Abstract:
A plasmin activity reducing agent for use in reducing visual refractive regression in an eye after occurrence of a wide area superficial ablation wound of the anterior corneal surface, by topically administering to the eye said plasmin activity reducing agent, e.g., a plasmin inhibitor such as aprotinin. Such refractive regression often appears in patients that undergo surgical procedures that create such a wound in an attempt to improve the visual acuity of the patient. The invention also relates to a method of preoperatively testing a tear sample from a potential patient for the risk of postoperative visual regression resulting from a procedure that creates such a wide area superficial ablation wound on the cornea, by determining the level of proteolytic agent in the sample as an indicator of potential postoperative visual regression.
Abstract:
Apparatus and methods are disclosed for reprofiling a surface (e.g., the cornea of the eye) by ablation. The apparatus is positioned between a source of ablative radiation and a surface so that the exposure area of the surface to which the radiation is delivered may be varied. In one embodiment, a masking means having apertures of predefined shapes is provided to selectively pass a portion of the radiation and drive means is employed to move the masking means across the beam of radiation in two different directions, thereby effecting two patterns of ablation at the surface, such that the cumulative effect of these two patterns is the selective ablation and reshaping of the surface.
Abstract:
Apparatus and methods to modify the intensity distribution of a beam of radiation, such as a laser, and for eroding surfaces with predetermined shapes. A rotatable mask (10) is formed with one or more apertures (12) that have a geometric spiral shape originating substantially at the center of rotation (14) on the mask. The mask is inserted to the beam for modification of the intensity of that beam, and additionally to form the desired etch pattern on a target surface. In a preferred embodiment, the invention is useful for performing kerotoplasty or keratomileusis.
Abstract:
Apparatus (10) and methods are disclosed for astigmatically ablating surfaces in order to impart new profiles and curvatures to such surfaces. A laser means (12), e.g., a rapidly pulsed laser radiation source, is aligned with a surface (24) to provide photoablative pulses of energy along an optical path to a target region on the surface. A light restricting means (14), such as an adjustable iris or profiled mask, is disposed within the optical path to spatially control the extent of the laser radiation striking the target surface. The light restricting means is adapted to permit orientation (e.g., tilting) in various planes relative to the optical path in order to modify the symmetry of the laser beam, e.g., from a circular shape to an elliptical shape, and thereby provide astigmatic ablation of the surface in a single step.
Abstract:
The invention is a system and method for measuring the shape of a surface. One specific design comprises a corneal topographer which consists of a transparent rigid reference member (2) having a reference surface of a predetermined shape applied to the surface of an eye (12), a light source (3) for irradiating the reference surface and a detection system (5, 7) for detecting light propagating from the reference member to determine information regarding the shape of the corneal surface. Several specific designs are shown that use optical, acoustic, acousto-optic or capacitive techniques to determine a multiplicity of data points, sufficient in number of spacing, to represent information regarding the local topography of the surface of the eye.
Abstract:
This invention is a beam profiler comprising: an intensity modifier (34) constructed and arranged to separately modify the intensity profile of different sub-beam portions of an initial beam to thereby create respective sub-beams each having a respective predetermined modification; and a sub-beam directing optical system constructed and arranged to direct the multiple sub-beams along respective sub-beam beam paths that substantially overlap in an overlap plane (40), whereby a resulting beam of radiation is created at the overlap plane that has an intensity profile equal to the optical incoherent summation of the predetermined intensity profiles of said overlapping sub-beams. The intensity modifier preferably comprises an array of intensity modifying profiling elements (36) disposed across the initial beam each producing a corresponding sub-beam.
Abstract:
Methods and apparatus are disclosed for the correction of presbyopia by reprofiling the cornea to create at least one region having a different focal point, and thereby assist the eye in accommodating for close-viewing conditions. According to the invention, at least one region of different curvature is created by photoablation of the cornea to permit the eye to accommodate for near objects. This "add" region is preferably located near the center of the optical zone and preferably within Bowman's membrane or the adjacent upper portions of the stroma, which lies directly below Bowman's membrane. Apparatus is disclosed, including a laser means and a beam-shaping means, disposed between the laser means and the surface of the cornea, which imposes a defined ablation profile upon the cornea. The system can also include a feedback control means for measuring the effectiveness of the laser during operation and for controlling the laser. The beam-shaping means can include either an aperture e.g., a beam-shaping stop means alone or in combination with a beam-shaping window, or a mask which is photodecomposable or otherwise graded in its absorptive capacity to present a predefined profile of resistance to the laser radiation.
Abstract:
A method and device for lifting the epithelium (1) from a selected area of the eye using a jet assembly (8) constructed to produce an epithelium-detaching fluid jet capable of detaching epithelium that is biologically attached to an underlying structure of the eye. The jet assembly directs the jet having a substantially tangential force to the eye surface in order to separate and remove the epithelium from the relatively hard underlying layer. The device shown also has an epithelium support structure (9) for supporting and maintaining the structural integrity of the lifted epithelium. The lifted epithelium can be biologically preserved and repositioned on the exposed surface of the eye.
Abstract:
Apparatus and methods are disclosed for distributing and delivering laser radiation with substantially uniform intensity to multi-spatial locations. Laser radiation (14) is directed into a fiber optic waveguide (20) which homogenizes the spatial intensity of the laser beam via mode-mixing. The laser radiation is then coupled from the mode-mixing waveguide to multiple distribution fibers (26) that are terminated at desired spatial locations, e.g., at the distal end of a surgical tool (45). The output from each of the multiple distribution fibers is laser radiation of substantially uniform intensity.
Abstract:
A calibration apparatus is disclosed for measuring the properties of a laser beam. The apparatus includes a photoreactive element having a composition which reacts with laser radiation in a manner proportional to the intensity or intensity profile of the laser beam and an alignment means for disposing the photoreactive element in the path of a laser beam, such that the beam can be activated to impinge upon the photoreactive element, and the properties of the beam are recorded by changes in the state of the calibration element.