公开(公告)号：JPS5927355B2

公开(公告)日：1984-07-05

申请号：JP1911776

申请日：1976-02-23

Applicant: Takeda Chemical Industries Ltd

Inventor： NISHIMURA TATSUO ,  NUMATA MITSUO

IPC: C07D501/04 ,  C07D501/28

公开(公告)号：JPS5831356B2

公开(公告)日：1983-07-05

申请号：JP10004481

申请日：1981-06-26

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  MINAMIDA ISAO ,  YAMAOKA MASAYOSHI ,  SHIRAISHI MITSURU ,  MYAWAKI TOSHIO

IPC: C07D501/20 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/22 ,  C07D501/34 ,  C07D501/36

公开(公告)号：JPS57114591A

公开(公告)日：1982-07-16

申请号：JP10004481

申请日：1981-06-26

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  MINAMIDA ISAO ,  YAMAOKA MASAYOSHI ,  SHIRAISHI MITSURU ,  MIYAWAKI TOSHIO

IPC: C07D501/20 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/22 ,  C07D501/34 ,  C07D501/36

Abstract: NEW MATERIAL:The cephalosporin derivative of formulaI[R is H or lower alkyl; X is O, S, or NR (R is H, lower alkyl, etc.); Y is H, lower acyloxy, or SR (R is nitrogen-containing 5-membered heterocyclic group which may have lower alkyl substituent group and may contain O or S)]. EXAMPLE:7-[2-(2-Aminothiaxol-4-yl)acetamido]-3-(1,3,4-thiadiazol-2-yl) thiomethyl- 3-cephem-4-carboxylic acid sodium salt. USE:Antimicrobial agent effective to respiratory infectious diseases, purulent diseases, infectious diseases of the urinary tract, puerperal infectious diseases, etc. Does: 5-20mg/kg daily by parenteral administration divided in 3-4 doses. PROCESS:The compound of formulaIis prepared by the dehydrative cyclization reaction of a novel compound of formula II in a solvent in the presence of an acid or a base. The starting compound of formula II can be prepared by reacting a novel compound of formula III (w is halogen) with a compound of formula IV.

公开(公告)号：JPS5430194A

公开(公告)日：1979-03-06

申请号：JP9446977

申请日：1977-08-06

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  NISHIMURA TATSUO

IPC: A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/46

Abstract: PURPOSE:[2-(syn)-carbamoyloxyiminoacetamide] cephalosporin and its salt of formula I (Y is H, OH, carbamoyloxy, acyloxy, quaternary ammonium, N-containing heterocyclic thio; R is alkyl, aralkyl, aryl; R is H, ester residue, anion; k is 0, 1).

公开(公告)号：MX156151A

公开(公告)日：1988-07-19

申请号：MX787677

申请日：1977-06-23

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  MINAMIDA ISAO ,  TSUSHIMA SUSUMU

IPC: A61K31/545 ,  C07D501/20

公开(公告)号：DK151026B

公开(公告)日：1987-10-12

申请号：DK5378

申请日：1978-01-05

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  MINAMIDA ISAO ,  YAMAOKA MASAYOSHI ,  SHIRAISHI MITSURU ,  MIYAWAKI TOSHIO

IPC: C07D20060101 ,  C07D501/28 ,  C07D501/36

公开(公告)号：DE3367102D1

公开(公告)日：1986-11-27

申请号：DE3367102

申请日：1983-07-16

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  MIYAKE AKIO ,  OCHIAI MICHIHIKO

IPC: C07D205/08 ,  A61K31/395 ,  A61K31/397 ,  A61K31/40 ,  A61K31/425 ,  A61K31/495 ,  A61P31/04 ,  C07D205/085 ,  C07D205/095 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07F7/10

公开(公告)号：HUT34505A

公开(公告)日：1985-03-28

申请号：HU213584

申请日：1984-05-31

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NISHIMURA TATSUO ,  YOSHIMURA YOSHINOBU ,  NUMATA MITSUO

IPC: C07D501/36 ,  A61K31/54 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C67/08 ,  C07D20060101 ,  C07D257/04 ,  C07D277/22 ,  C07D499/42 ,  C07D501/00 ,  C07D501/02 ,  C07D501/04 ,  C07D501/20 ,  C07D501/34 ,  C07D501/46 ,  C07D501/56

Abstract: A compound of the formula:wherein R. is a hydrogen atom or a lower alkyl group; R 2 is an unsubstituted or lower alkyl-substituted alicyclic alkyl group of 3 to 12 carbon atoms or a C 3-6 alicyclic alkyl-substituted lower alkyl group or a pharmaceutically acceptable salt thereof, processes for preparing the same, a pharmaceutical composition thereof are provided. The compound has an improved absorbability and can be orally applied as antibiotics.

公开(公告)号：FI67384B

公开(公告)日：1984-11-30

申请号：FI771951

申请日：1977-06-22

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  MINAMIDA ISAO ,  TSUSHIMA SUSUMU

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D257/04 ,  C07D277/38 ,  C07D277/40 ,  C07D277/46 ,  C07D499/00 ,  C07D501/00 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/28 ,  C07D501/34 ,  C07D501/36 ,  C07D501/38 ,  C07D501/46 ,  C07D501/56 ,  C07D501/60

Abstract: Disclosed are 2-(syn)-hydroxyimino-acetamide derivatives of the formula: wherein Y is hydrogen, hydroxyl, an acyloxy, carbamoyloxy, a quaternary ammonium or a nitrogen-containing heterocyclic ring-substituted thio group; or pharmaceutically acceptable salts or esters thereof are useful as antibacterial agents. Also disclosed are processes for producing them.

公开(公告)号：NO150083B

公开(公告)日：1984-05-07

申请号：NO744527

申请日：1974-12-16

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  MINAMIDA ISAO ,  YAMAOKA MASAYOSHI ,  SHIRAISHI MITSURU ,  MIYAWAKI TOSHIO

IPC: C07D20060101 ,  C07D501/34 ,  C07D501/36