A PLASMIN ACTIVITY REDUCING AGENT FOR TREATING A SUPERFICIAL CORNEAL ABLATION WOUND AND RELATED SCREENING METHOD
    1.
    发明申请
    A PLASMIN ACTIVITY REDUCING AGENT FOR TREATING A SUPERFICIAL CORNEAL ABLATION WOUND AND RELATED SCREENING METHOD 审中-公开
    一种用于治疗超级角膜闭塞的PLASMIN活动减少剂及相关筛查方法

    公开(公告)号:WO1994005322A1

    公开(公告)日:1994-03-17

    申请号:PCT/US1993008334

    申请日:1993-09-03

    CPC classification number: A61K38/57 A61K38/55 A61K31/56 A61K2300/00

    Abstract: A plasmin activity reducing agent for use in reducing visual refractive regression in an eye after occurrence of a wide area superficial ablation wound of the anterior corneal surface, by topically administering to the eye said plasmin activity reducing agent, e.g., a plasmin inhibitor such as aprotinin. Such refractive regression often appears in patients that undergo surgical procedures that create such a wound in an attempt to improve the visual acuity of the patient. The invention also relates to a method of preoperatively testing a tear sample from a potential patient for the risk of postoperative visual regression resulting from a procedure that creates such a wide area superficial ablation wound on the cornea, by determining the level of proteolytic agent in the sample as an indicator of potential postoperative visual regression.

    Abstract translation: 一种纤维蛋白溶酶活性降低剂,用于通过向眼睛局部施用所述纤溶酶活性降低剂,例如纤溶酶抑制剂如抑肽酶,从而减少眼前表面消融伤口后出现眼睛屈光回退 。 这种屈光回退通常出现在进行外科手术的患者中,这些外科手术创造出这样的伤口以试图改善患者的视力。 本发明还涉及一种从潜在的患者手术前测试泪液样本的方法,其中由于通过确定在角膜中的蛋白水解剂水平而产生在角膜上形​​成如此广泛的表面消融的手术所产生的术后视觉回归的风险 样本作为潜在术后视觉回归的指标。

    INTEGRATED LASER REPROFILING SYSTEMS
    2.
    发明申请
    INTEGRATED LASER REPROFILING SYSTEMS 审中-公开
    集成激光复制系统

    公开(公告)号:WO1996021407A1

    公开(公告)日:1996-07-18

    申请号:PCT/US1995017027

    申请日:1995-12-28

    Abstract: Apparatus and methods are disclosed for reprofiling a surface (e.g., the cornea of the eye) by ablation. The apparatus is positioned between a source of ablative radiation and a surface so that the exposure area of the surface to which the radiation is delivered may be varied. In one embodiment, a masking means having apertures of predefined shapes is provided to selectively pass a portion of the radiation and drive means is employed to move the masking means across the beam of radiation in two different directions, thereby effecting two patterns of ablation at the surface, such that the cumulative effect of these two patterns is the selective ablation and reshaping of the surface.

    Abstract translation: 公开了用于通过消融重新编织表面(例如,眼睛的角膜)的装置和方法。 该设备位于消融辐射源和表面之间,使得可以改变辐射被传送到的表面的曝光区域。 在一个实施例中,提供具有预定形状的孔的掩蔽装置以选择性地通过辐射的一部分,并且采用驱动装置在两个不同的方向上跨过辐射束移动掩蔽装置,由此在 使得这两种模式的累积效应是表面的选择性消融和整形。

    ROTATABLE APERTURE APPARATUS AND METHODS FOR SELECTIVE PHOTOABLATION OF SURFACES
    3.
    发明申请
    ROTATABLE APERTURE APPARATUS AND METHODS FOR SELECTIVE PHOTOABLATION OF SURFACES 审中-公开
    可旋转光孔装置及其选择性表面曝光的方法

    公开(公告)号:WO1994029760A1

    公开(公告)日:1994-12-22

    申请号:PCT/US1994006298

    申请日:1994-06-03

    Abstract: Apparatus and methods to modify the intensity distribution of a beam of radiation, such as a laser, and for eroding surfaces with predetermined shapes. A rotatable mask (10) is formed with one or more apertures (12) that have a geometric spiral shape originating substantially at the center of rotation (14) on the mask. The mask is inserted to the beam for modification of the intensity of that beam, and additionally to form the desired etch pattern on a target surface. In a preferred embodiment, the invention is useful for performing kerotoplasty or keratomileusis.

    Abstract translation: 改变辐射束的强度分布的装置和方法,例如激光,以及用于蚀刻具有预定形状的表面。 可旋转掩模(10)形成有一个或多个孔(12),其具有基本上位于掩模上的旋转中心(14)的几何螺旋形状。 将掩模插入到光束中以修改该光束的强度,并且另外在目标表面上形成期望的蚀刻图案。 在优选实施例中,本发明对于进行成形术或角膜磨镶术是有用的。

    LASER REPROFILING SYSTEM FOR CORRECTION OF ASTIGMATISMS
    4.
    发明申请
    LASER REPROFILING SYSTEM FOR CORRECTION OF ASTIGMATISMS 审中-公开
    用于校正ASTIGMATIS的激光再现系统

    公开(公告)号:WO1994004108A1

    公开(公告)日:1994-03-03

    申请号:PCT/US1992006893

    申请日:1992-08-14

    CPC classification number: B23K26/073 A61F9/00804 A61F9/00817 A61F2009/00872

    Abstract: Apparatus (10) and methods are disclosed for astigmatically ablating surfaces in order to impart new profiles and curvatures to such surfaces. A laser means (12), e.g., a rapidly pulsed laser radiation source, is aligned with a surface (24) to provide photoablative pulses of energy along an optical path to a target region on the surface. A light restricting means (14), such as an adjustable iris or profiled mask, is disposed within the optical path to spatially control the extent of the laser radiation striking the target surface. The light restricting means is adapted to permit orientation (e.g., tilting) in various planes relative to the optical path in order to modify the symmetry of the laser beam, e.g., from a circular shape to an elliptical shape, and thereby provide astigmatic ablation of the surface in a single step.

    Abstract translation: 公开了用于散光表面的装置(10)和方法,以便向这些表面赋予新的轮廓和曲率。 激光装置(12),例如快速脉冲的激光辐射源与表面(24)对准,以沿着表面上的目标区域的光路提供能量的光蚀刻脉冲。 诸如可调节虹膜或异形掩模的光限制装置(14)设置在光路内以便空间地控制射入目标表面的激光辐射的程度。 光限制装置适于允许相对于光路的各个平面中的取向(例如,倾斜),以便改变激光束的对称性,例如从圆形到椭圆形,从而提供散光消除 表面在一个单一的步骤。

    METHOD AND SYSTEM FOR TOPOGRAHIC MEASUREMENT
    5.
    发明申请
    METHOD AND SYSTEM FOR TOPOGRAHIC MEASUREMENT 审中-公开
    地质测量方法与系统

    公开(公告)号:WO1993021818A1

    公开(公告)日:1993-11-11

    申请号:PCT/US1993004158

    申请日:1993-05-03

    CPC classification number: A61B5/0095 A61B3/107

    Abstract: The invention is a system and method for measuring the shape of a surface. One specific design comprises a corneal topographer which consists of a transparent rigid reference member (2) having a reference surface of a predetermined shape applied to the surface of an eye (12), a light source (3) for irradiating the reference surface and a detection system (5, 7) for detecting light propagating from the reference member to determine information regarding the shape of the corneal surface. Several specific designs are shown that use optical, acoustic, acousto-optic or capacitive techniques to determine a multiplicity of data points, sufficient in number of spacing, to represent information regarding the local topography of the surface of the eye.

    Abstract translation: 本发明是用于测量表面形状的系统和方法。 一种具体设计包括角膜地形图,其由具有施加到眼睛表面上的预定形状的参考表面的透明刚性参考构件(2),用于照射参考表面的光源(3)和 检测系统(5,7),用于检测从参考构件传播的光,以确定关于角膜表面的形状的信息。 示出了使用光学,声学,声光或电容技术来确定足够数量的间隔的多个数据点以表示关于眼睛表面的局部形貌的信息的几个具体设计。

    PROFILING THE INTENSITY DISTRIBUTION OF OPTICAL BEAMS
    6.
    发明申请
    PROFILING THE INTENSITY DISTRIBUTION OF OPTICAL BEAMS 审中-公开
    分析光学强度分布

    公开(公告)号:WO1995027535A1

    公开(公告)日:1995-10-19

    申请号:PCT/US1995004101

    申请日:1995-04-03

    Abstract: This invention is a beam profiler comprising: an intensity modifier (34) constructed and arranged to separately modify the intensity profile of different sub-beam portions of an initial beam to thereby create respective sub-beams each having a respective predetermined modification; and a sub-beam directing optical system constructed and arranged to direct the multiple sub-beams along respective sub-beam beam paths that substantially overlap in an overlap plane (40), whereby a resulting beam of radiation is created at the overlap plane that has an intensity profile equal to the optical incoherent summation of the predetermined intensity profiles of said overlapping sub-beams. The intensity modifier preferably comprises an array of intensity modifying profiling elements (36) disposed across the initial beam each producing a corresponding sub-beam.

    Abstract translation: 本发明是一种光束轮廓仪,包括:强度调节器(34),其被构造和布置成单独地修改初始光束的不同子光束部分的强度分布,从而产生各自具有相应的预定修改的子光束; 以及子束定向光学系统,其被构造和布置成将多个子光束沿着在重叠平面(40)中基本重叠的各个子束束路径引导,由此在所述重叠平面上产生所得到的辐射束, 强度分布等于所述重叠子光束的预定强度分布的光学非相干相加。 强度调节剂优选地包括横跨初始光束布置的强度修改型材元件(36)的阵列,每个产生相应的子光束。

    CORRECTION OF PRESBYOPIA BY PHOTOREFRACTIVE KERATECTOMY
    7.
    发明申请
    CORRECTION OF PRESBYOPIA BY PHOTOREFRACTIVE KERATECTOMY 审中-公开
    通过光子学检验校正预聚物

    公开(公告)号:WO1993025166A1

    公开(公告)日:1993-12-23

    申请号:PCT/US1993005645

    申请日:1993-06-10

    Abstract: Methods and apparatus are disclosed for the correction of presbyopia by reprofiling the cornea to create at least one region having a different focal point, and thereby assist the eye in accommodating for close-viewing conditions. According to the invention, at least one region of different curvature is created by photoablation of the cornea to permit the eye to accommodate for near objects. This "add" region is preferably located near the center of the optical zone and preferably within Bowman's membrane or the adjacent upper portions of the stroma, which lies directly below Bowman's membrane. Apparatus is disclosed, including a laser means and a beam-shaping means, disposed between the laser means and the surface of the cornea, which imposes a defined ablation profile upon the cornea. The system can also include a feedback control means for measuring the effectiveness of the laser during operation and for controlling the laser. The beam-shaping means can include either an aperture e.g., a beam-shaping stop means alone or in combination with a beam-shaping window, or a mask which is photodecomposable or otherwise graded in its absorptive capacity to present a predefined profile of resistance to the laser radiation.

    Abstract translation: 公开了通过重新编织角膜来校正老花眼以产生具有不同焦点的至少一个区域的方法和装置,从而帮助眼睛适应近视状态。 根据本发明,通过角膜的光消融产生不同曲率的至少一个区域,以允许眼睛容纳近物体。 这个“添加”区优选地位于光学区的中心附近,优选位于Bowman膜的最上方,或位于Bowman膜正下方的基质的相邻上部。 公开了包括设置在激光装置和角膜表面之间的激光装置和光束成形装置的装置,其在角膜上施加限定的消融轮廓。 该系统还可以包括用于在操作期间测量激光器的有效性并用于控制激光器的反馈控制装置。 光束成形装置可以包括单独的光束整形停止装置或与光束整形窗口组合的光束成形止动装置,或者可光隔离或以其吸收能力分级的掩模,以呈现预定的阻抗曲线 激光辐射。

    REMOVAL OF EPITHELIUM FROM THE EYE
    8.
    发明申请
    REMOVAL OF EPITHELIUM FROM THE EYE 审中-公开
    从眼中去除上皮

    公开(公告)号:WO1993022988A1

    公开(公告)日:1993-11-25

    申请号:PCT/US1993004802

    申请日:1993-05-20

    CPC classification number: A61F9/013 A61B17/3203

    Abstract: A method and device for lifting the epithelium (1) from a selected area of the eye using a jet assembly (8) constructed to produce an epithelium-detaching fluid jet capable of detaching epithelium that is biologically attached to an underlying structure of the eye. The jet assembly directs the jet having a substantially tangential force to the eye surface in order to separate and remove the epithelium from the relatively hard underlying layer. The device shown also has an epithelium support structure (9) for supporting and maintaining the structural integrity of the lifted epithelium. The lifted epithelium can be biologically preserved and repositioned on the exposed surface of the eye.

    METHODS AND APPARATUS FOR DISTRIBUTING LASER RADIATION
    9.
    发明申请
    METHODS AND APPARATUS FOR DISTRIBUTING LASER RADIATION 审中-公开
    用于分布激光辐射的方法和装置

    公开(公告)号:WO1993014432A2

    公开(公告)日:1993-07-22

    申请号:PCT/US1993000297

    申请日:1993-01-13

    CPC classification number: G02B27/0927 A61B18/22 G02B6/421 G02B6/4296 G02B27/09

    Abstract: Apparatus and methods are disclosed for distributing and delivering laser radiation with substantially uniform intensity to multi-spatial locations. Laser radiation (14) is directed into a fiber optic waveguide (20) which homogenizes the spatial intensity of the laser beam via mode-mixing. The laser radiation is then coupled from the mode-mixing waveguide to multiple distribution fibers (26) that are terminated at desired spatial locations, e.g., at the distal end of a surgical tool (45). The output from each of the multiple distribution fibers is laser radiation of substantially uniform intensity.

    Abstract translation: 公开了用于将基本均匀的强度的激光辐射分配和传送到多空间位置的装置和方法。 激光辐射(14)被引导到光纤波导(20)中,其通过模式混合使激光束的空间强度均匀化。 然后将激光辐射从模式混合波导耦合到多个分配纤维(26),其在所需的空间位置例如在外科手术工具(45)的远端处终止。 来自多个分布光纤中的每一个的输出是强度基本均匀的激光辐射。

    CALIBRATION APPARATUS FOR LASER ABLATIVE SYSTEMS
    10.
    发明申请
    CALIBRATION APPARATUS FOR LASER ABLATIVE SYSTEMS 审中-公开
    激光雷达系统校准装置

    公开(公告)号:WO1994025836A1

    公开(公告)日:1994-11-10

    申请号:PCT/US1993004110

    申请日:1993-05-03

    Abstract: A calibration apparatus is disclosed for measuring the properties of a laser beam. The apparatus includes a photoreactive element having a composition which reacts with laser radiation in a manner proportional to the intensity or intensity profile of the laser beam and an alignment means for disposing the photoreactive element in the path of a laser beam, such that the beam can be activated to impinge upon the photoreactive element, and the properties of the beam are recorded by changes in the state of the calibration element.

    Abstract translation: 公开了一种用于测量激光束的性质的校准装置。 该装置包括光反应元件,其具有与激光束的激光辐射成反比的组成,该激光辐射与激光束的强度或强度分布成比例;以及对准装置,用于将光反应元件设置在激光束的路径中,使得光束可 被激活以撞击光反应元件,并且通过校准元件的状态的改变记录光束的属性。

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