公开(公告)号：EP0616544A1

公开(公告)日：1994-09-28

申请号：EP93900854.0

申请日：1992-12-04

Applicant: TARGET THERAPEUTICS, INC.

Inventor： SEPETKA, Ivan

IPC: A61F2 ,  A61B17 ,  A61B19

CPC classification number: A61B17/12022 ,  A61B17/1214 ,  A61B90/39 ,  A61B2017/12095

Abstract: On décrit un ensemble serpentin/poussoir vasoocclusif (11) que l'on fait avancer à travers un cathéter (24) vers un endroit à l'intérieur d'un vaisseau et que l'on manipule pour détacher le serpentin (13) de l'ensemble. Le poussoir (12) comporte une extrémité distale (17) qui est initialement enfilée dans l'extrémité proximale du serpentin (13). L'ensemble (11) comprend un manchon (14) que l'on fait coulisser sur le poussoir (12) et dont la bordure distale aboutit à l'extrémité distale du serpentin (13) afin de maintenir celui-ci en place alors que l'extrémité distale du poussoir (12) est retirée du serpentin (13) afin de détacher ce dernier (13) de l'endroit où il est placé.

Abstract translation: 公开了一种血管闭塞性线圈/推动器组件（11），其通过导管（24）前进到血管内的位置并被操纵以将线圈（13）从血管分离。 整体。 推动器（12）具有最初拧入线圈（13）近端的远端（17）。 组件（11）包括在推杆（12）上滑动并且其远端边缘终止于线圈（13）的远端以将线圈保持在适当位置的套筒（14） 推动器（12）的远端从线圈（13）移除以将线圈（13）从其放置的位置分离。

公开(公告)号：EP0744976A1

公开(公告)日：1996-12-04

申请号：EP93921535.0

申请日：1993-09-14

Applicant: TARGET THERAPEUTICS, INC.

Inventor： SEPETKA, Ivan ,  PHAM, Phong

IPC: A61M25 ,  A61M39

CPC classification number: A61M25/0069 ,  A61M2025/0057

Abstract: A catheter (11) for use in combination with a guide wire (12) for placement within a tortuous, small vessel and delivery of fluid to a target site. The catheter (11) comprises an elongated tubular body with a perforated flexible tip (20) located at the distal end (15) of the elongated tubular body.

公开(公告)号：EP0741590A1

公开(公告)日：1996-11-13

申请号：EP95909372.0

申请日：1995-01-26

Applicant: TARGET THERAPEUTICS, INC.

Inventor： RICHLING, Bernd ,  SEPETKA, Ivan ,  CHEE, Uriel, Hiram ,  HO, Liem ,  PHAM, Pete, Phong

IPC: A61M25 ,  A61F2

CPC classification number: A61M25/1006 ,  A61M25/0054 ,  A61M25/1025

Abstract: This invention is a microballoon (108) tipped catheter (100). The catheter has a shaft (104) which is of varying flexibility with the most flexible portion towards the distal tip. The balloon is of an elastic material. The catheter shaft has a main lumen (114) extending from the proximal end to the distal end so to allow the use of a guidewire (101) in placing the catheter's distal tip in remote regions. The catheter shaft has a wall that desirably is of multilayered construction. The wall preferably includes an independent lumen (110) which may be formed from a small diameter tubing that is placed between layers of the wall, for the inflation and deflation of the microballoon. The inflation lumen proceeds from the proximal end of the catheter and terminates near the distal end of the catheter but within the microballoon.

公开(公告)号：EP0708621A1

公开(公告)日：1996-05-01

申请号：EP95919135.0

申请日：1995-05-09

Applicant: TARGET THERAPEUTICS, INC.

Inventor： GRAVES, Virgil, B. ,  RAPPE, Alan ,  SEPETKA, Ivan ,  GIA, Son ,  PHAM, Pete, Phong ,  SAMSON, Gene

IPC: A61B17 ,  A61F2 ,  A61B19

CPC classification number: A61B17/221 ,  A61B17/12022 ,  A61B90/39 ,  A61B2017/22035 ,  A61B2017/2212

Abstract: A device for retrieving foreign bodies, such as a vaso-occlusive coil or other articles from within vessels such as those of the cardiovascular system. Two small snare coils (60, 62) are joined at their distal ends (68, 70) to form a loop. The proximal ends of the coils are attached to one or more elongated actuator members (20, 22). The loop size is adjusted by manipulation of one or more of the proximal ends (26, 44) of the elongated actuator members. This retrieval device may be used to ensnare and either reposition or remove foreign bodies within a vessel lumen.

公开(公告)号：EP0585359A1

公开(公告)日：1994-03-09

申请号：EP92912258.0

申请日：1992-05-06

Applicant: TARGET THERAPEUTICS, INC.

Inventor： SEPETKA, Ivan

IPC: A61M25 ,  A61M23

CPC classification number: A61M25/09 ,  A61M25/0054 ,  A61M2025/09091 ,  A61M2025/09166 ,  A61M2025/09175

Abstract: Fil de guidage (10) de cathéter comprenant: une section de fil proximale (13) flexible et à laquelle on peut imprimer un moment de torsion; une section intermédiaire (14) plus flexible recouverte par un tube de polymère souple (19); une section d'extrémité distale (15) très flexible. Une bobine de ruban hélicoïdal (22) s'enroule autour de la partie intermédiaire de l'âme située entre l'âme du fil et le tube en polymère, afin d'augmenter l'opacité aux rayons X et d'améliorer la transmission du moment de torsion, tout en maintenant la flexibilité.

Abstract translation: 一种导管导丝（10），包括：一个柔性的近端导线部分（13），可以施加一个扭转力矩; 由柔性聚合物管（19）覆盖的更柔性的中间部分（14）; 远端部分（15）非常柔韧。 螺旋带状物（22）卷绕在线芯和聚合物管之间的芯的中间部分以增加X射线不透明度并改善线的传输。 扭矩，同时保持灵活性。

公开(公告)号：EP0708621B1

公开(公告)日：2003-01-29

申请号：EP95919135.4

申请日：1995-05-09

Applicant: TARGET THERAPEUTICS, INC.

Inventor： GRAVES, Virgil, B. ,  RAPPE, Alan ,  SEPETKA, Ivan ,  GIA, Son ,  PHAM, Pete, Phong ,  SAMSON, Gene

IPC: A61B17/22

CPC classification number: A61B17/221 ,  A61B17/12022 ,  A61B90/39 ,  A61B2017/22035 ,  A61B2017/2212

Abstract: A device for retrieving foreign bodies, such as a vaso-occlusive coil or other articles from within vessels such as those of the cardiovascular system. Two small snare coils (60, 62) are joined at their distal ends (68, 70) to form a loop. The proximal ends of the coils are attached to one or more elongated actuator members (20, 22). The loop size is adjusted by manipulation of one or more of the proximal ends (26, 44) of the elongated actuator members. This retrieval device may be used to ensnare and either reposition or remove foreign bodies within a vessel lumen.

公开(公告)号：EP0616544B2

公开(公告)日：2000-12-27

申请号：EP93900854.6

申请日：1992-12-04

Applicant: TARGET THERAPEUTICS, INC.

Inventor： SEPETKA, Ivan

IPC: A61M29/00

CPC classification number: A61B17/12022 ,  A61B17/1214 ,  A61B90/39 ,  A61B2017/12095

Abstract: A pusher-vasoocclusive coil assembly (11) that is advanced through a catheter (24) to a site within a vessel and is manipulated to detach the coil (13) from the assembly. The pusher (12) has a distal end (17) that is initially threaded into the proximal end of the coil (13) and the assembly (11) includes a sleeve (14) that is slid over the pusher (12) and whose distal edge abuts the proximal end of the coil (13) to hold the coil (13) in place while the distal end of the pusher (12) is threaded out of the coil (13) to detach the coil (13) at the site.

公开(公告)号：EP0473697A1

公开(公告)日：1992-03-11

申请号：EP90908859.0

申请日：1990-05-22

Applicant: TARGET THERAPEUTICS, INC.

Inventor： ENGELSON, Erik, T. ,  SEPETKA, Ivan

IPC: A61M25

CPC classification number: A61M25/01 ,  A61M25/0012 ,  A61M25/0052 ,  A61M25/0054 ,  A61M25/09 ,  A61M2025/0046 ,  A61M2025/0047 ,  A61M2025/09091

Abstract: L'invention concerne un cathéter (12) permettant d'avoir accès à un site cible le long d'un chemin d'un petit vaisseau tortueux. Le cathéter comprend un segment distal flexible (26) qui est composé d'un tube polymère flexible et d'une surface tubulaire interne de faible friction. La surface permet au cathéter d'avancer et franchir des coudes prononcés et des boucles de petits diamètres dans un fil de guidage (14), pour faire avancer le cathéter le long du chemin d'un petit vaisseau. Divers modes de réalisation du cathéter sont divulgués, dans lesquels la surface tubulaire interne d'une portion distale du cathéter comprend une variété de construction différente qui sont constitués de matériaux différents dans le but d'éviter le coincement, le collement ou le blocage de l'extrémité distale ou de toute autre partie du fil de guidage contre la surface. Des constructions tressées en forme de manchons, des surfaces dans lesquelles sont noyées une multitude de petites particules et des surfaces constituées de divers matériaux anti-friction sont utilisées de manière à obtenir l'objet de l'invention.

公开(公告)号：EP0623012B1

公开(公告)日：1998-05-13

申请号：EP93923916.6

申请日：1993-10-15

Applicant: TARGET THERAPEUTICS, INC. ,  NEW YORK UNIVERSITY

Inventor： BERENSTEIN, Alejandro ,  SEPETKA, Ivan ,  CHEE, U., Hiram ,  ZENZEN, Wendy

IPC: A61B17/12

CPC classification number: A61B17/12022 ,  A61B17/1204 ,  A61B17/12109 ,  A61B17/1214 ,  A61B17/1215 ,  A61B17/12163 ,  A61B90/39 ,  A61B2017/00526 ,  A61B2017/00539 ,  A61B2017/12063 ,  A61B2017/1209

Abstract: This invention is an exceptionally flexible, ultrasoft vaso-occlusive or embolism forming device. It is made of radiopaque material which may be a braid (200), coil (100), or chain (600) which forms a long, thin thread-like device having little rigidity or column strength. The diameter of the device may be less than about 0.010 inches. The filamentary material making up the device used to form the coil (100), braid (200), or chain (600) is typically of a diameter less than about 0.002 inches. The device is sufficiently flexible and small that it may be hydraulically delivered to a site within the vasculature of the human body using an injected drug or fluid flush through a catheter (512). In some configurations, the device may be delivered using pushers (504, 512) to mechanically deliver the device through the catheter lumen. Various mechanical connections may be used to sever the coil by a simple connection of a dissimilar metal to allow electrolytic separation upon application of small voltage is desirable (Figs 5A, 5B).

公开(公告)号：EP0726745A1

公开(公告)日：1996-08-21

申请号：EP95900494.0

申请日：1994-11-01

Applicant: TARGET THERAPEUTICS, INC.

Inventor： PHAM, Pete Phong ,  DOAN, Hong ,  SEPETKA, Ivan

IPC: A61F2 ,  A61B17

CPC classification number: A61B17/12022 ,  A61B17/12113 ,  A61B17/12145 ,  A61B2017/00004 ,  A61B2017/12063

Abstract: This invention is an apparatus for endovascular occlusion through the formation of thrombi in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas. In particular, it deals with a sacrificial link (106) between an endovascular device (104) which is introducted to and is intended to remain at the desired thrombus formation site and the device (102) used to introduce the device. The invention further includes a method for introduction of the device and its electrolytic separation.

Abstract translation: 本发明是一种通过在动脉，静脉，动脉瘤，血管畸形和动静脉瘘中形成血栓来进行血管内闭塞的装置。 特别地，它涉及被引入并意图保持在期望的血栓形成部位处的血管内装置（104）与用于引入装置的装置（102）之间的牺牲连接（106）。 本发明还包括用于引入装置和其电解分离的方法。