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公开(公告)号：HRP20080611T3
公开(公告)日：2008-12-31
申请号：HRP20080611
申请日：2008-11-25
Applicant: SOLVAY PHARM BV
Inventor： WESKE MICHAEL , TURSKI LECHOSLAW A , IKONOMIDOU HRISSANTHI , ZIEGLER DIETER
Abstract: The invention relates to a novel use of known benzazepine, benzoxazepine, benzothiazepine-N-acetic acid and phosphono-substituted benzazepinone derivatives having neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity. The compounds of the invention are useful for the preparation of pharmaceutical compositions for prophylaxis and treatment of neurodegenerative disorders. The compounds of the invention are known from the European patents EP 0 733 642 and EP 0 916 679, and can be described by the general formula (1) wherein the symbols have the meanings as given above in the description.
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公开(公告)号：DE602005009487D1
公开(公告)日：2008-10-16
申请号：DE602005009487
申请日：2005-01-10
Applicant: SOLVAY PHARM BV
Inventor： WESKE MICHAEL , TURSKI LECHOSLAW A , IKONOMIDOU HRISSANTHI , ZIEGLER DIETER
Abstract: The invention relates to a novel use of known benzazepine, benzoxazepine, benzothiazepine-N-acetic acid and phosphono-substituted benzazepinone derivatives having neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity. The compounds of the invention are useful for the preparation of pharmaceutical compositions for prophylaxis and treatment of neurodegenerative disorders. The compounds of the invention are known from the European patents EP 0 733 642 and EP 0 916 679, and can be described by the general formula (1) wherein the symbols have the meanings as given above in the description.
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公开(公告)号：AT406899T
公开(公告)日：2008-09-15
申请号：AT05701469
申请日：2005-01-10
Applicant: SOLVAY PHARM BV
Inventor： WESKE MICHAEL , TURSKI LECHOSLAW A , IKONOMIDOU HRISSANTHI , ZIEGLER DIETER
Abstract: The invention relates to a novel use of known benzazepine, benzoxazepine, benzothiazepine-N-acetic acid and phosphono-substituted benzazepinone derivatives having neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity. The compounds of the invention are useful for the preparation of pharmaceutical compositions for prophylaxis and treatment of neurodegenerative disorders. The compounds of the invention are known from the European patents EP 0 733 642 and EP 0 916 679, and can be described by the general formula (1) wherein the symbols have the meanings as given above in the description.
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公开(公告)号：CA2551789C
公开(公告)日：2011-05-03
申请号：CA2551789
申请日：2005-01-10
Applicant: SOLVAY PHARM BV
Inventor： WESKE MICHAEL , TURSKI LECHOSLAW A , IKONOMIDOU HRISSANTHI , ZIEGLER DIETER
Abstract: The invention relates to a novel use of known benzazepine, benzoxazepine, benzothiazepine-N-acetic acid and phosphono-substituted benzazepinone derivatives having neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity. The compounds of the invention are useful for the preparation of pharmaceutical compositions for prophylaxis and treatment of neurodegenerative disorders. The compounds of the invention are known from the European patents EP 0 733 642 and EP 0 916 679, and can be described by the general formula (1) wherein the symbols have the meanings as given above in the description.
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公开(公告)号：ZA200908631B
公开(公告)日：2010-08-25
申请号：ZA200908631
申请日：2009-12-04
Applicant: SOLVAY PHARM BV
Inventor： TURSKI LECHOSLAW A , STOIT AXEL , KRUSE CORNELIS G , VADER SANDER , TULP MARTINUS TH M
IPC: A61K20060101 , A61P20060101 , C07C20060101
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Patent Agency Ranking
公开(公告)号：PT1706121E
公开(公告)日：2008-12-04
申请号：PT05701469
申请日：2005-01-10
Applicant: SOLVAY PHARM BV
Inventor： WESKE MICHAEL , TURSKI LECHOSLAW A , IKONOMIDOU HRISSANTHI , ZIEGLER DIETER
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公开(公告)号：BRPI0506750A
公开(公告)日：2007-05-22
申请号：BRPI0506750
申请日：2005-01-10
Applicant: SOLVAY PHARM BV
Inventor： WESKE MICHAEL , TURSKI LECHOSLAW A , IKONOMIDOU HRISSANTHI , ZIEGLER DIETER
Abstract: The invention relates to a novel use of known benzazepine, benzoxazepine, benzothiazepine-N-acetic acid and phosphono-substituted benzazepinone derivatives having neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity. The compounds of the invention are useful for the preparation of pharmaceutical compositions for prophylaxis and treatment of neurodegenerative disorders. The compounds of the invention are known from the European patents EP 0 733 642 and EP 0 916 679, and can be described by the general formula (1) wherein the symbols have the meanings as given above in the description.
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公开(公告)号：CA2551789A1
公开(公告)日：2005-07-28
申请号：CA2551789
申请日：2005-01-10
Applicant: SOLVAY PHARM BV
Inventor： TURSKI LECHOSLAW A , WESKE MICHAEL , ZIEGLER DIETER , IKONOMIDOU HRISSANTHI
Abstract: The invention relates to a novel use of known benzazepine, benzoxazepine, benzothiazepine-N-acetic acid and phosphono-substituted benzazepinone derivatives having neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity. The compounds of the invention are useful for the preparation of pharmaceutical compositions for prophylaxis an d treatment of neurodegenerative disorders. The compounds of the invention are known from the European patents EP 0 733 642 and EP 0 916 679, and can be described by the general formula (1) wherein the symbols have the meanings a s given above in the description.
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公开(公告)号：AU2005205067A1
公开(公告)日：2005-07-28
申请号：AU2005205067
申请日：2005-01-10
Applicant: SOLVAY PHARM BV
Inventor： IKONOMIDOU HRISSANTHI , WESKE MICHAEL , TURSKI LECHOSLAW A , ZIEGLER DIETER
IPC: A61K31/55
Abstract: The invention relates to a novel use of known benzazepine, benzoxazepine, benzothiazepine-N-acetic acid and phosphono-substituted benzazepinone derivatives having neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity. The compounds of the invention are useful for the preparation of pharmaceutical compositions for prophylaxis and treatment of neurodegenerative disorders. The compounds of the invention are known from the European patents EP 0 733 642 and EP 0 916 679, and can be described by the general formula (1) wherein the symbols have the meanings as given above in the description.
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公开(公告)号：BRPI0813658A2
公开(公告)日：2016-10-18
申请号：BRPI0813658
申请日：2008-06-23
Applicant: SOLVAY PHARM BV
Inventor： STOIT AXEL , KRUSE CORNELIS G , TURSKI LECHOSLAW A , TULP MARTINUS TH M , VADER SANDER
IPC: A61K31/135 , A61P25/24 , C07C291/04
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