公开(公告)号：NO880511D0

公开(公告)日：1988-02-05

申请号：NO880511

申请日：1988-02-05

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： TSUSHIMA SUSUMU ,  TAKATANI MUNEO ,  HIRATA MINORU

IPC: C07C271/10 ,  A61K20060101 ,  A61K31/27 ,  A61K31/325 ,  A61K31/335 ,  A61K31/395 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/4468 ,  A61P9/06 ,  C07C20060101 ,  C07C269/02 ,  C07C271/06 ,  C07C271/12 ,  C07C271/24 ,  C07C271/28 ,  C07C275/00 ,  C07C275/14 ,  C07C275/28 ,  C07C323/25 ,  C07C333/04 ,  C07C333/06 ,  C07C333/10 ,  C07D209/48 ,  C07D211/04 ,  C07D211/34 ,  C07D211/58 ,  C07D213/24 ,  C07D213/36 ,  C07D213/38 ,  C07D213/53 ,  C07D295/10 ,  C07D295/12 ,  C07D295/125 ,  C07D295/13 ,  C07D521/00 ,  C07C125/06 ,  C07C155/02 ,  C07D

公开(公告)号：DK45188D0

公开(公告)日：1988-01-29

申请号：DK45188

申请日：1988-01-29

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： TSUSHIMA SUSUMU ,  TAKATANI MUNEO ,  HIRATA MINORU

IPC: C07C271/10 ,  A61K20060101 ,  A61K31/27 ,  A61K31/325 ,  A61K31/335 ,  A61K31/395 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/4465 ,  A61K31/4468 ,  A61P9/06 ,  C07C20060101 ,  C07C269/02 ,  C07C271/06 ,  C07C271/12 ,  C07C271/24 ,  C07C271/28 ,  C07C275/00 ,  C07C275/14 ,  C07C275/28 ,  C07C323/25 ,  C07C333/04 ,  C07C333/06 ,  C07C333/10 ,  C07D209/48 ,  C07D211/04 ,  C07D211/34 ,  C07D211/58 ,  C07D213/24 ,  C07D213/36 ,  C07D213/38 ,  C07D213/53 ,  C07D295/10 ,  C07D295/12 ,  C07D295/125 ,  C07D295/13 ,  C07D521/00 ,  C07C125/07 ,  C07C155/02 ,  C07D213/72

公开(公告)号：NO155099C

公开(公告)日：1987-02-11

申请号：NO813034

申请日：1981-09-07

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： TSUSHIMA SUSUMU ,  SENDAI MICHIYUKI ,  SHIRAISHI MITSURI

IPC: C07D20060101 ,  C07D501/04 ,  C07D501/24

公开(公告)号：PH19543A

公开(公告)日：1986-05-20

申请号：PH27261

申请日：1982-05-11

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  TSUSHIMA SUSUMU ,  MINAMIDA ISAO

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D257/04 ,  C07D277/38 ,  C07D277/40 ,  C07D277/46 ,  C07D499/00 ,  C07D501/00 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/28 ,  C07D501/34 ,  C07D501/36 ,  C07D501/38 ,  C07D501/46 ,  C07D501/56 ,  C07D501/60

Abstract: Disclosed are 2-(syn)-hydroxyimino-acetamide derivatives of the formula: wherein Y is hydrogen, hydroxyl, an acyloxy, carbamoyloxy, a quaternary ammonium or a nitrogen-containing heterocyclic ring-substituted thio group; or pharmaceutically acceptable salts or esters thereof are useful as antibacterial agents. Also disclosed are processes for producing them.

公开(公告)号：CH636358A5

公开(公告)日：1983-05-31

申请号：CH242978

申请日：1978-03-06

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： TSUSHIMA SUSUMU ,  SENDAI MICHIYUKI ,  SHIRAISHI MITSURU

IPC: C07D501/04 ,  C07D501/18 ,  C07D501/26 ,  C07D501/36

公开(公告)号：CA1103236A

公开(公告)日：1981-06-16

申请号：CA352064

申请日：1980-05-15

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： TSUSHIMA SUSUMU ,  SENDAI MICHIYUKI ,  SHIRAISHI MITSURU

IPC: C07D501/16

Abstract: An improved process for preparing cephem compounds of the formula: Í! , wherein R1 represents hydrogen or an acyl group and R2 stands for a substituted or unsubstituted pyridinium or a residue of a nitrogen containing heterocyclic thiol, or a salt thereof, which comprises reacting a compound of the formula; ÍI! , wherein W represents acetonyl or a group represented by -X-COOH or -X-OH(in which X is a divalent carbon chain which is able to form a five- or sixmembered ring with or ,which may include a double bond or such an atom or atoms as oxygen, nitrogen or sulfur therein, and on which carbon chain suitable substituent or substituents may be attached) or a salt thereof with a substituted or unsubstituted pyridine or a nitrogen containing heterocyclic thiol. The procedure, using the above defined compound of formula(II) as starting material results in better yields and/or shorter reaction times.

公开(公告)号：CH616940A5

公开(公告)日：1980-04-30

申请号：CH1711474

申请日：1974-12-20

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： TSUSHIMA SUSUMU ,  MATSUMOTO NORICHIKA ,  NUMATA MITSUO

IPC: C07D499/10 ,  C07D499/00 ,  C07D499/04 ,  C07D499/21 ,  C07D499/42 ,  C07D501/04 ,  C07D501/18 ,  C07D501/60 ,  C07D499/18

Abstract: 7-Amino-3-cephem and 6-aminopenam compounds of the formula H2N-A are prepared either by solvolysis of a compound of the formula R -C(SX) = N-A in which R denotes an organic radical, X denotes chlorine or bromine and A denotes a 7-deamino-3-cephem or 6-deaminopenam radical of the formula: in which the carboxyl group can be protected and R represents a group which does not participate in the reaction, or by chlorination or bromination of a compound of the formula R -CS-NH-A and solvolysis of the resulting compound of the formula R -C(SX) = N-A. The process products are intermediates for the synthesis of penicillins and cephalosporins.

公开(公告)号：CH615188A5

公开(公告)日：1980-01-15

申请号：CH1711574

申请日：1974-12-20

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： TSUSHIMA SUSUMU ,  MATSUMOTO NORICHIKA ,  NUMATA MITSUO

IPC: C07D499/10 ,  C07D499/00 ,  C07D499/04 ,  C07D499/21 ,  C07D499/42 ,  C07D501/04 ,  C07D501/18

公开(公告)号：AU1134976A

公开(公告)日：1977-09-01

申请号：AU1134976

申请日：1976-02-23

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： TSUSHIMA SUSUMU ,  SENDAI MICHIYUKI ,  SHIRAISHI MITSURU

IPC: A61K9/02 ,  A61K31/43 ,  C07D501/04 ,  C07D501/16 ,  C07D501/18 ,  C07D501/26 ,  C07D501/34 ,  C07D501/36 ,  C07D501/28 ,  C07D501/40 ,  C07D501/30 ,  C07D501/32 ,  C07D501/50 ,  C07D501/56 ,  C07D501/46

Abstract: Novel 3-acyloxymethyl-cephem compounds of the formula: wherein R1 is hydrogen or an acyl group; W is acetonyl, or a group represented by -X-COOH or -X-OH (X is an organic residue) or salts thereof were found to be useful as starting materials for preparing cephalosporins of the formula: wherein R3 stands for a residue of a nucleophilic compound and R1 has the same meaning as above.

公开(公告)号：JPH0257555B2

公开(公告)日：1990-12-05

申请号：JP7622482

申请日：1982-05-06

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： TSUSHIMA SUSUMU ,  NISHIKAWA KOHEI

IPC: A61K31/685 ,  A61P9/12 ,  C07C43/178 ,  C07D295/205 ,  C07D319/06 ,  C07F9/09 ,  C07F9/10 ,  C07F9/58 ,  C07F9/6509 ,  C07F9/6533 ,  C07F9/6539