公开(公告)号：NO20076616A

公开(公告)日：2008-02-01

申请号：NO20076616

申请日：2007-12-21

Applicant: SOLVAY PHARM GMBH

Inventor： MESSINGER JOSEF ,  WESKE MICHAEL ,  KOSKIMIES PASI ,  THOLE HEINRICH-HUBERT ,  HUSEN BETTINA ,  PIRKKALA LILA

IPC: C07J41/00

CPC classification number: C07J71/0052 ,  C07J41/0072 ,  C07J43/003 ,  C07J71/0068

公开(公告)号：AU2006251154A1

公开(公告)日：2006-11-30

申请号：AU2006251154

申请日：2006-05-24

Applicant: SOLVAY PHARM GMBH

Inventor： MESSINGER JOSEF ,  KOSKIMIES PASI ,  THOLE HEINRICH-HUBERT ,  PIRKKALA LILA ,  HUSEN BETTINA ,  WESKE MICHAEL

IPC: C07J41/00 ,  A61K31/565 ,  A61K31/58 ,  A61P5/32 ,  C07J43/00 ,  C07J71/00

Abstract: The present invention relates to novel substituted steroid derivatives which represent selectiv inhibitors of the 17ß-hydroxysteroid dehydrogenase type I (17ß-HSD1) and, in addition, which may represent inhibitors of the steroid sulphatase, as well as to their salts, to pharmaceutical preparations containing these compounds and to processes for the preparation of these compounds. Furthermore, the invention concerns the therapeutic use of said novel substituted steroid derivatives, particularly their use in the treatment or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17ß-hydroxysteroid dehydrogenase type I and/or steroid sulphatase enzymes and/or requiring the lowering of the endogenous 17ß-estradiol concentration.

公开(公告)号：HK1117538A1

公开(公告)日：2009-01-16

申请号：HK08108101

申请日：2008-07-23

Applicant: SOLVAY PHARM GMBH

Inventor： MESSINGER JOSEF ,  HEINRICH-HUBERT THOLE H ,  HUSEN BETTINA ,  KOSKIMIES PASI ,  PIRKKALA LILA ,  WESKE MICHAEL

IPC: A61K20060101 ,  A61P20060101 ,  C07J20060101

Abstract: The present invention relates to novel substituted steroid derivatives which represent selectiv inhibitors of the 17ß-hydroxysteroid dehydrogenase type I (17ß-HSD1) and, in addition, which may represent inhibitors of the steroid sulphatase, as well as to their salts, to pharmaceutical preparations containing these compounds and to processes for the preparation of these compounds. Furthermore, the invention concerns the therapeutic use of said novel substituted steroid derivatives, particularly their use in the treatment or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17ß-hydroxysteroid dehydrogenase type I and/or steroid sulphatase enzymes and/or requiring the lowering of the endogenous 17ß-estradiol concentration.

公开(公告)号：NO20076616L

公开(公告)日：2008-02-01

申请号：NO20076616

申请日：2007-12-21

Applicant: SOLVAY PHARM GMBH

Inventor： MESSINGER JOSEF ,  WESKE MICHAEL ,  KOSKIMIES PASI ,  THOLE HEINRICH-HUBERT ,  HUSEN BETTINA ,  PIRKKALA LILA

IPC: C07J41/00

Abstract: The present invention relates to novel substituted steroid derivatives which represent selectiv inhibitors of the 17ß-hydroxysteroid dehydrogenase type I (17ß-HSD1) and, in addition, which may represent inhibitors of the steroid sulphatase, as well as to their salts, to pharmaceutical preparations containing these compounds and to processes for the preparation of these compounds. Furthermore, the invention concerns the therapeutic use of said novel substituted steroid derivatives, particularly their use in the treatment or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17ß-hydroxysteroid dehydrogenase type I and/or steroid sulphatase enzymes and/or requiring the lowering of the endogenous 17ß-estradiol concentration.

公开(公告)号：CA2609726A1

公开(公告)日：2006-11-30

申请号：CA2609726

申请日：2006-05-24

Applicant: SOLVAY PHARM GMBH

Inventor： HUSEN BETTINA ,  THOLE HEINRICH-HUBERT ,  KOSKIMIES PASI ,  PIRKKALA LILA ,  MESSINGER JOSEF ,  WESKE MICHAEL

IPC: C07J41/00 ,  A61K31/565 ,  A61K31/58 ,  A61P5/32 ,  C07J43/00 ,  C07J71/00

Abstract: The present invention relates to novel substituted steroid derivatives which represent selectiv inhibitors of the 17ß-hydroxysteroid dehydrogenase type I (17ß-HSD1) and, in addition, which may represent inhibitors of the steroid sulphatase, as well as to their salts, to pharmaceutical preparations containing these compounds and to processes for the preparation of these compounds. Furthermore, the invention concerns the therapeutic use of said novel substituted steroid derivatives, particularly their use in the treatment or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17ß-hydroxysteroid dehydrogenase type I and/or steroid sulphatase enzymes and/or requiring the lowering of the endogenous 17ß-estradiol concentration.