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公开(公告)号：JPH0830677B2
公开(公告)日：1996-03-27
申请号：JP18440388
申请日：1988-07-21
Applicant: SHIMADZU CORP
Inventor： ODA ICHIRO
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公开(公告)号：JPH0838480A
公开(公告)日：1996-02-13
申请号：JP19739894
申请日：1994-07-30
Applicant: SHIMADZU CORP
Inventor： TSUNASAWA YOSHIO , NAKAMURA KAN , EDA HIDEO , ODA ICHIRO
Abstract: PURPOSE:To provide a living body measuring device by a photon counting method by counting the signal from a light detector for detecting the light from a testee, which is irradiated with high speed modulated light, by a counter connected to a plurality of time gate circuits operated in mutually different phases, respectively, through a discriminator. CONSTITUTION:The modulated light from a laser diode 22 is applied to a testee 2, and the diffuse-transmitted reflected light is detected by a photomultiplier 30. A high voltage power source 34 applies a high voltage to the photomultiplier 30 with a frequency according to the harmonic pulse signal from an oscillator 32, and the frequency of the harmonic pulse signal from the oscillator 32 is set slightly different from the frequency for driving the laser diode 22. The output signal of the photomultiplier 30 is inputted in parallel into n-pieces of time gate circuits 40-1 to 40-n, the gate signal from a gate signal generating circuit 42 formed on the basis of the reference pulse from the oscillator 20 is applied to a gate driving circuit 44, and the measured values of counters 46-1 to 46-n are taken into a CPU 50.
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公开(公告)号：JPH04249746A
公开(公告)日：1992-09-04
申请号：JP41613390
申请日：1990-12-31
Applicant: SHIMADZU CORP
Inventor： ODA ICHIRO
Abstract: PURPOSE:To obtain an image being based only on an internal change and not affected by the movement of a body to be inspected, by a method wherein information on an external form on a sectional plane being an object is extracted from two tomographic images, correction in regard to the movement of the body is executed and a processing of subtraction is conducted between those images. CONSTITUTION:Information on an external form on the same sectional plane of a body to be inspected is extracted from original images f(i, j) and f'(i, j) and thereby binary-coded images g(i, j) and g'(i, j) are obtained. These two binary-coded images can be made to accord with each other by rotating one of the two images (g) and g' by theta and translating it by epsilon=( i, j). When an evaluation function S is defines as the equation and the values theta and epsilon are determined so that this function S be the minimum value, therefore, it is the amount of movement of the body to be inspected between the two images and values -theta and - epsilon are the amounts of modification. One of the original images (f) and f', e.g. the original image f', is corrected by these amounts of modification and thereby an image f''(i, j) is obtained By conducting subtraction between this image f'' and the image (f), a subtraction image f(i, j) representing only an internal change is obtained.
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公开(公告)号：JPH03285145A
公开(公告)日：1991-12-16
申请号：JP8585890
申请日：1990-03-31
Applicant: SHIMADZU CORP
Inventor： ODA ICHIRO
Abstract: PURPOSE:To efficiently collect data by performing the scanning due to laser beam within the limit range based on the table prepared corresponding to the size and shape of an object to be measured. CONSTITUTION:The laser beam from a laser oscillator 42 is reflected by the rotary mirror of a scanner 2 and shaken to perform the scanning of an object 1 to be measured. The region covered with the defecting angle phi of 1 - Nch (channel) of a detector 3 becomes a measuring range. Further, the rotary frame having the scanner 2 and the detector 3 mounted thereon is rotated around the object 1 to be measured by a rotary driving apparatus and stopped at every (K) divided positions to perform the scanning of the object 1 to be measured. At this time, a table performing the scanning only of the range Skch - Ekch matched with the size and shape of the object 1 to be measured is automatically formed by a scanning table forming apparatus. After the table is formed, scanning is performed within the range limited by a CPU and efficiency is enhanced and a measuring time is shortened.
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公开(公告)号：JP2014085188A
公开(公告)日：2014-05-12
申请号：JP2012233198
申请日：2012-10-22
Applicant: Shimadzu Corp , 株式会社島津製作所
Inventor： IKEHARA TATSUYA , ODA ICHIRO
IPC: G01N21/64
Abstract: PROBLEM TO BE SOLVED: To obtain an accurate result while decreasing measurement cost in fluorescence image reconstruction.SOLUTION: Using a plurality of system matrices prepared in advance so as to make their absorption and scattering coefficients different from each other at a suitable discretization distance for a model shape, the distribution of a fluorescence light source in a sample is reconstructed having the steps (A) to (D) described below. (A) An actually measured shape acquisition step in which a sample is actually measured to acquire an actually measured shape, which is a three-dimensional surface shape; (B) a shape error calculation step in which an error between the model shape and the actually measured shape is calculated; (C) a correction step in which a corrected discretization distance is obtained by correcting the discretization distance on the basis of the shape error, and also an optimum system matrix is obtained by selecting or correcting one from the plurality of system matrices; and (D) a fluorescence image reconstruction step in which the distribution of the fluorescence light source in the sample is reconstructed on the basis of a surface luminance distribution acquired by actually measuring the sample and on the basis of the corrected discretization distance and optimum system matrix acquired by the correction step.
Abstract translation: 要解决的问题：为了在降低荧光图像重建中的测量成本的同时获得准确的结果。解决方案：使用预先准备的多个系统矩阵，以便在适当的离散距离处使它们的吸收和散射系数彼此不同 模型形状，重建样品中荧光光源的分布，具有下述步骤（A）至（D）。 （A）实际测量的形状获取步骤，其中实际测量样本以获取作为三维表面形状的实际测量的形状; （B）计算出模型形状与实测形状之间的误差的形状误差计算步骤; （C）校正步骤，其中通过基于形状误差校正离散距离来获得校正的离散距离，并且通过从多个系统矩阵中选择或校正一个来获得最佳系统矩阵; 以及（D）荧光图像重建步骤，其中基于通过实际测量样品获取的表面亮度分布并且基于校正的离散距离和最佳系统矩阵来重建样品中的荧光光源的分布 通过校正步骤获得。
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Patent Agency Ranking
公开(公告)号：JPH10132519A
公开(公告)日：1998-05-22
申请号：JP30710896
申请日：1996-10-31
Applicant: SHIMADZU CORP
Inventor： KUMAZAWA YOSHIHIKO , EDA HIDEO , ODA ICHIRO , TSUNASAWA YOSHIO , KUMAGAI HIROAKI
Abstract: PROBLEM TO BE SOLVED: To improve the unevenness of sensibility at every position due to the irregularity of the surface of a detected body. SOLUTION: A thin optical beam is radiated from a laser beam irradiating device 10 toward a detected body 71, and the then transmitted beam is made incident on a solid image pickup element 12 through a multifiber optical element 23 which has a surface-shape suited to the irregularity of the surface of the detected body 71 and is stuck fast to the surface of the detected body 71 and a convex lens, and the optical beam is scanned to take out only a picture element data corresponding to a scanned position among image data for one sheet obtained from the solid image pickup element 12 at every scanned position for creating the image.
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公开(公告)号：JPH09152402A
公开(公告)日：1997-06-10
申请号：JP33796495
申请日：1995-11-30
Applicant: SHIMADZU CORP
Inventor： TSUNASAWA YOSHIO , ITO YASUNOBU , ODA ICHIRO
IPC: G01N21/27 , A61B5/145 , A61B5/1455 , A61B10/00 , G01N21/17 , G01N21/35 , G01N21/359 , G01N21/49 , A61B5/14
Abstract: PROBLEM TO BE SOLVED: To obtain positional resolutions even when a photodetector is separated from a sample equal to those when it contacts the sample. SOLUTION: A plurality of photodetecting ends 12-1, 12-2... are fixed at an equal interval on a holder 24 to receive measuring light transmitted through a sample 2 diffusing at measuring points on the surface thereof. Convex lenses 10-1, 10-2... are fixed on the holder 24 between the sample 2 and photodetecting ends 12-1, 12-2... as imaging optical system by which images at respective measuring points on the surface of the sample are formed at the photodetecting ends 21-1, 12-2.... Output light diffused and transmitted through the inside of the sample 2 is admitted simultaneously into the number of the photodetecting ends 12-1, 12-2... to be received. At this point, images at the respective measuring points on the surface of the sample 2 are formed at the photodetecting ends 12-1, 12-2... corresponding thereto by the lenses 10-1, 10-2....
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公开(公告)号：JPH05306993A
公开(公告)日：1993-11-19
申请号：JP13991992
申请日：1992-04-30
Applicant: SHIMADZU CORP
Inventor： ODA ICHIRO , TAKADA MICHINOSUKE
Abstract: PURPOSE:To make possible measurement of a large light receiving intensity change even by the use of a detector of a narrow dynamic range. CONSTITUTION:Light is received from an object 2 to be measured at a light receiving end 12 of an optical fiber 14 and its received light is introduced to a detector 20 through a lens 18 from an outgoing end 10 thereof. An optical filter 26 different in a transmission factor according to positions in an optical path between the lens 18 and the detector 20, a scanner mirror 24 for scanning the received light on the optical filter 26 and a recess face mirror 28 for gathering light transmitting through the optical filter 26 and introducing to the detector 20 are provided. A position through which light introduced to the detector 20 transmits the optical filter 26 is changed by means of the scanner mirror 24 for the purpose of changing the transmission factor by means of the filter 26 and making a light quantity incident on the detector 20 almost constant without any relation to a light reception position.
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公开(公告)号：JPH03118673A
公开(公告)日：1991-05-21
申请号：JP25561589
申请日：1989-09-30
Applicant: SHIMADZU CORP
Inventor： ODA ICHIRO
Abstract: PURPOSE:To automatically prepare a reconstructing mask exactly corresponding to the object of inspection and to shorten time required for reconstructing a picture regardless of the size, shape, set position and direction, etc., of the object by comparing the values of respective picture elements in the picture, which is obtained by the first scan concerning the object of the inspection, with a prescribed threshold value. CONSTITUTION:In the dynamic scan, picture data Fo(n1,n2) obtained at first by the reconstruction are used and from these data, the reconstruction mask is prepared. In an area where there is no inspection object, absorption is extremely reduced and in that area, the picture element value Fo is extremely small. Accordingly, a value slightly higher than this picture element value is set as a threshold value W and compared with the Fo. Then, it is decided whether the object of the inspection is the picture element to be existence or not. In such a way, a column number n1 of the picture element is defined as S1 and continuously, the number n1 of the picture element, for which a value larger than the W is started, is defined as the value of S2. Afterwards, by using these values S1 and S2, the reconstructing mask is prepared.
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公开(公告)号：JP2013238498A
公开(公告)日：2013-11-28
申请号：JP2012111940
申请日：2012-05-15
Applicant: Shimadzu Corp , 株式会社島津製作所
Inventor： IKEHARA TATSUYA , ODA ICHIRO , YAJIMA ATSUSHI , HIZUME KENTARO
Abstract: PROBLEM TO BE SOLVED: To reduce calculation cost while maintaining calculation accuracy in creating a fluorescent image using an optical diffusion equation.SOLUTION: An image processing device 2 includes: a forward problem analysis part 10 that theoretically calculates light propagation analysis for excitation light in a sample and fluorescent light by finite element analysis of an optical diffusion equation; and an inverse problem analysis part 20 that creates a fluorescent image of the inside of the sample, on the basis of three-dimensional surface shape data, fluorescence measurement data, and a result in the forward problem analysis part 10. The forward problem analysis part 10 includes: a mesh size deriving part 12 that derives an optimum mesh size for the finite element analysis of the sample from a specific conditional expression; and an excitation light intensity correction part 14 that corrects excitation light intensity for each mesh of the derived mesh size, by use of the three-dimensional surface shape data and an additionally determined irradiation distribution measurement value of the excitation light. The inverse problem analysis part 20 creates a fluorescent image by means of the mesh size determined in the forward problem analysis part 10 and the corrected excitation light intensity.
Abstract translation: 要解决的问题：降低计算成本，同时保持使用光学扩散方程产生荧光图像的计算精度。解决方案：图像处理装置2包括：正向问题分析部分10，其理论上计算激发光的光传播分析 样品和荧光灯通过光学扩散方程的有限元分析; 以及基于三维表面形状数据，荧光测量数据以及正向问题分析部10中的结果，生成样品内部的荧光图像的逆问题分析部20。正向问题分析部 10包括：网格尺寸导出部分12，其针对来自特定条件表达式的样本的有限元分析导出最佳网格尺寸; 以及通过使用三维表面形状数据和另外确定的激发光的照射分布测量值来校正衍生的网格尺寸的每个网格的激发光强度的激发光强度校正部分14。 反问题分析部20通过在前向问题分析部10中确定的网格尺寸和校正的激发光强度来生成荧光图像。
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