公开(公告)号：WO1995009561A1

公开(公告)日：1995-04-13

申请号：PCT/US1994011115

申请日：1994-09-30

Applicant: TARGET THERAPEUTICS, INC.

Inventor： TARGET THERAPEUTICS, INC. ,  SAMSON, Gene ,  VEGH, Gabriel, B. ,  DICKENS, Duane ,  RETTKE, Herbert, G.

IPC: A61B05/042

CPC classification number: A61B5/6851 ,  A61B5/0422

Abstract: This invention is a medical device. It is a multipolar catheter assembly (100) optionally in combination with a guidewire (300). Each of the catheter (100) and the guidewire (300) may be sheathed and have multiple electrodes (114, 306) at their distal ends (102, 322). Because of their size and flexibility, the catheter (100) and the guidewire (300), may be used at virtually any point within the vasculature particularly, however, within the cardiac arteries or veins, perhaps in conjunction with external electrocardiogram leads, tomap the body's electrical activity. When used in the heart, they may be used to determine the source of cardiac arrythmia. The intimate presence of the guidewire (300) or catheter (100) body in the cardiac vasculature allows the response time to changes in cardiac electrical activity to be very quick. The invention is also a method for mapping the electrical activity of the heart by use of one or more of these inventive guidewires (300) or catheters (100) in the cardiac arteries or veins. They may also be used to determine the local electrical activity of any site within the body, such as in the brain.

Abstract translation: 本发明是医疗装置。 它是可选地与导丝（300）组合的多极导管组件（100）。 导管（100）和导丝（300）中的每一个可以被包覆并且在其远端（102,322）处具有多个电极（114,306）。 由于其尺寸和柔性，导管（100）和导丝（300）可以在脉管系统中的几乎任何点处使用，特别是在心脏动脉或静脉内，或许与外部心电图引导相结合 身体的电活动。 当用于心脏时，它们可用于确定心脏性心律失常的来源。 导管（300）或导管（100）主体在心脏血管系统中的紧密存在使得心脏电活动的响应时间变得非常快。 本发明还是通过使用心脏动脉或静脉中的这些创造性导线（300）或导管（100）中的一个或多个来映射心脏的电活动的方法。 它们也可用于确定体内任何部位的局部电活动，例如在脑中。

公开(公告)号：WO1993003786A1

公开(公告)日：1993-03-04

申请号：PCT/US1992007035

申请日：1992-08-19

Applicant: TARGET THERAPEUTICS, INC.

Inventor： TARGET THERAPEUTICS, INC. ,  SAMSON, Gene

IPC: A61M25/00

CPC classification number: A61M25/0905

Abstract: An extendable guidewire assembly comprising: a guidewire (11) having a tapered proximal end; an extension wire (12) having a tapered distal end; and a polymeric tubular sleeve (13) that is fixedly attached about the tapered distal end of the extension wire such that the tapered distal end of the extension wire extends partly through the sleeve lumen, said lumen having a diameter that is smaller than the untapered diameter of the guidewire and wherein said lumen expands radially when the sleeve is under axial compression and contracts radially when the sleeve is under axial tension.

公开(公告)号：WO1996033763A2

公开(公告)日：1996-10-31

申请号：PCT/US1996005839

申请日：1996-04-26

Applicant: TARGET THERAPEUTICS, INC.

Inventor： TARGET THERAPEUTICS, INC. ,  SAMSON, Gene ,  CHEE, U., Hiram ,  NGUYEN, Kim ,  SNYDER, Edward, J. ,  ENGELSON, Erik, T.

IPC: A61M25/00

CPC classification number: A61M25/005 ,  A61M25/0053 ,  A61M25/0054 ,  A61M2025/0081

Abstract: This a catheter assembly and a section of that catheter assembly. That catheter assembly may be used in accessing a tissue target within the body, typically a target which is accessible through the vascular system. Central to the invention is the use of a braided metallic reinforcing member, typically of superelastic alloy ribbon, situated within the catheter body in such a way to create a catheter having an exceptionally thin wall, controlled stiffness, high resistance to kinking, and complete recovery in vivo from kinking situations. The braid may have a single pitch or may vary in pitch along the axis of the catheter or catheter section. The braided ribbon reinforcing member typically is placed between a flexible outer tubing member and an inner tubing member to produce a catheter section which is very flexible but highly kink resistant. The catheter sections made according to this invention may be used alone or in conjunction with other catheter sections either made using the concepts shown herein or made in other ways. The more proximal sections of the catheter assembly are often substantially stiffer than the more distal sections due to the presence of stiff polymeric tubing or metallic tubing or composite materials in the stiffer section.

Abstract translation: 这是导管组件和该导管组件的一部分。 该导管组件可用于进入体内的组织靶，通常是通过血管系统可接近的靶。 本发明的中心是使用位于导管主体内的编织金属加强构件，通常为超弹性合金带，以便产生具有特别薄壁，受控刚度，高耐扭结和完全恢复的导管 在体内从扭结的情况。 编织物可以具有单个间距，或者可以沿着导管或导管部分的轴线变化。 编织带加强构件通常放置在柔性外管构件和内管构件之间以产生非常柔性但高度扭结的导管部分。 根据本发明制造的导管部分可以单独使用或与使用本文所示的概念或以其他方式制成的其它导管部分结合使用。 由于在刚性部分中存在刚性聚合物管或金属管或复合材料，导管组件的较近的部分通常比较远的部分更坚硬。

公开(公告)号：WO1993016630A1

公开(公告)日：1993-09-02

申请号：PCT/US1992011024

申请日：1992-12-16

Applicant: TARGET THERAPEUTICS, INC.

Inventor： TARGET THERAPEUTICS, INC. ,  SAMSON, Gene

IPC: A61B05/00

CPC classification number: A61M39/0613

Abstract: The invention comprises a proximal end fitting (13) for use within a guidewire assembly wherein the proximal end fitting comprises an elongated radially compressible tube. When in use, the tube is compressed against the O-ring seal (38) in the fitting (13) to better facilitate the seal between the O-ring (38) and the guidewire (11) and thereby better control blood reflux.

公开(公告)号：WO1992013589A1

公开(公告)日：1992-08-20

申请号：PCT/US1992000726

申请日：1992-01-28

Applicant: TARGET THERAPEUTICS, INC.

Inventor： TARGET THERAPEUTICS, INC. ,  SAMSON, Gene

IPC: A61M29/00

CPC classification number: A61M29/02 ,  A61M25/0054 ,  A61M25/0075 ,  A61M2025/1063

Abstract: A single lumen valved balloon catheter assembly is disclosed that consists of a single lumen catheter tube (18) that has a distally located integral balloon (42) and a built-in guidewire (16) that has a distal valve member (54) that may be moved axially to engage and block the distal end of the catheter. The diameter of the guidewire is reduced at its distal end and the diameter of the lumen of the catheter tube distally of the balloon is reduced to below that of the proximal diameter of the balloon so that the axial movement of the guidewire distally is limited.

公开(公告)号：EP0722289A1

公开(公告)日：1996-07-24

申请号：EP94929973.0

申请日：1994-09-30

Applicant: TARGET THERAPEUTICS, INC.

Inventor： SAMSON, Gene ,  VEGH, Gabriel B. ,  DICKENS, Duane ,  RETTKE, Herbert G.

IPC: A61B5

CPC classification number: A61B5/6851 ,  A61B5/0422

Abstract: This invention is a medical device. It is a multipolar catheter assembly (100) optionally in combination with a guidewire (300). Each of the catheter (100) and the guidewire (300) may be sheathed and have multiple electrodes (114, 306) at their distal ends (102, 322). Because of their size and flexibility, the catheter (100) and the guidewire (300), may be used at virtually any point within the vasculature particularly, however, within the cardiac arteries or veins, perhaps in conjunction with external electrocardiogram leads, tomap the body's electrical activity. When used in the heart, they may be used to determine the source of cardiac arrythmia. The intimate presence of the guidewire (300) or catheter (100) body in the cardiac vasculature allows the response time to changes in cardiac electrical activity to be very quick. The invention is also a method for mapping the electrical activity of the heart by use of one or more of these inventive guidewires (300) or catheters (100) in the cardiac arteries or veins. They may also be used to determine the local electrical activity of any site within the body, such as in the brain.

公开(公告)号：EP0708621B1

公开(公告)日：2003-01-29

申请号：EP95919135.4

申请日：1995-05-09

Applicant: TARGET THERAPEUTICS, INC.

Inventor： GRAVES, Virgil, B. ,  RAPPE, Alan ,  SEPETKA, Ivan ,  GIA, Son ,  PHAM, Pete, Phong ,  SAMSON, Gene

IPC: A61B17/22

CPC classification number: A61B17/221 ,  A61B17/12022 ,  A61B90/39 ,  A61B2017/22035 ,  A61B2017/2212

Abstract: A device for retrieving foreign bodies, such as a vaso-occlusive coil or other articles from within vessels such as those of the cardiovascular system. Two small snare coils (60, 62) are joined at their distal ends (68, 70) to form a loop. The proximal ends of the coils are attached to one or more elongated actuator members (20, 22). The loop size is adjusted by manipulation of one or more of the proximal ends (26, 44) of the elongated actuator members. This retrieval device may be used to ensnare and either reposition or remove foreign bodies within a vessel lumen.

公开(公告)号：EP0570517B1

公开(公告)日：1996-08-14

申请号：EP92906796.5

申请日：1992-01-28

Applicant: TARGET THERAPEUTICS, INC.

Inventor： SAMSON, Gene

IPC: A61M29/00 ,  A61M29/02

CPC classification number: A61M29/02 ,  A61M25/0054 ,  A61M25/0075 ,  A61M2025/1063

Abstract: A single lumen valved balloon catheter assembly is disclosed that consists of a single lumen catheter tube (18) that has a distally located integral balloon (42) and a built-in guidewire (16) that has a distal valve member (54) that may be moved axially to engage and block the distal end of the catheter. The diameter of the guidewire is reduced at its distal end and the diameter of the lumen of the catheter tube distally of the balloon is reduced to below that of the proximal diameter of the balloon so that the axial movement of the guidewire distally is limited.

公开(公告)号：EP0702576A1

公开(公告)日：1996-03-27

申请号：EP94917372.0

申请日：1994-05-13

Applicant: TARGET THERAPEUTICS, INC.

Inventor： SAMSON, Gene ,  ENGELSON, Erik, T. ,  CHEE, Uriel, Hiram ,  WOODARD, Robert, E.

IPC: A61M25

CPC classification number: A61M25/008 ,  A61M25/0043 ,  A61M25/0053 ,  A61M25/0068 ,  A61M25/09 ,  A61M2025/0057 ,  A61M2025/0073

Abstract: The invention is a surgical instrument and specifically is a catheter (100) for treating a target site by delivering a controlled amount of therapeutic or diagnostic agent (the target site being accessible by a tortuous path through the vasculature), the perfusion tip (110) assembly on first catheter, and a process of using that catheter to deliver fluids to the selected vascular site.

公开(公告)号：EP0601044A1

公开(公告)日：1994-06-15

申请号：EP92918716.0

申请日：1992-08-19

Applicant: TARGET THERAPEUTICS, INC.

Inventor： SAMSON, Gene

IPC: A61B ,  A61M25

CPC classification number: A61M25/0905

Abstract: Un ensemble fil de guidage extensible comprend: un fil de guidage (11) présentant une extrémité proximale conique, un fil prolongateur (12) présentant une extrémité distale conique, ainsi qu'un manchon tubulaire polymère (13) fixé fermement autour de l'extrémité distale conique dudit fil prolongateur de manière que l'extrémité distale conique dudit fil prolongateur s'étende partiellement dans la lumière du manchon, ladite lumière ayant un diamètre plus petit que le diamètre non conique du fil de guidage, et ladite lumière s'élargissant radialement lorsque le manchon est comprimé axialement et se contractant radialement lorsque ledit manchon est tendu axialement.