公开(公告)号：WO1994024968A1

公开(公告)日：1994-11-10

申请号：PCT/US1993004171

申请日：1993-05-03

Applicant: SUMMIT TECHNOLOGY, INC.

Inventor： SUMMIT TECHNOLOGY, INC. ,  KLOPOTEK, Peter, J.

IPC: A61F09/00

CPC classification number: A61F9/00802 ,  A61B2017/00694 ,  A61B2017/306 ,  A61F9/00819 ,  A61F9/009 ,  A61F2009/00846 ,  A61F2009/00872

Abstract: Systems and methods are disclosed for aligning and confining laser beam (18) exposure to a defined target region (42) of biological tissue during laser surgery by employing a floating lens (24) which is mechanically coupled to a reference element, such as a target tissue securing assembly (16), in order to compensate for movements of the target during surgical procedures. The floating lens forms part of the imaging optics and, by its design, directs the laser beam to follow the movements of the target tissue regardless of translational movements of the target.

Abstract translation: 公开了用于在激光手术期间对准和限制激光束（18）暴露于生物组织的限定目标区域（42）的系统和方法，其通过采用机械耦合到诸如目标的参考元件的浮动透镜（24） 组织固定组件（16），以便在外科手术过程中补偿靶的运动。 浮动透镜构成成像光学元件的一部分，并且通过其设计，引导激光束跟随目标组织的运动，而不管目标的平移运动如何。

公开(公告)号：WO1994004107A1

公开(公告)日：1994-03-03

申请号：PCT/US1992006864

申请日：1992-08-14

Applicant: SUMMIT TECHNOLOGY, INC.

Inventor： SUMMIT TECHNOLOGY, INC. ,  SEILER, Theo ,  KLOPOTEK, Peter, J.

IPC: A61F09/00

CPC classification number: B23K26/073 ,  A61F9/00804 ,  A61F9/00817 ,  A61F2009/00872

Abstract: Laser surface ablation methods and apparatus are disclosed reprofiling surfaces astigmatically. An optical system (10) includes cylindrically-powered elements (18) to form an elliptical laser irradiation pattern (30) on a target surface. By successively altering the area of the elliptical irradiation, an astigmatic, bi-powered ablation profile is achieved. Preferably, the invention is used with an excimer laser for excimer laser keratoplasty, keratomileusis or other ablative eye surgeries.

Abstract translation: 公开了激光表面消融方法和装置，使散射表面变得模糊。 光学系统（10）包括圆柱形供电元件（18），以在目标表面上形成椭圆形激光照射图案（30）。 通过依次改变椭圆辐射的面积，实现散光，双功率消融轮廓。 优选地，本发明与准分子激光器用于准分子激光角膜移植术，角膜磨镶术或其它烧蚀性眼科手术一起使用。

公开(公告)号：WO1996017566A1

公开(公告)日：1996-06-13

申请号：PCT/US1995015877

申请日：1995-12-04

Applicant: SUMMIT TECHNOLOGY, INC.

Inventor： SUMMIT TECHNOLOGY, INC. ,  MULLER, David, F.

IPC: A61F09/00

CPC classification number: G02B3/04 ,  A61F9/00804 ,  A61F9/0081 ,  A61F9/00819 ,  A61F2009/00844 ,  A61F2009/00872 ,  B23K26/0734

Abstract: Methods and systems are disclosed for corneal reprofiling employing an annular beam of ablative radiation to correct refractive errors in vision, and/or create "blend zones" in order to reduce any surface discontinuities on the cornea following hyperopia-correcting or astigmatism-correcting procedures. Preferably, the methods and systems of the present invention also operate to change the intensity distribution of the light beam, such that the annulus of radiation has a varying intensity as a function of radius and, thereby, achieves a blending or other desired effect with the least number of pulses. Methods of photorefractive keratectomy (PRK) are disclosed, including the steps of (a) selectively reprofiling a cornea of an eye by removing a volume of corneal tissue with ablative radiation to form a reprofiled region in the optical zone which steepens, at least in part, the central curvature of the cornea; and (b) applying to a peripheral region of the cornea an annular beam of ablative radiation having an intensity which varies radially from an inner to an outer segment of the annular beam to create a blend zone, thereby providing a smooth transition between the reprofiled region and an unablated region of the cornea. Optical lens elements also are disclosed having a generally conic front face and a rear face which is generally perpendicular to the path of the incident beam. Light passing through this optical element will be refracted into an annular beam. Variations in the intensity profile of the annular beam can be introduced by employing an initial beam which has a non-uniform profile, or by modifying the shape of either the front face or the rear face of the optical element.

Abstract translation: 公开了使用消融辐射的环形光束矫正视力中的屈光不正的角膜再生方法和系统，和/或创建“混合区域”，以便在远视矫正或散光矫正程序之后减少角膜上的任何表面不连续性。 优选地，本发明的方法和系统还用于改变光束的强度分布，使得辐射环带具有作为半径的函数的变化的强度，从而实现与 脉冲数量最少。 公开了光折射角膜切除术（PRK）的方法，包括以下步骤：（a）通过用消融辐射去除一定体积的角膜组织来选择性地重新生成眼睛的角膜，以在光学区域中形成复原区域，至少部分地陡峭 ，角膜的中心曲率; 和（b）向角膜的周围区域施加环形辐射辐射束，其具有从环形光束的内部到外部部分径向变化的强度，以产生混合区域，从而在再现区域 和角膜的一个无节段的区域。 公开了光学透镜元件，其具有大致圆锥前表面和大体上垂直于入射光束的路径的后表面。 穿过该光学元件的光将折射成环形光束。 可以通过采用具有不均匀轮廓的初始光束或通过改变光学元件的正面或背面的形状来引入环形光束的强度分布的变化。

公开(公告)号：WO1995027534A1

公开(公告)日：1995-10-19

申请号：PCT/US1995004042

申请日：1995-04-07

Applicant: SUMMIT TECHNOLOGY, INC.

Inventor： SUMMIT TECHNOLOGY, INC. ,  MULLER, David, F. ,  SACHAROFF, Alex, C. ,  KLOPOTEK, Peter, J.

IPC: A61N05/02

CPC classification number: A61F9/008 ,  A61B90/30 ,  A61B2017/00017 ,  A61B2017/00176 ,  A61B2017/00181 ,  A61B2017/00194 ,  A61F9/00804 ,  A61F9/00808 ,  A61F2009/00844 ,  A61F2009/00848 ,  A61F2009/00872 ,  A61F2009/00895

Abstract: A method and system are described for performing photorefractive keratectomy, a desired refractive correction in the corneal tissue. The method and system employ control (32) of the effect of ocular fluid at the corneal surface so as to reduce the disturbance of such fluid on the desired ablation process while maintaining hydration of the corneal tissue. Controlling the average repetition rate (26) of the radiation pulses (24) applied to the corneal surface so as to reduce intrapulse fluid accumulation at the corneal surface without dehydrating the corneal tissue, selecting an increased fluence level of the pulse applied to the corneal surface to reduce the effect of fluid accumulation at the corneal surface, and applying evaporative energy to the site of incidence of a pulse of an ablative beam prior to incidence of said pulse at said site are shown as ways to effect this control. Application of the new method and system to wide area ablation techniques and to scanning techniques are described.

Abstract translation: 描述了用于进行光折射角膜切除术，角膜组织中期望的屈光矫正的方法和系统。 该方法和系统采用对角膜表面的眼液的影响的控制（32），以便在保持角膜组织水合的同时减少所需消融过程中的这种流体的干扰。 控制施加到角膜表面的辐射脉冲（24）的平均重复率（26），以减少角膜表面的脉冲内液体积聚，而不会使角膜组织脱水，选择增加到角膜表面的脉冲的注量水平 以减少在角膜表面的液体积聚的影响，并且在所述位置处的所述脉冲入射之前将消耗能量施加到烧蚀光束的脉冲的入射部位被示出为实现该控制的方式。 描述了新方法和系统对广域消融技术和扫描技术的应用。

公开(公告)号：WO1995027436A1

公开(公告)日：1995-10-19

申请号：PCT/US1995004177

申请日：1995-04-05

Applicant: SUMMIT TECHNOLOGY, INC.

Inventor： SUMMIT TECHNOLOGY, INC. ,  MULLER, David, F. ,  D'AGATI, Mike ,  FRIEDMAN, Marc ,  HARMON, Troy ,  KLOPOTEK, Peter ,  SACHAROFF, Alex ,  SHERR, Evan

IPC: A61B05/05

CPC classification number: A61F9/008 ,  A61F9/00804 ,  A61F9/00817 ,  A61F2009/00844 ,  A61F2009/00872

Abstract: The invention features improvements in PRK procedures that relate to preventing non-uniform removal of material from the corneal surface. It has been realized that protoablation by-products resulting during the PRK procedure can affect the accuracy and the predictability of the procedure. Under certain conditions, the plume of photoablation by-products (44) that have left the corneal surface (60) can non-uniformly redeposit onto the ablation area and thus affect the uniformity of subsequent material removal. The plume of photoablation by-products, in the space above the corneal surface, can also non-uniformly affect the escape of further photoablation products from the surface. In addition to the plume effects, it has been realized that the hydration level of the corneal tissue during the PRK procedure can vary over the ablation area and likewise non-uniformly affect the PRK procedure.

Abstract translation: 本发明的特征在于PRK程序的改进涉及防止材料从角膜表面的不均匀去除。 已经意识到，在PRK程序期间产生的原型化副产物可能影响程序的准确性和可预测性。 在某些条件下，离开角膜表面（60）的光消除副产物（44）的羽毛可能不均匀地再沉积到消融区域上，从而影响随后的材料去除的均匀性。 在角膜表面以上的空间中，光消融副产物的羽毛也可以不均匀地影响进一步的光消化产物从表面的逸出。 除了羽流效应之外，已经认识到在PRK程序期间角膜组织的水合水平可以在消融区域上变化，并且同样不均匀地影响PRK程序。

公开(公告)号：WO1994007424A1

公开(公告)日：1994-04-14

申请号：PCT/US1993009580

申请日：1993-10-07

Applicant: SUMMIT TECHNOLOGY, INC.

Inventor： SUMMIT TECHNOLOGY, INC. ,  MULLER, David, F. ,  SACHAROFF, Alex, C.

IPC: A61B17/36

CPC classification number: A61F9/00821 ,  A61F2009/00844 ,  A61F2009/00853 ,  A61F2009/00872

Abstract: The invention is a system and method for modifying the corneal curvature by irradiating the cornea to deliver thermal energy to the stroma (134). The system includes multiple irradiation ports for introducing electromagnetic radiation; positioning means (42) such as a hemispherical dome (12) with several tracks (14) for positioning the irradiation ports, respectively, at locations of a pre-selected geometric pattern relative to the pretreated cornea, the geometric pattern being selected to correspond to a desired modified shape of the cornea; transmission means (76) adapted to deliver controlled amounts of the radiation to introduce the radiation to treatment volumes (140) of the stroma in a cooperative manner to induce desired shrinkage of the collagenous stromal tissue and cause change in the corneal curvature.

Abstract translation: 本发明是通过照射角膜以将热能传递给基质（134）来改变角膜曲率的系统和方法。 该系统包括用于引入电磁辐射的多个辐射端口; 定位装置（42），例如具有多个轨道（14）的半球形圆顶（12），用于分别在相对于预处理角膜的预选几何图案的位置处定位照射端口，所述几何图案被选择为对应于 角膜的期望的修改形状; 传输装置（76），其适于递送受控量的辐射，以以协作的方式将辐射引入基质的治疗体积（140），以诱导胶原性基质组织的期望收缩并引起角膜曲率的改变。

公开(公告)号：WO1987005496A1

公开(公告)日：1987-09-24

申请号：PCT/GB1987000193

申请日：1987-03-19

Applicant: SUMMIT TECHNOLOGY, INC. ,  RAVEN, Antony, Lovell ,  MARSHALL, John ,  MULLER, David, F.

Inventor： SUMMIT TECHNOLOGY, INC.

IPC: A61F09/00

CPC classification number: A61F9/009 ,  A61B2017/306 ,  A61F9/00804 ,  A61F9/00819 ,  A61F2009/00872 ,  B23K26/066

Abstract: A laser system for reprofiling a surface (18) such as a cornea, comprising a laser (10) and an erodable masking means (14) disposed between the laser and the surface (18) for providing a predefined profile of resistance to the laser radiation, and control means (22) for controlling the laser such that upon irradiation part of the radiation is selectively absorbed and part is transmitted to the surface in accordance with the mask profile, to selectively erode the surface. The masking means may comprise a lens (36) in a rigid structure (30) which is affixed to the surface to position the lens just above or in contact with the surface. A transparent platform (34) may support and position the lens. With a peripheral wall, such a platform may be contoured to form an appropriate lens shaping surface for a quantity of flowable material such as a liquid or gel, which then forms the lens. The masking means may comprise a contact-type lens (40) which is disposed directly upon and preferably affixed to, the surface. The resistance profile can be created by varying the thickness or composition of the masking means. The masking means (1$) may also be eroded as the surface is eroded or may simply alter the intensity of the radiation over the surface, to provide the said profile.

公开(公告)号：WO1986006642A1

公开(公告)日：1986-11-20

申请号：PCT/US1986001022

申请日：1986-05-07

Applicant: SUMMIT TECHNOLOGY, INC.

Inventor： SUMMIT TECHNOLOGY, INC. ,  CLARKE, Richard, H. ,  MULLER, David, F.

IPC: A61N05/00

CPC classification number: G02B6/4296 ,  A61B18/245 ,  A61B90/39 ,  A61B2017/00154 ,  A61B2017/00194 ,  A61B2017/22051 ,  G02B2006/4297

Abstract: A laser therapy system (10) having improved effectiveness in surgical use, particularly in laser angioplasty, can be formed by employing a pulsed source of radiation. The pulsed energy source is preferably an excimer laser (14) having a coherent beam of ultraviolet radiation and preferably is employed in conjunction with a dye laser (20) to produce an output beam which is tunable over a wide portion of the ultraviolet and visible spectrum. The output beam is coupled via a novel coupling device to an optical fiber (48) disposed within a surgical instrument, for example, a percutaneous catheter (80). The operative components are sealed in gas-tight, liquid-tight housing (12). An electronic controller (46) monitors and adjusts the output energy density, duration, and pulse repetition rate. In operation, a pulsed, high energy beam of extremely short duration is available to remove atherosclerotic plaque with less damage to the underlying tissue and less chance of perforating the blood vessel wall.