-alkoxy group Provided are processes for the preparation of compounds if the formula (I) and descriptions of their use in the preparation of medicaments for treatment of disorders of the melatoninergic system.

公开(公告)号：HK1067121A1

公开(公告)日：2005-04-01

申请号：HK04110086

申请日：2004-12-21

Applicant: SERVIER LAB

Inventor： POISSONNIER-DURIEUX SOPHIE ,  WALLEZ VALERIE ,  GASNEREAU ANNE ,  YOUS SAID ,  LESIEUR DANIEL ,  DELAGRANGE PHILIPPE ,  RENARD PIERRE ,  BENNEJEAN CAROLINE ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE

IPC: C07D217/14 ,  A61K20090101 ,  A61K31/472 ,  A61P20090101 ,  A61P1/00 ,  A61P3/02 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D20090101 ,  C07D217/16 ,  C07D217/24

公开(公告)号：ES2223110T3

公开(公告)日：2005-02-16

申请号：ES98400711

申请日：1998-03-26

Applicant: SERVIER LAB

Inventor： PEGLION JEAN-LOUIS ,  GOUMENT BERTRAND ,  MILLAN MARK ,  GOBERT ALAIN ,  AUDINOT VALERIE

IPC: A61K31/443 ,  A61K31/4433 ,  A61K31/445 ,  A61P3/00 ,  A61P9/00 ,  A61P25/04 ,  A61P25/18 ,  A61P25/30 ,  C07D405/04 ,  C07D409/04 ,  C07D411/04 ,  C07D471/04 ,  A61K31/40

Abstract: N - ARIL PIPERIDINAS DE FORMULA I: DONDE M = 1-5; N = 1,2; R REPRESENTA UN ATOMO DE HIDROGENO, UN RADICAL ALQUILO O ARALQUILO; E REPRESENTA UN ATOMO DE HIDROGENO O UN RADICAL METILO; AR REPRESENTA: A REPRESENTA: Y X, X 1 , X 2 , X 3 Y X 4 REPRESENTAN UN ATOMO DE HIDROGENO O CIERTOS SUSTITUTIVOS. ESTOS COMPUESTOS SON LIGANDOS DEL RECEPTOR 5 - HT 1 B Y RESULTAN UTILES PARA EL TRATAMIENTO DE ENFERMEDADES EN LAS QUE ESTE IMPLICADO EL SISTEMA SEROTONINERGICO.