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    17beta-HSD1 and STS inhibitors
    2.
    发明专利
    17beta-HSD1 and STS inhibitors 未知

    公开(公告)号：AU2006251154B2

    公开(公告)日：2012-06-28

    申请号：AU2006251154

    申请日：2006-05-24

    Applicant: SOLVAY PHARM GMBH

    Inventor： PIRKKALA LILA ,  MESSINGER JOSEF ,  HUSEN BETTINA ,  THOLE HEINRICH-HUBERT ,  WESKE MICHAEL ,  KOSKIMIES PASI

    IPC: C07J41/00 ,  A61K31/565 ,  A61K31/58 ,  A61P5/32 ,  C07J43/00 ,  C07J71/00

    Abstract: The present invention relates to novel substituted steroid derivatives which represent selectiv inhibitors of the 17&bgr;-hydroxysteroid dehydrogenase type I (17&bgr;-HSD1) and, in addition, which may represent inhibitors of the steroid sulphatase, as well as to their salts, to pharmaceutical preparations containing these compounds and to processes for the preparation of these compounds. Furthermore, the invention concerns the therapeutic use of said novel substituted steroid derivatives, particularly their use in the treatment or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17&bgr;-hydroxysteroid dehydrogenase type I and/or steroid sulphatase enzymes and/or requiring the lowering of the endogenous 17&bgr;-estradiol concentration.

    17BETA-HSD1 E INHIBIDORES STS.
    6.
    发明专利
    17BETA-HSD1 E INHIBIDORES STS. 未知

    公开(公告)号：MX2007014736A

    公开(公告)日：2008-02-15

    申请号：MX2007014736

    申请日：2006-05-24

    Applicant: SOLVAY PHARM GMBH

    Inventor： KOSKIMIES PASI ,  WESKE MICHAEL ,  MESSINGER JOSEF ,  THOLE HEINRICH-HUBERT ,  HUSEN BETTINA ,  PIRKKALA LILA

    IPC: C07J41/00 ,  A61K31/565 ,  A61K31/58 ,  A61P5/32 ,  C07J43/00 ,  C07J71/00

    Abstract: La presente invencion se refiere a nuevos derivados de esteroides sustituidos que representan inhibidores selectivos de la enzima 17??-hidroxiesteroide deshidrogenasa tipo I (17??-HSD1) y, ademas, que pueden representar inhibidores del esteroide sulfatasa, asi como a sus sales, a preparaciones farmaceuticas que contienen a estos compuestos y a procedimientos para la preparacion de estos compuestos. Ademas de ello, la invencion concierne al uso terapeutico de dichos nuevos derivados de esteroides sustituidos, en particular a su uso en el tratamiento o la prevencion de enfermedades o trastornos dependientes de hormonas esteroides, tales como enfermedades o trastornos dependientes de la hormona esteroide que requieren la inhibicion de las enzimas 17??-hidroxiesteroide deshidrogenasa tipo I y/o sulfatasa esteroide y/o que requieren la reduccion de la concentracion de 17??-estradiol endogena.

    9.
    发明专利
    未知

    公开(公告)号：UA92348C2

    公开(公告)日：2010-10-25

    申请号：UAA200714185

    申请日：2006-05-24

    Applicant: SOLVAY PHARM GMBH

    Inventor： MESSINGER JOSEF ,  THOLE HEINRICH-HUBERT ,  HUSEN BETTINA ,  KOSKIMIES PASI ,  PIRKKALA LILA ,  WESKE MICHAEL

    IPC: C07J41/00 ,  A61K31/565 ,  A61K31/58 ,  A61P5/32 ,  C07J43/00 ,  C07J71/00

    Abstract: Взаявкеописаныновыезамещенныепроизводныестероидов, которыеявляютсяселективнымиингибиторами 17β-гидроксистероиддегидрогеназытипаИ (17β-ГСД1) икоторыедополнительномогутбытьингибиторамистероидсульфатазы, атакжеихсоли, фармацевтическиепрепараты, которыесодержатэтисоединения, испособыполученияэтихсоединений. Крометого, взаявкеописаноприменениеуказанныхновыхзамещенныхпроизводныхстероидовдлялечения, особенноихприменениедлялеченияилипредупреждениязависимыхотстероидногогормоназаболеванийилинарушений, такихкакзависимыеотстероидногогормоназаболеванияилинарушения, длякоторыхнеобходимоингибированиефермента 17β-гидроксистероиддегидрогеназытипаИ и/илистероидсульфатазыи/илинеобходимоснижениеконцентрацииэндогенного 17β-эстрадиола.

    10.
    发明专利
    未知

    公开(公告)号：BRPI0611623A2

    公开(公告)日：2010-09-21

    申请号：BRPI0611623

    申请日：2006-05-24

    Applicant: SOLVAY PHARM GMBH

    Inventor： THOLE HEINRICH-HUBERT ,  HUSEN BETTINA ,  KOSKIMIES PASI ,  PIRKKALA LILA ,  WESKE MICHAEL ,  MESSINGER JOSEF

    IPC: C07J41/00 ,  A61K31/565 ,  A61K31/58 ,  A61P5/32 ,  C07J43/00 ,  C07J71/00

    Abstract: The present invention relates to novel substituted steroid derivatives which represent selectiv inhibitors of the 17ß-hydroxysteroid dehydrogenase type I (17ß-HSD1) and, in addition, which may represent inhibitors of the steroid sulphatase, as well as to their salts, to pharmaceutical preparations containing these compounds and to processes for the preparation of these compounds. Furthermore, the invention concerns the therapeutic use of said novel substituted steroid derivatives, particularly their use in the treatment or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17ß-hydroxysteroid dehydrogenase type I and/or steroid sulphatase enzymes and/or requiring the lowering of the endogenous 17ß-estradiol concentration.

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