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公开(公告)号：NO20063623L
公开(公告)日：2006-10-12
申请号：NO20063623
申请日：2006-08-10
Applicant: SOLVAY PHARM BV
Inventor： WESKE MICHAEL , TURSKI LECHOSLAW A , IKONOMIDOU HRISSANTHI , ZIEGLER DIETER
IPC: A61K31/55
Abstract: The invention relates to a novel use of known benzazepine, benzoxazepine, benzothiazepine-N-acetic acid and phosphono-substituted benzazepinone derivatives having neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity. The compounds of the invention are useful for the preparation of pharmaceutical compositions for prophylaxis and treatment of neurodegenerative disorders. The compounds of the invention are known from the European patents EP 0 733 642 and EP 0 916 679, and can be described by the general formula (1) wherein the symbols have the meanings as given above in the description.
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公开(公告)号：AU2005205067B2
公开(公告)日：2009-10-22
申请号：AU2005205067
申请日：2005-01-10
Applicant: SOLVAY PHARM BV
Inventor： IKONOMIDOU HRISSANTHI , WESKE MICHAEL , TURSKI LECHOSLAW A , ZIEGLER DIETER
IPC: A61K31/55
Abstract: The invention relates to a novel use of known benzazepine, benzoxazepine, benzothiazepine-N-acetic acid and phosphono-substituted benzazepinone derivatives having neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity. The compounds of the invention are useful for the preparation of pharmaceutical compositions for prophylaxis and treatment of neurodegenerative disorders. The compounds of the invention are known from the European patents EP 0 733 642 and EP 0 916 679, and can be described by the general formula (1) wherein the symbols have the meanings as given above in the description.
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公开(公告)号：SI1706121T1
公开(公告)日：2009-02-28
申请号：SI200530457
申请日：2005-01-10
Applicant: SOLVAY PHARM BV
Inventor： WESKE MICHAEL , TURSKI LECHOSLAW A , IKONOMIDOU HRISSANTHI , ZIEGLER DIETER
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公开(公告)号：DK1706121T3
公开(公告)日：2009-01-05
申请号：DK05701469
申请日：2005-01-10
Applicant: SOLVAY PHARM BV
Inventor： WESKE MICHAEL , TURSKI LECHOSLAW A , IKONOMIDOU HRISSANTHI , ZIEGLER DIETER
Abstract: The invention relates to a novel use of known benzazepine, benzoxazepine, benzothiazepine-N-acetic acid and phosphono-substituted benzazepinone derivatives having neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity. The compounds of the invention are useful for the preparation of pharmaceutical compositions for prophylaxis and treatment of neurodegenerative disorders. The compounds of the invention are known from the European patents EP 0 733 642 and EP 0 916 679, and can be described by the general formula (1) wherein the symbols have the meanings as given above in the description.
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公开(公告)号：HK1109568A1
公开(公告)日：2008-06-13
申请号：HK08100232
申请日：2008-01-09
Applicant: SOLVAY PHARM BV
Inventor： WESKE MICHAEL , TURSKI LECHOSLAW A , IKONOMIDOU HRISSANTHI , ZIEGLER DIETER
IPC: A61K20060101 , A61P20060101
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Patent Agency Ranking
公开(公告)号：CY1108588T1
公开(公告)日：2014-04-09
申请号：CY081101348
申请日：2008-11-24
Applicant: SOLVAY PHARM BV
Inventor： WESKE MICHAEL , TURSKI LECHOSLAW A , IKONOMIDOU HRISSANTHI , ZIEGLER DIETER
Abstract: Ηεφεύρεσησχετίζεταιμεμιανέαχρήσηγνωστώνπαραγώγωνβενζαζεπίνης, βενζοξαζεπίνης, βενζοθειαζεπινο-Ν-οξικούοξέοςκαιφωσφονο-υποκατεστημένηςβενζαζεπινόνηςταοποίαέχουνανασταλτικήδράσητηςουδέτερηςενδοπεπτιδάσης (ΝΕΡ) ή/καιτηςανθρώπινηςδιαλυτήςενδοπεπτιδάσης (hSEP). Οιενώσειςτηςεφεύρεσηςείναιχρήσιμεςγιατηνπαρασκευήφαρμακευτικώνσυνθέσεωνγιατηνπροφύλαξηκαιθεραπείανευροεκφυλιστικώνπαθήσεων. ΟιενώσειςτηςεφεύρεσηςείναιγνωστέςαπόταευρωπαϊκάδιπλώματαΕΡ 0 733 642 καιΕΡ 0 916 679, καιμπορούνναπεριγραφούνμετονγενικότύπο (1) στονοποίοτασύμβολαέχουντιςσημασίεςόπωςδίδονταιανωτέρωστηνπεριγραφή.
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公开(公告)号：ES2313279T3
公开(公告)日：2009-03-01
申请号：ES05701469
申请日：2005-01-10
Applicant: SOLVAY PHARM BV
Inventor： WESKE MICHAEL , TURSKI LECHOSLAW A , IKONOMIDOU HRISSANTHI , ZIEGLER DIETER
Abstract: Uso de un compuesto de fórmula general (1) (Ver fórmula) donde R1 representa un grupo de fórmula (2) o (3): (Ver fórmulas) A representa CH2, O ó S, R2 y R3 representan independientemente hidrógeno o halógeno, R4 y R6 representan independientemente hidrógeno o un grupo que forma un éster carboxílico biolábil; R5 se selecciona del grupo que consiste en alcoxi(C1-C6)alquilo(C1-C6) que puede estar substituído por alcoxi(C1-C6), fenil-alquilo(C1-C6) y feniloxi-alquilo(C1-C6) donde el grupo fenilo puede estar substituído con alquilo(C1-C6), alcoxi(C1-C6) o halógeno, y naftil-alquilo(C1-C6), R7 y R8 representan independientemente hidrógeno o un grupo que forma un éster de ácido fosfónico biolábil, todos los estereoisómeros, así como sales farmacológicamente aceptables de los mismos, para la preparación de composiciones farmacéuticas para la profilaxis y el tratamiento de afecciones seleccionadas del grupo que consiste en lesión cerebral traumática, encefalomielitis aguda diseminada, lesión cerebral relacionada con epilepsia, lesión de la médula espinal, meningitis y meningoencefalitis bacteriana o viral, enfermedades priónicas, envenenamientos con compuestos neurotóxicos, lesión cerebral inducida por radiación y para la profilaxis de íctus isquémico, con la condición de que tales composiciones farmacéuticas no contengan un antagonista del receptor de aldosterona.
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公开(公告)号：NO20063623A
公开(公告)日：2006-10-12
申请号：NO20063623
申请日：2006-08-10
Applicant: SOLVAY PHARM BV
Inventor： WESKE MICHAEL , TURSKI LECHOSLAW A , IKONOMIDOU HRISSANTHI , ZIEGLER DIETER
IPC: A61K31/55
CPC classification number: A61K31/55
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公开(公告)号：HRP20080611T3
公开(公告)日：2008-12-31
申请号：HRP20080611
申请日：2008-11-25
Applicant: SOLVAY PHARM BV
Inventor： WESKE MICHAEL , TURSKI LECHOSLAW A , IKONOMIDOU HRISSANTHI , ZIEGLER DIETER
Abstract: The invention relates to a novel use of known benzazepine, benzoxazepine, benzothiazepine-N-acetic acid and phosphono-substituted benzazepinone derivatives having neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity. The compounds of the invention are useful for the preparation of pharmaceutical compositions for prophylaxis and treatment of neurodegenerative disorders. The compounds of the invention are known from the European patents EP 0 733 642 and EP 0 916 679, and can be described by the general formula (1) wherein the symbols have the meanings as given above in the description.
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公开(公告)号：DE602005009487D1
公开(公告)日：2008-10-16
申请号：DE602005009487
申请日：2005-01-10
Applicant: SOLVAY PHARM BV
Inventor： WESKE MICHAEL , TURSKI LECHOSLAW A , IKONOMIDOU HRISSANTHI , ZIEGLER DIETER
Abstract: The invention relates to a novel use of known benzazepine, benzoxazepine, benzothiazepine-N-acetic acid and phosphono-substituted benzazepinone derivatives having neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity. The compounds of the invention are useful for the preparation of pharmaceutical compositions for prophylaxis and treatment of neurodegenerative disorders. The compounds of the invention are known from the European patents EP 0 733 642 and EP 0 916 679, and can be described by the general formula (1) wherein the symbols have the meanings as given above in the description.
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